1,061 research outputs found
Single nucleotide polymorphism (SNP) array-based signature of low hypodiploidy in acute lymphoblastic leukemia.
- Author
- Publication venue
- Publication date
- 03/05/2021
- Field of study
Low hypodiploidy (30-39 chromosomes) is one of the most prevalent genetic subtypes among adults with ALL and is associated with a very poor outcome. Low hypodiploid clones can often undergo a chromosomal doubling generating a near-triploid clone (60-78 chromosomes). When cytogenetic techniques detect a near triploid clone, a diagnostic challenge may ensue in differentiating presumed duplicated low hypodiploidy from good risk high hyperdiploid ALL (51-67 chromosomes). We used single-nucleotide polymorphism (SNP) arrays to analyze low hypodiploid/near triploid (HoTr) (n=48) and high hyperdiploid (HeH) (n=40) cases. In addition to standard analysis, we derived log2 ratios for entire chromosomes enabling us to analyze the cohort using machine-learning techniques. Low hypodiploid and near triploid cases clustered together and separately from high hyperdiploid samples. Using these approaches, we also identified three cases with 50-60 chromosomes, originally called as HeH, which were, in fact, HoTr and two cases incorrectly called as HoTr. TP53 mutation analysis supported the new classification of all cases tested. Next, we constructed a classification and regression tree model for predicting ploidy status with chromosomes 1, 7 and 14 being the key discriminators. The classifier correctly identified 47/50 (94%) HoTr cases. We validated the classifier using an independent cohort of 44 cases where it correctly called 7/7 (100%) low hypodiploid cases. The results of this study suggest that HoTr is more frequent among older adults with ALL than previously estimated and that SNP array analysis should accompany cytogenetics where possible. The classifier can assist where SNP array patterns are challenging to interpret. This article is protected by copyright. All rights reserved
Ligation and mucopexy for prolapsing hemorrhoids – a ten year experience
- Author
- Publication venue
- BioMed Central
- Publication date
- Field of study
Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+
- Author
- Alekseev MG
- Alexakhin VY
- Alexandrov Y
- Alexeev GD
- Amoroso A
- Austregesilo A
- Badelek B
- Balestra F
- Ball J
- Barth J
- Baum G
- Bedfer Y
- Bernhard J
- Bertini R
- Bettinelli M
- Birsa R
- Bisplinghoff J
- Bordalo P
- Bradamante F
- Bravar A
- Bressan A
- Brona G
- Burtin E
- Bussa MP
- Chapiro A
- Chiosso M
- Chung SU
- Cicuttin A
- Colantoni M
- Crespo ML
- d'Hose N
- Dafni T
- Dalla Torre S
- Das S
- Dasgupta SS
- Denisov OY
- Dhara L
- Diaz V
- Dinkelbach AM
- Donskov SV
- Doshita N
- Duic V
- Dunnweber W
- Efremov A
- El Alaoui A
- Eversheim PD
- Eyrich W
- Faessler M
- Ferrero A
- Finger M
- Finger M
- Fischer H
- Franco C
- Friedrich JM
- Garfagnini R
- Gautheron F
- Gavrichtchouk OP
- Gazda R
- Gerassimov S
- Geyer R
- Giorgi M
- Gobbo B
- Goertz S
- Grabmuller S
- Grajek OA
- Grasso A
- Grube B
- Gushterski R
- Guskov A
- Haas F
- Hasegawa T
- Heckmann J
- Heinsius FH
- Hermann R
- Herrmann F
- Hess C
- Hinterberger F
- Hoppner C
- Horikawa N
- Ilgner C
- Ishimoto S
- Ivanov O
- Ivanshin Y
- Iwata T
- Jahn R
- Jasinski P
- Jegou G
- Joosten R
- Kabuss E
- Kang D
- Ketzer B
- Khaustov GV
- Khokhlov YA
- Kisselev Y
- Klein F
- Klimaszewski K
- Koblitz S
- Koivuniemi JH
- Kolosov VN
- Komissarov EV
- Kondo K
- Konigsmann K
- Konopka R
- Konorov I
- Konstantinov VF
- Korzenev A
- Kotzinian AM
- Kouznetsov O
- Kowalik K
- Kral A
- Kramer M
- Kroumchtein ZV
- Kuhn R
- Kunne F
- Kurek K
- Lauser L
- Le Goff JM
- Lednev AA
- Lehmann A
- Levorato S
- Lichtenstadt J
- Liska T
- Maggiora A
- Maggiora M
- Magnon A
- Mallot GK
- Mann A
- Marchand C
- Marroncle J
- Martin A
- Marzec J
- Massmann F
- Matsuda T
- Maximov AN
- Meyer W
- Michigami T
- Mikhailov YV
- Moinester MA
- Mutter A
- Nagaytsev A
- Nagel T
- Nassalski J
- Negrini T
- Nerling F
- Neubert S
- Neyret D
- Nikolaenko VI
- Olshevsky AG
- Ostrick M
- Padee A
- Panknin R
- Panzieri D
- Parsamyan B
- Paul S
- Pawlukiewicz-Kaminska B
- Perevalova E
- Pesaro G
- Peshekhonov DV
- Piragino G
- Platchkov S
- Pochodzalla J
- Polak J
- Polyakov VA
- Pontecorvo G
- Pretz J
- Quintans C
- Rajotte JF
- Ramos S
- Rapatsky V
- Reggiani D
- Reicherz G
- Richter A
- Robinet F
- Rocco E
- Rondio E
- Ryabchikov DI
- Samoylenko VD
- Sandacz A
- Santos H
- Sapozhnikov MG
- Sarkar S
- Savin IA
- Sbrizzai G
- Schiavon P
- Schill C
- Schluter T
- Schmitt L
- Schopferer S
- Schroder W
