374 research outputs found
PCSK9 induces a pro-inflammatory response in macrophages.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Intraplaque release of inflammatory cytokines from macrophages is implicated in atherogenesis by inducing the proliferation and migration of media smooth muscle cells (SMCs). PCSK9 is present and released by SMCs within the atherosclerotic plaque but its function is still unknown. In the present study, we tested the hypothesis that PCSK9 could elicit a pro-inflammatory effect on macrophages. THP-1-derived macrophages and human primary macrophages were exposed to different concentrations (0.250\u2009\uf7\u20092.5\u2009\ub5g/ml) of human recombinant PCSK9 (hPCSK9). After 24\u2009h incubation with 2.5\u2009\ub5g/ml PCSK9, a significant induction of IL-1\u3b2, IL-6, TNF-\u3b1, CXCL2, and MCP1 mRNA, were observed in both cell types. Co-culture of THP-1 macrophages with HepG2 overexpressing hPCSK9 also showed the induction of TNF-\u3b1 (2.4\u2009\ub1\u20090.5 fold) and IL-1\u3b2 (8.6\u2009\ub1\u20091.8 fold) mRNA in macrophages. The effect of hPCSK9 on TNF-\u3b1 mRNA in murine LDLR-/- bone marrow macrophages (BMM) was significantly impaired as compared to wild-type BMM (4.3\u2009\ub1\u20091.6 fold vs 31.1\u2009\ub1\u20096.1 fold for LDLR-/- and LDLR+/+, respectively). Finally, a positive correlation between PCSK9 and TNF-\u3b1 plasma levels of healthy adult subjects (males 533, females 537) was observed (B\u2009=\u20098.73, 95%CI 7.54\u2009\uf7\u20099.93, p\u2009<\u20090.001). Taken together, the present study provides evidence of a pro-inflammatory action of PCSK9 on macrophages, mainly dependent by the LDLR
Maraviroc intensification for HIV-1-positive immunological non-responders (INRs) despite virological suppression during HAART
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/11/2010
- Field of study
The Dynamin Chemical Inhibitor Dynasore Impairs Cholesterol Trafficking and Sterol-Sensitive Genes Transcription in Human HeLa Cells and Macrophages
- Author
- A Frolov
- A Radhakrishnan
- AR Tall
- B Bonet
- B Schroeder
- Benoît Védie
- Christophe Lamaze
- E Ikonen
- E Macia
- EL Eskelinen
- Emmanuelle Girard
- HY Choi
- Jean Louis Paul
- JL Goldstein
- JR Duncan
- L Kritharides
- L Kritharides
- L Liscum
- LP Sun
- Ludger Johannes
- M Amessou
- M Cuchel
- MD Wang
- MP Adorni
- MS Brown
- N Attia
- N Khelef
- N Sakashita
- Natalie Fournier
- NL Jones
- P Robinet
- Philippe Beaune
- PK Smith
- R McPherson
- R Out
- R Ross
- RE Soccio
- RJ Cenedella
- S Larrede
- S Sugii
- SW Waldo
- T Kirchhausen
- TY Chang
- W Romer
- Wanjin Hong
- X Du
- X Fu
- XD Zhu
- ZF Stephan
- Publication venue
- Public Library of Science
- Publication date
- 19/12/2011
- Field of study
Intracellular transport of cholesterol contributes to the regulation of cellular cholesterol homeostasis by mechanisms that are yet poorly defined. In this study, we characterized the impact of dynasore, a recently described drug that specifically inhibits the enzymatic activity of dynamin, a GTPase regulating receptor endocytosis and cholesterol trafficking. Dynasore strongly inhibited the uptake of low-density lipoprotein (LDL) in HeLa cells, and to a lower extent in human macrophages. In both cell types, dynasore treatment led to the abnormal accumulation of LDL and free cholesterol (FC) within the endolysosomal network. The measure of cholesterol esters (CE) further showed that the delivery of regulatory cholesterol to the endoplasmic reticulum (ER) was deficient. This resulted in the inhibition of the transcriptional control of the three major sterol-sensitive genes, sterol-regulatory element binding protein 2 (SREBP-2), 3-hydroxy-3-methyl-coenzymeA reductase (HMGCoAR), and low-density lipoprotein receptor (LDLR). The sequestration of cholesterol in the endolysosomal compartment impaired both the active and passive cholesterol efflux in HMDM. Our data further illustrate the importance of membrane trafficking in cholesterol homeostasis and validate dynasore as a new pharmacological tool to study the intracellular transport of cholesterol
