Peran Production Assistant dalam Rumah Produksi Seven Sunday Films

Kebutuhan promosi sebuah produk semakin meningkat dikarenakan banyaknya produk yang beredar. Peningkatan jumlah produk ataupun jasa memberikan lapangan kerja yang luas untuk industri iklan. Menjadi seorang Produser mengharuskan seseorang untuk memahami setiap aspek pekerjaan dari setiap divisi. Demikian seorang Asisten Produksi cenderung mempelajari fundamental dari sebuah produksi. Rumah produksi Seven Sunday Films bergerak di bidang periklanan dengan standar internasional. Seven Sunday Films merupakan pilihan yang tepat untuk penulis mencari pengalaman kerja di dunia periklanan secara profesional sebagai seorang Asisten Produksi. Tugas yang didapatkan penulis cukup bervariasi mulai dari menyusun creative deck, mencari referensi, mencatat hasil dari setiap meeting, mengoordinasikan kru ketika produksi, hingga melayani klien dan agensi. Workflow yang cepat mengharuskan penulis untuk cekatan dalam menjalani sebuah tugas. Multi-tasking menjadi sebuah skill yang penting ketika menjadi bagian dari tim produksi. Selain itu, berkomunikasi dengan baik juga menjadi sebuah hal yang cukup penting untuk mencegah miskomunikasi antar divisi dalam sebuah produksi. Penulis menyarakan untuk menyiapkan mental dan juga peralatan seperti laptop yang memadai ketika ingin melakukan program kerja magang

Penerapan Motivated Lighting dalam Membangun Mood Dramatis di Film Pendek "Perangai"

Film pendek "Perangai" berbicara tentang penolakan serta labelling atau stigma terhadap tato yang dialami oleh seorang guru SD sekaligus suami dari seorang istri. Film ini bercerita maju mundur secara parallel yang memiliki dua treatment visual berbeda ketika karakter Harun berada di sekolah dan di rumahnya. Penulis sebagai Gaffer memiliki tanggung jawab penuh atas pengeksekusian pencahayaan yang telah dirancang bersama DP. Penulis menerapkan motivated lighting sebagai aspek untuk membangun mood dramatis dalam film pendek ini. Penulis kemudian berpacu pada beberapa langkah dalam menata motivated lighting menurut Kyle (2021) yaitu pengenalan terhadap sebuah set, penambahan practical lights, dan pemilihan color temperature yang tepat. Mood dramatis yang ingin dicapai penulis adalah dengan kontras rasio yang tinggi atau teknik low-key lighting dan hadirnya warna hangat dari color temperature yang dihasilkan oleh sistem pencahayaan. Kedua aspek ini kemudian hadir dan ditata bersama untuk membangun mood dramatis pada scene ketika Harun berada dirumah bersama istrinya

Th17 Cells in Immunity and Autoimmunity

Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. In this review we have provided a comprehensive overview of Th17 pathogenicity and function, including novel evidence for a protective role of Th17 cells in conjunction with the microbiota gut flora in T1D onset and progression

Taiko: Its Past and Present in Japanese Society

The significance of Taiko in Japanese culture is far beyond being a percussion instrument. “Taiko” also refers to the art of drumming and is claimed to represent the spirit of Japanese people. Since ancient times, Taiko was used in the battlefield, Shinto and Buddhist religious ceremonies, festivals, royal courts, and theatrical arts performance. However, the origin of the Taiko remains unclear as well as its connection with Korean drum. The sacred power of Taiko for Japanese people is difficult to clarify in modern context. Japan is moving toward modernization, while promoting the importance of cultural preservation. It is important to understand the connection of the belief in Taiko that has been passed down since it first evidence appeared in the 6th century in Japan, from generation to generation, and how it survives in this modern Japanese society. To study the norm, performance practices, and its reception by musicians, religious leaders, and the public, an in-depth study of Taiko is necessary. The research, therefore aims to trace back its evolution, value, and its function in Japanese society. Results of the research display Taiko in relation to Japanese legend, development of Taiko, types of Taiko drum, and material used in Taiko manufacturing. More over, through research conducted, the connection of the past and present has provided Taiko with a new function in the modern society including of fusion music, contemporary music composition, and film music. Popular ensembles have brought Taiko to bridge the gap of traditional music of the past and Pop-Rock music of this modern world

Illicit drug use and cerebral microbleeds in stroke and transient ischemic attack patients

