253 research outputs found
Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin
- Author
- A Azuma
- A Fine
- A Laffon
- A Moeller
- A Moretta
- A Scriabine
- AG Santis
- B Hu
- B Manoury
- C Garcia-Monzon
- D Sancho
- DB Chandler
- E Cavarra
- E Esplugues
- F Saito
- J Chen
- J Kelley
- J Zhao
- K Murata
- K Zhang
- LA Ortiz
- LH Einhorn
- M Cebrian
- M Gharaee-Kermani
- M Lopez-Cabrera
- ME Cosulich
- ML Lohmann-Matthes
- N Khalil
- R De Maria
- R Gavioli
- R Marzio
- R Marzio
- R Testi
- RK Scheule
- S Sleijfer
- SF Ziegler
- SF Ziegler
- SM Hecht
- T Ashcroft
- T Hara
- T Miki-Hosokawa
- T Morii
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Cluster of differentiation 69 (CD69), an early activation marker antigen on T and B cells, is also expressed on activated macrophages and neutrophils, suggesting that CD69 may play a role in inflammatory diseases. To determine the effect of CD69 deficiency on bleomycin(BLM)-induced lung injury, we evaluated the inflammatory response following intratracheal BLM administration and the subsequent fibrotic changes in wild type (WT) and CD69-deficient (CD69<sup>-/-</sup>) mice.</p> <p>Methods</p> <p>The mice received a single dose of 3 mg/kg body weight of BLM and were sacrificed at 7 or 14 days post-instillation (dpi). Lung inflammation in the acute phase (7 dpi) was investigated by differential cell counts and cytokine array analyses of bronchoalveolar lavage fluid. In addition, lung fibrotic changes were evaluated at 14 dpi by histopathology and collagen assays. We also used reverse transcription polymerase chain reaction to measure the mRNA expression level of transforming growth factor β1 (TGF-β1) in the lungs of BLM-treated mice.</p> <p>Results</p> <p>CD69<sup>-/- </sup>mice exhibited less lung damage than WT mice, as shown by reductions in the following indices: (1) loss of body weight, (2) wet/dry ratio of lung, (3) cytokine levels in BALF, (4) histological evidence of lung injury, (5) lung collagen deposition, and (6) TGF-β1 mRNA expression in the lung.</p> <p>Conclusion</p> <p>The present study clearly demonstrates that CD69 plays an important role in the progression of lung injury induced by BLM.</p
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang GM
- Abajobir AA
- Abate KH
- Abbafati C
- Abbas KM
- Abd-Allah F
- Abdulle AM
- Abera SF
- Abraham B
- Abu-Raddad LJ
- Abyu GY
- Adebiyi AO
- Adedeji IA
- Ademi Z
- Adou AK
- Adsuar JC
- Afshin A
- Agardh EE
- Agarwal A
- Agrawal A
- Ajala ON
- Akinyemiju TF
- Al-Aly Z
- Alam K
- Alam NKM
- Aldhahri SF
- Aldridge RW
- Alemu ZA
- Alexander LT
- Ali R
- Alkerwi A
- Alla F
- Allebeck P
- Alsharif U
- Altirkawi KA
- Alvarez Martin E
- Alves Silveira DG
- Alvis-Guzman N
- Amare AT
- Amberbir A
- Amegah AK
- Amini H
- Ammar W
- Amrock SM
- Andersen HH
- Anderson BO
- Anderson HR
- Antonio CAT
- Anwar P
- Aquino Faraon EJ
- Arnlov J
- Artaman A
- Asayesh H
- Asghar RJ
- Assadi R
- Atique S
- Avokpaho EFGA
- Awasthi A
- Azzopardi P
- Bacha U
- Badawi A
- Baernighausen T
- Bahit MC
- Balakrishnan K
- Bans C
- Barac A
- Barber RM
- Barker-Collo SL
- Barquera S
- Barregard L
- Barrero LH
- Basu S
- Bazargan-Hejazi S
- Beardsley J
- Beatriz Heredia-Pi I
- Beatriz Lawrynowicz AE
- Bedi N
- Beghi E
- Bell ML
- Bello AK
- Bennett DA
- Bensenor IM
- Berhane A
- Bernabe E
- Betsu BD
- Beyene AS
- Bhala N
- Bhansali A
- Bhatt S
- Bhutta ZA
- Biadgilign S
- Bicer BK
- Bikbov B
- Biryukov S
- Bisanzio D
- Bjertness E
- Blore JD
- Borschmann R
- Boufous S
- Bourne RRA
- Brainin M
- Brauer M
- Brazinova A
- Breitborde NJK
- Brenner H
- Broday DM
- Brugha TS
- Brunekreef B
- Burnett R
- Butt ZA
- Cahill LE
- Caicedo AJP
- Calabria B
- Cardenas R
- Carmen Gomez-Cabrera M
- Carpenter D
- Casey DC
- Castaneda-Oquela CA
- Castillo Rivas J
- Catala-Lopez F
- Cercy K
- Chang J-C
- Charlson FJ
- Chiang PP-C
- Chibalabala M
- Chimed-Ochir O
- Chisumpa VH
- Chitheer AA
- Choi J-YJ
- Christensen H
- Christopher DJ
- Ciobanu LG
- Coates MM
- Cohen AJ
- Colquhoun SM
- Cooper LT
- Cooperrider K
- Cornaby L
- Cortinovis M
- Crump JA
- Cuevas-Nasu L
- Damasceno A
- Dandona L
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- Darby SC
- Dargan PI