- Shevchenko OY
- Siebert HW
- Silva L
- Sinha L
- Sissakian AN
- Slunecka M
- Smirnov GI
- Sosio S
- Sozzi F
- Srnka A
- Stolarski M
- Sulc M
- Sulej R
- Takekawa S
- Tessaro S
- Tessarotto F
- Teufel A
- Tkatchev LG
- Uhl S
- Uman I
- Venugopal G
- Virius M
- Vlassov NV
- von Harrach D
- Vossen A
- Weitzel Q
- Windmolders R
- Wislicki W
- Wollny H
- Zaremba K
- Zavertyaev M
- Zemlyanichkina E
- Zhao J
- Zhuravlev N
- Ziembicki M
- Zvyagin A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 02/11/2009
- Field of study
The COMPASS experiment at the CERN SPS has studied the diffractive
dissociation of negative pions into the pi- pi- pi+ final state using a 190
GeV/c pion beam hitting a lead target. A partial wave analysis has been
performed on a sample of 420000 events taken at values of the squared
4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances
a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data
show a significant natural parity exchange production of a resonance with
spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The
resonant nature of this wave is evident from the mass-dependent phase
differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a
resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2
is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged;
version 3 updated authors, text shortened, data unchange
Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
- Author
- Agartz I
- Allen P
- Andreassen OA
- Antoniades M
- Atkinson K
- Bachman P
- Baeza I
- Baldwin H
- Bartholomeusz CF
- Bin Kwak Y
- Chee MWL
- Colibazzi T
- Cooper RE
- Corcoran CM
- Cropley VL
- Ebdrup BH
- ENIGMA Clinical High Risk for Psychosis Working Group
- Fortea A
- Frangou S
- Fusar-Poli P
- Glenthøj LB
- Haas SS
- Hamilton HK
- Haut KM
- Hayes RA
- He Y
- Heekeren K
- Kaess M
- Kasai K
- Katagiri N
- Kim M
- Kindler J
- Klaunig MJ
- Koike S
- Koppel A
- Kristensen TD
- Kwon JS
- Lawrie SM
- Lebedeva I
- Lee J
- Lin A
- Radua J
- Sugranyes Ernest Gisela
- Publication venue
- Publication date
- 12/07/2023
- Field of study
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the 'normativeness' of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5?SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.© 2022. The Author(s)
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov AV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Arslan O
- Artamonov A
- Artoni G
- Asai S
- Asbah N
- Ask S
- Asman B
- Asquith L
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- Atkinson M
- Atlay NB
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- Aurousseau M
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- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Badescua E
- Bagiacchi P
- Bagnaia P
- Bai Y
- Bailey DC
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- Baines JT
- Baker OK
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- Balli F
- Banas E
- Banerjee S
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- Barajas CAC
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- Bednyakov VA
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- Cervelli A
- Cetin SA
- Chafaq A
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- Chalupkova I
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- Charlton DG
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- Chekulaev SV
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- Coniavitis E
- Conidi MC
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- Crescioli F
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- Crosetti G
- Cuciuc C-M
- Cummings J
- Curatolo M
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- Czodrowski P
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- Ernst J
- Ernst M
- Ernst M
- Ernwein J
- Ernwein J
- Errede D
- Errede D
- Errede S
- Errede S
- Ertel E
- Ertel E
- Escalier M
- Escalier M
- Esch H
- Esch H
- Escobar C
- Escobar C
- Espinal Curull X
- Espinal Curull X
- Esposito B
- Esposito B
- Etienne F
- Etienne F
- Etienvre AI
- Etienvre AI
- Etzion E
- Etzion E
- Evans H
- Evans H
- Fabbri L
- Fabbri L
- Facini G
- Facini G
- Fajardo LSG
- Fajardo LSG
- Fakhrutdinov RM
- Fakhrutdinov RM
- Falciano S
- Falciano S
- Faltova J
- Faltova J
- Fang Y
- Fang Y
- Fanti M
- Fanti M
- Farbin A
- Farbin A
- Farilla A
- Farilla A
- Farooque T
- Farooque T
- Farrell S
- Farrell S
- Farrington SM
- Farrington SM
- Farthouat P
- Farthouat P
- Fassi F
- Fassi F
- Fassnacht P
- Fassnacht P
- Fassouliotis D
- Fassouliotis D
- Favareto A
- Favareto A
- Fayard L
- Fayard L
- Federic P
- Federic P
- Fedin OL
- Fedin OL