Background: Cerebral microbleeds (CMB) signal cerebral small vessel disease and are associated with ischemic stroke (IS) incidence, recurrence, and complications. While illicit drug use (IDU) is associated with cerebral small vessel disease, the association between CMB and IDU is understudied. We sought to delineate differences in vascular risk factors between IDU and CMB and determine the effect of this relationship on outcomes in IS/transient ischemic attack (TIA) patients. Methods: We included 2001 consecutive IS and TIA patients (years 2009-2018) with a readable T2*gradient-echo MRI sequence. CMB rating followed standardized guidelines and CMB were grouped topographically into lobar, deep or infratentorial. IDU data (history and/or urine toxicology) was available for 1746 patients. The adverse composite outcome included pneumonia, urinary tract infection, deep venous thrombosis or death during hospitalization. Good functional outcome was defined as modified Rankin scale score < 3 and ambulatory on discharge. Univariate analysis was used to assess vascular risk factors and multivariable logistic regression was used to characterize the IDU/CMB relationship on outcomes. Results: We observed IDU in 13.8 % (n=241), and CMB in 32.9% (n=575, 53.8% lobar, 27.3% deep and 18.8% infratentorial). Patients with IDU and at least one CMB were older (53.6±10.5 vs. 56.9±11.5, p=0.04), had a lower BMI (28.1±5.9 vs. 26.6±4.4, p=0.04), and were more likely to have had a previous IS/TIA (25.1% vs. 41.9%, p=0.01). IDU trended higher for those with severe CMB (10+) compared with those without CMB and 1-9 CMB (25% [n=9] vs 14.3% [n=1171] and 12.1% [n=65] respectively; p=0.07) without individual drug deviations from this pattern. Adverse and good functional outcomes were observed in 177 and 905 total patients, respectively. No significant interaction was observed between IDU and CMB with either adverse or functional composite outcomes. Conclusion: IDU prevalence was high in our urban study population, and showed a borderline association with increasing CMB burden. Patients with CMB and IDU history were older and more likely to have had a previous IS/TIA. Further studies are required to clarify the clinical consequences related to the relationship between IDU and CMB.Author Disclosures: B. Petrie: None. H. Lau: None. F. Cajiga-Pena: None. S. Abbas: None. B. Finn: None. K. Dam: None. A. Cervantes-Arslanian: None. T.N. Nguyen: None. H. Aparicio: None. D. Greer: None. J.R. Romero: Speakers' Bureau; Modest; Received speaker honoraria from Ferrer Group

Multi-AGV's Temporal Memory-based RRT Exploration in Unknown Environment

With the increasing need for multi-robot for exploring the unknown region in a challenging environment, efficient collaborative exploration strategies are needed for achieving such feat. A frontier-based Rapidly-Exploring Random Tree (RRT) exploration can be deployed to explore an unknown environment. However, its' greedy behavior causes multiple robots to explore the region with the highest revenue, which leads to massive overlapping in exploration process. To address this issue, we present a temporal memory-based RRT (TM-RRT) exploration strategy for multi-robot to perform robust exploration in an unknown environment. It computes adaptive duration for each frontier assigned and calculates the frontier's revenue based on the relative position of each robot. In addition, each robot is equipped with a memory consisting of frontier assigned and share among fleets to prevent repeating assignment of same frontier. Through both simulation and actual deployment, we have shown the robustness of TM-RRT exploration strategy by completing the exploration in a 25.0m x 54.0m (1350.0m2) area, while the conventional RRT exploration strategy falls short.Comment: 8 pages, 10 Figure

Inhibition of Cholinergic Signaling Causes Apoptosis in Human Bronchioalveolar Carcinoma

Recent case-controlled clinical studies show that bronchioalveolar carcinomas (BAC) are correlated with smoking. Nicotine, the addictive component of cigarettes, accelerates cell proliferation through nicotinic acetylcholine receptors (nAChR). In this study, we show that human BACs produce acetylcholine (ACh) and contain several cholinergic factors including acetylcholinesterase (AChE), choline acetyltransferase (ChAT), choline transporter 1 (CHT1, SLC5A7), vesicular acetylcholine transporter (VAChT, SLC18A3), and nACh receptors (AChRs, CHRNAs). Nicotine increased the production of ACh in human BACs, and ACh acts as a growth factor for these cells. Nicotine-induced ACh production was mediated by α7-, α3β2-, and β3-nAChRs, ChAT and VAChT pathways. We observed that nicotine upregulated ChAT and VAChT. Therefore, we conjectured that VAChT antagonists, such as vesamicol, may suppress the growth of human BACs. Vesamicol induced potent apoptosis of human BACs in cell culture and nude mice models. Vesamicol did not have any effect on EGF or insulin-like growth factor-II–induced growth of human BACs. siRNA-mediated attenuation of VAChT reversed the apoptotic activity of vesamicol. We also observed that vesamicol inhibited Akt phosphorylation during cell death and that overexpression of constitutively active Akt reversed the apoptotic activity of vesamicol. Taken together, our results suggested that disruption of nicotine-induced cholinergic signaling by agents such as vesamicol may have applications in BAC therapy

