60 research outputs found
A qualitative study of independent fast food vendors near secondary schools in disadvantaged Scottish neighbourhoods
- Author
- A Ellaway
- AL Strauss
- Anne Ellaway
- AS Alberga
- C Economos
- C Enz
- C Harper
- C Pope
- D Neumark-Sztainer
- E Chell
- F Crawford
- FH Leite
- Fiona Crawford
- Geraldine McNeill
- H Gebauer
- I Dar-Nimrod
- J Clark
- J Jabs
- J Withall
- L Beghin
- L Gostin
- LF Masson
- M Heroux
- Michelle Estrade
- NKV Maniadakis
- OTCD Mytton
- Public Health Responsibility Deal
- R Patterson
- R Sharpe
- RJ Beeken
- Ruth Jepson
- RW Jeffery
- Smita Dick
- SRA Smed
- T Lobstein
- W Sichert-Hellert
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Background:
Preventing and reducing childhood and adolescent obesity is a growing priority in many countries. Recent UK data suggest that children in more deprived areas have higher rates of obesity and poorer diet quality than those in less deprived areas. As adolescents spend a large proportion of time in school, interventions to improve the food environment in and around schools are being considered. Nutrient standards for school meals are mandatory in the UK, but many secondary pupils purchase foods outside schools at break or lunchtime that may not meet these standards.
Methods:
Qualitative interviews were conducted with fast food shop managers to explore barriers to offering healthier menu options. Recruitment targeted independently-owned shops near secondary schools (pupils aged c.12-17) in low-income areas of three Scottish cities. Ten interviews were completed, recorded, and transcribed for analysis. An inductive qualitative approach was used to analyse the data in NVivo 10.
Results:
Five themes emerged from the data: pride in what is sold; individual autonomy and responsibility; customer demand; profit margin; and neighbourhood context. Interviewees consistently expressed pride in the foods they sold, most of which were homemade. They felt that healthy eating and general wellbeing are the responsibility of the individual and that offering what customers want to eat, not necessarily what they should eat, was the only way to stay in business. Most vendors felt they were struggling to maintain a profit, and that many aspects of the low-income neighbourhood context would make change difficult or impossible.
Conclusions:
Independent food shops in low-income areas face barriers to offering healthy food choices, and interventions and policies that target the food environment around schools should take the neighbourhood context into consideration
CDPKs CPK6 and CPK3 Function in ABA Regulation of Guard Cell S-Type Anion- and Ca(2+)- Permeable Channels and Stomatal Closure
- Author
- Albrecht
- Allan
- Allen
- Allen
- Allen
- Allen
- Allen
- Allen
- Alonso
- Bachmann
- Bachmann
- Birnbaum
- Blatt
- Cheng
- Choi
- Cousson
- Curvetto
- DeSilva
- Frachisse
- Garbers
- Ghelis
- Gilroy
- Grabov
- Grabov
- Grabov
- Guo
- Hamilton
- Han
- Harmon
- Harper
- Hedrich
- Hepler
- Hervé Tiriac
- Hetherington
- Hetherington
- Hetherington
- Hey
- Hille
- Hrabak
- Hugouvieux
- Ichida
- Ivashuta
- Izumi C Mori
- James Carrington
- Jeffery F Harper
- Jose M Alonso
- Joseph R Ecker
- Julian I Schroeder
- June M Kwak
- Keller
- Kinoshita
- Klüsener
- Kwak
- Kwak
- Köhler
- Leckie
- Lee
- Leonhardt
- Leonhardt
- Levchenko
- Li
- Li
- Li
- Linder
- MacRobbie
- MacRobbie
- Martin
- McAinsh
- McAinsh
- McCubbin
- McMichael
- Miyawaki
- Murata
- Nagai
- Nakamura
- Ohto
- Outlaw
- Pandey
- Peck
- Pei
- Pei
- Pei
- Raschke
- Roelfsema
- Roelfsema
- Romano
- Romeis
- Satoh
- Schmidt
- Schroeder
- Schroeder
- Schroeder
- Schroeder
- Schwarz
- Schwarz
- Shannon Andreoli
- Shao
- Sheen
- Shimazaki
- Shintaro Munemasa
- Staxén
- Sugiyama
- Szczegielniak
- Teige
- Torres
- Wachter
- Ward
- Ward
- Webb
- Wu
- Yang
- Yashar
- Yingzhen Yang
- Yong-Fei Wang
- Yoon
- Yoshiyuki Murata
- Young
- Yuasa
- Zhang
- Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/10/2006
- Field of study
Abscisic acid (ABA) signal transduction has been proposed to utilize cytosolic Ca(2+) in guard cell ion channel regulation. However, genetic mutants in Ca(2+) sensors that impair guard cell or plant ion channel signaling responses have not been identified, and whether Ca(2+)-independent ABA signaling mechanisms suffice for a full response remains unclear. Calcium-dependent protein kinases (CDPKs) have been proposed to contribute to central signal transduction responses in plants. However, no Arabidopsis CDPK gene disruption mutant phenotype has been reported to date, likely due to overlapping redundancies in CDPKs. Two Arabidopsis guard cell–expressed CDPK genes, CPK3 and CPK6, showed gene disruption phenotypes. ABA and Ca(2+) activation of slow-type anion channels and, interestingly, ABA activation of plasma membrane Ca(2+)-permeable channels were impaired in independent alleles of single and double cpk3cpk6 mutant guard cells. Furthermore, ABA- and Ca(2+)-induced stomatal closing were partially impaired in these cpk3cpk6 mutant alleles. However, rapid-type anion channel current activity was not affected, consistent with the partial stomatal closing response in double mutants via a proposed branched signaling network. Imposed Ca(2+) oscillation experiments revealed that Ca(2+)-reactive stomatal closure was reduced in CDPK double mutant plants. However, long-lasting Ca(2+)-programmed stomatal closure was not impaired, providing genetic evidence for a functional separation of these two modes of Ca(2+)-induced stomatal closing. Our findings show important functions of the CPK6 and CPK3 CDPKs in guard cell ion channel regulation and provide genetic evidence for calcium sensors that transduce stomatal ABA signaling