- Fedorko W
- Fedorko W
- Fehling-Kaschek M
- Fehling-Kaschek M
- Feigl S
- Feigl S
- Feligioni L
- Feligioni L
- Feng C
- Feng C
- Feng EJ
- Feng EJ
- Feng H
- Feng H
- Fenyuk AB
- Fenyuk AB
- Fernando W
- Fernando W
- Ferrag S
- Ferrag S
- Ferrando BMS
- Ferrando J
- Ferrando J
- Ferrara V
- Ferrara V
- Ferrari A
- Ferrari A
- Ferrari P
- Ferrari P
- Ferrari R
- Ferrari R
- Ferrer A
- Ferrer A
- Ferrere D
- Ferrere D
- Ferretti C
- Ferretti C
- Fiascaris M
- Fiascaris M
- Fiedler F
- Fiedler F
- Filipcic A
- Filipcic A
- Filipuzzi M
- Filipuzzi M
- Filthaut F
- Filthaut F
- Fincke-Keeler M
- Fincke-Keeler M
- Finelli KD
- Finelli KD
- Fiolhais MCN
- Fiolhais MCN
- Fiorini L
- Fiorini L
- Firan A
- Firan A
- Fischer J
- Fischer J
- Fisher MJ
- Fisher MJ
- Fitzgerald EA
- Fitzgerald EA
- Flechl M
- Flechl M
- Fleck I
- Fleck I
- Fleischmann P
- Fleischmann P
- Fleischmann S
- Fleischmann S
- Fletcher G
- Fletcher G
- Fletcher GT
- Fletcher GT
- Flick T
- Flick T
- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
- Flowerdew MJ
- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
- Fortin D
- Fournier D
- Fournier D
- Fox H
- Fox H
- Francavilla P
- Francavilla P
- Franchini M
- Franchini M
- Franchino S
- Franchino S
- Francis D
- Francis D
- Franklin M
- Franklin M
- Franz S
- Franz S
- Fraternali M
- Fraternali M
- Fratin S
- Fratina S
- French ST
- French ST
- Friedrich C
- Friedrich C
- Friedrich F
- Friedrich F
- Froidevaux D
- Froidevaux D
- Frost JA
- Frost JA
- Fukunaga C
- Fukunaga C
- Fulsom BG
- Fulsom BG
- Fuster J
- Fuster J
- Gabaldon C
- Gabaldon C
- Gabizon O
- Gabizon O
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gadatsch S
- Gadatsch S
- Gadomski S
- Gadomski S
- Gagliardi G
- Gagliardi G
- Gagnon P
- Gagnon P
- Galea C
- Galea C
- Galhardo B
- Galhardo B
- Gallas EJ
- Gallas EJ
- Gallo V
- Gallo V
- Gallop BJ
- Gallop BJ
- Gallus P
- Gallus P
- Galster G
- Galster G
- Gan KK
- Gan KK
- Gandrajula RP
- Gandrajula RP
- Gao J
- Gao YS
- Gao YS
- Gaob J
- Garberson F
- Garberson F
- Garcia Navarro JE
- Garcia Navarro JE
- Garcia BRM
- Garcia C
- Garcia C
- Garcia JAB
- Garcia-Sciveres M
- Garcia-Sciveres M
- Gardner RW
- Gardner RW
- Garelli N
- Garelli N
- Garonne V
- Garonne V
- Garrido MDMC
- Gatti C
- Gatti C
- Gaudio G
- Gaudio G
- Gaur B
- Gaur B
- Gauthier L
- Gauthier L
- Gauzzi P
- Gauzzi P
- Gavrilenko IL
- Gavrilenko IL
- Gay C
- Gay C
- Gaycken G
- Gaycken G
- Gazis EN
- Gazis EN
- Ge P
- Ge P
- Gecse Z
- Gecse Z
- Gee CNP
- Gee CNP
- Geerts DAA
- Geerts DAA
- Geich-Gimbel C
- Geich-Gimbel C
- Gellerstedt K
- Gellerstedt K
- Gemme C
- Gemme C
- Gemmell A
- Gemmell A
- Genest MH
- Genest MH
- Gentile S
- Gentile S
- George M
- George M
- George S
- George S
- Gerbaudo D
- Gerbaudo D
- Gershon A
- Gershon A
- Ghazlane H
- Ghazlane H
- Ghodbane N
- Ghodbane N
- Giacobbe B
- Giacobbe B
- Giagu S
- Giagu S
- Giangiobbe V
- Giangiobbe V
- Giannetti P
- Giannetti P
- Gianotti F
- Gianotti F
- Gibbard B
- Gibbard B
- Gibson SM
- Gibson SM
- Gilchriese M
- Gilchriese M
- Gillam TPS
- Gillam TPS
- Gillberg D
- Gillberg D
- Gillman AR
- Gillman AR
- Gingrich DM
- Gingrich M
- Giokaris N
- Giokaris N
- Giordani MP
- Giordani MP
- Giordano R
- Giordano R
- Giorgi FM
- Giorgi FM
- Giraud PF
- Giraud PF
- Giugni D
- Giugni D
- Giuliani C
- Giuliani C
- Giunta M
- Giunta M
- Gjelsten BK
- Gjelsten BK
- Gkialas I
- Gkialas I
- Gladilin LK
- Gladilin LK
- Glasman C
- Glasman C
- Glatzer J
- Glatzer J
- Glazov A
- Glazov A
- Glonti GL
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- Goddard JR
- Godfrey J
- Godfrey J
- Godlewski J
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- Goeringer C
- Goeringer C
- Goessling C
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- Goldfarb S
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- Golling T
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- Golubkov D
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- Gomes A
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- Gonalo R
- Goncalo R
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- Gonzalez de la Hoz S
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- Gonzalez Parra G
- Gonzalez Parra G
- Gonzalez BA
- Gonzalez-Sevilla S
- Gonzalez-Sevilla S
- Goossens L
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- Gorbounov PA
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- Gordon HA
- Gordon HA
- Gorelov I
- Gorelov I
- Gorini B
- Gorini B
- Gorini E
- Gorini E
- Gorisek A
- Gorisek A
- Gornicki E
- Gornicki E
- Goshaw AT
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- Gostkin MI
