61 research outputs found
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+T cell dysregulation and accumulation
- Author
- Al-Eryani Ghamdan
- Apps Gabrielle
- Avery Danielle T.
- Brink Robert
- Brothers Shannon
- Chua Ignatius
- Cooper Megan A.
- Goodnow Christopher C.
- Heiskanen Kaarina
- Jackson Katherine J. L.
- Jara Christopher J.
- Kainulainen Leena
- Kingham Jennifer
- Leiding Jennifer W.
- Ma Cindy S.
- Masle-Farquhar Etienne
- Mustjoki Satu
- O'Sullivan Michael
- Payne Kathryn J.
- Peters Timothy J.
- Preece Kahn
- Rao Geetha
- Reed Joanne H.
- SeppÀnen Mikko R. J.
- Singh Mandeep
- Skvortsova Ksenia
- Suan Daniel
- Swarbrick Alexander
- Tangye Stuart G.
- Uzel Gulbu
- Vogel Tiphanie P.
- Publication venue
- Publication date
- 13/12/2022
- Field of study
The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co -exist-ing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8+ T cell clonal expansions and autoimmunity, we analyzed patients and mice with germline STAT3 GOF mutations. STAT3 GOF mutations drove the accumulation of effector CD8+ T cell clones highly expressing NKG2D, the receptor for stress-induced MHC-class-I-related molecules. This subset also expressed genes for granzymes, perforin, interferon-y, and Ccl5/Rantes and required NKG2D and the IL-15/IL-2 receptor IL2RB for maximal accumula-tion. Leukocyte-restricted STAT3 GOF was sufficient and CD8+ T cells were essential for lethal pathology in mice. These results demonstrate that STAT3 GOF mutations cause effector CD8+ T cell oligoclonal accumu-lation and that these rogue cells contribute to autoimmune pathology, supporting the hypothesis that somatic mutations in leukemia/lymphoma driver genes contribute to autoimmune disease.Peer reviewe
Hundreds of variants clustered in genomic loci and biological pathways affect human height
- Author
- A Johansson
- A Superti-Furga
- Aila Rissanen
- Aki S. Havulinna
- Alan F. Wright
- Alan R. Sanders
- Alan R. Shuldiner
- Albert Hofman
- Albert Vernon Smith
- Alessandro De Grandi
- Alex N. Parker
- Alice M. Arnold
- Alistair S. Hall
- Ana Marusic
- Anders Hamsten
- Andrea Maschio
- Andreas Ziegler
- Andres Metspalu
- Andrew A. Hicks
- Andrew C. Heath
- Andrew P. Morris
- Andrew R. Wood
- Andrew T. Hattersley
- André G. Uitterlinden
- Anke Tönjes
- Anna Dominiczak
- Anna L. Dixon
- Anna-Liisa Hartikainen
- Anne U. Jackson
- Anneli Pouta
- Anthony J. Balmforth
- Antonella Mulas
- Antti Jula
- Arthur W. Musk
- Astrid Petersmann
- AV SegrĂš
- Ayellet V. SegrĂš
- B Devlin
- Barbara McKnight
- Ben Oostra
- Benjamin F. Voight
- Brenda W. Penninx
- Cameron Palmer
- Carlo Rivolta
- Carlos Iribarren
- Caroline Hayward
- Caroline S. Fox
- Carsten Oliver Schmidt
- CD Campbell
- Cecilia M. Lindgren
- Charles C. White
- Christian Gieger
- Christian Hengstenberg
- Christopher J. OâDonnell
- Claes Ohlsson
- Constance Chen
- Cornelia M. van Duijn
- Cristen J. Willer
- Dale R. Nyholt
- Daniel Gudbjartsson
- Daniel I. Chasman
- Daniele Cusi
- David J. Hunter
- David P. Strachan
- David S. Siscovick
- David Schlessinger
