Uso de acidólisis por fosfolipasa A1 inmovilizada para la producción de fosfatidilcolina estructurada con elevado contenido de ácido linoleico conjugado

Structured phosphatidylcholine (SPC) was successfully produced via immobilized phospholipase A1 (PLA1) – catalyzed acidolysis of phosphatidylcholine (PC) with conjugated linoleic acid (CLA). The effects of enzyme loading (2, 5, 10, 15 and 20%, with respect to the weight of substrates), temperature (20, 30, 40, 50 and 60 °C) and the molar ratio of substrates (1:2, 1:4, 1:6, 1:8 and 1:10, PC/CLA) were evaluated to maximize the incorporation of CLA into PC. The maximum incorporation of CLA achieved was ca. 90% for 24 h of reaction at 50 °C and 200 rpm, using a 1:4 substrate molar ratio and an enzyme loading of 15%.Fosfatidilcolina estructurada (SPC) fue producida por acidólisis de fosfatidilcolina (PC) y ácido linoleico conjugado (CLA) usando fosfolipasa A1 (PLA1) inmovilizada. Los efectos de carga de enzima (2, 5, 10, 15 y 20%, respecto al peso de los sustratos), temperatura (20, 30, 40, 50 y 60 °C) y la relación molar de sustratos (1:2, 1:4, 1:6, 1:8 y 1:10, PC/CLA) fueron evaluados para alcanzar la más elevada incorporación de CLA en PC. La máxima incorporación de CLA obtenida fue de 90% a 50 °C y 200 rpm, para una relación molar 1:4 con una carga de enzima de 15% después de 24 h

An Electromagnetic Study of the Impact of Brain Anatomy on Deep Brain Stimulation

An electromagnetic simulation was performed to assess the volume of tissue activated on deep brain stimulation for two patients randomly selected. The finite element method is used to calculate the electric field distribution that predicts the volume of tissue activated. High-resolution magnetic resonance images are utilized to create patient-specific anatomical models of the subthalamic nucleus and the internal pallidum. The results confirmed the influence of brain anatomy leading to different shape and volume of tissue activated despite similar technical features. Thus, a patient-specific model and an adequate choice of stimulation parameters are crucial on deep brain stimulation outcomes.S

Glicerolisis de aceite de pescado catalizada por lipasa para producir diacilglicéridos

Diacylglycerols (DAG) rich in n-3 residues were successfully produced by Novozym 435-catalysed glycerolysis of n-3 PUFA rich fish oil. Orbital and magnetic agitations were evaluated in order to minimize mass transfer limitations and thus assure the homogeneity of the reactant mixture. Different temperatures (65, 70, 75, 80, 85 and 90 °C) and speeds (300, 500, 700 and 900 rpm) were tested. Optimal conditions to obtain the highest amount of DAG were: 65 °C, with a substrate molar ratio of 3:1 (oil:glycerol), 500 rpm and 15% enzyme load after 2.5 h, with a yield of 60%.Diacilglicéridos (DAG) ricos en n-3 fueron producidos en la glicerolisis de aceite de pescado rico en n-3 PUFA catalizada por Novozym 435. Las agitaciones orbital y magnética fueron evaluadas con el propósito de minimizar las limitaciones de transferencia de masa y garantizar la homogeneidad de la mezcla de reactivos. Diferentes temperaturas (65, 70, 75, 80, 85 y 90 °C) y velocidades de agitación (300, 500, 700 y 900 rpm) fueron empleadas. Las condiciones óptimas para alcanzar la mayor cantidad de DAG fueron: 65 °C, una relación molar de sustratos 3:1 (aceite:glicerol), 500 rpm y 15% de enzima, después de 2.5 h, con un rendimiento de 60%

Functional insight into the reciprocal paracrine crosstalk of stromal fibroblasts in the head and neck cancer microenvironment

Trabajo presentado en el 18th ASEICA International Congress, celebrado en Santiago de Compostela (España) del 16 al 18 de noviembre de 2022

Unha proposta innovadora para educación infantil dende o proxecto KidsInnScience: as patacas poden medrar no aire

A proposta innovadora “As patacas poden medrar no aire” está destinada para o alumnado de educación infantil e enmárcase no proxecto europeo KidsInnScience: turning kids on to science. Neste proxecto participan dez países, dous latinoamericanos e no que participa a Universidade de Santiago de Compostela xunto con outros sete países europeos e dous latinoamericanosEste traballo forma parte do proxecto europeo “KidsINNscience (KIS): turning kids on to science” financiado polo séptimo programa marco, código SIS-CT-2010-244265S

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured