408 research outputs found
Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/11/2014
- Field of study
This study set out to explore the attitudes of a representative sample of the British public towards genetic testing in children to predict disease in the future. We sought opinions about genetic testing for adult-onset conditions for which no prevention/treatment is available during childhood, and about genetic 'carrier' status to assess future reproductive risks. The study also examined participants' level of agreement with the reasons professional organisations give in favour of deferring such testing. Participants (n=2998) completed a specially designed questionnaire, distributed by email. Nearly half of the sample (47%) agreed that parents should be able to test their child for adult-onset conditions, even if there is no treatment or prevention at time of testing. This runs contrary to professional guidance about genetic testing in children. Testing for carrier status was supported by a larger proportion (60%). A child's future ability to decide for her/himself if and when to be tested was the least supported argument in favour of deferring testing.European Journal of Human Genetics advance online publication, 5 November 2014; doi:10.1038/ejhg.2014.221
Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana – an eight year study
- Author
- AL Weber
- BW Neville
- D Dequanter
- D Harrison
- D Simon
- DJ Theodorou
- ET Adebayo
- ET Adebayo
- GEA Parkins
- George Armah
- Grace EA Parkins
- GT Arotiba
- GT Arotiba
- I Bruce
- JC Watkinson
- JP Sapp
- LR Eversole
- M Sato
- M Ulmansky
- MM Chidzonga
- MM Chidzonga
- MM Chidzonga
- MM Chidzonga
- N Tanaka
- NJ Meguinness
- OF Ajayi
- P Malara
- Patrick Ampofo
- R Laski
- S Anil
- SH Chen
- T Al-Khateeb
- T Baykul
- T Daley
- VJ Lund
- W Lerda
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>The oro-facial region including the jawbones, the maxilla and mandible and related tissues can be the site of a multitude of neoplastic conditions. These tumours have a predilection for the entire facial region; however, odontogenic tumours tend to affect the mandible more than the maxilla, especially, in West African children. We report results from a retrospective study spanning eight years on the frequency, clinical presentation, sites and character of lower face tumours seen in the main referral hospital in Ghana.</p> <p>Patients and methods</p> <p>Records of consecutive patients of all age and sex seen by the first author's team at the Department of Oral and Maxillofacial Surgery, Korle-Bu Teaching Hospital with tumours affecting the lower part of the face from January 1996 to December 2003 were retrieved, coded and entered into a database. The data were then analyzed by age, sex, presenting signs and symptoms, site of lesion, and their histology.</p> <p>Results</p> <p>A total of 394 patients with oro-facial swellings were retrieved from the registry out of which 210 had lower face tumour and tumour-like lesions. The complete data set was obtained for 171 patients, comprising 99 (58%) males and 72 (42%) females. The most common clinical presenting features were mandibular facial swelling (63%), intra-oral swelling (55%), pain (41%) and ulceration (29%). The tumours were predominantly found in the right (43%), anterior (19%) and left (18%) aspects of the lower face. The remainder making up 20% were found in the floor of the mouth, tongue and lips. Seventy eight (45.6%) of the patients presented with lesions that were classified as malignant of which 54 (62%) were diagnosed as squamous cell carcinoma (SCC). Sixty-two (36.3%) had benign odontogenic tumours and thirty-one (18.1%) had non-odontogenic tumour-like lesions. Fifty-four (62%) of malignant tumours were squamous cell carcinoma; 58 (93.6%) of the benign odontogenic tumours were classified as ameloblastoma. The mean age at presentation of all lesions was 40.4 years with over 50% of benign lesions in patients aged between 11 and 30 years. Malignant tumours were more commonly detected in patients between 41 and 70 years (63%).</p> <p>Conclusion</p> <p>Tumours and tumour-like lesions of the lower face comprising the mandible, tongue and adjacent structures are a diverse group of neoplasm and are seen commonly in practice of Maxillofacial surgery. Both malignant and benign tumours are seen in the Ghanaian population. In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 65% of all tumours.</p