- Dawn Waterworth
- DB Goldstein
- Devin Absher
- DF Gudbjartsson
- Dominique J. Verlaan
- Dorret I. Boomsma
- Douglas F. Levinson
- Eco J. C. Geus
- Eero Kajantie
- Eleanor Wheeler
- Elin Grundberg
- Elisabeth Widen
- Elizabeth K. Speliotes
- Elizabeth L. Altmaier
- EM Kofoed
- ER Neptune
- Eric Boerwinkle
- Eric E. Schadt
- Erik Ingelsson
- Erika Salvi
- Eva Albrecht
- F Galton
- Fernando Rivadeneira
- Florian Ernst
- Francis S. Collins
- Frank B. Hu
- Fredrik Wiklund
- G Lettre
- G. Bragi Walters
- G. Mark Lathrop
- Gabrielle Boucher
- Gert-Jan van Ommen
- Gonneke Willemsen
- Gonçalo R. Abecasis
- Grant W. Montgomery
- Gudmar Thorleifsson
- Gudny Eiriksdottir
- Guillaume Lettre
- Guillaume Paré
- H.-Erich Wichmann
- Hana Lango Allen
- Harry Campbell
- Heather M. Stringham
- Heikki V. Huikuri
- Helene Alavere
- Henrik Grönberg
- Henry Völzke
- Heribert Schunkert
- Hugh Watkins
- Ida Surakka
- Igor Rudan
- Inga Prokopenko
- Ingrid B. Borecki
- Inke R. König
- InĂȘs Barroso
- Irene Pichler
- Iris M. Heid
- Ivana Kolcic
- J Yang
- Jaakko Kaprio
- Jaakko Tuomilehto
- Jaana Laitinen
- Jacques S. Beckmann
- James F. Wilson
- Jan H. Smit
- Jeanette Erdmann
- Jeffrey R. OâConnell
- Jennie Hui
- Jennifer G. Sambrook
- Jerome I. Rotter
- JH Park
- Jian Yang
- Jianfeng Xu
- Jianjun Liu
- Jianxin Shi
- Jianâan Luan
- Jing Hua Zhao
- Joel N. Hirschhorn
- Johan G. Eriksson
- Johannes Kettunen
- John D. Rioux
- John F. Peden
- John P. Beilby
- John R. B. Perry
- John R. Thompson
- Jonathan P. Tyrer
- Jorma Viikari
- Joshua C. Randall
- Joshua W. Knowles
- Jouke-Jan Hottenga
- Joyce B. J. van Meurs
- Ju-Hyun Park
- Jubao Duan
- Juha Sinisalo
- Julius Suh Ngwa
- K Estrada
- KA Frazer
- Karen L. Mohlke
- Kari E. North
- Kari Stefansson
- Karol Estrada
- Katja K. Aben
- Ke Hao
- Ken Sin Lo
- Keri L. Monda
- Kevin B. Jacobs
- Kirsi H. PietilÀinen
- Kristin G. Ardlie
- L. Adrienne Cupples
- LA Hindorff
- Lachlan Coin
- Lambertus Kiemeney
- Larry D. Atwood
- Laura Zagato
- Lee M. Kaplan
- Leena Peltonen
- Leif C. Groop
- Lenore J. Launer
- Liesbeth Vandenput
- Liming Liang
- Lina Zgaga
- Lorena Citterio
- Lu Qi
- Lyle J. Palmer
- M Weinstein
- M. Carola Zillikens
- M. Juhani Junttila
- Manfred Kayser
- Manuela Uda
- Mari Nelis
- Mari-Liis Tammesoo
- Marja-Liisa Lokki
- Marjo-Riitta Jarvelin
- Marjolein J. Peters
- Mark I. McCarthy
- Mark J. Caulfield
- Markku Koiranen
- Markku S. Nieminen
- Markus Perola
- Martin den Heijer
- Martin Farrall
- Martin RidderstrÄle
- Martina MĂŒller
- Mary F. Feitosa
- Massimo Mangino
- Matthew N. Cooper
- Mattias Lorentzon
- Michael A. Province
- Michael Boehnke
- Michael C. Turchin
- Michael E. Goddard
- Michael N. Weedon
- Michael Preuss
- Michael Stumvoll
- Mika KÀhönen
- MN Weedon
- MN Weedon
- N Soranzo
- Najaf Amin
- Nancy L. Heard-Costa
- Neil R. Robertson
- Nelson B. Freimer
- Nicholas G. Martin
- Nicholas J. Wareham
- Nicola Glorioso
- Nicole L. Glazer
- Nicole Soranzo
- Nigel W. Rayner
- Niina Pellikka
- Nilanjan Chatterjee
- Nilesh J. Samani
- Olle Melander
- Olli Raitakari
- Ozren Polasek
- Paavo Zitting
- Pablo V. Gejman
- Panos Deloukas
- Patricia B. Munroe
- Paul Elliott
- Paul M. Ridker
- Per Hall
- Peter Almgren
- Peter Kovacs
- Peter Kraft
- Peter M. Visscher
- Peter P. Pramstaller
- PM Visscher
- Quince Gibson
- RA Fisher
- Rany M. Salem
- Reedik MĂ€gi
- Richard B. Hayes
- Richard N. Bergman
- Robert C. Kaplan
- Robert J. Weyant
- Robert W. Lawrence
- Roberto Elosua
- Ruth J. F. Loos
- S Raychaudhuri
- S Sanna
- Sailaja Vedantam
- Samuli Ripatti
- Sarah H. Wild
- Sekar Kathiresan
- Seppo Koskinen
- Serena Sanna
- Shamika Ketkar
- Shaun Purcell
- Shen Haiqing
- SM Purcell
- Sonja I. Berndt
- Soumya Raychaudhuri
- SP Dickson
- Stefan Schreiber
- Stephen J. Chanock
- Suzanne Rafelt
- Sven Bergmann
- TA Manolio
- Talin Haritunians
- Tamara B. Harris
- Teresa Ferreira
- Terho LehtimÀki
- Themistocles L. Assimes
- Thomas Illig
- Thomas Kocher
- Thomas Meitinger
- Thomas Quertermous
- Thomas W. Winkler
- Thor Aspelund
- Timothy D. Spector
- Timothy M. Frayling
- Toby Johnson
- Tom H. Mosley Jr
- Tomi Pastinen
- Tony Kwan
- Tsegaselassie Workalemahu
- Tuomas O. KilpelÀinen
- Tushar Bhangale
- TÔnu Esko
- Ulf Gyllensten
- Ulla Sovio
- Unnur Thorsteinsdottir
- Valgerdur Steinthorsdottir
- Veikko Salomaa
- Veronique Vitart
- Vilmundur Gudnason
- Vincent Mooser
- Wendy L. McArdle
- Willem H. Ouwehand
- Wilmar Igl
- Wolfgang Hoffman
- Yurii S. Aulchenko
- ZoltĂĄn Kutalik
- Ă sa Johansson
- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 01/01/2010
- Field of study
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (Pâ<â0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
- Author
- (AAGC) Australian Asthma Genetics Consortium
- Altmaier Elisabeth
- Alves Alexessander Couto
- Arnold Andreas
- Bacelis Jonas
- Barton Sheila J
- Bataille Veronique
- Bauerfeind Anja
- Baurecht Hansjörg
- Bisgaard Hans
- Boomsma Dorret I
- Brown Sara J
- Bunyavanich Supinda
- Burchard Esteban G
- Bustamante Mariona
- BĂžnnelykke Klaus
- Campbell Linda E
- Carstensen Lisbeth
- Cichon Sven
- Consortium Lifecourse Epidemiology (EAGLE) Eczema
- Curjuric Ivan
- Curtin John A
- Custovic Adnan
- de Jongste Johan C
- den Dekker Herman T
- Duijts Liesbeth
- Elbert Niels J
- Eng Celeste
- Esparza-Gordillo Jorge
- Evans David M
- Fahy Caoimhe M R
- Feenstra Bjarke
- Ferreira Manuel A
- Franke Andre
- Fölster-Holst Regina
- Geller Frank
- Genetics EArly
- Gieger Christian
- Glass Daniel
- Godfrey Keith M
- Gonzalez Juan R
- Grarup Niels
- Groen-Blokhuis Maria M
- Hakonarson Hakon
- Heinrich Joachim
- Henderson A John
- Hinds David A
- Hirota Tomomitsu
- Hofman Albert
- Holloway John W
- Homuth Georg
- Horikoshi Momoko
- Hottenga Jouke Jan
- Hotze Melanie
- Hu Donglei
- Huntsman Scott
- Husemoen Lise L
- Hysi Pirro
- HĂŒbner Norbert
- Imboden Medea
- Irvine Alan D
- Jacobsson Bo
- Jaddoe Vincent W V
- Jarvelin Marjo-Riitta
- Jarvis Deborah
- Kalb Birgit
- Keil Thomas
- Kemp John P
- Koppelman Gerard H
- Kreiner-MĂžller Eskil
- Kubo Michiaki
- Kumar Ashish
- Kurek Michael
- Lau Susanne
- Lee Young-Ae
- Lee-Kirsch Min Ae
- Levin Albert M