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
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- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
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- Anagnou A
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- Applewhaite C
- Aquino LPG
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- Asudo F
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
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- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald KL
- Maceviciute K
- Macfarlane A
- Machaca M
- Machain Vega GM
- Machain Vega GM
- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi AA
- Magri D
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
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- Maher ME
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud MA
- Mahmoud MI
- Mahmoud S
- Mahmoud SME
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs NG
- Maison K
- Maistry N
- Majauskyte D
- Majbar A
- Majid AHHA
- Majid K
- Major CP
- Major P
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- Mak T
- Mak TWC
- Makama J
- Makinde M
- Makupe A
- Malaga B
- Malavenda M
- Malik K
- Malik P
- Malik TAM
- Mamdouh E
- Mamdouh R
- Manatakis DK
- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marcelo Delgado J
- Marey A
- Marey AS
- Margaritis M
- Maria Garcia-Perez J
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret J-B
- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
- Mas R
- Mason C
- Mat TNT
- Mata LPS
- Matheu A
- Mathew SW
- Matos-Puig R
- Mattar O
- Matter SM
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
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- Mcaleer S
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- McGarvie S
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- Mclean AL
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- McMorran D
- Mcnish D
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- Mehdi A
- Mehrez S
- Melo Cardozo RA
- Melo R
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- Mendoza Arango MC
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mercado Rodriguez L-A
- Mericliler M
- Merlini D
- Merlini D
- Merlo MS
- Mesbah N
- Meshref A
- Messa Aguilar WL
- Messa Aguilar WL
- Metwally MM
- Migliore M
- Mihaljevic AL
- Mihaljevic AL
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez Garcia J
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul AR
- Mitul AR
- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
- Molina G
- Monaghan E
- Monaghan E
- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
- Morgan C
- Morgan C
- Morshedy EM
- Morsi A
- Morsi M
- Morton D
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- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin ADF
- Muktar U
- Mukuzunga C
- Muller C
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- Muller J
- Munera A
- Munhoz MM
- Munipalle PC
- Muntean L
- Muntean LI
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa AEK
- Musleh A
- Musowoya J
- Mussad A
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- Mustafa M
- Mustafa M-A
- Musyoka CK
- Mutabazi A
- Mutabazi AZ
- Mutabazi AZ
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
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- Nada F
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- Nadkarni S
- Naess PA
- Nagy GS
- Nahar SN
- Nair H
- Najjar M
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
- Narayanan R
- Narvestad JK
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir AA
- Nasir WNWM
- Nasr A
- Nasr M
- Nasr M
- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
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- Nayel AR
- Nazir M
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- Ndajiwo A
- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
- Neo YT
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng JCK
- Ng S
- Ng YK
- Ng ZH
- Ngayu N
- Ngwa TE
- Niazi AK
- Nicholson L
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- Nikoloudis N
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
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- Notarnicola M
- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
- Nsengiyumva C
- Ntirenganya F
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- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- O'neill M
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- Palomino Castillo VD
- Paludi MA
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- Panteli C
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- Papandrea M
- Papaskarlatos I-A
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- Parseliunas A
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- Patoulias I
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- Pena L
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- Perez Velasquez CI
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- Pertersen Servin GR
- Pesenti G
- Petrikenas S
- Peycelon M
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- Pezas T
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- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
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- Pinkney T
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- Pino W
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- Powell A
- Prabhudesai A