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
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- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
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- Alonso F
- Alpigiani C
- Alshehri AA
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- Alviggi MG
- Amaral Coutinho Y
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- Booth CD
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- Caltabiano A
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- Casper DW
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- Chevalerias TJA
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- Zivkovic L
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- Zoccoli A
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- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
The Effects of Apolipoprotein F Deficiency on High Density Lipoprotein Cholesterol Metabolism in Mice
- Author
- AF Hoofnagle
- AM Vaughan
- AP Serdyuk
- Arthi Kumaravel
- AY Tu
- B Miao
- BF Asztalos
- CA Hogarth
- D Bashtovyy
- Daniel J. Rader
- David W. Fields
- Denise Drazul-Schrader
- E Koren
- George H. Rothblat
- J Contois
- JB Massey
- JC Leong
- JP Kane
- JP Segrest
- JR Day
- JS Cohn
- JS Leong
- K Wu
- Kaijin Wu
- L Izem
- LR Boone
- LU Gerdes
- Margarita de la Llera-Moya
- Massimo Federici
- MK Jones
- MP Adorni
- Nathaniel Weintraub
- P Davidsson
- PS Green
- R Korstanje
- RC Montelaro
- RE Morton
- RE Morton
- RE Morton
- RE Morton
- RJ Brown
- Sarah F. Hamm-Alvarez
- SM Gordon
- SO Olofsson
- Sumeet A. Khetarpal
- T Nishide
- T Vaisar
- T Wu
- TM Teslovich
- TP Carr
- V Guyard-Dangremont
- VM Paromov
- Wen Lin
- William R. Lagor
- WR Lagor
- WR Lagor
- WS Davidson
- X Wang
- XC Jiang
- Y He
- Publication venue
- Public Library of Science
- Publication date
- 20/02/2012
- Field of study
Apolipoprotein F (apoF) is 29 kilodalton secreted sialoglycoprotein that resides on the HDL and LDL fractions of human plasma. Human ApoF is also known as Lipid Transfer Inhibitor protein (LTIP) based on its ability to inhibit cholesteryl ester transfer protein (CETP)-mediated transfer events between lipoproteins. In contrast to other apolipoproteins, ApoF is predicted to lack strong amphipathic alpha helices and its true physiological function remains unknown. We previously showed that overexpression of Apolipoprotein F in mice reduced HDL cholesterol levels by 20–25% by accelerating clearance from the circulation. In order to investigate the effect of physiological levels of ApoF expression on HDL cholesterol metabolism, we generated ApoF deficient mice. Unexpectedly, deletion of ApoF had no substantial impact on plasma lipid concentrations, HDL size, lipid or protein composition. Sex-specific differences were observed in hepatic cholesterol content as well as serum cholesterol efflux capacity. Female ApoF KO mice had increased liver cholesteryl ester content relative to wild type controls on a chow diet (KO: 3.4+/−0.9 mg/dl vs. WT: 1.2+/−0.3 mg/dl, p<0.05). No differences were observed in ABCG1-mediated cholesterol efflux capacity in either sex. Interestingly, ApoB-depleted serum from male KO mice was less effective at promoting ABCA1-mediated cholesterol efflux from J774 macrophages relative to WT controls
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
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- Abulaiti Y
- Acharya BS
- Adachi S
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- Adelman J
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- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
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- Aguilar-Saavedra JA
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- Akesson TPA
- Akilli E
- Akimov AV
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- Alberghi GL
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- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Alhroob M
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- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner SV
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang DF
- Zhang F
- Zhang G