- Li Jin
- Lieb Wolfgang
- Linneberg Allan
- Lockett Gabrielle A
- Macek Milan
- Mangold Elisabeth
- Marenholz Ingo
- Marks Guy B
- Martin Nicholas G
- Matanovic Anja
- Matheson Melanie C
- McAleer Maeve A
- McArdle Wendy L
- McLean W H Irwin
- Melbye Mads
- Melén Erik
- Meyers Deborah A
- Middeldorp Christel M
- Myers Rachel A
- Myhre Ronny
- Novak Natalija
- Nystad Wenche
- Nöthen Markus M
- O'Regan Grainne M
- Ober Carole
- Pahukasahasram Badri
- Pasmans Suzanne G M A
- Paternoster Lavinia
- Pekkanen Juha
- Pennell Craig E
- Peters Annette
- Pino-Yanes Maria
- Postma Dirkje S
- Probst-Hensch Nicole M
- Raby Benjamin A
- Relton Caroline L
- Ried Janina S
- Rivadeneira Fernando
- Robertson Colin F
- RodrĂguez Elke
- RĂŒschendorf Franz
- Schmidt Carsten O
- Sebert Sylvain
- Simpson Angela
- Sleiman Patrick M A
- Smith George Davey
- Spector Tim
- Standl Marie
- Strachan David P
- Sun Liang Dan
- Sunyer Jordi
- SöderhÀll Cilla
- Takahashi Atsushi
- Tamari Mayumi
- Thiering Elisabeth
- Thompson Philip J
- Thyssen Jacob P
- Tian Chao
- Tiesler Carla M T
- Tung Joyce Y
- Uitterlinden André G
- Venturini Cristina
- Vilor-Tejedor NatĂ lia
- Waage Johannes
- Wang Carol A
- Weidinger Stephan
- Weiss Scott T
- Williams L Keoki
- Xiao Feng Li
- Xu Cheng-Jian
- Yang James J
- Yin Xian Yong
- Zhang Xue Jun
- Zheng Jie
- Zheng Xiao Dong
- Zuo Xian Bo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis
Neuromatch Academy: a 3-week, online summer school in computational neuroscience
- Author
- \u27t Hart Bernard Marius
- Achakulvisut Titipat
- Adeyemi Ayoade
- Akrami Athena
- Alicea Bradly
- Alonso-Andres Alicia
- Alzate-Correa Diego
- Ash Arash
- Ballesteros Jesus J.
- Balwani Aishwarya
- Batty Eleanor
- Beierholm Ulrik
- Benjamin Ari S.
- Bhalla Upinder
- Blohm Gunnar
- Blohm Joachim C. H.
- Bonnen Kathryn
- Brigham Marco
- Brunton Bingni W.
- Butler John
- Caie Brandon
- Castillo Itzel Olivos
- Chatterjee Sharbatanu
- Chavlis Spyridon
- Chen Ruidong
- Cheng You
- Chow H. M.
- Chua Raymond
- Dai Yunwei
- David Isaac
- Denis Julien
- DeWitt Eric E. J.
- Dipani Alish
- Dorschel Arianna
- Drugowitsch Jan
- Dwivedi Kshitij
- Escola Sean
- Fan Haoxue
- Farhoodi Roozbeh
- Fei Yicheng
- Fiquet Pierre-Ătienne
- Fontolan Lorenzo
- Forest Jeremy
- Fujishima Yuki
- Gajic N Alex Cayco
- Galbraith Byron V.
- Galdamez Mario
- Gao Richard
- Gjorgjieva Julijana
- Gonzalez Alexander
- Gu Qinglong
- Guo Yueqi
- Guo Ziyi
- Gupta Pankaj K.
- Gurbuz Busra Tugce
- Haimerl Caroline
- Harrod Jordan B.
- Hyafil Alexandre
- Irani Martin
- Jacobson Daniel
- Johnson Michelle
- Jones Ilenna Simone
- Karni Gili
- Kass Robert E.
- Kim Hyosub Edward
- Kist Andreas M.
- Koene Randal
- Kording Konrad
- Krause Matthew R.
- Kumar Arvind
- KĂŒhn Norma K.
- Laporte Matthew L.
- LC Ray
- Lee Junseok
- Li Songting
- Lin Sikun
- Lin Yang
- Liu Shuze
- Liu Tony
- Livezey Jesse A.
- Lu Linlin
- Macke Jakob H.
- Mahaffy Kelly
- Martins A. Lucas
- Martorell NicolĂĄs
- MartĂnez Manolo
- Mattar Marcelo G.
- Menendez Jorge Aurelio
- Miller Kenneth D.
- Mineault Patrick J.
