Effective Values of Komar Conserved Quantities and Their Applications

We calculate the effective Komar angular momentum for the Kerr-Newman (KN) black hole. This result is valid at any radial distance on and outside the black hole event horizon. The effcetive values of mass and angular momentum are then used to derive an identity ($K_{\chi^{\mu}}=2ST$) which relates the Komar conserved charge ($K_{\chi^{\mu}}$) corresponding to the null Killing vector ($\chi^{\mu}$) with the thermodynamic quantities of this black hole. As an application of this identity the generalised Smarr formula for this black hole is derived. This establishes the fact that the above identity is a local form of the inherently non-local generalised Smarr formula.Comment: v3, minor modifications over v2; LaTex, 9 pages, no figures, to appear in Int. Jour. Theo. Phy

Corrections to Hawking-like Radiation for a Friedmann-Robertson-Walker Universe

Recently, a Hamilton-Jacobi method beyond semiclassical approximation in black hole physics was developed by \emph{Banerjee} and \emph{Majhi}\cite{beyond0}. In this paper, we generalize their analysis of black holes to the case of Friedmann-Robertson-Walker (FRW) universe. It is shown that all the higher order quantum corrections in the single particle action are proportional to the usual semiclassical contribution. The corrections to the Hawking-like temperature and entropy of apparent horizon for FRW universe are also obtained. In the corrected entropy, the area law involves logarithmic area correction together with the standard inverse power of area term.Comment: 10 pages, no figures, comments are welcome; v2: references added and some typoes corrected, to appear in Euro.Phys.J.C; v3:a defect corrected. We thank Dr.Elias Vagenas for pointing out a defect of our pape

Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV

Peer reviewe

Search for heavy resonances decaying into a vector boson and a Higgs boson in final states with charged leptons, neutrinos, and b quarks

Peer reviewe

Search for high-mass diphoton resonances in proton-proton collisions at 13 TeV and combination with 8 TeV search

Peer reviewe

Measurement of the mass difference between top quark and antiquark in pp collisions at root s=8 TeV

Peer reviewe

Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV

Peer reviewe

Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum.

High-risk neuroblastoma is a poor prognosis cancer of the sympathetic nervous system that accounts for a disproportionate number of childhood cancer deaths. Many viable biological targets have been identified, and the number of potential combinations is even larger. Several products have attained marketing authorization for treatment of patients with neuroblastoma. Patient outcomes remain poor, with approximately 50% of children with newly diagnosed high-risk neuroblastoma cured of their disease. International, multistakeholder Neuroblastoma Drug Development Strategy (NDDS) meetings were established more than a decade ago. This third NDDS meeting included academia, industry, regulatory, and patient advocacy representatives to prioritize agents and to address key challenges in drug development in this disease. Given the central role that anti-GD2 therapy plays, novel GD2-directed combinations were a key focus, including epigenetic enzymes such as EZH2 and immunologic targets such as IL15 and TIGIT as potential combination partners. GD2-directed chimeric antigen receptor (CAR)-T cells were a top priority, along with emerging CAR-T targets such as B7-H3 and GPC2. Recognizing that combination therapies are likely to be most impactful for patients and for advancing therapies to frontline, another key focus was on high priority combinations of targeted therapies, including Aurora A kinase plus BCL2 or ATR inhibitors. Additional targets and agents were prioritized or deprioritized based upon current data. Access to drugs for clinical trials was viewed as a major barrier to progress. Strategies to overcome this challenge focused on united efforts by the international scientific and advocacy community and early engagement by industry with regulatory authorities

Modified Friedmann Equations From Debye Entropic Gravity

A remarkable new idea on the origin of gravity was recently proposed by Verlinde who claimed that the laws of gravitation are no longer fundamental, but rather emerge naturally as an entropic force. In Verlinde derivation, the equipartition law of energy on the holographic screen plays a crucial role. However, the equipartition law of energy fails at the very low temperature. Therefore, the formalism of the entropic force should be modified while the temperature of the holographic screen is very low. Considering the Debye entropic gravity and following the strategy of Verlinde, we derive the modified Newton's law of gravitation and the corresponding Friedmann equations which are valid in all range of temperature. In the limit of strong gravitational field, i.e. high temperature compared to Debye temperature, $T\gg T_D$, one recovers the standard Newton's law and Friedmann equations. We also generalize our study to the entropy corrected area law and derive the dynamical cosmological equations for all range of temperature. Some limits of the obtained results are also studied.Comment: 9 pages, no figures. The text was revised and new references added. Presented in national conferences in gravity and cosmology at Tehran Universit