Case Report: Paclitaxel-Induced Pneumonitis in Early Breast Cancer: A Single Institution Experience and Review

Taxane-based chemotherapy regimens are in widespread use as standard of care treatment for patients with early breast cancer, though rarely its use can be complicated by taxane-induced pneumonitis (TIP). While breast cancer is the most diagnosed cancer in women worldwide, TIP remains under-described in this setting. Key questions relate to its incidence, diagnosis and management, potential predictive biomarkers, and the balance between this life-threatening toxicity and curatively intended treatment. At a single Australian institution, 6 cases of TIP are identified among 132 patients treated with a paclitaxel-containing regimen for early breast cancer (4.55%, 95% confidence interval 1.69-9.63%). This review first outlines the presentation, management, and outcomes for these cases, then answers these questions and proposes an approach to suspected TIP in patients with breast cancer

The effectiveness, acceptability and cost-effectiveness of psychosocial interventions for maltreated children and adolescents: an evidence synthesis.

BACKGROUND: Child maltreatment is a substantial social problem that affects large numbers of children and young people in the UK, resulting in a range of significant short- and long-term psychosocial problems. OBJECTIVES: To synthesise evidence of the effectiveness, cost-effectiveness and acceptability of interventions addressing the adverse consequences of child maltreatment. STUDY DESIGN: For effectiveness, we included any controlled study. Other study designs were considered for economic decision modelling. For acceptability, we included any study that asked participants for their views. PARTICIPANTS: Children and young people up to 24 years 11 months, who had experienced maltreatment before the age of 17 years 11 months. INTERVENTIONS: Any psychosocial intervention provided in any setting aiming to address the consequences of maltreatment. MAIN OUTCOME MEASURES: Psychological distress [particularly post-traumatic stress disorder (PTSD), depression and anxiety, and self-harm], behaviour, social functioning, quality of life and acceptability. METHODS: Young Persons and Professional Advisory Groups guided the project, which was conducted in accordance with Cochrane Collaboration and NHS Centre for Reviews and Dissemination guidance. Departures from the published protocol were recorded and explained. Meta-analyses and cost-effectiveness analyses of available data were undertaken where possible. RESULTS: We identified 198 effectiveness studies (including 62 randomised trials); six economic evaluations (five using trial data and one decision-analytic model); and 73 studies investigating treatment acceptability. Pooled data on cognitive-behavioural therapy (CBT) for sexual abuse suggested post-treatment reductions in PTSD [standardised mean difference (SMD) -0.44 (95% CI -4.43 to -1.53)], depression [mean difference -2.83 (95% CI -4.53 to -1.13)] and anxiety [SMD -0.23 (95% CI -0.03 to -0.42)]. No differences were observed for post-treatment sexualised behaviour, externalising behaviour, behaviour management skills of parents, or parental support to the child. Findings from attachment-focused interventions suggested improvements in secure attachment [odds ratio 0.14 (95% CI 0.03 to 0.70)] and reductions in disorganised behaviour [SMD 0.23 (95% CI 0.13 to 0.42)], but no differences in avoidant attachment or externalising behaviour. Few studies addressed the role of caregivers, or the impact of the therapist-child relationship. Economic evaluations suffered methodological limitations and provided conflicting results. As a result, decision-analytic modelling was not possible, but cost-effectiveness analysis using effectiveness data from meta-analyses was undertaken for the most promising intervention: CBT for sexual abuse. Analyses of the cost-effectiveness of CBT were limited by the lack of cost data beyond the cost of CBT itself. CONCLUSIONS: It is not possible to draw firm conclusions about which interventions are effective for children with different maltreatment profiles, which are of no benefit or are harmful, and which factors encourage people to seek therapy, accept the offer of therapy and actively engage with therapy. Little is known about the cost-effectiveness of alternative interventions. LIMITATIONS: Studies were largely conducted outside the UK. The heterogeneity of outcomes and measures seriously impacted on the ability to conduct meta-analyses. FUTURE WORK: Studies are needed that assess the effectiveness of interventions within a UK context, which address the wider effects of maltreatment, as well as specific clinical outcomes. STUDY REGISTRATION: This study is registered as PROSPERO CRD42013003889. FUNDING: The National Institute for Health Research Health Technology Assessment programme