- Pranevicius R
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- Preckailaite E
- Primavesi F
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- Pronin S
- Prudhomme T
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- Punja V
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- Qureshi AU
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- Ramarez Cabrera CC
- Ramazzini P
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- Razi SAU
- Razmdjou S
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- Sahel S
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- Sakr A
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- Salah OM
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- Samalavicius NE
- Samaraweera DI
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- Samy S
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- Sandoval Barrantes AM
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- Schivo D
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- Schuetz T
- Schultz JK
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- Scott M
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- Seisa M
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- Semeda N
- Semiz A
- Sena-Ruiz F
- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
- Seto DM
- Seyoum N
- Sfougaris D
- Sgroi G
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- Shachykava T
- Shah A
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- Shaharuddin S
- Shahbaz AR
- Shaheen A
- Shahine A
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- Shaikh N
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- Shalabi A
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- Shillito S
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- Sii SSY
- Sileri P
- Silvani P
- Silvestre BP
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- Sinha Y
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- Sivaganesh S
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- Sleem AS
- Sleem M
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- Smart N
- Smart NJ
- Smedley A
- Smith C
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- Smith D
- Snaith AC
- Snyder E
- Soares Miguel GP
- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
- Soley R
- Soliman A
- Soliman A
- Soliman AR
- Soliman N
- Soliman NA
- Soliman S
- Soliman Y
- Sollazzo V
- Soltani N
- Som R
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- Song J
- Soon WC
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- Soreide JA
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- Souaibou YI
- Souaibou YI
- Soulou V
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- Spence R
- Spence R
- Spence R
- Spence R
- Spina A
- Sproule L
- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
- Sroor F
- Sruogiene EZ
- Staerkle RF
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
- Stephen A
- Stewart D
- Stock S
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- Stourton F
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- Strupas K
- Strupas K
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- Stuva J
- Styles K
- Suarez A
- Suarez AAB
- Subocius A
- Suleiman SI
- Summerour V
- Sund M
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- Sunderland G
- Sundstrom SM
- Suresh S
- Sutandi N
- Sutanto EPR
- Sutton P
- Sutton P
- Suyadi A
- Swann J
- Swaroop M
- Swaroop M
- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
- Szeto KJ-Y
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
- Taher M
- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan CL
- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
- Tew YY
- Tewari S
- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thomas HS
- Thompson B
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- Thorarinsdottir H
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- Thurairaja R
- Tierney G
- Tilston TW
- Timothy OK
- Ting JRS
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- Todd KO
- Toeema AG
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
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- YS Cho
- Yufang Shi
- Z Cai
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- Z Zhang
- Z Zhong
- Zahra Zakeri
- ZG Liu
- ZN Oltvai
- ZT Schafer
- ZX Chen
- ZX Chen
- Publication venue
- Cell Death Differ
- Publication date
- 01/01/2018
- Field of study
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
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- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
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- Hamilton Matt
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- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
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- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
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- Hashimoto Wakako
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- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
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- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Holtzer Caleb
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- Homsi Farah J.
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- Imo Kelvin C.
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- Ishikawa Sabine K.
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- Nakato Eriko
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- Okumura Reina
- Okwuonu Geoffrey O.
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- Olson Maynard V.