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- Davletov K
- De la Cruz-Gongora V
- De Leo D
- Defo BK
- Degenhardt L
- Del Gobbo LC
- del Pozo-Cruz B
- Dellavalle RP
- Deribew A
- Des Jarlais DC
- Dharmaratne SD
- Dhillon PK
- Diaz-Tome C
- Dicker D
- Dimbuene ZT
- Ding EL
- Dolores Sanchez-Nino M
- Dorsey ER
- Doyle KE
- Driscoll TR
- Duan L
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- Endries AY
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- Fernandes JG
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- Hosgood HD
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- Jakovljevic MB
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- Jayatilleke AU
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- Liu PY
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- Logroscino G
- Lopez AD
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- Lunevicius R
- Maclntyre M
- Mahdavi M
- Mahesh PA
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- Malta DC
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- Mapoma CC
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- Mensink GBM
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- Mozaffarian D
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- Naghavi M
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- Obermeyer CM
- Ogbo FA
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- Parry CD
- Parsaeian M
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- Pourmalek F
- Prasad NM
- Qorbani M
- Quintanilla BPA
- Rabiee RHS
- Radfar A
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- Rahimi-Movaghar V
- Rahman M
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- Rahman SU
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- Resnikoff S
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- Ricardo Campos-Nonato I
- Rivera JA
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- Rojas-Rueda D
- Rolm HS
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- Ronfani L
- Roshandel G
- Roth GA
- Rothenbacher D
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- Salomon JA
- Sanabria JR
- Sanchez-Pimienta TG
- Sandar L
- Santomauro DF
- Santos IS
- Sarmiento-Suarez R
- Sartorius B
- Satpathy M
- Savic M
- Sawhney M
- Schmidhuber J
- Schmidt MI
- Schneider IJC
- Schoettker B
- Schutte AE
- Schwebel DC
- Scott JG
- Seedat S
- Sepanlou SG
- Servan-Mori EE
- Shaheen A
- Shahraz S
- Shaikh MA
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- Shigematsu M
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- Silverberg JI
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- Singh JA
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- Sorensen RJD
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- Westerman R
- Whiteford HA
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- Wiysonge CS
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- Yadav AK
- Yakob B
- Yalew AZ
- Yano Y
- Yaseri M
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- Yip P
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- Younis MZ
- Yu C
- Zaidi Z
- Zaki MES
- Zhao Y
- Zhou M
- Zhu J
- Zipkin B
- Zodpey S
- Zuhlke LJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
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- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
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- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
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- Anh TV
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- Argyropoulos S
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- Bai Y
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- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
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- Beauchemin PH
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- Bobbink GJ
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- Bocchetta SS
- Bocci A
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- Borissov G
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- Zurzolo G
- Zutshi V
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