- Mohammadi Nosratullah
- Mohsenzadeh Yalda
- Morgenroth Elenor
- Morshedzadeh Taha
- Mosberger Alice Claudia
- Muliya Madhuvanthi
- Mur Marieke
- Murray John D.
- Naud Richard
- Nayak Prakriti
- ND Yashas
- Oak Anushka
- Orouji Seyedmehdi
- Otero-Millan Jorge
- Pachitariu Marius
- Pandey Biraj
- Paredes Renato
- Parent Jesse
- Park Il Memming
- Peters Megan A. K.
- Pitkow Xaq
- Poirazi Panayiota
- Popal Haroon
- Prabhakaran Sandhya
- Qiu Tian
- Ragunathan Srinidhi
- Rodriguez-Cruces Raul
- Rolnick David
- Sahoo Ashish Kumar
- Salehinajafabadi Saeed
- Savin Cristina
- Saxena Shreya
- Schrater Paul
- Schroeder Karen
- Schwarze Alice C.
- Sedigh-Sarvestani Madineh
- Sekhar K. Yuvaraj
- Shadmehr Reza
- Shanechi Maryam M.
- Sharma Siddhant
- Shea-Brown Eric
- Shenoy Krishna V.
- Shimabukuro Carolina L.
- Shuvaev Sergey
- Sin Man Ching Alison
- Smith Maurice
- Steinmetz Nicholas A.
- Stosio Karolina
- Straley Elizabeth
- Strandquist Gabrielle
- Stringer Carsen
- Tomar Rimjhim
- Tran Ngoc
- Triantafillou Sofia
- Udeigwe Lawrence
- Uquillas Federico dâOleire
- Valeriani Davide
- Valton Vincent
- van Viegen Tara
- Vaziri-Pashkam Maryam
- Vincent Peter
- Vishne Gal
- Wallisch Pascal
- Wang Peiyuan
- Ward Claire
- Waskom Michael
- Wei Kunlin
- Wu Anqi
- Wu Zhengwei
- Wyble Brad
- Zhang Lei
- Zysman Daniel
- Publication venue
- Technological University Dublin
- Publication date
- 01/01/2022
- Field of study
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- AasarĂžd Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso InĂȘs
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- BlĂŒher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
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- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
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- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
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- Tönjes Anke
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- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
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- van Gilst Wiek H
- van Heemst Diana
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- van Wingerden Sophie
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- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
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- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
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- Völker Uwe
- Völzke Henry
- Wadén Johan
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- Waeber GĂ©rard
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- Waggott Daryl
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- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
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- Wheeler Heather E
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- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
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- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- WĂŒrtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo LoĂŻc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia MarĂa T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ărnlöv Johan
- Ăsterholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (PÂ <Â 5Â ĂÂ 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
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- Aubin Keith
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- Coggill Penelope
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- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
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- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
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- Hepa Victor
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- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
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- Holroyd Simon
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- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
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- Howard Philip
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- Howden Philip
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- Huang Wei
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- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Jackson Terri
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- Jaklevic Michael
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- Jones Steven
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- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
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- Lander Eric S.
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
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- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lucier Raymond L.
- Ludeman Thom
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
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- Mareth David
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- Marquis-Homeyer Catherine
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- Marra Marco
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- McLeod Michael P.
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- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
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- Mehta Nalini
- Meidi Patrick
- Meier Elke
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- Menuge Noel
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- Mercado Iracema C.
- Mercer Simon
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- Mesirov Jill P.
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- Mu Feng
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- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
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- Murayama Yuji
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- Murphy Michael
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- Nagamine Kentaro
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- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
- Negus David
- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
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- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
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- Obayashi Izumi
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
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- Oviedo Rodolfo J.
- Ow David
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- Parkin Kim
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- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
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- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
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- Pearce Alexandra
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- Pelletier Eric
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- Peng Yi
- Peng Ze
- Peng Ze
- Pennacchio Len A.
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- Percy Chantel
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- Perez Lesette M.
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- Pourrajabi Nima M.
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- Ricke Darryl O.
- Ridler Kerry
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- Rise Cecil
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- Robinson Melanie
- Rochford Rebecca
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- Rong Li
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- Sasaki Takashi
- Satpathy Suraj
- Saunders David
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- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
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- Sivadasan Shanthi
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- Skuce Carl
- Skuce Carl
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- Sonnhammer Erik
- Sonnhammer Erik
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- Sutherland Robert D.
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- Tin-Wollam Aye M.