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- Gouighri M
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- Goujdami D
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- Goulette MP
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- Goussiou AG
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- Goy C
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- Gozpinar S
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- Grabas HMX
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- Graber L
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- Grafstroem P
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- Grancagnolo S
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- Grancagnoloa F
- Grassi V
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- Gratchev V
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- Gray HM
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- Graziani E
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- Grebenyuk OG
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- Greenwood ZD
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- Gregersen K
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- Gregor IM
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- Grenier P
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- Griffiths J
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- Grillo AA
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- Griso SP
- Grivaz J-F
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- Grohs JP
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- Grohsjean A
- Gross AGE
- Gross E
- Grosse-Knetter J
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- Grossi GC
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- Groth-Jensen J
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- Grout ZJ
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- Guan L
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- Guescini F
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- Guest D
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- Gueta O
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- Guicheney C
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- Guido E
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- Gutierrez P
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- Guttman N
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- Guyot C
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- Harenberg T
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- Hasegawa Y
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- Hawkings RJ
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- Hernandez Jimenez Y
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- Lapoire C
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- Lavrijsen W
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- Le Dortz O
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- Loevschall-Jensen AE
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- Lukas W
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- Lundberg O
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- Miguens JM
- Mijovic L
- Mikenberg G
- Mikestikova M
- Mikuz M
- Miller DW
- Mills C
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- Milov A
- Milstead DA
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- Minashvili IA
- Mincer AI
- Mindur B
- Mineev M
- Ming Y
- Miotto GL
- Mir LM
- Mirabelli G
- Mitani T
- Mitrevski J
- Mitsou VA
- Mitsui S
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- Miyagawa PS
- Mjornmark JU
- Moa T
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- Monini C
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- Mornacchi G
- Morris JD
- Morvaj L
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- Mosidzeb M
- Moss J
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- Mouraviev SV
- Moyse EJW
- Muanza S
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- Munwes Y
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- Musto E
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- Myska M
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- Namasivayam H
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- Negri G
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- Nemethy P
- Nepomuceno AA
- Nessi M
- Neubauer MS
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- Neusiedl A
- Neves RM
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- Nickerson RB
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- Nikolic-Audit I
- Nikolics K
