Patterns and risk of first and subsequent recurrences in women within ten years after primary invasive breast cancer

Background: Previous studies suggest a distinct pattern and a number of predictive factors for breast cancer recurrence. However, only few studies include data on recurrence site and no study provides data regarding second and third breast cancer recurrence after local and regional recurrence. The aim of this study was to analyse the occurrence, timing and predictive factors of first and subsequent local (LR), regional (RR) or distant (DM) recurrence during the first 10 years after treatment for primary invasive breast cancer in women. Methods: Women with stage I-III invasive breast cancer diagnosed in 2003 and treated with curative intent were selected from the Netherlands Cancer Registry (N = 9797). Median follow-up was 10 years. Multivariable cox proportional hazards regression was used to model the hazard of recurrence over time for site-specific first recurrence and for subsequent recurrences after LR or RR. Predictive factors were identified for first and for subsequent recurrences. All tests were two-sided and probability values of 2 cm, grade III and negative ER were predictive factors for first RR and tumour size >2 cm, grade II or III, increasing number of involved lymph nodes and negative progesterone-receptor (PR) status were predictive factors for first DM. After a LR 109/379 patients (28.7%) developed subsequent recurrence: 11 patients had another LR (2.9%), 13 patients had RR (3.4%) and 85 patients (22.4%) had DM. Median time to second recurrence was 1.1 year (IQR 0.3–2.5 year). Tumour size >2 cm, grade III, primary tumour histology (other vs invasive ductal), >3 positive lymph nodes and negative PR-status were predictive factors for a second recurrence after LR. After a first RR 79/156 patients (50.6%) developed subsequent recurrence: 8 patients had LR (5.1%), 3 patients had RR (1.9%) and 68 patients (43.6%) had DM. Median time to second recurrence was 1.1 year (IQR 0.5–2.1 year). In multivariable analysis, no predictive factor for a second recurrence after RR was identified. After previous LR or RR a third subsequent recurrence occurred in 18 patients (9.6%). Conclusions: The pattern of first recurrence was similar for LR, RR and DM. To improve personalized follow-up, predictive factors could be taken into account. However, this study showed no explicit predictive factor for site specific recurrence and subsequent recurrences after LR and RR. Future studies that take treatment characteristics into account are needed

Patterns and risk of first and subsequent recurrences in women within ten years after primary invasive breast cancer

Background: Previous studies suggest a distinct pattern and a number of predictive factors for breast cancer recurrence. However, only few studies include data on recurrence site and no study provides data regarding second and third breast cancer recurrence after local and regional recurrence. The aim of this study was to analyse the occurrence, timing and predictive factors of first and subsequent local (LR), regional (RR) or distant (DM) recurrence during the first 10 years after treatment for primary invasive breast cancer in women. Methods: Women with stage I-III invasive breast cancer diagnosed in 2003 and treated with curative intent were selected from the Netherlands Cancer Registry (N = 9797). Median follow-up was 10 years. Multivariable cox proportional hazards regression was used to model the hazard of recurrence over time for site-specific first recurrence and for subsequent recurrences after LR or RR. Predictive factors were identified for first and for subsequent recurrences. All tests were two-sided and probability values of <0.05 were considered statistically significant. Results: In total 379 patients had LR, 156 patients had RR and 1412 patients had DM as first recurrence. The risk of first recurrence was highest around 2 years post-diagnosis (HR 0.040 95% CI 0.036–0.044) with a similar pattern for LR, RR and DM. Multivariable analysis showed that lower age and negative estrogen-receptor (ER) status were predictive factors for first LR. Tumour size >2 cm, grade III and negative ER were predictive factors for first RR and tumour size >2 cm, grade II or III, increasing number of involved lymph nodes and negative progesterone-receptor (PR) status were predictive factors for first DM. After a LR 109/379 patients (28.7%) developed subsequent recurrence: 11 patients had another LR (2.9%), 13 patients had RR (3.4%) and 85 patients (22.4%) had DM. Median time to second recurrence was 1.1 year (IQR 0.3–2.5 year). Tumour size >2 cm, grade III, primary tumour histology (other vs invasive ductal), >3 positive lymph nodes and negative PR-status were predictive factors for a second recurrence after LR. After a first RR 79/156 patients (50.6%) developed subsequent recurrence: 8 patients had LR (5.1%), 3 patients had RR (1.9%) and 68 patients (43.6%) had DM. Median time to second recurrence was 1.1 year (IQR 0.5–2.1 year). In multivariable analysis, no predictive factor for a second recurrence after RR was identified. After previous LR or RR a third subsequent recurrence occurred in 18 patients (9.6%). Conclusions: The pattern of first recurrence was similar for LR, RR and DM. To improve personalized follow-up, predictive factors could be taken into account. However, this study showed no explicit predictive factor for site specific recurrence and subsequent recurrences after LR and RR. Future studies that take treatment characteristics into account are needed

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters

Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV

The Lambda(b) differential production cross section and the cross section ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7 TeV using data collected by the CMS experiment at the LHC. The measurements are based on Lambda(b) decays reconstructed in the exclusive final state J/Psi Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and Lambda to proton pion, using a data sample corresponding to an integrated luminosity of 1.9 inverse femtobarns. The product of the cross section times the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls faster than that of b mesons. The measured value of the cross section times the branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06 +/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are statistical and systematic, respectively.Comment: Submitted to Physics Letters

Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV

A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 inverse femtobarns. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this paper.Comment: Replaced with published version. Added journal reference and DO

Measurement of isolated photon production in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV

Isolated photon production is measured in proton-proton and lead-lead collisions at nucleon-nucleon centre-of-mass energies of 2.76 TeV in the pseudorapidity range |eta|<1.44 and transverse energies ET between 20 and 80 GeV with the CMS detector at the LHC. The measured ET spectra are found to be in good agreement with next-to-leading-order perturbative QCD predictions. The ratio of PbPb to pp isolated photon ET-differential yields, scaled by the number of incoherent nucleon-nucleon collisions, is consistent with unity for all PbPb reaction centralities.Comment: Submitted to Physics Letters

Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV

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Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

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Measurement of the mass difference between top quark and antiquark in pp collisions at root s=8 TeV

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