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
Identification of boosted Higgs bosons decaying into b-quark pairs with the ATLAS detector at 13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
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- Adamek L
- Adelman J
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- Adiguzel A
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- Affolder AA
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- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
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- Aielli G
- Akatsuka S
- Akesson TPA
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- Alberghi GL
- Albert J
- Alconada Verzini MJ
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- Zhemchugov A
- Zheng Z
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- Zinonos Z
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- Zu Theenhausen HM
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/10/2019
- Field of study
This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H→bb¯ , for proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy s√=13 TeV . These decays are reconstructed from calorimeter jets found with the anti- kt R=1.0 jet algorithm. To tag Higgs bosons, a combination of requirements is used: b-tagging of R=0.2 track-jets matched to the large-R calorimeter jet, and requirements on the jet mass and other jet substructure variables. The Higgs boson tagging efficiency and corresponding multijet and hadronic top-quark background rejections are evaluated using Monte Carlo simulation. Several benchmark tagging selections are defined for different signal efficiency targets. The modelling of the relevant input distributions used to tag Higgs bosons is studied in 36 fb −1 of data collected in 2015 and 2016 using g→bb¯ and Z(→bb¯)γ event selections in data. Both processes are found to be well modelled within the statistical and systematic uncertainties
Search for heavy neutral Higgs bosons produced in association with b-quarks and decaying into b-quarks at root s=13 TeV with the ATLAS detector
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- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
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- Yuen SPY
- Zabinski B
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- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeiner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
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- Zhang F
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- Zhang G
- Zhang H
- Zhang J
- Zhang L
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- Zhang M
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 13/08/2020
- Field of study
A search for heavy neutral Higgs bosons produced in association with one or two
b
-quarks and decaying to
b
-quark pairs is presented using
27.8
fb
−
1
of
√
s
=
13
TeV
proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider during 2015 and 2016. No evidence of a signal is found. Upper limits on the heavy neutral Higgs boson production cross section times its branching ratio to
b
¯
b
are set, ranging from 4.0 to 0.6 pb at 95% confidence level over a Higgs boson mass range of 450 to 1400 GeV. Results are interpreted within the two-Higgs-doublet model and the minimal supersymmetric Standard Model
Erratum: Measurement of angular and momentum distributions of charged particles within and around jets in Pb + Pb and pp collisions at √sNN = 5.02 TeV with the ATLAS detector [Phys. Rev. C 100 , 064901 (2019)]
- Author
- Aad G
- Abbott B
- Abbott Dc
- Abed Abud A
- Abeling K
- Abhayasinghe Dk
- Abidi Sh
- Abouzeid Os
- Abraham Nl
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya Bs
- Achkar B
- Adachi S
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder Aa
- Afik Y
- Agapopoulou C
- Agaras Mn
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra Ja
- Ahmadov F
- Ahmed Ws
- Ai X
- Aielli G
- Akatsuka S
- Akesson Tpa
- Akilli E
- Akimov Av
- Al Khoury K
- Alberghi Gl
- Albert J
- Alconada Verzini Mj
- Alderweireldt S
- Aleksa M
- Aleksandrov In