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- Un Chun
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- Williamson Helen
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- Wong Gane K-S
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- Woodeson Sharon
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- Worley Kim Carlyle
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- Wright Debbie
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- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
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- Wu Jung-Rung
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- Wu Qingfa
- Wu Qingfa
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- Wu Xiaojing
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- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
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- Xi Yan
- Xi Yingying
- Xie Fei
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- Xiong Hui
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- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
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- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
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- You Bo
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- Young Shelia
- Younger Ruth
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- Yu Fuli
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- Yu Jun
- Yu Jun
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- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Global disparities in surgeonsâ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study
- Author
- Abdelkhalek Mohamed
- AbellaÌn Antonio Melero
- AbelloÌ David
- Abu-Arish Hamdoon
- Acevedo Ana Karen Radilla
- Adamina Michel
- Adamovich Dmitry Mikhailovich
- Addeo Pietro
- Adewunmi Olayinka Lukman
- Aeschbacher Pauline
- Afolabi Akinwale Ibrahim
- Agastra Ervis
- Agresta Ferdinando
- Aguilar Juan Carlos Cardozo
- Ahmed Bensaad
- Ahmed Nauman
- Aimal Aimal Khan
- Aiolfi Alberto
- Akay Omer
- al-Najami Issam
- Al-Shehari Mohammed
- Alconchel Felipe
- Alesina Pier Francesco
- Alhazmi Ahmad
- Ali Mahmoud Ibrahim
- Aliyev Vusal
- Alonso Patricia
- Aloun Ali
- Altinel Yuksel
- Altomare Michele
- Alvarez-Gallego Mario
- Ammendola Michele
- Ammerata Giorgio
- Anania Marco
- Anas Abdelhmed
- Andreuccetti Jacopo
- Andriola Valeria
- Andriola Valeria
- Anelli Ferdinando M.
- Anestiadou Elissavet
- Angrisani Marco
- Antonacci Nicola
- Antonacci Nicola
- Antonelli Amedeo
- Antropoli Carmine
- Aparicio Antonio Carlos Maya
- Apostolou Konstantinos
- Arcudi Claudio
- Aregawi Alazar Berhe
- Argenio Giulio
- Ascari Francesca
- Asfaw Fitsum Terefe
- Athar Rahmatullah
- Atici Semra Demirli
- Au Stephanie
- Augustin Goran
- Avella Pasquale
- Avellaneda Nicolas
- Awad Ahmed K.
- Awad Selmy S.
- Awad Selmy S.
- Ayalew Alem Mekete
- Aytac Erman
- Aytac Erman
- Azevedo JoseÌ
- Baba Arshad Ahmed
- Bacchiocchi Giulia
- Bagaglini Giulia
- Bagaria Dinesh
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bala Miklosh
- Balaphas Alexandre
- Balassone Valerio
- Baldi Caterina
- Baldini Edoardo
- Balla Andrea
- Ballester Cristina
- Bandaru Kalyan Vijay Kumar
- Bandyopadhyay Samik K.
- Bannone Elisa
- Barba Leonardo A.
- Barberis Andrea
- Barone Mirko
- Barranquero Alberto G.
- Barugola Giuliano
- Barzola Ernesto J.
- Batıkan OgÌuzkagÌan
- Bavikatte Akshay Prasannakumar
- Bayileyegn Nebiyou Simegnew
- Bedros Nicole Mary
- Beisani Marc
- Bejiga Gosa Hundie
- Bekana Bekana L.
- Belay Tatek
- Belia Francesco
- Belkacem Acidi
- Bellanova Giovanni
- Bellato Vittoria
- Bellido-luque Juan
- Bellini Maria Irene
- Bellver Pedro PalazoÌn
- Benzoni Enrico
- Benzoni Ilaria
- Bergna Alessandro
- Bhat Pawan Singh
- Bhattacharya Kaushik
- Bhattacharya Neela
- Bhatti Hamza Waqar
- Bianchi Valentina
- Bianco Giuseppe
- Biloslavo Alan
- Biniam Ewnte
- Blanco-Antona Francisco
- Bocchino Antonio
- Bointas Georgios
- Bollino Ruggero
- Bonavina Luigi
- Bondurri Andrea
- Bonilla Fernando
- Bonito Alba Correa
- Bono Dario
- Borges Nuno
- Botelho Pedro
- Bottari Andrea
- Bottcher Sofia Maria Jaume
- Bourguiba Mohamed Aboulkacem
- Bourmpouteli Eirini
- Bouzid Chafik
- Braccio Bartolomeo
- Brady Richard R. W.
