25 research outputs found
Interactions between proteins bound to biomembranes
We study a physical model for the interaction between general inclusions
bound to fluid membranes that possess finite tension, as well as the usual
bending rigidity. We are motivated by an interest in proteins bound to cell
membranes that apply forces to these membranes, due to either entropic or
direct chemical interactions. We find an exact analytic solution for the
repulsive interaction between two similar circularly symmetric inclusions. This
repulsion extends over length scales of order tens of nanometers, and contrasts
with the membrane-mediated contact attraction for similar inclusions on
tensionless membranes. For non circularly symmetric inclusions we study the
small, algebraically long-ranged, attractive contribution to the force that
arises. We discuss the relevance of our results to biological phenomena, such
as the budding of caveolae from cell membranes and the striations that are
observed on their coats.Comment: 22 pages, 2 figure
Particle Physics Implications for CoGeNT, DAMA, and Fermi
Recent results from the CoGeNT collaboration (as well as the annual
modulation reported by DAMA/LIBRA) point toward dark matter with a light (5-10
GeV) mass and a relatively large elastic scattering cross section with nucleons
(\sigma ~ 10^{-40} cm^2). In order to possess this cross section, the dark
matter must communicate with the Standard Model through mediating particles
with small masses and/or large couplings. In this Letter, we explore with a
model independent approach the particle physics scenarios that could
potentially accommodate these signals. We also discuss how such models could
produce the gamma rays from the Galactic Center observed in the data of the
Fermi Gamma Ray Space Telescope. We find multiple particle physics scenarios in
which each of these signals can be accounted for, and in which the dark matter
can be produced thermally in the early Universe with an abundance equal to the
measured cosmological density.Comment: 4 pages, 2 figure
Physics searches at the LHC
With the LHC up and running, the focus of experimental and theoretical high
energy physics will soon turn to an interpretation of LHC data in terms of the
physics of electroweak symmetry breaking and the TeV scale. We present here a
broad review of models for new TeV-scale physics and their LHC signatures. In
addition, we discuss possible new physics signatures and describe how they can
be linked to specific models of physics beyond the Standard Model. Finally, we
illustrate how the LHC era could culminate in a detailed understanding of the
underlying principles of TeV-scale physics.Comment: 184 pages, 55 figures, 14 tables, hundreds of references; scientific
feedback is welcome and encouraged. v2: text, references and Overview Table
added; feedback still welcom
Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo
This article is hosted on a website external to the CBCRA Open Access Archive. Selecting "View/Open" below will launch the full-text article in another browser windo
Inhibition of cyclin D1 gene transcription by Brg-1
The evolutionarily conserved SWI-SNF chromatin remodeling complex regulates cellular proliferation. A catalytic subunit, BRG-1, is frequently down regulated, silenced or mutated in malignant cells, however, the mechanism by which BRG-1 may function as a tumor suppressor or block breast cancer cellular proliferation is not understood. The cyclin D1 gene is a collaborative oncogene overexpressed in greater than 50% of human breast cancers. Herein, BRG-1 inhibited DNA synthesis and cyclin D1 expression in human MCF-7 breast cancer epithelial cells. The cyclin D1 promoter AP-1 and CRE sites were required for repression by BRG-1 in promoter assays. BRG-1 deficient cells abolished and siRNA to BRG-1 reduced, formation of the BRG-1 chromatin complex. The endogenous cyclin D1 promoter AP-1 site bound BRG-1. Estradiol treatment of MCF7 cells induced recruitment of BRG-1 to the endogenous hpS2 gene promoter. Estradiol, which induced cyclin D1 abundance, was associated with a reduction in recruitment of the co-repressors HP1α/HDAC1 to the endogenous cyclin D1 promoter AP-1/BRG-1 binding sites. These studies suggest the endogenous cyclin D1 promoter BRG-1 binding site functions as a molecular scaffold in the context of local chromatin upon which coactivators and corepressors are recruited to regulate cyclin D1
Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia
Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies
The MAL Proteolipid Is Necessary for the Overall Apical Delivery of Membrane Proteins in the Polarized Epithelial MadinâDarby Canine Kidney and Fischer Rat Thyroid Cell Lines
p27Kip1 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/ÎČ-Cantenin Signaling
The journal Cancer Research is the original source of the material