Shroud Effects on Load-independent Power Loss of High-speed Rotorcraft Gearing

High-speed rotorcraft transmissions are subject to load-independent power losses consisting of drag loss and pumping loss. Tightly conforming shrouds enclosing the transmission gears are often incorporated to reduce the drag component of the total loadindependent losses. However, tightly conforming axial shrouds can result in an increase in the pumping loss component. Quantifying the pumping loss of shrouded gear transmissions has been the subject of many studies. This study presents a new approach for estimating pumping loss based on the concept of swept volume and examines the applicability of the approach to various shroud configurations. The drag loss and pumping loss of shrouded cylindrical gear pairs have been determined through testing using the NASA Glenn Research Center (GRC) Gear Windage Test Facility. The results from this testing have been compared to theoretical results using the formulations presented in this study. In addition, computational fluid dynamic (CFD) analysis has been conducted for the various shroud configurations tested at NASA GRC. The results from the CFD analysis confirm the theoretical and empirical results and provide insight into the applicability of the swept volume approach for estimating pumping power loss of shrouded gear transmissions

Initial Experiments of High-Speed Drive System Windage Losses

High speed gearing performance is very important to the overall drive system efficiency. Certain losses such as gear meshing and bearing drag can be minimized by design changes such as pressure angle of the gears and the geometry and type of bearings being used. One component that can have a large effect on the overall performance of high-speed drive systems is the parasitic drag known as gear windage. This loss mechanism is not well understood and minimizing this component is usually accomplished through much trial and error. The results presented in this paper will document some of the design parameter effects on the amount of windage losses. A new test facility at NASA Glenn has been assembled to systematically study the design variables. Results from recent tests will be presented. The tests are for a single gear, with and without lubricants, and some initial studies using shroud

Swept Volume Approach for the Characterization of Pumping Loss of Shrouded Meshed Cylindrical Gears

High speed rotorcraft transmissions are subject to load-independent power losses consisting of drag and pumping loss. Tightly conforming shrouds enclosing the transmission gears are often incorporated to reduce the drag component of the total load-independent losses. However, tightly conforming axial shrouding can result in an increase in the pumping loss component. Quantifying the pumping loss of shrouded gear transmissions has been the subject of many studies. This study presents a new approach for estimating pumping loss based on the concept of swept volume borrowed from the positive displacement pump and compressor industry. In this study, pumping loss of shrouded gear transmissions is considered to be related to the swept volume of the gear sets and the downstream flow resistance created by the shroud clearances. The drag loss and pumping loss of a spur gear pair have been determined through testing using the NASA Glenn Research Center Gear Windage Test Facility. The results from this testing have been compared to theoretical results using the formulations presented in this study. Good correlation exist between the test pumping power loss and the predicted pumping power loss for tightly conforming axial shroud configurations

Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line.

Protein localisation and translocation between intracellular compartments underlie almost all physiological processes. The hyperLOPIT proteomics platform combines mass spectrometry with state-of-the-art machine learning to map the subcellular location of thousands of proteins simultaneously. We combine global proteome analysis with hyperLOPIT in a fully Bayesian framework to elucidate spatiotemporal proteomic changes during a lipopolysaccharide (LPS)-induced inflammatory response. We report a highly dynamic proteome in terms of both protein abundance and subcellular localisation, with alterations in the interferon response, endo-lysosomal system, plasma membrane reorganisation and cell migration. Proteins not previously associated with an LPS response were found to relocalise upon stimulation, the functional consequences of which are still unclear. By quantifying proteome-wide uncertainty through Bayesian modelling, a necessary role for protein relocalisation and the importance of taking a holistic overview of the LPS-driven immune response has been revealed. The data are showcased as an interactive application freely available for the scientific community

Evidence of coupling in ocean-atmosphere dynamics over the North Atlantic

Coupling between the ocean and the atmosphere is investigated in reanalysis data sets. Projecting the data sets onto a dynamically defined subspace allows one to isolate the dominant modes of variability of the coupled system. This coupled projection is then analyzed using multichannel singular spectrum analysis. The results suggest that a dominant low-frequency signal with a 25-30 year period already mentioned in the literature is a common mode of variability of the atmosphere and the ocean. A new score for evaluating the internal nature of the common variability is then introduced, and it confirms the presence of coupled dynamics in the ocean-atmosphere system that impacts the atmosphere at large scale. The physical nature of this coupled dynamics is then discussed

The coexistence of peace and conflict in South America: toward a new conceptualization of types of peace

South America's predominant democratic regimes and its increasing interdependence on regional trade have not precluded the emergence of militarized crises between Colombia and Venezuela or the revival of boundary claims between Chile and Peru. This way, how can we characterize a zone that, in spite of its flourishing democracy and dense economic ties, remain involved in territorial disputes for whose resolution the use of force has not yet been discarded? This article contends that existing classifications of zones of peace are not adequate to explain this unusual coexistence. Thus, its main purpose is to develop a new analytical category of regional peace for assessing this phenomenon: the hybrid peace. It aims to research the evolution of security systems in South America during the previous century and build a new, threefold classification of peace zones: negative peace zones, hybrid peace zones, and positive peace zones

Biomarkers of Nutrition for Development (BOND)—Iron Review

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant knowledge regarding iron biology, public health implications, and the relative usefulness of currently available biomarkers of iron status from deficiency to overload. Approaches to assessing intake, including bioavailability, are also covered. The report also covers technical and laboratory considerations for the use of available biomarkers of iron status, and concludes with a description of research priorities along with a brief discussion of new biomarkers with potential for use across the spectrum of activities related to the study of iron in human health. The I-EP concluded that current iron biomarkers are reliable for accurately assessing many aspects of iron nutrition. However, a clear distinction is made between the relative strengths of biomarkers to assess hematological consequences of iron deficiency versus other putative functional outcomes, particularly the relationship between maternal and fetal iron status during pregnancy, birth outcomes, and infant cognitive, motor and emotional development. The I-EP also highlighted the importance of considering the confounding effects of inflammation and infection on the interpretation of iron biomarker results, as well as the impact of life stage. Finally, alternative approaches to the evaluation of the risk for nutritional iron overload at the population level are presented, because the currently designated upper limits for the biomarker generally employed (serum ferritin) may not differentiate between true iron overload and the effects of subclinical inflammation