Intra- and Inter-Subunit Disulfide Bond Formation Is Nonessential in Adeno-Associated Viral Capsids
- Author
- Aravind Asokan
- BS Albright
- CE Wobus
- DE Bowles
- F Ding
- F Ding
- F Sonntag
- HJ Dyson
- HJ Nam
- J Reguera
- JC Grieger
- Jianming Qiu
- JW Nelson
- L Govindasamy
- L Riolobos
- M Carrillo-Tripp
- M Li
- M Sapp
- M Schelhaas
- MS Chapman
- N DiPrimio
- N Pulicherla
- N Takahashi
- Nagesh Pulicherla
- Nikolay V. Dokholyan
- O Pornillos
- P Wu
- PP Li
- PP Li
- Pradeep Kota
- Q Xie
- R Ng
- R Perez
- S Bleker
- S Bleker
- S Mukherjee
- SW Raso
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The capsid proteins of adeno-associated viruses (AAV) have five conserved cysteine residues. Structural analysis of AAV serotype 2 reveals that Cys289 and Cys361 are located adjacent to each other within each monomer, while Cys230 and Cys394 are located on opposite edges of each subunit and juxtaposed at the pentamer interface. The Cys482 residue is located at the base of a surface loop within the trimer region. Although plausible based on molecular dynamics simulations, intra- or inter-subunit disulfides have not been observed in structural studies. In the current study, we generated a panel of Cys-to-Ser mutants to interrogate the potential for disulfide bond formation in AAV capsids. The C289S, C361S and C482S mutants were similar to wild type AAV with regard to titer and transduction efficiency. However, AAV capsid protein subunits with C230S or C394S mutations were prone to proteasomal degradation within the host cells. Proteasomal inhibition partially blocked degradation of mutant capsid proteins, but failed to rescue infectious virions. While these results suggest that the Cys230/394 pair is critical, a C394V mutant was found viable, but not the corresponding C230V mutant. Although the exact nature of the structural contribution(s) of Cys230 and Cys394 residues to AAV capsid formation remains to be determined, these results support the notion that disulfide bond formation within the Cys289/361 or Cys230/394 pair appears to be nonessential. These studies represent an important step towards understanding the role of inter-subunit interactions that drive AAV capsid assembly
Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.
- Author
- Al-Olabi L
- Andrews KA
- Baird W
- Barnacle A
- Biesecker LG
- Bulstrode N
- Clark G
- Dowsett K
- Glover M
- Gordon K
- Hargrave D
- Huson SM
- Jacques TS
- James G
- Joseph AP
- Kangesu L
- Keppler-Noreuil KM
- Khan A
- Kinsler VA
- Knox R
- Kondolf H
- Lindhurst MJ
- Lipson M
- Mahon C
- Mansour S
- Mosica A
- Moss C
- Murthy A
- O'Hara J
- Ong J
- Parker VE
- Patton EE
- Pittman A
- Polubothu S
- Rivière J-B
- Sapp JC
- Sebire NJ
- Semple RK
- Shah R
- Sivakumar B
- Stadnik P
- Thomas A
- Topf M
- Virasami A
- Waelchli R
- Zeng Z
- Publication venue