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- Zhang Xiuqing
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- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Attard M
- Attia A
- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
- Aziz Na
- Azizeldine Mg
- Azmitia Jra
- Azodo Ia
- Azzie G
- Azzie G
- Azzis O
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- Bachri H
- Badawy M
- Badenjki Ma
- Badicel M
- Badr A
- Badr Mfm
- Badwi Nm
- Badwi Nm
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila Rmh
- Balkan Aza
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis Vj
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal Gs
- Baraka H
- Barakat Sae
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas Gn
- Barnacle J
- Barneo L
- Barrantes Ams
- Barreda Lma
- Barrientos Lam
- Barrios E
- Barrios E
- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
- Basson S
- Basto Caa
- Batt J
- Bautista Acm
- Bautista Acm
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada Ag
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet Ah
- Bekhet Nm
- Beleñ
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai Rm
- Benons N
- Bentounsi Z
- Benyaiche C
- Bermú
- Bernardo Cg
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezzina M
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj Is
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal Kf
- Bhopal Kf
- Bianco F
- Bigaran A
- Billy M
- Birindelli A
- Birring A
- Bisset C
- Bjö
- Bjö
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksø
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda-Luque G
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- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botero Jam
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
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- Boyce T
- Bré
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu Mr
- Bratu Rm
- Braungart S
- Bravo Jac
- Bray Ld
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat Sd
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
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- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt Mt
- Cabrera Ccrr
- Cacurri A
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- Cahill R
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- Calua Ac
- Camacho R
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- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan Jf
- Campagnaro T
- Canto Md
- Capito C
- Capleton P
- Carabott K
- Cardozo Jt
- Cardozo Ram
- Careta Mc
- Carlucci M
- Carmona Jm
- Carneros Vj
- Carpio J
- Carrasco N
- Carreira Ja
- Cassar K
- Castillo Vdp
- Castro Mr
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
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- Celis Jmv
- Cengiz Tb
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
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- Cevik M
- Chabok A
- Chachulski W
- Chai Ca
- Chai Fy
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan Tk
- Chan Xw
- Chan Z
- Chandrakumar C
- Chang K
- Chang Ky
- Chapman A
- Chapman Sj
- Charles A
- Cheah Aez
- Chen Cy
- Chen Jhc
- Chen Ky
- Chen Tl
- Chenn R
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- Chetta N
- Cheung Yhe
- Chew Ls
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin Px
- Chin Yr
- Chiong Jac
- Chiong Jac
- Chiu S
- Chiu S
- Chiu Smy
- Choi J
- Choi P
- Chong Bfhk
- Chong Cl
- Chong Cl
- Chong Cl
- Chong Cs
- Chong Hy
- Chong Hy
- Choudhry A
- Chow Cyn
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung Kj
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark Dj
- Clark T
- Clegg-Lampety Jn
- Clegg-Lamptey Jn
- Clement Kd
- Clements Jm
- Clerico G
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- Cloro Lm
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- Cohen F
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- Coletti M
- Collado Mv
- Colombani Jf
- Cona C
- Conci S
- Confalonieri G
- Conlon Kc
- Connor K
- Connor K
- Contreras E
- Contreras-Vergara Al
- Coomber R
- Coompson Cl
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Correa Jc
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz Dh
- Cruz H
- Cucumazzo S
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- Curletti G
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- Currow C
- Cury Adl
- Dé
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk Mo
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- Dahy A
- Dainius E
- Dakubo J
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish Ak
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
- Davies R
- Davor A
- Dawnay G
- Dawood K
- Dawoud H
- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Castro Segundo LCB
- De Franciscis S
- De Freitas AVC
- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
- de Lima CVB
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
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- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
- Doughan S
- Doughty J
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- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
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- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
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- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
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- Elhadary Nm
- Elhadry S
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- Elhamouly S
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- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
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- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
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- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
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- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
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- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
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- Garcia-Marin Ja
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- Garland A
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- Gemeah M
- Gemenetzis G
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
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- Ghanem S
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- Ghannam M
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- Ghazy Aa
- Gheith A
- Ghetia M
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- Ghoneim O
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- Giardino Fr
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- Giuriato Tf
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- Glynn M
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- Goldin E
- Golding D
- Gomaa A
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- Goodstein M
- Gosling S
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- Grasset E
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- Grassi V
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- Grizhja B
- Grobler Dc
- Grosos C
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- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
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- Gustafsson U
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- Gyedu A
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- Habeebullah A
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- Haddad N
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- Hafiz S
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- Hajeh H
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- Halhouli O
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- Halicioglu I
- Hall E
- Hall N
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- Hamaguchi Jlh
- Hamarshi A
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- Hamdan A
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- Hanoun S
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- Hany E
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- Har Pa
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- Harper E
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- Harrison N
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- Hartford L
- Harvey N
- Hasan A
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- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
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- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
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- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
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- Herebat A
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- Horobjowsky A
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- Hossameldin A
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- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
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- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
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- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
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- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
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- Irwin G
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- Israelsson L
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- Jabbar A
- Jaber S
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- Jacobe M
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- Jain P
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- Javed O
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- Kotobi H
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- Kouraklis G
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- Laurie K
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- Law Jh
- Lawal A
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- Lawther R
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- Lee C
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- Lee F
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- Leone N
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- Leung Kw
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- Leusink A
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- Lim G
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- Lo Conte A
- Loaloa Mr
- Lockey J
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- Loizides S
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- Macchitella Y
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- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
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- Maffioli A
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- Magdy A
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- Magdy H
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- Marey A
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- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
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- Mentula P
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- Miranda C
- Mircea H
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- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Modolo Mm
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- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
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- Mohammed Ae
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- Mohammed H
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- Mohammed S
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- Molina G
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- Monaghan E
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
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- Montes I
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- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Moreira G
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- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
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- Mowafy B
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- Mshelbwala P
- Msiska N
- Msosa V
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- Mukuzunga C
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- Nada F
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- Nagy Gs
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- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Ndajiwo A
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- Ndegwa W
- Ndlovu Sr
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- Negida A
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- Nel D
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- Neo Yn
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- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
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- Nicholson L
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- Nikoloudis N
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Notarnicola M
- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
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- Ntirenganya F
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- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Redota Map
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Woodward Z.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
25th annual computational neuroscience meeting: CNS-2016
- Author
- Abbott L.F.