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- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
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- Alimonti G
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- Allbrooke BMM
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- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walls FMG
- Walsh B
- Wang C
- Wang C
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang K
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- Wang SM
- Wang T
- Wang X
- Wanotayaroj C
- Warburton A
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- Wardrope DR
- Warsinsky M
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- Wasicki C
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- Watson AT
- Watson IJ
- Watson MF
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- Webb S
- Weber MS
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- Webster JS
- Weidberg AR
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- Weinert B
- Weingarten J
- Weiser C
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- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
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- Werner P
- Wessels M
- Wetter J
- Whalen K
- White A
- White MJ
- White R
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- Whiteson D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilkens HG
- Will JZ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yakabe R
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
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- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups
- Author
- Abraham Oomman
- Accini Mendoza Jose Luis
- Agarwal R
- Aggarwal N
- Aizenberg D
- Akiyama Hitoshi
- Alamartine Eric
- Albisu Jp
- Alvarisqueta A
- Amodeo C
- Andreeva V
- Angelova A
- Aoki Hiromi
- Arcos Edgar
- Aronson R
- Asano Akimichi
- Avendano Jorge
- Bajaj H
- Bakris G
- Bartaskova Dagmar
- Bartolacci I
- Barton Petr
- Belobradkova Jana
- Berli Ma
- Bhushan Raju Sree
- Bompoint S
- Bonadonna Riccardo
- Bordonava A
- Borot Sophie
- Bregman R
- Brenner Bm
- Bull S
- Burst Volker
- Calella P
- Canani Lh
- Cannon Cp
- Cantero Mc
- Capuano G
- Cariou Bertrand
- Cartasegna Lr
- Casabella Ts
- Castellino Pietro
- Cercos E
- Ceriello Antonio
- Chacra Ar
- Charytan Dm
- Chen Nan
- Chen Qinkai
- Cherney D
- Cheung Nw
- Chiovato Luca
- Chouinard G
- Colaso Pdg
- Coloma Gc
- Colombo H
- Commendatore V
- Contieri Fld
- Conway J
- Cournoyer S
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado J
- Cuneo Ca
- Cunha Borges Jl
- Cusumano Am
- D'Avila D
- da Costa Faa
- Danos Peter
- Daroza G
- de Almeida Rs
- de Brito Cm
- De Cosmo Salvatore
- de la Fuente Ral
- De Nicola Luca
- De Serres S
- de Souza P
- de Zeeuw D
- Deak Laszlo
- Deboni Lm
- Deepak Dewan
- Derosa Giuseppe
- Di Carlo Alberto
- Di Cianni Graziano
- Diaz Ruiz Jorge Ernesto Andres
- Diego Higuera Juan
- Dimitrov S
- Dohnalova Lenka
- Douthat Wg
- Dran Rd
- Drasnar Tomas
- Droste C
- Dube F
- Dudas Mihaly
- Dussol Bertrand
- Edwards R
- Edwin Fernando M.
- Faghih Markus
- Farias E
- Faulmann Grit
- Fauvel Jean-Pierre
- Felicio Js
- Ferkl Richard
- Fernandez Montenegro Maria Alicia
- Fernandez Mf
- Finkelstein H
- Fragale G
- Fraige F
- Franco Rjd
- Frasca Giovanni
- Fraser I
- Fretes Jo
- Fuiano Giorgio
- Gambaro Giovanni
- Gan Shenglian
- Garcia Ortiz Luis Hernando
- Garcia Nh
- Garibotto Giacomo
- Gastaldi A
- Gelersztein E
- Genadieva V
- Genova-Hristova G
- Giorda Carlo
- Glenny Ja
- Godoy Jorquera Juan Gonzalo
- Goldenberg R
- Gomes M
- Gonzalez Orellana Ronaldo Arturo
- Gonzalez Alexander
- Gonzalez Jp
- Gopalakrishnan Natarajan
- Gourdy Pierre
- Goycoa C
- Gracious Noble
- Greene T
- Greloni Gc
- Guerrero Raa
- Guinsburg A
- Gupta A
- Gupta M
- Hachmann Jct
- Halciakova Katarina
- Haller Hermann
- Hansraj Alva
- Harcsa Eleonora
- Hayashida Cy
- Heerspink Hjl
- Henein S
- Hermida S
- Hernandez Triana Eric
- Hissa Mn
- Hristozov K
- Iitsuka Tadashi
- Ines Molina de Salazar Dora
- Jain Dinesh
- Jardine Mj
- Jerwan-Keim Reinhold
- Johnson D
- Juncos Li
- Kajiyama Shizuo
- Kamenov Z
- Kashine Susumu
- Kawada Toshio
- Keitel E
- Keltai Katalin
- Keresztesi Sandor
- Keshavamurthy C. B.