- Braholli Eriol
- Brasset Camille
- Brillantino Antonio
- Brillantino Antonio
- Briones Cristhian Gonzalo Aspiazu
- Brisinda Giuseppe
- Brito Ismael
- Brookes Charlotte Elisabeth
- Brucchi Francesco
- Bulte Joris P.
- Buonomo Oreste Claudio
- Butler Rebecca Jayne
- Cacciaguerra Andrea Benedetti
- Caldeira Beatriz
- Calini Giacomo
- Calu Valentin
- Calussi Marco
- Calussi Marco
- Cammarat Roberto
- Cammarata Roberto
- Campagnaro Tommaso
- Campanelli Michela
- Campisi Andrea
- Campus Federica
- Candilio Giuseppe
- Cannavo Maurizio
- Cannistra Marco
- Cannistra Marco
- Cano-Valderrama Oscar
- Canonico Giuseppe
- Cantarino Frederico
- Capitano Sante
- Capolupo Gabriella Teresa
- Cappuccio Micaela
- Capuano Marianna
- Capuano Marianna
- Caputo Damiano
- Carannante Filippo
- Carbone Ludovico
- Cardinali Luca
- Carneros Virginia JimeÌnez
- Carrabetta Salvatore
- Caruso Riccardo
- Carvas JoaÌo M.
- Carvas JoaÌo M. B.
- Casagranda Biagio
- Casas Maria Agustina
- Cascales-Sanchez Pedro
- Cassese Gianluca
- Castaldi Antonio
- Castaldi Antonio
- Castellano Javier Rivera
- Castro Ernest
- Castro Maria J.
- CC Tommaso
- Celentano Valerio
- Celotti Andrea
- CerdaÌn-Santacruz Carlos
- Cereda Marco Angelo
- Ceresoli Marco
- Cero Mariagiulia Dal
- Cestaro Giovanni
- Cestino Luca
- Chai Feng Yih
- Chalkoo Mushtaq A.
- Charalabopoulos Alexandros
- Charalabopoulos Alexandros
- Charitaki Evgenia
- Chessa Antonella
- Chessa Antonella
- Chevallay Mickael
- Chia Chi Fung
- Chillarge Gauri
- Chimenti Federica
- Chitul Andrei
- Chiu Jennifer H. F.
- Chooklin Serge
- Choudhry Asad
- Chouliaras Christos
- Chowdhury Ashim
- Christodoulou Prokopis
- Chrysikos Michael
- Chukwu Isaac Sunday
- Cianci Pasquale
- Ciarleglio Francesco A.
- Cicerchia Pierfranco Maria
- Ciesielski Wojciech J.
- Cigognini Maria
- Cillara Nicola
- Cioffi Stefano Piero Bernardo
- Ciro Mauricio Pedraza
- Clementi Marco
- Clocchiatti Lucrezia
- Colak Elif
- ColaÌs-Ruiz Enrique
- Coletta Diego
- Colombari Renan C.
- Colombo Francesco
- Colucci Gianluca
- Conte Luigi E.
- Conti Luigi
- Coppola Alessandro
- Corallino Diletta
- Corronca Federico
- Corrons Laia Codina
- Corvasce Arianna
- Costantini Giulia
- Costanzo Antonio
- Costea Radu V.
- Cotsoglou Christian
- Cozza Valerio
- Creavin Ben
- Cremona Simone
- CricriÌ Michele
- Crosbie Gonzalo Gabriel
- Cuccomarino Salvatore
- Cuk Vladica
- Cunha Miguel
- Curcio Silvia
- Curro Giuseppe
- Dajti Irida
- Daniel Clerc
- Dardanov Dragomir
- Davey Matthew G.
- Davies Justin
- Davis Daniel G.
- De AndreÌs-Asenjo Beatriz
- De Campos Tercio
- De Carlis Riccardo
- de las Casas Sara GortaÌzar
- De Luca Alessandro
- De Luca Raffaele
- De Lucia Chiara
- De Nobili Giovanni
- de Oliveira Gabriel Paiva
- De Padua Cristina
- De Rosa Michele
- de Sa Tiago Correia
- de Santos Iglesias Francisco Juan
- De Simone Belinda
- de Vries Hilbert S.
- Debela Bizuneh Sime
- Debena Dawit Gebregiorgis
- Deerenberg Eva B.