- Abeysuriya Romesh G.
- Aertsen Ad
- Agnes Everton J.
- Ahamed Tosif
- Ahmadabadi Majid Nili
- Ahn Sora
- Aihara Kazuyuki
- Aihara Kazuyuki
- Andreassen Ole A.
- Andreassen Ole A.
- Ardestani Mohammad Hovaidi
- Ardestani Mohammad Hovaidi
- Arroyo David
- Aton Sara J.
- Babichev Andrey
- Bachmann Claudia
- Badel Laurent
- Baek Hyeon-Man
- Baek JeongHun
- Baek Kwangyeol
- Bahuguna Jyotika
- Bak Ji Hyun
- Baker Chris I.
- Bakker Rembrandt
- Balaguer‑Ballester Emili
- Bard G.
- Barnett William H.
- Baroni Fabiano
- Basnayake Kanishka
- Baysal Velt
- Bennett Matthew R.
- Bernard Christophe
- Berry Hugues
- Beuth Frederick
- Bezgin` Gleb
- Bill Johannes
- Birgolias Justas
- Blackwell Justin
- Bohnenkamp Lisa
- Bojak Ingo
- Borisyuk Roman
- Bos Hannah
- Bradley Samual P.
- Breakspear Michael
- Breitwieser Oliver
- Briaire` Jeroen J.
- Briggman Kevin L
- Brinkman Braden A.
- Brown John
- Brown Ritchie E.
- Brunel Nicolas
- Buhry Laure
- Buice Michael
- Burkitt Anthony N.
- Burton Shawn D.
- Buttler Simone
- Bytschok Ilja
- Cantarelli Matteo
- Chakravarthy V.Srinivasa
- Chan Ho Ka
- Chapman Phillip D.
- Chatzikalymniou Alexandra Pierri
- Chavane Frédéric
- Chen Liang
- Chen Weiliang
- Cheung Chung Ching
- Chhabria Karishma
- Chintaluri Chaitanya
- Choe Yoonsuck
- Choi Hannah
- Choi Hansol
- Choi Ilhwan
- Choi Jee Hyun
- Choi Woochul
- Choi Yun Seo
- Choung Oh‑hyeon
- Chung SueYeon
- Clarke Eric F.
- Clements Katie
- Cloherty Shaun L.
- Clopath Claudia
- Cocchi Luca
- Cohen Yale E.
- Cook Mark
- Crook Sharon M.
- Cserpán Dorottya
- Culmone Viviana
- Dabaghian Yuri
- Dabaghian Yuri
- Dale Anders M.
- Daly Kevin C.
- Dasgupta Sakyasingha
- Davey Neil
- Davey Neil
- Davison Andrew
- de Weerd Peter
- Deco Gustavo
- Demkó László
- Demutz Harald
- Denk Cornelia
- Destexhe Alain
- Devor Anna
- DeVuti Justin
- Diamond Alan
- Diesmann Markus
- Dillen Kim
- Doya Kenji
- Dragoi Valentin
- Draguljić Daniel
- Drew Jordan
- Drysdale Peter M.
- Duarte Renato
- Dura‑Bernal Salvador
- Dura‑Bernal Salvador
- Dura‑Bernal Salvador
- Edwards Andy
- Einevoll Gaute T.
- Elices Irene
- Elnevoll Gaute T.
- Ernst Udo A.
- Esler Timothy B.
- Esposito Elric
- Faraji Mohammad Java
- Fedorov Leonid A.
- Fenk Lisa M.
- Ferguson Katie
- Ferrario Andrea
- Filipovi Marko
- Fink Christian G.
- Fink Gereon R.
- Fishman Yonatan I.