- Alexa C
- Alexandre D
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire Sp
- Allaire C
- Allbrooke Bmm
- Allen Bw
- Allport Pp
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri Aa
- Alvarez Estevez M
- Alvarez Piqueras D
- Alviggi Mg
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos Sp
- Amoroso S
- Amrouche Cs
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders Cf
- Anders Jk
- Andreazza A
- Andrei V
- Anelli Cr
- Angelidakis S
- Angerami A
- Anisenkov Av
- Annovi A
- Antel C
- Anthony Mt
- Antonelli M
- Antrim Dja
- Anulli F
- Aoki M
- Aparisi Pozo Ja
- Aperio Bella L
- Arabidze G
- Araque Jp
- Araujo Ferraz V
- Araujo Pereira R
- Arcangeletti C
- Arce Ath
- Arduh Fa
- Arguin J-
- Argyropoulos S
- Arling J-
- Armbruster Aj
- Armstrong A
- Arnaez O
- Arnold H
- Arrubarrena Tame Zp
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Asimakopoulou Em
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Atkin Rj
- Atkinson M
- Atlay Nb
- Atmani H
- Augsten K
- Avolio G
- Avramidou R
- Ayoub Mk
- Azoulay Am
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey Aj
- Bailey Vr
- Baines Jt
- Bajic M
- Bakalis C
- Baker Ok
- Bakker Pj
- Bakshi Gupta D
- Balaji S
- Baldin Em
- Balek P
- Balli F
- Balunas Wk
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura Aae
- Barak L
- Barbe Wm
- Barberio El
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-
- Barkeloo J
- Barklow T
- Barnea R
- Barnes Sl
- Barnett Bm
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- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr Aj
- Barranco Navarro L
- Barreiro Guimaraes Da Costa J
- Barreiro F
- Barsov S
- Bartoldus R
- Bartolini G
- Barton Ae
- Bartos P
- Basalaev A
- Bassalat A
- Basso Mj
- Bates Rl
- Batlamous S
- Batley Jr
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer Kt
- Bawa Hs
- Beacham Jb
- Beau T
- Beauchemin Ph
- Becherer F
- Bechtle P
- Beck Hc
- Beck Hp
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall Aj
- Bednyakov Va
- Bedognetti M
- Bee Cp
- Beermann Ta
- Begalli M
- Begel M
- Behera A
- Behr Jk
- Beisiegel F
- Bell As
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev Nl
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin Dp
- Benoit M
- Bensinger Jr
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Bergsten Lj
- Beringer J
- Berlendis S
- Bernard Nr
- Bernardi G
- Bernius C
- Berry T
- Berta P
- Bertella C
- Bertram Ia
- Bessidskaia Bylund O
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan Aj
- Beyer J
- Bhattacharya Ds
- Bhattarai P
- Bi R
- Bianchi Rm
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz Nv
- Biglietti M
- Billoud Trv
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birman M
- Bisanz T
- Biswal Jp
- Biswas D
- Bitadze A
- Bittrich C
- Bjorke K
- Black Km
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink Gj
- Bobrovnikov Vs
- Bocchetta Ss
- Bocci A
- Boerner D
- Bogavac D
- Bogdanchikov Ag
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev As
- Bolz Ae
- Bomben M
- Bona M
- Bonilla Js
- Boonekamp M
- Booth Cd
- Borecka-Bielska Hm
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola Jd
- Bouaouda K
- Boudreau J
- Bouhova-Thacker Ev
- Boumediene D
- Boutle Sk
- Boveia A
- Boyd J
- Boye D
- Boyko Ir
- Bozson Aj
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau Je
- Breaden Madden Wd
- Brendlinger K
- Brenner L
- Brenner R
- Bressler S
- Brickwedde B
- Briglin Dl
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks Wk
- Brost E
- Broughton Jh
- Bruckman De Renstrom Pa
- Bruncko D
- Bruni A
- Bruni G
- Bruni Ls
- Bruno S
- Brunt Bh
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley Ag
- Budagov Ia
- Bugge Mk
- Buhrer F
- Bulekov O
- Burch Tj
- Burdin S
- Burgard Cd
- Burger Am
- Burghgrave B
- Burr Jtp
- Burton Cd
- Burzynski Jc
- Buscher V
- Buschmann E
- Bussey Pj
- Butler Jm
- Buttar Cm
- Butterworth Jm
- Butti P
- Buttinger W
- Buxo Vazquez Cj
- Buzatu A
- Buzykaev Ar
- Cabras G
- Cabrera Urban S
- Caforio D
- Cai H
- Cairo Vmm
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba Lp
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet Tp