- Khandwala H
- Khullar Dinesh
- Kiss
- Klein Alexandre
- Klokocnikova Vera
- Klyver Mi
- Kodera Takamoto
- Kohara Sk
- Kong Yaozhong
- Kono Hiroshi
- Konyves Laszlo
- Koundurdjiev A
- Kovar Richard
- Koyama Kazunori
- Kraft F
- Krynski F
- Kumeda Yasuro
- Lanchiotti Pv
- Lastuvka Jiri
- Le Meur Yannick
- Leiter L
- Levin A
- Levin A
- Li Detian
- Li Wenge
- Li Xuemei
- Lin Hongli
- Lisboa Hrk
- Liu Jian
- Lozanov L
- Lu Weiping
- Lukac Martin
- Madore F
- Mah Pm
- Mahaffey Kw
- Major Lajos
- Malaver Natalia
- Malberti Fabio
- Mandreoli Marcora
- Manisha Sahay
- Mannucci Edoardo
- Mao Hong
- Marchetta N
- Margaritov V
- Maxeiner Stephan
- Mcmahon A
- Medina Farina Marcelo
- Mele P
- Milagres R
- Mileder Margit
- Miyauchi Shozo
- Mizuyama Kazuyuki
- Molnar Marta
- Montenegro R
- Moreira Diaz Juan Pablo
- Mucsi Janos
- Muirhead N
- Neal B
- Neto Bg
- Nicholls K
- Nicolai S.
- Niiya Tetsuji
- Nonchev B
- Noronha I
- Novoa Pa
- Oishi Hiroko
- Orio Si
- Oroszlan Tamas
- Orsi Emanuela
- Ory Ivan
- Ota Satoshi
- Otreras F
- Oviedo A
- Packham D
- Panarotto D
- Papini Nr
- Paragh Gyorgy
- Paschen Bjoern
- Paul Haase Franklin
- Pecoits R
- Penfornis Alfred
- Pereira Ma
- Peringat Jayameena
- Perkovic V
- Pesickova Satu
- Peterfai Eva
- Peterka Karel
- Petro Gizella
- Petry Tbz
- Piatti Piermarco
- Pichette V
- Plassmann Georg
- Pollock C
- Portes Ed
- Prasad Narayan
- Proietto J
- Pumprla Jiri
- Rabasa-Lhoret R
- Raduan Ra
- Raffaele P
- Ramirez Roca Luis Alberto
- Ramos Cs
- Rangelov R
- Ren Yan
- Resk Jh
- Revesz Katalin
- Rista L
- Roberts A
- Roger S
- Rose Ludger
- Rosenthal N
- Rosero Ricardo
- Roussel Ronan
- Rychlik Ivan
- Saavedra Gajardo Victor
- Sabbag Arn
- Sakakibara Terue
- Sala J
- Sanches Fcc
- Sanchez Arenales Jose Antonio
- Sanchez Polo Jose Vicente
- Santoro Domenico
- Santos Jc
- Saporito W
- Saraiva Jfk
- Sasso Ferdinando Carlo
- Satyanarayana Rao K.