- Fornito Alex
- Forrow Csaba
- Fouquet Coralie
- Frangou Sophia
- Freestone Dean R.
- Frijns Johan H. M.
- Fulcher Ben D.
- Fung Felix
- Gajic N. Alex Cayco
- Gallimore Andrew R.
- Gallinaro Júlia
- Gerkin Richard C.
- Gerstner Wulfram
- Giaffar Hamza
- Giese Martin
- Giese Martin
- Giese Martin A.
- Gilson Matthieu
- Gips Bart
- Gleeson Padraig
- Gliske Stephen V.
- Glomb Katharina
- Goetze Felix
- Goldsworthy Mitchell R.
- Gollo Leonardo L.
- Goncharenko Julia
- Goodarzinic Abdorreza
- Graham Bruce P.
- Grayden David B.
- Grayden David B.
- Grewe Jan
- Hadrava Michal
- Hagen Espen
- Halnes Geir
- Halnes Geir
- Hamade Khaldoun
- Hamker Fred H.
- Han Hio-Been
- Han Seung Kee
- Hansen Mads
- Harper Zachary J.
- He Hu
- Helias Moritz
- Hermann Christoph S.
- Hilgetag` Claus‑Christian
- Hines Michael L.
- Hlinka Jaroslav
- Hof Patrick R.
- Holman Katherine A.
- Hong Sungho
- Hordacre Brenton
- Howard Jr. James H.
- Huang Guang-Bin
- Huang Haiping
- Huerta Ramon
- Huh Dongsung
- Hutt Axel
- Hwang Dong‑Uk
- Hwang Eunjin
- Hye Jr. Eoon
- Iannella Nicolangelo
- Iannella Nicolangelo
- Ibbotson Michael R.
- Ionta Silvlo
- Ishii Shin
- Issa Fadi A.
- Iyer Ramakrishnan
- Jacobs Heidi
- Jang Hyun Jae
- Jang Jaeson
- Jang Jaeson
- Jensen Ole
- Jeong Jaeseung
- Jeong Jaesung
- Jeong Yong
- Jirsa Viktor K.
- Jo Sumin
- Joo Pangyu
- Josić Kresimir
- Ju Huiwen
- Jun Eunji
- Jun Sang Beom
- Jung Nam
- Jung Woo-Sung
- Jung Younginha
- Kahng B.
- Kale Penelope J.
- Kalkman Randy K.
- Kameneva Tatiana
- Kameneva Tatiana
- Kang Jiyoung
- Karoly Philippa J.
- Kasumi Ohta
- Kavalali Enge T.
- Kawato Mitsuo
- Kazama Hokto
- Kedziora David J.
- Kekona Tyler
- Keller Daniel
- Kennedy Henry
- Kepple Daniel
- Kerr Cliff C.
- Kerr Robert R.
- Kilpatrick Zachary P.
- Kim Ammo J.
- Kim Bowon
- Kim Bowon
- Kim Chang Sub
- Kim DaeEun
- Kim Hojeong
- Kim Hoon-Hee
- Kim Hyoungkyu
- Kim Jae Kyoung
- Kim Jimin
- Kim Jinseop
- Kim Juhee
- Kim Minjung
- Kim Seongkyun
- Kim Su Hyun
- Kim Sung-Phil
- Kim Sung-Phil
- Kim Tae
- Kim Taegyo
- Kim Won Sup
- Kim Youngsoo
- Kiser Seth A.
- Klanner Felix
- Kleberg Florence I.
- Klingbeil Guido
- Knösche Thomas
- Koren Veronika
- Koren Veronika
- Kotaleski Jeanette Hellgren
- Koulakov Alex
- Kralik Jerald D.
- Kringelbach Morten L.
- Kruscha Alexandra
- Kuhlmann Levin
- Kukolja Juraj
- Kumar Arvind
- Kumar Arvind
- Kundu Prantik
- Kunze Tim
- Kuravi Pradeep
- Kwag Jeehyun
- Kwon Jaehyung
- Lai Pik‑Yin
- Lakatos Peter
- Latorre Roberto
- Leahy Will
- Lee Changju
- Lee Chungho
- Lee Dan D.
- Lee Do-won
- Lee Heonsoo
- Lee Hyang Jung
- Lee Hyang Woon
- Lee Hyeonsu
- Lee Jae Woo
- Lee Jaejin
- Lee Jeungmin
- Lee Joonwon
- Lee Jung H.