- 'American Society for Clinical Investigation'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain. Therapeutic options are severely limited, and multidisciplinary management remains challenging, particularly for high-flow arteriovenous malformations (AVM). METHODS: To investigate the pathogenesis of sporadic intracranial and extracranial VMs in 160 children in which known genetic causes had been excluded, we sequenced DNA from affected tissue and optimized analysis for detection of low mutant allele frequency. RESULTS: We discovered multiple mosaic-activating variants in 4 genes of the RAS/MAPK pathway, KRAS, NRAS, BRAF, and MAP2K1, a pathway commonly activated in cancer and responsible for the germline RAS-opathies. These variants were more frequent in high-flow than low-flow VMs. In vitro characterization and 2 transgenic zebrafish AVM models that recapitulated the human phenotype validated the pathogenesis of the mutant alleles. Importantly, treatment of AVM-BRAF mutant zebrafish with the BRAF inhibitor vemurafinib restored blood flow in AVM. CONCLUSION: Our findings uncover a major cause of sporadic VMs of different clinical types and thereby offer the potential of personalized medical treatment by repurposing existing licensed cancer therapies. FUNDING: This work was funded or supported by grants from the AVM Butterfly Charity, the Wellcome Trust (UK), the Medical Research Council (UK), the UK National Institute for Health Research, the L'Oreal-Melanoma Research Alliance, the European Research Council, and the National Human Genome Research Institute (US)
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro Guimarães da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
- Becker S
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
- Bellagamba L
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez Garcia JA
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernat P
- Bernhard R
- Bernius C
- Bernlochner FU
- Berry T
- Bertella C
- Bertin A
- Bertolucci F
- Besana MI
- Besjes GJ
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bittner B
- Black CW
- Black JE
- Black KM
- Blair RE
- Blanchard JB
- Blazek T
- Bloch I
- Blocker C
- Blocki J
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boek TT
- Boelaert N
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Bohm J
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bomben M
- Bona M
- Boonekamp M
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borri M
- Borroni S
- Bortfeldt J
- Bortolotto V
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Bousson N
- Boutouil S
- Boveia A
- Boyd J
- Boyko IR
- Bozovic-Jelisavcic I
- Bracinik J
- Branchini P
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brazzale SF
- Brelier B
- Bremer J
- Brendlinger K
- Brenner R
- Bressler S
- Bristow TM
- Britton D
- Brochu FM
- Brock I
- Brock R
- Broggi F
- Bromberg C
- Bronner J
- Brooijmans G
- Brooks T
- Brooks WK
- Brown G
- Bruckman de Renstrom PA
- Bruncko D
- Bruneliere R
- Brunet S
- Bruni A
- Bruni G
- Bruschi M
- Bryngemark L
- Buanes T
- Buat Q
- Bucci F
- Buchanan J
- Buchholz P
- Buckingham RM
- Buckley AG
- Buda SI
- Budagov IA
- Budick B
- Bugge L
- Bulekov O
- Bundock AC
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
- Bussey P
- Buszello CP
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Byszewski M
- Büscher V
- Cabrera Urbán S
- Caforio D
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
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- Camacho Toro R
- Camarri P
- Cameron D
- Caminada LM
- Caminal Armadans R
- Campana S
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- Canale V
- Canelli F
- Canepa A
- Cantero J
- Cantrill R
- Cao T
- Capeans Garrido MD
- Caprini I
- Caprini M
- Capriotti D
- Capua M
- Caputo R
- Cardarelli R
- Carli T
- Carlino G
- Carminati L
- Caron S
- Carquin E
- Carrillo-Montoya GD
- Carter AA
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
- Cascella M
- Caso C
- Castaneda-Miranda E
- Castillo Gimenez V
- Castro NF
- Cataldi G
- Catastini P
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cavaliere V
- Cavalleri P
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Chafaq A
- Chakraborty D
- Chalupkova I
- Chan K
- Chang P
- Chapleau B
- Chapman JD
- Chapman JW
- Charlton DG
- Chavda V
- Chavez Barajas CA
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
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- Chen H
- Chen S
- Chen X
- Chen Y
- Cheng Y