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- Nuti F
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- Oakham FG
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- Olivito D
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- Panitkin S
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- Parzefall U
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- Petrolo E
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- Piacquadio G
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- Picazio A
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- Piegaia R
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- Pilkington AD
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- Plucinski P
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- Polifka R
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- Popeneciu GA
- Popovic DS
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- Pospelov GE
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- Potamianos K
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- Przysiezniak H
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- Pueschel E
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- Pylypchenko Y
- Pysztor G
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- Quayle WB
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- Quilty D
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- Ragusa F
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- Rebuzzi DM
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- Renaud A
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- Rezanov OL
- Reznicek P
- Rezvani R
- Richter R
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- Rimoldi A
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- Riu I
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- Robinson JEM
- Robson A
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- Roe S
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- Romano M
- Romeo G
- Romero Adam E
- Rompotis N
- Roos L
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- Rossi LP
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- Rotaru M
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- Rothberg J
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- Rurikova Z
- Rusakovich NA
- Ruschke A
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- Ruthmann N
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- Sacerdoti S
- Saddique A
- Sadeh I
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- Sadykov R
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- Sakurai Y
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- Salamon A
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- Salihagic D
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- Sanchez A
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- Sarrazin B
- Sartisohn G
- Sasaki O
- Sasaki Y
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- Savu DO
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- Scannicchio DA
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- Schacht P
- Schaefer D
- Schaefer U
- Schaelicke A
- Schaepe S
- Schaetzel S
- Schaffer AC
- Schaile D
- Schamberger RD
- Scharf V
- Schegelsky VA
- Scheirich D
- Schernau M
- Scherzer MI
- Schiavi C
- Schieck J
- Schillo C
- Schioppa M
- Schlenker S
- Schmidt E
- Schmieden K
- Schmitt C
- Schmitt C
- Schmitt S
- Schneider B
- Schnellbach YJ
- Schnoor U
- Schoeffel L
- Schoening A
- Schoenrock BD
- Schorlemmer ALS
- Schott M
- Schouten D
- Schovancova J
- Schramm S
- Schreyer M
- Schroeder C
- Schroeder TV
- Schuh N
- Schultens MJ
- Schultz-Coulon H-C
- Schulz H
- Schumacher M
- Schumm BA
- Schune P
- Schwartzman A
- Schwegler P
- Schwemling P
- Schwienhorst R
- Schwindling J
- Schwindt T
- Schwoerer M
- Sciacca FG
- Scifo E
- Sciolla G
- Scott WG
- Scuri F
- Scutti F
- Searcy J
- Sedov G
- Sedykh E
- Seidel SC
- Seiden A
- Seifert F
- Seixas JM
- Sekhniaidze G
- Sekula SJ
- Selbach KE
- Seliverstov DM
- Sellers G
- Seman M
- Semprini-Cesari N
- Serfon C
- Serin L
- Serkin L
- Serre T
- Seuster R
- Severini H
- Sforza F
- Sfyrla A
- Shabalina E
- Shamim M
- Shan LY
- Shank JT
- Shao QT
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- Shatalov PB
- Shaw K
- Sherwood P
- Shimizu S
- Shimmin CO
- Shimojima M
- Shiyakova M
- Shmeleva A
- Shochet MJ
- Short D
- Shrestha S
- Shulga E
- Shupe MA
- Shushkevich S
- Sicho P
- Sidorov D
- Sidoti A
- Siegert F
- Sijacki D
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- Silva MLG
- Silva MLG
- Silver Y
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- Silverstein SB
