Synthesis of fused indoline-cyclobutanone derivatives via an intramolecular [2+2] cycloaddition

We thank the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT, grant code EP/L016419/1, R.M.N.) for funding. We thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013) ERC grant agreement no. 279850 (A.D.S.). A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Service at Swansea. The research data supporting this publication can be accessed at https://doi.org/10.17630/00aff760-0732-438f-a9d1-30c7cf3a87a0A serendipitously-discovered process for the synthesis of heterocyclic products containing a novel fused indoline-cyclobutanone ring system is reported. This process is believed to take place through in situ generation of a ketene intermediate, followed by intramolecular [2+2] cycloaddition with a pendant enamide. The formation of a ketene intermediate in this process is significant as the reaction conditions employed are analogous to those commonly used in tertiary amine Lewis base catalysis, where the potential intermediacy of ketenes is an important consideration that is often overlooked.PostprintPeer reviewe

Social Class

Discussion of class structure in fifth-century Athens, historical constitution of theater audiences, and the changes in the comic representation of class antagonism from Aristophanes to Menander

Generating a Generation of Proteasome Inhibitors: From Microbial Fermentation to Total Synthesis of Salinosporamide A (Marizomib) and Other Salinosporamides

The salinosporamides are potent proteasome inhibitors among which the parent marine-derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical trials for the treatment of various cancers. Methods to generate this class of compounds include fermentation and natural products chemistry, precursor-directed biosynthesis, mutasynthesis, semi-synthesis, and total synthesis. The end products range from biochemical tools for probing mechanism of action to clinical trials materials; in turn, the considerable efforts to produce the target molecules have expanded the technologies used to generate them. Here, the full complement of methods is reviewed, reflecting remarkable contributions from scientists of various disciplines over a period of 7 years since the first publication of the structure of 1

Data structure simulation for the reform of the teaching process of university computer courses

Initially we applied the same data structure to grid generation, with further research, we found that the overall calculation efficiency of such a design is not high, and it is difficult to maintain. Finally, we designed different data structures based on the different characteristics of the two parts, in the grid generation, more consideration is given to flexibility and maintainability, a method to determine the flux function through the boundary of a triangular mesh is given. This method first obtains the two-dimensional Euler equations in the normal direction of the boundary of the control volume element, in the system of projection equations, the flux along the tangent to the boundary can be regarded as passive convection, therefore, the one-dimensional Riemann problem solver can be directly used to calculate the flux function passing through the boundary of the triangular control unit. This method under various flow conditions, including supersonic pipe flow and subsonic isentropic flow with strong shock waves, all have high precision and good stability

Isothiourea-mediated one-pot synthesis of functionalized pyridines

This work was supported by the Royal Society, Syngenta/EPSRC, The Carnegie Trust for the Universities of Scotland and ERC.Publisher PDFPeer reviewe

Effect of functionalized MWCNTs/water nanofluids on thermal resistance and pressure fluctuation characteristics in oscillating heat pipe

An influence of multi-walled carbon nanotube (MWCNT) based aqueous nanofluids with different concentrations on the heat transport and the relevant pressure distribution in oscillating heat pipe (OHP) has been investigated. The present paper describes the heat transfer phenomena in terms of thermal resistance, pressure and frequency of pressure fluctuation in multi-loop oscillating heat pipe (OHP) charged by aqueous nanofluids with MWCNT loadings of 0.05 wt.%, 0.1 wt.%, 0.2 wt.% and 0.3 wt.%. The multi-loop OHP with 3 mm inner diameter has been conducted in the experiment at 60% filling ratio. Experimental results show that thermal characteristics are significantly inter-related with pressure distribution and strongly depend upon the number of pressure fluctuations with time. The investigation shows that the 0.2 wt.% MWCNTs based aqueous nanofluids obtain maximum number of the fluctuation frequency and low thermal resistance at any evaporator power input. Based on the experimental results, we discuss the reasons for enhancement and decrement of thermal characteristics of the nanofluids.Md. Riyad Tanshen, B. Munkhbayar, Md. J. Nine, Hanshik Chung, Hyomin Jeon