- Cheplakov A
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
- Chizhov MV
- Choudalakis G
- Chouridou S
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- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
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- Ciftci AK
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- Cindro V
- Ciocio A
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- Cirkovic P
- Citron ZH
- Citterio M
- Ciubancan M
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- Clark PJ
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- Clemens JC
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- Coggeshall J
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- Compostella G
- Conde Muiño P
- Coniavitis E
- Conidi MC
- Consonni SM
- Consorti V
- Constantinescu S
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- Conti G
- Conventi F
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- Cooper BD
- Cooper-Sarkar AM
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- Cortiana G
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- Costa MJ
- Costanzo D
- Cottin G
- Courneyea L
- Cowan G
- Cox BE
- Cranmer K
- Crescioli F
- Cristinziani M
- Crosetti G
- Crépé-Renaudin S
- Cuciuc CM
- Cuenca Almenar C
- Cuhadar Donszelmann T
- Cummings J
- Curatolo M
- Curtis CJ
- Cuthbert C
- Cwetanski P
- Czirr H
- Czodrowski P
- Czyczula Z
- Côté D
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dallaire F
- Dallapiccola C
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- Damiani DS
- Danielsson HO
- Dao V
- Darbo G
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- Dassoulas JA
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- Dawe E
- Dawson I
- Daya-Ishmukhametova RK
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- De Castro S
- De Cecco S
- de Graat J
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- De Lorenzi F
- De Nooij L
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- De Vivie De Regie JB
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- Dearnaley WJ
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- Debenedetti C
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- Dedovich DV
- Degenhardt J
- Del Peso J
- Del Prete T
- Delemontex T
- Deliyergiyev M
- Dell'acqua A
- Dell'asta L
- Della Pietra M
- Della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
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- Desch K
- Deviveiros PO
- Dewhurst A
- Dewilde B
- Dhaliwal S
- Dhullipudi R
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- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
- Diaz MA
- Diehl EB
- Dietrich J
- Dietzsch TA
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- Dingfelder J
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- Dionisi C
- Dita P
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- Dittus F
- Djama F
- Djobava T
- do Vale MA
- Do Valle Wemans A
- Doan TK
- Dobbs M
- Dobos D
- Dobson E
- Dodd J
- Doglioni C
- Doherty T
- Dohmae T
- Doi Y
- Dolejsi J
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donini J
- Dopke J
- Doria A
- Dos Anjos A
- Dotti A
- Dova MT
- Doyle AT
- Dressnandt N
- Dris M
- Dubbert J
- Dube S
- Dubreuil E
- Duchovni E
- Duckeck G
- Duda D
- Dudarev A
- Dudziak F
- Duerdoth IP
- Duflot L
- Dufour MA
- Duguid L
- Dunford M
- Duran Yildiz H
- Duxfield R
- Dwuznik M
- Dührssen M
- Düren M
- Ebenstein WL
- Ebke J
- Eckweiler S
- Edson W
- Edwards CA
- Edwards NC
- Ehrenfeld W
- Eifert T
- Eigen G
- Einsweiler K
- Eisenhandler E
- Ekelof T
- El Kacimi M
- Ellert M
- Elles S
- Ellinghaus F
- Ellis K
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Engelmann R
- Engl A
- Epp B
- Erdmann J
- Ereditato A
- Eriksson D
- Ernst J
- Ernst M
- Ernwein J
- Errede D
- Errede S
- Ertel E
- Escalier M
- Esch H
- Escobar C
- Espinal Curull X
- Esposito B
- Etienne F
- Etienvre AI
- Etzion E
- Evangelakou D
- Evans H