- Simak V
- Simard O
- Simic L
- Simion S
- Simioni E
- Simmons B
- Simoniello R
- Simonyan M
- Sinervo P
- Sinev NB
- Sipica V
- Siragusa G
- Sircar A
- Sisakyan AN
- Sivoklokov SY
- Sjolin J
- Sjursen TB
- Skinnari LA
- Skottowe HP
- Skovpen KY
- Skubic P
- Slater M
- Slavicek T
- Sliwa K
- Smakhtin V
- Smart BH
- Smestad L
- Smirnov SY
- Smirnov Y
- Smirnova LN
- Smirnova O
- Smith KM
- Smizanska M
- Smolek K
- Snesarev AA
- Snidero G
- Snyder S
- Sobie R
- Socher F
- Soffer A
- Soh DA
- Solans CA
- Solar M
- Solc J
- Soldatov EY
- Soldevila U
- Solodkov AA
- Solovyanov OV
- Solovyev V
- Sommer P
- Soni N
- Sood A
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- Sopko V
- Sosebee M
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- Soukharev AM
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- Spano F
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- Spighi R
- Spigo G
- Spousta M
- Spreitzer T
- Spurlock B
- St Denis RD
- Stahlman J
- Stamen R
- Stanecka E
- Stanek RW
- Stanescu C
- Stanescu-Bellu M
- Stanitzki MM
- Stapnes S
- Starchenko EA
- Stark J
- Staroba P
- Starovoitov P
- Staszewski R
- Stavina P
- Steele G
- Steinberg P
- Stelzer B
- Stelzer HJ
- Stelzer-Chilton O
- Stenzel H
- Stern S
- Stewart GA
- Stillings JA
- Stockton MC
- Stoebe M
- Stoerig K
- Stoicea G
- Stonjek S
- Stradling AR
- Straessner A
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- Strandberg S
- Strandlie A
- Strauss E
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- Stroehmer R
- Strom DM
- Stroynowski R
- Stucci SA
- Stugu B
- Stumer I
- Styles NA
- Su D
- Su J
- Subramania HS
- Subramaniam R
- Succurro A
- Sugaya Y
- Suhr C
- Suk M
- Sulin VV
- Sultansoy S
- Sumida T
- Sun X
- Sundermann JE
- Suruliz K
- Susinno G
- Sutton MR
- Suzuki Y
- Svatos M
- Swedish S
- Swiatlowski M
- Sykora I
- Sykora T
- Ta D
- Tackmann K
- Taenzer J
- Taffard A
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- Taiblum N
- Takahashi Y
- Takai H
- Takashima R
- Takeda H
- Takeshita T
- Takubo Y
- Talby M
- Talyshev AA
- Tam JYC
- Tamsett MC
- Tan KG
- Tanaka J
- Tanaka R
- Tanaka S
- Tanaka S
- Tanasijczuk AJ
- Tani K
- Tannoury N
- Tapprogge S
- Tarem S
- Tarrade F
- Tartarelli GF
- Tas P
- Tasevsky M
- Tashiro T
- Tassi E
- Tavares Delgado A
- Tayalati Y
- Taylor C
- Taylor FE
- Taylor GN
- Taylor W
- Tehrani FS
- Teischinger FA
- Teixeira-Dias P
- Temming KK
- Ten Kate H
- Teng PK
- Terada S
- Terashi K
- Terron J
- Terzo S
- Testa M
- Teuscher RJ
- Therhaag J
- Theveneaux-Pelzer T
- Thoma S
- Thomas JP
- Thomas-Wilsker J
- Thompson AS
- Thompson EN
- Thompson PD
- Thompson PD
- Thomsen LA
- Thomson E
- Thomson M
- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tiouchichine E
- Tipton P
- Tisserant S
- Todorov T
- Todorova-Nova S
- Toggerson B
- Tojo J
- Tokar S
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- Toro RC
- Torregros EF
- Torregrosa EF
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- Touchard F
- Tovey DR
- Tran HL
- Trefzger T
- Tremblet L
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Tripiana MF
- Triplett N
- Trischuk W
- Trocme B
- Troncon C
- Trottier-McDonald M
- Trovatelli M
- True P
- Trzebinski M
- Trzupek A
- Tsarouchas C
- Tseng JC-L
- Tsiareshka PV
- Tsionou D
- Tsipolitis G
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tua A
- Tudorache A
- Tudorache V
- Tuna AN
- Tupputi SA
- Turchikhin S
- Turecek D
- Turra R
- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Uchida K
- Ueda I
- Ueno R
- Ughetto M
- Ugland M
- Uhlenbrock M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Urbaniec D
- Urquijo P
- Usai G
- Usanova A
- Vacavant L
- Vacek V
- Vachon B
- Valencic N
- Valentinetti S
- Valero A
- Valery L
- Valkar S
- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
- Van der Deijl PC
- van der Geer R
- van der Graaf H
- Van der Leeuw R
- van der Ster D
- van Eldik N
- van Gemmeren P
- van Huysduynen LH
- Van Nieuwkoop J
- van Vulpen I
- van Woerden MC
- Vanadia M
- Vandelli W
- Vaniachine A
- Vankov P
- Vannucci F
- Vaque FV
- Vardanyan G
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vazeille F
- Vazquez JGP
- Veatch J
- Veloso F
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Venturini A
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Vest A
- Vetterli MC
- Viazlo O
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Vigne R
- Villa M
- Villaplana Perez M
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Virzi J
- Vitells O
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahrmund S
- Wakabayashi J
- Walder J
- Walker R
- Walkowiak W
