Understanding the development of temporary agency work in Europe

This article develops an explanatory framework for understanding the growth and development of temporary agency work (TAW) and the related industry. The analysis shows that explanations based on economic logic are helpful in understanding the choice of TAW in general. These explanations, however, fall short when trying to explain the growth of agency work over time or the variation in its use among European countries. To cope with these shortcomings, we extend our explanatory base to include a variety of sociocultural dynamics. Our analysis shows how deep-seated national work-related values ('deep embeddedness') affect the way TAW is regulated nationally. It also demonstrates how differences in more changeable norms, attitudes and practices ('dynamic embeddedness') affect the process of embedding agency work as a societally acceptable phenomenon, providing a basis for its subsequent proliferation

Expanding organisational knowledge online: the role of bridging members in knowledge expansion in online groups

In this paper we hypothesise about the role of bridging members – people who connect otherwise unconnected online groups – on an enterprise social network (ESN) and in what manner their role affects their group’s knowledge expansion. Analysing data from an ESN of a Dutch health insurance company, we show how online groups can benefit from their bridging members who take advantage of the affordances of the digital platform. We find that a larger proportion of bridging members within a group mitigates the decrease in knowledge expansion over time. This research contributes to the literature on online knowledge sharing and social networks by showing the effect of bridging members on knowledge expansion in a digital environment. Our study has implications for organisations who want to leverage knowledge sharing for innovation

Intergroup bridging dynamics affecting organizational knowledge sharing over time

This paper investigates the social structure between online groups within an Enterprise Social Network (ESN). We analyze the nature and composition of bridges between groups over time and how they affect the intergroup network. We perform regression analyses of data generated by an ESN within a Dutch youth-care organization. We find that the intergroup network develops small world characteristics and suggest that this will foster organizational knowledge sharing. We follow development of bridges and their composition week after week over a period of five years. We show the relative importance of so-called flexible bridging members who recurrently bridge the same groups over time. The importance of relatively more flexible compared to stable bridging members changes over time, so that flexible bridging members are more important in earlier stages of the ESN adoption lifecycle, and stable bridging members at later stages. Further, we show that there is a difference in how early adopters versus late adopters are active on the bridges and how this bridging behavior develops over time. Our findings are enhanced by interview data with bridging members. This study contributes to the understanding of brokerage dynamics by zooming in on how the intergroup network changes over time due to stable and flexible bridges, and we suggest that this affects organizational knowledge sharing over time

Fecal Microbiota Transplantation for Immune Checkpoint Inhibitor-Induced Colitis Is Safe and Contributes to Recovery: Two Case Reports

Immune checkpoint inhibitors (ICIs) have improved the prognosis in multiple cancer types. However, ICIs can induce immune-related adverse events such as immune-mediated enterocolitis (IMC). The gut microbiota may be implicated in IMC development. Therefore, we investigated fecal microbiota transplantation (FMT) as a treatment option for 2 patients with metastatic cancer suffering from refractory IMC. The patients were treated with, respectively, 1 and 3 FMTs after vancomycin pre-treatment. We monitored defecation frequency, fecal calprotectin, and microbiota composition. After FMT, both patients improved in defecation frequency, were discharged from the hospital, and received lower dosage of immunosuppressive therapy. Patient 1 developed an invasive pulmonary aspergillosis deemed to be related to prolonged steroid exposure. Patient 2 suffered from a Campylobacter jejuni infection after the first FMT and was treated with meropenem, resulting in a low-diversity microbiota profile and increased calprotectin levels and defecation frequency. After a second and third FMT, bacterial diversity increased and defecation frequency and calprotectin levels decreased. Pre-FMT, both patients showed low bacterial richness, but varying bacterial diversity. After FMT, diversity and richness were similar to healthy donor levels. In conclusion, FMT resulted in improvement of IMC symptoms and corresponding microbial changes in 2 cancer patients with refractory IMC. While more research is warranted, microbiome-modulation could be a promising new therapeutic option for IMC

TRILEGAL, a TRIdimensional modeL of thE GALaxy: Status and FutureRed Giants as Probes of the Structure and Evolution of the Milky Way

We briefly describe TRILEGAL, a TRIdimensional modeL of thE GALaxy, and its more recent developments. Particularly relevant is the recent inclusion of a kinematical module to the code, and the present efforts to provide a more solid calibration of Milky Way parameters based on 2MASS and SDSS data

Transmission of Antibiotic-Susceptible Causing Urinary Tract Infections in a Fecal Microbiota Transplantation Recipient: Consequences for Donor Screening?

Fecal microbiota transplantation (FMT) has been reported to decrease the incidence of recurrent urinary tract infections (UTIs), presumably by restoring microbiome diversity and/or uropathogen competition. We report a 16-year-old female with recurrent UTIs caused by multidrug-resistant Klebsiella pneumoniae, for which frequent intravenous broad-spectrum antibiotic treatment was necessary. The patient was treated with FMT from a well-screened healthy donor without multidrug-resistant bacteria in the feces. After FMT, she developed several UTIs with an antibiotic-susceptible Escherichia coli that could be treated orally. The uropathogenic E. coli could be cultured from donor feces, and whole genome sequencing confirmed donor-to-recipient transmission. Our observation should stimulate discussion on long-term follow-up of all infections after FMT and donor fecal screening for antibiotic-susceptible Enterobacterales

How to prepare stool banks for an appropriate response to the ongoing COVID-19 pandemic: Experiences in the Netherlands and a retrospective comparative cohort study for faecal microbiota transplantation.

BACKGROUND: Faecal microbiota transplantation (FMT) is an efficacious treatment for patients with recurrent Clostridioides difficile infections (rCDI). Stool banks facilitate FMT by providing screened faecal suspensions from highly selected healthy donors. Due to the ongoing coronavirus disease 2019 (COVID-19) pandemic and the potential risk of SARS coronavirus-2 (SARS-CoV-2) transmission via FMT, many stool banks were forced to temporarily halt and adjust donor activities. GOAL: The evaluation of a strategy to effectively continue stool banking activities during the ongoing COVID-19 pandemic. STUDY: To restart our stool banking activities after an initial halt, we implemented periodic SARS-CoV-2 screening in donor faeces and serum, and frequent donor assessment for COVID-19 related symptoms. FMT donor and recipient data obtained before (2016–2019) and during the COVID-19 pandemic (March 2020-August 2021) were compared to assess stool banking efficacy. RESULTS: Two out of ten donors developed COVID-19. No differences during versus before the COVID-19 pandemic were observed in the number of approved faeces donations (14 vs 22/month, p = 0.06), FMT requests for rCDI (3.9 vs 4.3/month, p = 0.6); rCDI patients eligible for FMT (80.6% vs 73.3%, p = 0.2); rCDI cure rate (90.3% vs 89.2%, p = 0.9); CDI-free survival (p = 0.7); the number of non-rCDI patients treated with FMT (0.5/month vs 0.4/month), and the number of possibly FMT related adverse events (9.5% vs 7.8%, p = 0.7). Two FMTs for rCDI were delayed due to COVID-19. CONCLUSIONS: There is a continued need for FMT treatment of rCDI during the COVID-19 pandemic. Appropriate donor screening and SARS-CoV-2 infection prevention measures can be implemented in existing protocols without increasing the burden for donors, and allow safe, effective and efficient FMT during the ongoing COVID-19 pandemic. Stool banks should evaluate their SARS-CoV-2 donor screening protocols for long-term sustainability and efficacy, and share their experiences to help the utilisation, standardisation and improvement of stool banks worldwide