- Fabbri L
- Fabre C
- Facini GJ
- Fakhrutdinov RM
- Falciano S
- Fang Y
- Fanti M
- Farbin A
- Farilla A
- Farley J
- Farooque T
- Farrell S
- Farrington SM
- Farthouat P
- Fassi F
- Fassnacht P
- Fassouliotis D
- Fatholahzadeh B
- Favareto A
- Fayard L
- Federic P
- Fedin OL
- Fedorko W
- Fehling-Kaschek M
- Feligioni L
- Feng C
- Feng EJ
- Fenyuk AB
- Ferencei J
- Fernando W
- Ferrag S
- Ferrando J
- Ferrara V
- Ferrari A
- Ferrari P
- Ferrari R
- Ferreira de Lima DE
- Ferrer A
- Ferrere D
- Ferretti C
- Ferretto Parodi A
- Fiascaris M
- Fiedler F
- Filipčič A
- Filthaut F
- Fincke-Keeler M
- Fiolhais MC
- Fiorini L
- Firan A
- Fischer J
- Fisher MJ
- Fitzgerald EA
- Flechl M
- Fleck I
- Fleischmann P
- Fleischmann S
- Fletcher G
- Fletcher GT
- Flick T
- Floderus A
- Flores Castillo LR
- Florez Bustos AC
- Flowerdew MJ
- Fonseca Martin T
- Formica A
- Forti A
- Fortin D
- Fournier D
- Fowler AJ
- Fox H
- Francavilla P
- Franchini M
- Franchino S
- Francis D
- Frank T
- Franklin M
- Franz S
- Fraternali M
- Fratina S
- French ST
- Friedrich C
- Friedrich F
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- Zevi Della Porta G
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- Zibell A
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- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
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- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
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- Zurzolo G
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
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- Alimonti G
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- Allbrooke BMM
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- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuanh T
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlberg H
- Wahrmund S
- Wakabayashi J
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walls FMG
- Walsh B
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- Wang H
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- Wang K
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- Wang SM
- Wang T
- Wang X
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watkins PM
- Watson AT
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- Watts G
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- Webb S
- Weber MS
- Weber SW
- Webster JS
- Weidberg AR
- Weigell P
- Weinert B
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
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- Wessels M
- Wetter J
- Whalen K
- White A
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- Whiteson D
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- Wickens FJ
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- Wienemann P
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- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
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- Wilkens HG
- Will JZ
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- Williams S
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- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yakabe R
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS
- Author
- A Banfi
- A Djouadi
- A Idilbi
- A. A. E. Bannoura
- A. A. Grillo
- A. A. Komar
- A. A. Korol
- A. A. Maier
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. Snesarev
- A. A. Solodkov
- A. A. Talyshev
- A. Aloisio
- A. Alonso
- A. Altheimer
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Annovi
- A. Antonaki
- A. Antonov
- A. Artamonov
- A. Ashkenazi
- A. B. Fenyuk
- A. Baas
- A. Baroncelli
- A. Bassalat
- A. Basye
- A. Beddall
- A. Bellerive
- A. Bingul
- A. Bocci
- A. Bogouch
- A. Borisov
- A. Boveia
- A. Brandt
- A. Bruni
- A. Buzatu
- A. C. Bundock
- A. C. Daniells
- A. C. Florez Bustos
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. Calandri
- A. Campoverde
- A. Canepa
- A. Castelli
- A. Catinaccio