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Cameron D
- Caminal Armadans R
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
- Canesse A
- Cano Bret M
- Cantero J
- Cao T
- Cao Y
- Capeans Garrido Mdm
- Capua M
- Cardarelli R
- Cardillo F
- Carducci G
- Carli I
- Carli T
- Carlino G
- Carlson Bt
- Carminati L
- Carney Rmd
- Caron S
- Carquin E
- Carra S
- Carter Jws
- Casado Mp
- Casha Af
- Casper Dw
- Castelijn R
- Castillo Gimenez V
- Castillo Fl
- Castro Nf
- Catinaccio A
- Catmore Jr
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Ceradini F
- Cerda Alberich L
- Cerny K
- Cerqueira As
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin Sa
- Chadi Z
- Chakraborty D
- Chan Sk
- Chan Ws
- Chan Wy
- Chapman Jd
- Chargeishvili B
- Charlton Dg
- Charman Tp
- Chau Cc
- Che S
- Chekanov S
- Chekulaev Sv
- Chelkov Ga
- Chelstowska Ma
- Chen B
- Chen C
- Chen Ch
- Chen H
- Chen J
- Chen J
- Chen S
- Chen Sj
- Chen X
- Chen Y
- Chen Y-
- Cheng Hc
- Cheng Hj
- Cheplakov A
- Cheremushkina E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalerias Tja
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm As
- Chitan A
- Chiu I
- Chiu Yh
- Chizhov Mv
- Choi K
- Chomont Ar
- Chouridou S
- Chow Ys
- Chu Mc
- Chu X
- Chudoba J
- Chuinard Aj
- Chwastowski Jj
- Chytka L
- Cieri D
- Ciesla Km
- Cinca D
- Cindro V
- Cioara Ia
- Ciocio A
- Cirotto F
- Citron Zh
- Citterio M
- Ciubotaru Da
- Ciungu Bm
- Clark A
- Clark Mr
- Clark Pj
- Clement C
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Cohen H
- Coimbra Aec
- Colasurdo L
- Cole B
- Colijn Ap
- Collot J
- Conde Muino P
- Coniavitis E
- Connell Sh
- Connelly Ia
- Constantinescu S
- Conventi F
- Cooper-Sarkar Am
- Cormier F
- Cormier Kjr
- Corpe Ld
- Corradi M
- Corrigan Ee
- Corriveau F
- Cortes-Gonzalez A
- Costa Mj
- Costanza F
- Costanzo D
- Cowan G
- Cowley Jw
- Crane J
- Cranmer K
- Crawley Sj
- Creager Ra
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cuhadar Donszelmann T
- Cukierman Ar
- Cunningham Wr
- Czekierda S
- Czodrowski P
- D'Amen G
- D'Amico V
- D'Auria S
- D'Eramo L
- D'Onofrio A
- D'Onofrio M
- Da Cunha Sargedas De Sousa Mj
- Da Fonseca Pinto Jv
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damp J
- Dandoy Jr
- Daneri Mf
- Dang Np
- Dann Ns
- Danninger M
- Dao V
- Darbo G
- Dartsi O
- Dattagupta A
- Daubney T
- Davey W
- David C
- Davidek T
- Davis Dr
- Dawson I
- De Asmundis R
- De Beurs M
- De Castro S
- De Cecco S
- De Groot N
- De Jong P
- De La Torre H
- De Maria A
- De Pedis D
- De Salvo A
- De Sanctis U
- De Santis M
- De Santo A
- De Vasconcelos Corga K
- De Vivie De Regie Jb
- De K
- Debenedetti C
- Dedovich Dv
- Deiana Am
- Del Gaudio M
- Del Peso J
- Delabat Diaz Y
- Delgove D
- Deliot F
- Delitzsch Cm
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- Della Volpe D
- Delmastro M
- Delporte C
- Delsart Pa
- Demarco Da
- Demers S
- Demichev M
- Demontigny G
- Denisov Sp
- Denysiuk D
- Derendarz D
- Derkaoui Je
- Derue F
- Dervan P
- Desch K
- Deterre C
- Dette K
- Deutsch C
- Devesa Mr
- Deviveiros Po
- Dewhurst A
- Di Bello Fa
- Di Ciaccio A
- Di Ciaccio L
- Di Clemente Wk
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Micco B
- Di Nardo R
- Di Petrillo Kf
- Di Sipio R
- Di Valentino D
- Diaconu C
- Dias Do Vale T
- Dias Fa
- Diaz Ma
- Dickinson J
- Diehl Eb
- Dietrich J
- Diez Cornell S
- Dimitrievska A
- Ding W
- Dingfelder J
- Dittus F
- Djama F
- Djobava T
- Djuvsland Ji
- Do Vale Mab
- Dobre M
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Donadelli M
- Dong B
- Donini J
- Dopke J
- Doria A
- Dova Mt
- Doyle At
- Drechsler E
- Dreyer E
- Dreyer T
- Drobac As
- Du D
- Duan Y
- Dubinin F
- Dubovsky M
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducourthial A
- Ducu Oa
- Duda D
- Dudarev A
- Dudder Ac
- Duffield Em
- Duflot L
- Duhrssen M
- Dulsen C
- Dumancic M
- Dumitriu Ae
- Duncan Ak
- Dunford M
- Duperrin A
- Duran Yildiz H
- Duren M
- Durglishvili A
- Duschinger D
- Dutta B
- Duvnjak D
- Dyckes Gi
- Dyndal M
- Dysch S
- Dziedzic Bs
- Ecker Km
- Edgar Rc
- Eggleston Mg
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Jarrari H