- Lee Sang Wan
- Lee Sang-Hun
- Lee Seungjun
- Lee Soohyun
- Lee Sue-Hyun
- Lee Tae Ho
- Lee Won Hee
- Lee Yong‑il
- Lefebvre Baptiste
- Lefebvre Jérémie
- Leleu Timothée
- Leng Luziwei
- Levi Rafael
- Levina Anna
- Levy Brandon A.
- Li Luozheng
- Liang Guangsheng
- Lidner Benjamin
- Liedtke Joscha
- Lim Daeseob
- Lim Sewoong
- Lin Xiahoan
- Linder Benjamin
- Lines Glenn T.
- Lizler Joseph T.
- Lochmann Timm
- Lowet Eric
- Luebke Jennifer
- Lytton William W.
- Lytton William W.
- Lyu Cheng
- Ma Hailin
- Maeng Seung Eu
- Malmon Gabby
- Mandall Alekhya
- Maouene M.
- Marcelli Angelo
- Marin Boris
- Markin Sergey
- Markram Henry
- Marre Olivier
- Marsalek Petr
- Marsat Gary
- Martel Roman
- Marucci Lucia
- Maturana Matias I.
- McCarley Robert W.
- McDonnell Mark D.
- McDonnell Mark D.
- McKenna James T.
- McLauchlan Campbell
- Meffin Hamish
- Meffin Hamish
- Mehta Hima
- Meier Karlheinz
- Meijas Jorge F.
- Mellen Nick
- Memmeshei Raol-Martin
- Menzies Rosemary J.
- Merriosn-Hort Robert
- Metzner Christoph
- Mi Yuanyuan
- Mi Yuanyuan
- Mihalas Stefan
- Miller Thomas
- Moezzi Bahar
- Moezzi Bahar
- Molkov Yaroslav I.
- Moon Jangsup
- Moon Seok-hun
- Morris Laurel S.
- Morrison Abigail
- Mosqueiro Thiago S
- Mu Shang
- Muler Eilif
- Muralidharan Vignesh
- Murray John D.
- Murray Micha M.
- Mäki‑Marttunen Tuomo
- Neymotin Samuel
- Neymotin Samuel A.
- Niry Mohammad
- Nishikawa Isao
- Nolte Max
- Nowotny Thomas
- Oba Shigeyuki
- Obermayer Klaus
- Obermayer Klaus
- Ognjanovski Nicolette
- Ouyang Guang
- Ozer Mahmut
- Paik Se-Bum
- Paik Se‑Bum
- Palmer S.E.
- Palva Matias J.
- Paninski Liam
- Pariz Aref
- Park Chang-hyun
- Park Choongseok
- Park Hae‑Jeong
- Park Ji Sung
- Park Memming
- Park Sang-Min
- Park Sol
- Parsi Shervin S.
- Parziale Antonio
- Pasupathy Anitha
- Perotti Luca
- Peterson Andre
- Petkoski Spase
- Petrovici Mihai A.
- Petterson Klas H.
- Philips Ryan T.
- Phillips Ryan S.
- Pillow Jonathan
- Pittà Maurizio De
- Plogmacher Lukas
- Podlaski William
- Pollonini Luca
- Ponce‑Alvarez Adrián
- Popp Pamela Osborn
- Preuschoff Kerstin
- Priesemann Viola
- Priesemann Viola
- Priyadharsini B. Praga
- Psarrou Maria
- Quang Le Anh
- Quintana Adrian
- Ramsey Julia
- Ranjan Rajnish
- Rankin James
- Rankin James
- Rasch Malte J.
- Rasuli Nader
- Ratnadurai‑Giridharan Shivakeshavan
- Reig Ramon
- Reimann Michael W.
- Rennle Chris J.
- Reyes Amy
- Richter René
- Ridding Michael C.
- Rieke Fred
- Rinberg Dima
- Rinzel John
- Ritter Petra
- Roach James P.
- Robb Daniel T.
- Roberts Mark J.
- Robinson Peter A.
- Robinson Peter A.
- Rodriguez Francisco B.
- Rotter Stefan
- Rubchinsky Leonid L.
- Rubinov Mikail
- Rumbell Timothy
- Rupp André
- Rybak Ilya A.
- Ryu Juhyoung
- Sadeh Sadra
- Saggio Maria L.
- Sander Leonard M.
- Sanger Terence D.
- Sanz-Leon Paula
- Sanz‑Leon Paula
- Saska Daniel
- Schaworonkow Natalie
- Schemmel Johannes
- Scheutz Matthias
- Schiff Steven J.
- Schilstra Maria
- Schilstra Marla
- Schmidt Maximilian
- Schmidt Robert
- Schottdorf Manual
- Schutter Erik De
- Schwikard Achim
- Seeholzer Alexander
- Seidenstein Alexandra
- Sejnowski Terrence J.