- A. Cattai
- A. Cerri
- A. Cervelli
- A. Chafaq
- A. Chegwidden
- A. Cheplakov
- A. Chilingarov
- A. Chitan
- A. Ciocio
- A. Clark
- A. Coccaro
- A. Corso-Radu
- A. Cortes-Gonzalez
- A. D. Hawkins
- A. D. Pilkington
- A. Dafinca
- A. Dattagupta
- A. De Salvo
- A. De Santo
- A. Dell’Acqua
- A. Demilly
- A. Dewhurst
- A. Di Ciaccio
- A. Di Domenico
- A. Di Girolamo
- A. Di Mattia
- A. Di Simone
- A. Dimitrievska
- A. Do Valle Wemans
- A. Doria
- A. Dudarev
- A. Durglishvili
- A. E. Barton
- A. E. Kiryunin
- A. E. Loevschall-Jensen
- A. Ereditato
- A. Ezhilov
- A. F. Saavedra
- A. Farbin
- A. Farilla
- A. Favareto
- A. Ferrari
- A. Ferrer
- A. Ferretto Parodi
- A. Filipčič
- A. Firan
- A. Fischer
- A. Floderus
- A. Formica
- A. Forti
- A. G. Bogdanchikov
- A. G. Buckley
- A. G. Goussiou
- A. G. Leister
- A. G. Myagkov
- A. G. Olchevski
- A. Gabrielli
- A. Gabrielli
- A. Gemmell
- A. Gershon
- A. Glazov
- A. Gomes
- A. Gorišek
- A. Grohsjean
- A. Haas
- A. Hamilton
- A. Hasib
- A. Henrichs
- A. Hoecker
- A. Hoummada
- A. I. Butt
- A. I. Etienvre
- A. I. Mincer
- A. Irles Quiles
- A. J. Armbruster
- A. J. Barr
- A. J. Beddall
- A. J. Brennan
- A. J. Lankford
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- A. Juste Rozas
- A. K. Ciftci
- A. K. Kopp
- A. K. Morley
- A. Kaczmarska
- A. Kamenshchikov
- A. Kapliy
- A. Kastanas
- A. Katre
- A. Khanov
- A. Khodinov
- A. Khomich
- A. Khoroshilov
- A. Klimentov
- A. Knue
- A. Korn
- A. Kotwal
- A. Koutsman
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- A. Kravchenko
- A. Kruse
- A. Kugel
- A. Kuhl
- A. Kupco
- A. L. Maslennikov
- A. L. Read
- A. L. S. Schorlemmer
- A. L. Yen
- A. La Rosa
- A. Lehan
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- A. M. Cooper-Sarkar
- A. M. Henriques Correia
- A. M. Leyko
- A. M. Litke
- A. M. Nairz
- A. M. Soukharev
- A. M. Zaitsev
- A. Macchiolo
- A. Madsen
- A. Maio
- A. Manfredini
- A. Mann
- A. Manousakis-Katsikakis
- A. Marzin
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- A. McCarn
- A. Meade
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- A. Miucci
- A. N. Karyukhin
- A. N. Sisakyan
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- A. Nagarkar
- A. Negri
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- A. Ochi
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- A. Olszewski
- A. Onofre
- A. Ouraou
- A. Ovcharova
- A. P. Colijn
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- A. Policicchio
- A. Polini
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- A. Pranko
- A. Quadt
- A. Qureshi
- A. R. Davison
- A. R. Stradling
- A. R. Weidberg
- A. Redelbach
- A. Renaud
- A. Rimoldi
- A. Robichaud-Veronneau
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- A. Rozanov
- A. Ruiz-Martinez
- A. Ruschke
- A. S. Boldyrev
- A. S. Cerqueira
- A. S. Chisholm
- A. S. Hard
- A. S. Kozhin
- A. S. Mete
- A. S. Randle-Conde
- A. S. Thompson
- A. Saddique
- A. Salamon
- A. Salnikov
- A. Salvucci
- A. Salzburger
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- A. Sbrizzi
- A. Schoening
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- A. Sfyrla
- A. Shmeleva
- A. Sidoti
- A. Sircar
- A. Soffer
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- A. Sopczak
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- A. Succurro
- A. T. Doyle
- A. T. Goshaw
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- A. V. Akimov
- A. V. Anisenkov
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- A. Vaniachine
- A. Vartapetian
- A. Ventura
- A. Venturini
- A. Vest
- A. Vogel
- A. Warburton
- A. Washbrook
- A. White
- A. Wildauer
- A. Wilson
- A. Yamamoto
- A. Yurkewicz
- A. Zaman
- A. Zemla
- A. Zhemchugov
- A. Zibell
- A. Zoccoli
- AD Martin
- AL Read
- ATLAS collaboration
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- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
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- B. D. Schoenrock