- Saudek Frantisek
- Saulnier Pierre-Jean
- Schiavi Lb
- Schuch T
- Scotton As
- Serviddio Gaetano
- Sessa H
- Shinkov A.
- Song Weihong
- Sreedhar Reddy
- Sreelatha Melemadathil
- Steele A
- Stella Andrea
- Sudhakar Bhimavarapu
- Sun Jiao
- Sun Lin
- Sun T
- Takacs Robert
- Takai Masahiko
- Tangri N
- Temelkova M
- Terront Lozano Monica Alexandra
- Tesar Vladimir
- Thervet Eric
- Thome F
- Tomonaga Osamu
- Torshizi A
- Trevisan Roberto
- Tsang V
- Tsujimoto Mitsuru
- Tu Ping
- Turatti Laa
- Turcios Juarez Erick
- Ulla Mr
- Valderrama Cometa Luis
- Valdez M
- Valenzuela Alex
- Valis Martin
- Vallejos A
- Vangel Sandor
- Vargas Alonso Ruben Dario
- Vasas Szilard
- Vejar Margarita
- Velichkova E
- Vencio Sac
- Veronelli Anna Maria
- Villarino A
- Villegas Ivan
- Visco Ve
- Vyasam Ramesh Chandra
- Wada Takashi
- Wakasugi Masakiyo
- Wakida Yasushi
- Wang Guixia
- Wassermann A
- Watanabe Takayuki
- Weiner Pavel
- Wheeler Dc
- Woo V
- Yakov A
- Yamada Masayo
- Yamada S
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yavin Y
- Yin Aiping
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cj
- Zalunardo Nadia
- Zanella Mt
- Zanoli Luca
- Zaoui Philippe
- Zemek Stanislav
- Zhang H
- Zhao Minghui
- Zheng Hongguang
- Zinman B
- Zsom Marianna
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
- Alvarez Garcia P
- Alvarisqueta A
- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
- Angelescu Lm
- Angelova A
- Anghel V
- Antic S
- Aoki H
- Aquitania G
- Arauz-Pacheco C
- Arcos E
- Arfeen S
- Arif A
- Aronson R
- Arutchelvam V
- Arvind M
- Asano A
- Asmarats Mercadal L
- Atray N
- August P
- Avendano J
- Avram Ri
- Awad A
- Babikova J
- Badat A
- Bajaj H
- Baker J
- Bakris G
- Bakris George
- Barbarash O
- Barna O
- Barnard M
- Barnhill P
- Barranco E
- Barrera C
- Barrios C
- Bartaskova D
- Bartolacci I
- Barton P
- Barysheva O
- Beacom M
- Behara V
- Bellary S
- Belo D
- Belobradkova J
- Bentley-Lewis R
- Benusova O
- Berenguer R
- Berli Ma
- Bermudez L
- Bernardo M
- Bhushan Rs
- Bijata-Bronisz R
- Bilyk Sd
- Bin Shudim Ss
- Biscoveanu M
- Bompoint Severine
- Bonadonna R
- Bordonava A
- Borot S
- Botsyurko V
- Bowman-Stroud C
- Brandon D
- Breedt J
- Bregman R
- Brenner Barry M
- Brenner Bm
- Brusco O
- Buganova I
- Bull Scott
- Burst V
- Busch R
- Busegeanu Mm
- Calella P
- Camelo Sanches Fc
- Canaan Y
- Canani Lh
- Cannon Christopher P
- Cannon Cp
- Cantero Mc
- Capuano George
- Caringal C
- Cariou B
- Cartasegna Lr
- Castellino P
- Cercos E
- Cereto Castro F
- Ceriello A
- Chacra Ar
- Chae Dw
- Chang Ct
- Chang T
- Chapin L
- Charytan David M
- Charytan Dm
- Che Yusof Md
- Cheifetz A
- Chen E
- Chen N
- Chen Q
- Cherney D 3rd
- Chertow G
- Cheung Nw
- Chilito A
- Chiovato L
- Chizhov D
- Cho Ym
- Chouinard G
- Christensen T
- Christiano C
- Christofides E
- Chu Pei-Ling
- Chuang Lm
- Chuateco C
- Cif A
- Cigarran Guldris S
- Coffee L
- Cohen K
- Cohen R
- Cohen S
- Cohen-Stein D
- Coloma Gc
- Colombo H
- Comia Rs
- Commendatore V
- Conway J
- Cook C
- Correa Rotter Jr
- Cosma D
- Cournoyer S
- Coyne D
- Crisan C
- Cruz Jb
- Csecsei G
- Csiky B
- Cuadrado J
- Culak J
- Cuneo Ca
- Cunha Borges Jl
- Cunha V\ueancio Sa
- Cusumano Am
- D'Avila D
- da Silva Franco Rj
- Daboul N
- Danos P
- Daroza G
- Darwish R
- Daswani A
- David C
- Davies E
- Davies M
- Davies S
- Dawson A
- De Brouwer K
- de Carvalho Contieri Fl
- De Cosmo S
- De Nicola L
- De Serres S
- de Souza Portes E
- de Souza P
- de Zeeuw D
- de Zeeuw Dick
- Deak L
- Deboni Lm
- Deck K
- Deepak D
- Delos Santos L
- Demian Ld
- Derosa G
- Desouza C
- Destree M
- Dev D
- Dhillon M
- Di Carlo A
- Di Cianni G
- Diaz Escalante T
- Diaz Ruiz Jea
- Dimitrov S
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- Djordjevic M
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- Fernandez Fresnedo G
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- Feuerstein J
- Filho Ff
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- Fragale G
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- Fulcher G
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- G\uf3rriz Jl
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- Goldenberg R
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- Gomez Rangel Jd
- Gomez O
- Gonzalez Colaso Pdc
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- Gonzalez A
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- Gopalakrishnan N