- El Kacimi M
- El Kosseifi R
- Ellajosyula V
- Ellert M
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- Elmsheuser J
- Elsing M
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- Emerman A
- Enari Y
- Epland Mb
- Erdmann J
- Ereditato A
- Errenst M
- Escalier M
- Escobar C
- Estrada Pastor O
- Etzion E
- Evans H
- Ezhilov A
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Faisca Rodrigues Pereira Rm
- Fakhrutdinov Rm
- Falciano S
- Falke Pj
- Falke S
- Faltova J
- Fang Y
- Fang Y
- Fanourakis G
- Fanti M
- Faraj M
- Farbin A
- Farilla A
- Farina Em
- Farooque T
- Farrell S
- Farrington Sm
- Farthouat P
- Fassi F
- Fassnacht P
- Fassouliotis D
- Faucci Giannelli M
- Fawcett Wj
- Fayard L
- Fedin Ol
- Fedorko W
- Feickert M
- Feligioni L
- Fell A
- Feng C
- Feng Ej
- Feng M
- Fenton Mj
- Fenyuk Ab
- Ferrando J
- Ferrante A
- Ferrari A
- Ferrari P
- Ferrari R
- Ferreira De Lima De
- Ferrer A
- Ferrere D
- Ferretti C
- Fiedler F
- Filipcic A
- Filthaut F
- Finelli Kd
- Fiolhais Mcn
- Fiorini L
- Fischer F
- Fisher Wc
- Fleck I
- Fleischmann P
- Fletcher Rrm
- Flick T
- Flierl Bm
- Flores Castillo Lr
- Flores L
- Follega Fm
- Fomin N
- Foo Jh
- Forcolin Gt
- Formica A
- Forster Fa
- Forti Ac
- Foster Ag
- Foti Mg
- Fournier D
- Fox H
- Francavilla P
- Francescato S
- Franchini M
- Franchino S
- Francis D
- Franconi L
- Franklin M
- Fray An
- Freeman Pm
- Freund B
- Freund Ws
- Freundlich Em
- Frizzell Dc
- Froidevaux D
- Frost Ja
- Fukunaga C
- Fullana Torregrosa E
- Fumagalli E
- Fusayasu T
- Fuster J
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- Gach Gp
- Gadatsch S
- Gadow P
- Gagliardi G
- Gagnon Lg
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- Gallardo Ge
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- Gallop Bj
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- Garcia Pascual Ja
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- Gardner Rw
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- Gargiulo S
- Garonne V
- Gaudiello A
- Gaudio G
- Gavrilenko Il
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- Gazis En
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- Gee Cm
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- Geisler Mp
- Gemme C
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- Gentile S
- George S
- Geralis T
- Gerlach Lo
- Gessinger-Befurt P
- Gessner G
- Ghasemi Bostanabad M
- Ghasemi S
- Ghosh A
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- Giacobbe B
- Giagu S
- Giangiacomi N
- Giannetti P
- Giannini A
- Giannini G
- Gibson Sm
- Gignac M
- Gillberg D
- Gilles G
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- Giordani Mp
- Giorgi Fm
- Giraud Pf
- Giugliarelli G
- Giugni D
- Giuli F
- Gkaitatzis S
- Gkialas I
- Gkougkousis El
- Gkountoumis P
- Gladilin Lk
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- Glatzer J
- Glaysher Pcf
- Glazov A
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- Golubkov D
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- Gonzalez De La Hoz S
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- Gonzalvo Rodriguez Gr
- Goossens L
- Gorbounov Pa
- Gordon Ha
- Gorini B
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- Gorisek A
- Goshaw At
- Gostkin Mi
- Gottardo Ca
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- Henriques Correia Am
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- Herde H
- Herget V
- Hernandez Jimenez Y
- Herr H
- Herrmann Mg
- Herrmann T
- Herten G
- Hertenberger R
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- Herwig Tc
- Hesketh Gg
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- Hoad X
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- Ibragimov I
- Iconomidou-Fayard L
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- Karyukhin An
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- Yexley Mr
- Yigitbasi E
- Yorita K
- Yoshihara K
- Young C
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- Yu J
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- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev Am