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- Walls FMG
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- Walsh B
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- Wang F
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- Wang K
- Wang R
- Wang SM
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- Wang X
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watanabe I
- Watkins PM
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- Watson MF
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- Watts S
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- Waugh BM
- Webb S
- Weber MS
- Weber SW
- Webster JS
- Weidberg AR
- Weigell P
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
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- Werner P
- Wessels M
- Wetter J
- Whalen K
- White A
- White MJ
- White R
- White S
- Whiteson D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilkens HG
- Will JZ
- Williams HH
- Williams S
- Willocq S
- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
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- Abhayasinghe DK
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
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- Yusuff I
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- Zaidan R
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- Zambito S
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- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
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- Zhao Z
- Zhemchugov A
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
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- Alonso F
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- Alviggi MG
- Amako K
- Amelung C
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- Amorim A
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- Anastopoulos C
- Ancu LS
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- Anders CF
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- Andrade Filho LMD
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- van Huysduynen LH
- Van Nieuwkoop J
- van Vulpen I
- Van Woerden MC
- Vanadia M
- Vandelli W
- Vanguri R
- Vaniachine A
- Vankov P
- Vannucci F
- Vaque FV
- Vardanyan G
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vazeille F
- Vazquez JGP
- Veatch J
- Veloso F
- Velz T
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Venturini A
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Verzini MJA
- Vest A
- Vetterli MC
- Viazlo O
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Vigne R
- Villa M
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Virzi J
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuanh T
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlberg H
- Wahrmund S
- Wakabayashi J
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walls FMG
- Walsh B
- Wang C
- Wang C
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang K
- Wang R
- Wang SM
- Wang T
- Wang X
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
- Watts S
- Waugh BM
- Webb S
- Weber MS
- Weber SW
- Webster JS
- Weidberg AR
- Weigell P
- Weinert B
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Wessels M
- Wetter J
- Whalen K
- White A
- White MJ
- White R
- White S
- Whiteson D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilkens HG
- Will JZ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yakabe R
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Covalent Protein Modification with ISG15 via a Conserved Cysteine in the Hinge Region
- Author
- A Dastur
- A Okumura
- AL Haas
- C Lai
- C Zhao
- C Zhao
- CM Sorensen
- DJ Lenschow
- Dong-Yan Jin
- DW Leaman
- E Guenzi
- E Knight Jr
- E Padovan
- F Flohr
- F Okumura
- F Okumura
- Gerrit J. K. Praefcke
- GJ Praefcke
- J Bothos
- J Brusky
- J D’Cunha
- J Narasimhan
- J Pavlovic
- JB Schulz
- JD Gregory
- JJ Wong
- Jochen Nickels
- K Hochrainer
- KI Kim
- Kirstin Keusekotten
- KJ Ritchie
- KP Knobeloch
- KR Loeb
- LA Durfee
- LB Hersh
- M Owhashi
- M Schnellhardt
- MJ Kim
- MP Malakhov
- MP Malakhov
- N Reich
- NV Giannakopoulos
- OA Malakhova
- PJ Farrell
- RM Hofmann
- S McKenna
- SJ Shah
- SR Weisshaar
- T Takeuchi
- T Takeuchi
- TA Nyman
- U Boehm
- Veronika N. Bade
- W Yuan
- W Zou
- W Zou
- Y Guo
- Publication venue
- Public Library of Science
- Publication date
- 05/06/2012
- Field of study
The ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) is strongly induced by type I interferons and displays antiviral activity. As other ubiquitin-like proteins (Ubls), ISG15 is post-translationally conjugated to substrate proteins by an isopeptide bond between the C-terminal glycine of ISG15 and the side chains of lysine residues in the substrates (ISGylation). ISG15 consists of two ubiquitin-like domains that are separated by a hinge region. In many orthologs, this region contains a single highly reactive cysteine residue. Several hundred potential substrates for ISGylation have been identified but only a few of them have been rigorously verified. In order to investigate the modification of several ISG15 substrates, we have purified ISG15 conjugates from cell extracts by metal-chelate affinity purification and immunoprecipitations. We found that the levels of proteins modified by human ISG15 can be decreased by the addition of reducing agents. With the help of thiol blocking reagents, a mutational analysis and miRNA mediated knock-down of ISG15 expression, we revealed that this modification occurs in living cells via a disulphide bridge between the substrates and Cys78 in the hinge region of ISG15. While the ISG15 activating enzyme UBE1L is conjugated by ISG15 in the classical way, we show that the ubiquitin conjugating enzyme Ubc13 can either be classically conjugated by ISG15 or can form a disulphide bridge with ISG15 at the active site cysteine 87. The latter modification would interfere with its function as ubiquitin conjugating enzyme. However, we found no evidence for an ISG15 modification of the dynamin-like GTPases MxA and hGBP1. These findings indicate that the analysis of potential substrates for ISG15 conjugation must be performed with great care to distinguish between the two types of modification since many assays such as immunoprecipitation or metal-chelate affinity purification are performed with little or no reducing agent present
The waking brain: an update
- Author
- A Adamantidis
- A Khateb
- A Philippu
- A Shekhar
- AA Borbely
- AA Borbely
- AA Borbely
- AA Grace
- B Ford
- B Jones
- BE Jones
- BE Jones
- BE Jones
- BE Jones
- BE Jones
- BL Krilowicz
- BY Mileykovskiy
- C Anaclet
- C Blanco-Centurion
- C Cirelli
- C Economo von
- C Kohler
- C Peyron
- CB Saper
- CB Saper
- CB Saper
- CH Vanderwolf
- Christelle Anaclet
- CL Wilson
- D Gerashchenko
- D Nitz
- DA McCormick
- DA McCormick
- DJ McGinty
- DN Jones
- DV Madison
- F Belardetti
- F Bremer
- F Casamenti
- F Petitjean
- FG Wouterlood
- G Aston-Jones
- G Buzsaki
- G Moruzzi
- G Vanni-Mercier
- GD Prell
- HC Dringenberg
- Helmut L. Haas
- HL Haas
- HL Haas
- HL Haas
- HL Haas
- I Arnulf
- J John
- J Lu
- J Stehle
- JA Hobson
- JC Bittencourt
- JC Schwartz
- JE Sherin
- JH Benington
- Jian-Sheng Lin
- JJ Hagan
- JL Valdes
- JM Arrang
- JM Monti
- JM Siegel
- JM Zeitzer
- JN Marcus
- JP Huston
- JP Kukkonen
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JS Lin
- JT Willie
- K Fuxe
- K Sakai
- K Sakai
- K Sakai
- K Sakai
- K Sakai
- K Takahashi
- K Takahashi
- K Takahashi
- K Takahashi
- KG Reymann
- KS Eriksson
- L Bayer
- L Lecea de
- LB Jaeger
- LE Nelson
- M Denoyer
- M Radulovacki
- M Sallanon
- M Sallanon
- M Steriade
- M Steriade
- M Steriade
- M Steriade
- M Steriade
- M Steriade
- M Steriade
- ME Carter
- MG Lee
- MH Schmidt
- MMD Gonzalez
- N Gorelova
- N Suntsova
- N Takeda
- N Tsujino
- O Selbach
- O Selbach
- OA Sergeeva
- OK Hassani
- Olga A. Sergeeva
- P Panula
- PB Reiner
- PJ Martins
- R Leurs
- R Parmentier
- R Parmentier
- R Parmentier
- R Szymusiak
- R Szymusiak
- RE Brown
- RE Strecker
- RH Williams
- RM Bauer
- S Kiyono
- S Nishino
- S Nishino
- SL Foote
- T Gallopin
- T Mochizuki
- T Porkka-Heiskanen
- T Sakurai
- T Sakurai
- T Sakurai
- T Watanabe
- TC Chou
- TE Bjorness
- TF Freund
- TG Waldrop
- TL Steininger
- TM Korotkova
- WG Barnes
- WHJ Nauta
- WW Douglas
- Y Date
- Y Ohshima
- Y Yoshimoto
- YW Liu
- Publication venue
- SP Birkhäuser Verlag Basel
- Publication date
- 01/01/2011
- Field of study
Wakefulness and consciousness depend on perturbation of the cortical soliloquy. Ascending activation of the cerebral cortex is characteristic for both waking and paradoxical (REM) sleep. These evolutionary conserved activating systems build a network in the brainstem, midbrain, and diencephalon that contains the neurotransmitters and neuromodulators glutamate, histamine, acetylcholine, the catecholamines, serotonin, and some neuropeptides orchestrating the different behavioral states. Inhibition of these waking systems by GABAergic neurons allows sleep. Over the past decades, a prominent role became evident for the histaminergic and the orexinergic neurons as a hypothalamic waking center
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