- B. Dechenaux
- B. Di Girolamo
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- B. G. Pope
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- B. Gaur
- B. Giacobbe
- B. Gibbard
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- B. Heinemann
- B. J. Gallop
- B. J. O’Brien
- B. Jackson
- B. K. B. Chow
- B. K. Gjelsten
- B. K. Wosiek
- B. Kaplan
- B. Laforge
- B. Lemmer
- B. Lenzi
- B. Li
- B. Li
- B. Liberti
- B. Liu
- B. Lopez Paredes
- B. Lund-Jensen
- B. M. Barnett
- B. M. M. Allbrooke
- B. M. Waugh
- B. M. Wynne
- B. Malaescu
- B. Mandelli
- B. Mansoulie
- B. Martin
- B. Martin
- B. Martin dit Latour
- B. Meirose
- B. Mindur
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- B. Osculati
- B. P. Kerševan
- B. Penning
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- B. Simmons
- B. Sopko
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- B. Stugu
- B. T. King
- B. T. Winter
- B. Toggerson
- B. Trocmé
- B. Vachon
- B. Walsh
- B. Weinert
- B. Yabsley
- B. Zabinski
- B. Zhou
- B. Åsman
- C Anastasiou
- C Anastasiou
- C Anastasiou
- C. A. Chavez Barajas
- C. A. Jung
- C. A. Lee
- C. A. Solans
- C. Alexa
- C. Alpigiani
- C. Amelung
- C. Anastopoulos
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- C. Bacci
- C. Becot
- C. Belanger-Champagne
- C. Bernard
- C. Bernius
- C. Bertella
- C. Bertsche
- C. Betancourt
- C. Bini
- C. Blocker
- C. Bock
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- C. Bourdarios
- C. Bromberg
- C. C. Chau
- C. C. Ohm
- C. Chen
- C. Clement
- C. Conta
- C. Cuthbert
- C. Da Via
- C. Dallapiccola
- C. David
- C. Debenedetti
- C. Deluca
- C. Deterre
- C. Di Donato
- C. Dionisi
- C. Doglioni
- C. Escobar
- C. F. Anders
- C. Feng
- C. Ferretti
- C. Friedrich
- C. Fukunaga
- C. G. Lester
- C. G. Zhu
- C. Gabaldon
- C. Galea
- C. García
- C. Gatti
- C. Gay
- C. Gemme
- C. Giuliani
- C. Glasman
- C. Goeringer
- C. Goy
- C. Guicheney
- C. Gumpert
- C. Gutschow
- C. Guyot
- C. Gwenlan
- C. Gössling
- C. Haber
- C. Heller
- C. Helsens
- C. Hengler
- C. Hensel
- C. Hsu
- C. Isaksson
- C. Issever
- C. J. Oram
- C. J. Potter
- C. J. S. Young
- C. Jeske
- C. Kourkoumelis
- C. L. Lampen
- C. Lacasta
- C. Lapoire
- C. Leggett
- C. Leonidopoulos
- C. Leroy
- C. Limbach
- C. Luci
- C. M. Buttar
- C. M. Delitzsch
- C. M. Hawkes
- C. M. Lester
- C. Maiani
- C. Maidantchik
- C. Malone
- C. Meineck
- C. Melachrinos
- C. Meroni
- C. Meyer
- C. Meyer
- C. Mills
- C. Monini
- C. N. Marques
- C. N. P. Gee
- C. O. Shimmin
- C. Oropeza Barrera
- C. P. Bee
- C. P. Buszello
- C. P. Hays
- C. P. Marino
- C. P. Ward
- C. Padilla Aranda
- C. Pahl
- C. Peng
- C. Petridou
- C. Pizio
- C. R. Boddy
- C. R. Royon
- C. Rangel-Smith
- C. Rembser
- C. Roda
- C. Rudolph
- C. S. Pollard
- C. Sandoval
- C. Santoni
- C. Sawyer
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- C. Schwanenberger
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- C. Wang
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- CMS collaboration
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- E Laenen
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- V. Radescu
- V. Rossetti
- V. S. Bobrovnikov
- V. S. Lang
- V. Sanchez Martinez
- V. Scarfone
- V. Scharf
- V. Simak
- V. Sipica
- V. Smakhtin
- V. Solovyev
- V. Sopko
- V. Sorin
- V. Tsiskaridze
- V. Tsulaia
- V. Tudorache
- V. V. Kostyukhin
- V. V. Sulin
- V. Vacek
- V. Vercesi
- V. Vorobel
- V. Vrba
- V. Zutshi
- W Beenakker
- W Beenakker
- W-M. Yao
- W. A. Cribbs
- W. A. Leight
- W. B. Quayle
- W. Bhimji
- W. Blum
- W. Buttinger
- W. C. Fisher
- W. Cleland
- W. Dabrowski
- W. Davey
- W. Edson
- W. Ehrenfeld
- W. F. Mader
- W. Fedorko
- W. G. Scott
- W. H. Bell
- W. Iwanski
- W. J. Dearnaley
- W. J. Murray
- W. K. Brooks
- W. Kozanecki
- W. Lampl
- W. Lavrijsen
- W. Liebig
- W. Lukas
- W. M. Thong
- W. Mohr
- W. Okamura
- W. R. Spearman
- W. S. Lockman
- W. Taylor
- W. Trischuk
- W. Van Den Wollenberg