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas Dr
- Zeissner Sv
- Zeitnitz C
- Zemaityte G
- Zeng Jc
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang B
- Zhang Df
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou Ms
- Zhou N
- Zhou Y
- Zhu C
- Zhu Cg
- Zhu H
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- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine Ni
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas Tg
- Zou R
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2020
- Field of study
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
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- Aguilar-Saavedra JA
- Ahmad A
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- Aielli G
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- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
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- Anastopoulos C
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- Andeen T
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- Andrean SY
- Andreazza A
- Andrei V
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
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- Antrim DJA
- Anulli F
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- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Aranzabal N
- Araujo Ferraz V
- Arcangeletti C
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- Argyropoulos S
- Arling J-H
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- Assahsah J
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- Atlay NB
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- Austrup VA
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- Barreiro Guimarães da Costa J
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- Carlson EM
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- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
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- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chau CC
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
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- Chen CH
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- Cheng CL
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- Cheplakov A
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- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
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- Ciesla KM
- Cindro V
- Cioară IA
- Ciocio A
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- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
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- Connelly IA
- Conroy EI
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- Cooper-Sarkar AM
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- Cueto A
- Cuhadar Donszelmann T
- Cui H
- Cukierman AR
- Cunningham WR
- Czekierda S
- Czodrowski P
- Czurylo MM
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- De Asmundis R
- De Beurs M
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- de Jong P
- De la Torre H
- De Maria A
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- De Salvo A
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- Demichev M
- Denisov SP
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- Derkaoui JE
- Derue F
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- Dette K
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- Deviveiros PO
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- Di Girolamo A
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- Di Luca A
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- Didenko M
- Diehl EB
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- Dimitrievska A
- Ding W
- Dingfelder J
- Dinu I-M
- Dittmeier SJ
- Dittus F
- Djama F
- Djobava T
- Djuvsland JI
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- Dodsworth D
- Doglioni C
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- Zeißner SV
- Zemaityte G
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- Zhemchugov A
- Zheng Z
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
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