- Sekulić Vladisla
- Senatore Rosa
- Senk Johanna
- Seo Sat Byul
- Seung H. Sebastian
- Sharpee Tatyana O.
- Shea Steven
- Shea-Brown Eric
- Shea‑Brown Eric
- Shen Kelly
- Shiau LieJune
- Shimazaki Hideaki
- Shin Hee‑sup
- Shin In-Seob
- Shivkumar Sabyasach
- Shlizerman Eli
- Shomali Safura Rashid
- Siep Silvan F.
- Silberberg Gilad
- Silver Angus
- Silver R. Angus
- Skiker K.
- Skilling Quinton M.
- Skinner Frances K.
- Skinner Frances K.
- Smit Daniel
- Smith Brian
- Smith Jeffrey
- Soh Jaehyun
- Soman Karthik
- Somogyvári Zoltán
- Sompolinsky Haim
- Song Min
- Song Min-Ho
- Song Youngjo
- Soundry Daniel
- Sourina Olga
- Spampinato Giulia Lia Beatrice
- Spiegler Andreas
- Spinney Richard E.
- Sprecher Simon
- Stacey William C.
- Stacey William C.
- Stephens Greg
- Stern Merav
- Steuber Volker
- Steyn-Ross D. Alistair
- Steyn-Ross Moira L.
- Stimberg Marcel
- Strube‑Bloss Martin F.
- Stöckel David
- Su Jianzhong
- Sun Haoqi
- Sweeney Yann
- Tabas Alejandro
- Tahayori Bahman
- Takashima Akira
- Tam Nicoladie D.
- Tamagnini Francesco
- Tang Rongxiang
- Tang Yi-Yuan
- Tang Yi-Yuan
- Teka Wondimu
- Tetzlaff Tom
- Tezuka Taro
- Toporikova Natalia
- Torres Joaquin J.
- Toyoizumi Taro
- Tran Patricia H. P.
- Trembleau Alain
- Triesch Jochen
- Trisch Jochen
- Tsaneva‑Atanasova Krasimira
- Tsuchimoto Yoshiko
- Tuomo Maki-Martun
- Tveito Aslak
- Valizadeh Alireza
- Valizadeh Alireza
- van Albada Sacha J
- van Albada Sacha J.
- van der Eerden Jan
- Varona Pablo
- Varona Pablo
- Veale Richard
- Viriyopase Atthaphon
- Vitay Julien
- Vogels Rufin
- Vogels Tim
- Vogels Tim P.
- Vogt Simon M.
- Voon Valerie
- Voronenko Sergej O.
- Vuust Peter
- Vörös János
- Wallentin Mikkel
- Wang Dahui
- Wang Jisung
- Wang Sheng-Ju
- Wang Yuzhe
- Warburton Julia M.
- Weaver Christina M.
- Wegener Detlef
- Weidel Philipp
- Welzig Charles M.
- Werdt Stephen Van
- Wibral Michael
- Wickens Jeffery R.
- Widmer Yves
- Witek Maria A. G.
- Witting Jens
- Wolf Fred
- Wong Michael
- Wu Si
- Wu Sl
- Wójcik Daniel K.
- Xu Zhiheng
- Yamada Yasnori
- Yamamura Yorkio
- Yang Huei-Fang
- Yang Xu
- Yeon Ji Won
- Yger Pierre
- Yilmaz Ergin
- Yoo Minsu
- Yoon Sangsup
- Yoshimoto Junichiro
- Young-Ah Rho
- Yu Suin
- Zaho Yuan
- Zamora Criseida
- Zaptocky Martin
- Zhang Mingsha
- Zhang Wenhao
- Zhao Chang
- Zhao Xiaochen
- Zhao Xuelong
- Zhou Changsong
- Zochowski Michal
- Zochowski Michal R.
- Zouridakis George
- Zurowski Bartosz
- Publication venue
- BMC
- Publication date
- 01/01/2016
- Field of study
The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Clifford S.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Dimitri P.
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- Durrington H.
- Duru I.
- Dymond H.
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- D’Mello A.
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- Early J.
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- Elgohary A.
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- Emberson Jonathan R.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farzana S.
- Fatemi A.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
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- Jamal A.
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- Jarvis C.
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- Jeebun V.
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- Johnstone E.
- Jones A.
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- Judge P.
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- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lodhia K.
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- Logan M.
- Logue C. A.
- Lokanathan S.
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- Majumdar Jaydip
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
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