The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study

Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters.Research design and methods: The study was a parallel, double-blind, placebo-controlled study where patients with diet or metformin controlled type 2 diabetes were randomized to, casein soy protein with or without isoflavones (SPI, SP), and with or without cocoa (SPIC, SPC) arms for an 8 week period. Glycemic control and cardiovascular risk factors were assessed prior to and after the completion of the dietary intervention. Sixty participants completed the study.Results: Soy protein improved HbA1c compared to casein (p < 0.05). The addition of isoflavones improved indices of insulin resistance and LDL [delta QUICKIE (SPI: −0.12 ± 0.04 vs. SP: 0.03 ± 0.06, p = 0.03); delta LDL (−0.27 ± 0.41 vs. 0.22 ± 0.43, p = 0.02); percentage change in HOMA (31.02 ± 54.75 vs. −14.42 ± 27.07, p = 0.02); percentage change in QUICKIE (−3.89 ± 7.07 vs. 6.11 ± 10.54, p = 0.01)]. However, the addition of cocoa provided no benefit with or without isoflavones.Summary: Soy protein had intrinsic activity on glycemic control compared to casein. Isoflavones improved both insulin resistance and LDL, but cocoa did not have added benefit on these indices

The Study of Corporate M&As

Abstract According to the objective and inherent logical coherence of research subject, the thesis is composed of six chapters. The first chapter provides the theoretical background for the thesis. The author reviews and analyzes the western motive theories of corporate M&amp;As so as to clearly recognize them. The commemt and analysis lay a foundation for discussion of the related problem...学位：经济学博士院系专业：经济学院经济系_世界经济学号：B20010901

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

Seizures induced by visual stimulation (photosensitive epilepsy; PSE) represent a common type of epilepsy in humans, but the molecular mechanisms and genetic drivers underlying PSE remain unknown, and no good genetic animal models have been identified as yet. Here, we show an animal model of PSE, in Drosophila, owing to defective cortex glia. The cortex glial membranes are severely compromised in ceramide phosphoethanolamine synthase (cpes)-null mutants and fail to encapsulate the neuronal cell bodies in the Drosophila neuronal cortex. Expression of human sphingomyelin synthase 1, which synthesizes the closely related ceramide phosphocholine (sphingomyelin), rescues the cortex glial abnormalities and PSE, underscoring the evolutionarily conserved role of these lipids in glial membranes. Further, we show the compromise in plasma membrane structure that underlies the glial cell membrane collapse in cpes mutants and leads to the PSE phenotype

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Measurement of inclusive jet and dijet cross-sections in proton-proton collisions at s √ =13 TeV with the ATLAS detector

Inclusive jet and dijet cross-sections are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV. The measurement uses a dataset with an integrated luminosity of 3.2 fb−1 recorded in 2015 with the ATLAS detector at the Large Hadron Collider. Jets are identified using the anti-kt algorithm with a radius parameter value of R = 0.4. The inclusive jet cross-sections are measured double-differentially as a function of the jet transverse momentum, covering the range from 100 GeV to 3.5 TeV, and the absolute jet rapidity up to |y| = 3. The double-differential dijet production cross-sections are presented as a function of the dijet mass, covering the range from 300 GeV to 9 TeV, and the half absolute rapidity separation between the two leading jets within |y| < 3, y∗, up to y∗ = 3. Next-to-leading-order, and next-to-next-to-leading-order for the inclusive jet measurement, perturbative QCD calculations corrected for non-perturbative and electroweak effects are compared to the measured cross-sections

Evolution of the WLCG Information Infrastructure

The WLCG project aimed to develop, build, and maintain a global computing facility for storage and analysis of the LHC data. While currently most of the LHC computing resources are being provided by the classical grid sites, over the last years the LHC experiments have been using more and more public clouds and HPCs, and this trend will certainly continue. The heterogeneity of the LHC computing resources is not limited to the procurement mode. It also implies variety of storage solutions and types of computer architecture which represent new challenges for the topology and configuration description of the LHC computing resources. The WLCG Information infrastructure has to evolve in order to meet these challenges and to be flexible enough to follow technology innovation. It should provide a complete and reliable description of all types of the storage and computing resources to ensure their effective use. This implies changes at all levels, starting from the primary information providers, through data publishing, transportation mechanism and central aggregators. This paper describes the proposed changes in the WLCG Information Infrastructure, their implementation and deployment

Evolution of the WLCG Information Infrastructure

The WLCG project aimed to develop, build, and maintain a global computing facility for storage and analysis of the LHC data. While currently most of the LHC computing resources are being provided by the classical grid sites, over the last years the LHC experiments have been using more and more public clouds and HPCs, and this trend will certainly continue. The heterogeneity of the LHC computing resources is not limited to the procurement mode. It also implies variety of storage solutions and types of computer architecture which represent new challenges for the topology and configuration description of the LHC computing resources. The WLCG Information infrastructure has to evolve in order to meet these challenges and to be flexible enough to follow technology innovation. It should provide a complete and reliable description of all types of the storage and computing resources to ensure their effective use. This implies changes at all levels, starting from the primary information providers, through data publishing, transportation mechanism and central aggregators. This paper describes the proposed changes in the WLCG Information Infrastructure, their implementation and deployment

GLUE v. 2.0 – Reference Realization to XML Schema

The GLUE 2 specification is an information model for Grid entities described in natural language enriched with a graphical representation using UML Class Diagrams. This document presents a realization of this information model as XML Schema

GLUE Specification v. 2.0

The GLUE specification is an information model for Grid entities described using the natural language and UML Class Diagrams. As a conceptual model, it is designed to be independent from the concrete data models adopted for its implementation. Rendering to concrete data models such XML Schema, LDAP Schema and SQL are provided in a separate document