- W. Vandelli
- W. Verkerke
- W. Wagner
- W. Walkowiak
- W. Wiedenmann
- X. Chen
- X. Hu
- X. Ju
- X. Lei
- X. Lou
- X. Portell Bueso
- X. Ruan
- X. S. Anduaga
- X. Sun
- X. Wang
- X. Wu
- X. Zhang
- X. Zhuang
- Y. A. Kurochkin
- Y. Abulaiti
- Y. Amaral Coutinho
- Y. Arai
- Y. Azuma
- Y. B. Pan
- Y. Bai
- Y. Benhammou
- Y. Chen
- Y. Chen
- Y. Cheng
- Y. Coadou
- Y. Davygora
- Y. Enari
- Y. F. Ryabov
- Y. Fang
- Y. Hasegawa
- Y. Heng
- Y. Hernández Jiménez
- Y. Horii
- Y. Huang
- Y. Ikegami
- Y. Ilchenko
- Y. Inamaru
- Y. J. Schnellbach
- Y. Jiang
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. Li
- Y. Liu
- Y. Makida
- Y. Ming
- Y. Munwes
- Y. Nagai
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Qin
- Y. Rozen
- Y. S. Gao
- Y. Sakurai
- Y. Sasaki
- Y. Silver
- Y. Smirnov
- Y. Sugaya
- Y. Suzuki
- Y. Takubo
- Y. Tayalati
- Y. Unno
- Y. V. Grishkevich
- Y. Wu
- Y. Yamaguchi
- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhu
- Yu. A. Tikhonov
- Z. Barnovska
- Z. Czyczula
- Z. D. Greenwood
- Z. Dolezal
- Z. Gecse
- Z. H. Citron
- Z. Hajduk
- Z. Hubacek
- Z. J. Grout
- Z. Kohout
- Z. L. Ren
- Z. Liang
- Z. M. Karpova
- Z. Marshall
- Z. Rurikova
- Z. V. Krumshteyn
- Z. Vykydal
- Z. Weng
- Z. Yan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations
Non invasive prenatal testing for single gene disorders:Exploring the ethics
- Author
- A de Jong
- A Hall
- A Sommerville
- A van den Heuvel
- AJ Newson
- AN Barrett
- B Heyman
- B Modell
- BA Bernhardt
- C Baillie
- C Lewis
- C Lewis
- C Meaney
- Celine Lewis
- E Dormandy
- E Garcia
- F Mujezinovic
- FL Raymond
- FM Lun
- FM Lun
- H Skirton
- HC Fan
- J Garcia
- J Hodgson
- J Narveson
- JC Sapp
- KM Finning
- KT Maliszewski
- L Henneman
- L Kooij
- L Locock
- LC Sayres
- LS Chitty
- Lyn S Chitty
- M Berkenstadt
- M Hill
- M Hill
- M Hill
- M McAllister
- M Nicol
- M van den Berg
- Melissa Hill
- N Press
- NB Tsui
- O O’Neil
- PA Benn
- R Chadwick
- R Favre
- R Rapp
- S Galbiati
- S Sherwin
- SA Metcalfe
- SE Kelly
- SE Kelly
- T Beauchamp
- T Lau
- TM Marteau
- V Bot-Robin
- V Seavilleklein
- V Tsianakas
- V Tsianakas
- Y Lo
- YM Lo
- YM Lo
- Z Deans
- Zuzana Deans
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/11/2012
- Field of study
Non-invasive prenatal testing for single gene disorders is now clearly on the horizon. This new technology offers obvious clinical benefits such as safe testing early in pregnancy. Before widespread implementation, it is important to consider the possible ethical implications. Four hypothetical scenarios are presented that highlight how ethical ideals of respect for autonomy, privacy and fairness may come into play when offering non-invasive prenatal testing for single gene disorders. The first scenario illustrates the moral case for using these tests for ‘information only', identifying a potential conflict between larger numbers of women seeking the benefits of the test and the wider social impact of funding tests that do not offer immediate clinical benefit. The second scenario shows how the simplicity and safety of non-invasive prenatal testing could lead to more autonomous decision-making and, conversely, how this could also lead to increased pressure on women to take up testing. In the third scenario we show how, unless strong safeguards are put in place, offering non-invasive prenatal testing could be subject to routinisation with informed consent undermined and that woman who are newly diagnosed as carriers may be particularly vulnerable. The final scenario introduces the possibility of a conflict of the moral rights of a woman and her partner through testing for single gene disorders. This analysis informs our understanding of the potential impacts of non-invasive prenatal testing for single gene disorders on clinical practice and has implications for future policy and guidelines for prenatal care
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