- Gorelick P
- Gorson D
- Gourdy P
- Govender R
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- Gracious N
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- Hillis G
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- Kissela B
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- Kodera T
- Kohara Sk
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- Kolansky D
- Kolesnyk I
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- Komisarenko I
- Kong Wy
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- Koppolu D
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- Koundurdjiev A
- Kovar R
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- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
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- Zanzi D
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- Zemla A
- Zengel K
- Zenin O
- Zenis T
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- Zhemchugov A
- Zhong J
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- Zhu CG
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √s=8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT>120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between EmissT>150 GeV and EmissT>700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presented
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov AV
- Anjos N
- Annovi A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnold H
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- Artamonov A
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- Bai Y
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- Baker OK
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- Banerjee S
- Bannoura AAE
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- Barajas CAC
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- Yen AL
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- Yorita K
- Yoshida R
- Yoshihara K
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- Youssef S
- Yu DR
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- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
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- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
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- Zhao X
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- Zhemchugov A
- Zhong J
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- Zhu CG
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Measurement of the transverse polarization of Λ and Λ¯ hyperons produced in proton-proton collisions at √s=7 TeV using the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
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- Aguilar-Saavedra JA
- Agustoni M
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- Akerstedt H
- Akesson TPA
- Akimoto G
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- Alberghi GL
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- Aleksa M
- Aleksandrov IN
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- Alhroob M
- Alimonti G
- Alio L
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- Allison LJ
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- Zemla A
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- Zhemchugov A
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- Zobernig G
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- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/12/2014
- Field of study
The transverse polarization of Λ and Λ¯ hyperons produced in proton-proton collisions at a center-of-mass energy of 7 TeV is measured. The analysis uses 760 μb−1 of minimum bias data collected by the ATLAS detector at the LHC in the year 2010. The measured transverse polarization averaged over Feynman xF from 5×10−5 to 0.01 and transverse momentum pT from 0.8 to 15 GeV is −0.010±0.005(stat)±0.004(syst) for Λ and 0.002±0.006(stat)±0.004(syst) for Λ¯. It is also measured as a function of xF and pT, but no significant dependence on these variables is observed. Prior to this measurement, the polarization was measured at fixed-target experiments with center-of-mass energies up to about 40 GeV. The ATLAS results are compatible with the extrapolation of a fit from previous measurements to the xF range covered by this measurement
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