- Del Monte Simone Rossi
- del Olmo Juan Carlos MartiÌn
- Delaune Vaihere
- Delgado Ander Timoteo
- Delis Spiros
- Delogu Daniele
- Delvecchio Antonella
- Demir Anıl
- Devriendt Stefanie
- Di Bella Annamaria
- Di Carlo Isidoro
- Di Filippo Giacomo
- Di Franco Gregorio
- Di Lascio Pierpaolo
- Di Marco Federica
- Di Marco Federica
- Di Marco Federica
- Di Martino Marcello
- Di Martino Marcello
- Di Meo Giovanna
- di Mola Fabio F.
- Di Santo Albini Andrea G.
- Di Saverio Salomone
- Di Saverio Salomone
- Di Venere Beatrice
- Diaz-Elizondo Jose Antonio
- Diaz-Elizondo Jose Antonio
- Digne-Malcolm Holly Jane
- Dimitrov Evgeni
- Dinagde Tesfaye Aga
- DiÌaz Carlos JGoÌmez
- Don Cristine Brooke Pathirannehalage
- Dorovinis Panagiotis
- Douka Eleftheria
- Drogouti Maria
- Dudi-Venkata Nagendra N.
- Dulskas Audrius
- Dulskas Audrius
- Dziakova Jana
- DâAcapito Fabrizio
- DâAmbrosio Marco
- DâAmbrosio Marco
- DâUgo Stefano
- Efetov Sergey
- Efetov Sergey
- Elfeki Hossam
- Elghadban Hosam Mohamed
- Emile Sameh
- Ercolani Giorgio
- ErdogÌan Emre
- Ermias Nebiyou
- Escalante Karol S.
- Espino Eduardo Morales
- Esposito Francesco
- Esposito Giuseppe
- Estaire-GoÌmez Mercedes
- Fabbri NicoloÌ
- Fabbrizio Tiziana
- Farazi-Chongouki Christos
- Faro Carmelo Lo
- Faro Carmelo Lo
- Farolfi Tommaso
- Farooqui Marryam Riaz
- Farrarons Sara SentiÌ
- FarreÌ Silvia PeÌrez
- Farrukh Maira
- Fazio Federico
- Feituri Nura
- Feleke Tsega Terefe
- Felsenreich Daniel M.
- Fernandez Carmen Cagigas
- FernaÌndez FernaÌndez June
- Fernicola Agostino
- Ferrara Francesco
- Ferrari Davide
- Ferrario Luca
- Ferreira Rodrigo Vaz
- Ferretti Carlotta
- Ferronetti Antonio
- Festa Federico
- Fichera Alessandro
- Fiore Felicia
- Fleming Andrew Martin
- Fleres Francesco
- Florio Gaetano
- Folliero Cristina
- Fonseca Vinicius Cordeiro
- ForcignanoÌ Edoardo
- Foreman Michaael L.
- Formisano Giampaolo
- Fortuna Laura
- Franchi Eloisa
- Francis Fayez Maged
- Francone Elisa
- Francone Elisa
- Fransvea Pietro
- Frazzetta Giuseppe
- Freixa Celia Caula
- Frontali Alice
- Frountzas Maximos
- Funk Geoffrey A.
- Fuschillo Giacomo
- Gachabayov Mahir
- Galeev Shamil I.
- Galiffa Giampaolo
- Gall Malina ECaraiman
- Gallardo Cristian
- Gallo Gaetano
- Garoufalia Zoe
- Garzali Ibrahim Umar
- Gauci Chahaya M.
- Gazia Carlo
- Gerogiannis Ioannis
- Gervasi Maria Clelia
- Gessa Emanuela
- Ghannam Wagih
- Gherardi Dario
- Ghignone Federico
- Gialamas Eleftherios
- Giambusso Mauro
- Gica Nicolae
- Giordano Alessio
- Giordano Marco
- Giovine Gennaro
- Giuffrida Maria Carmela
- Giuffrida Mario
- Giuliani Antonio
- Giuliani Giuseppe
- Glasbey James
- Gomes Carlos Augusto
- Gonfa Kebebe Bekele
- Gonsaga Ricardo Alessandro Teixeira
- Gonzalez Ana
- GonzaÌlez Lluis GarciÌa
- GonzaÌlez Tomas Elosua
- Gourgiotis Stavros
- GoÌmez Marta JimeÌnez
- GoÌmez Marta JimeÌnez
- GoÌktepe Berk
- Grama Florin A.
- Granata Roberta
- Gravante Gianpiero
- Greco Antonio
- Grimaldi Luciano
- Grossi Ugo
- Guerci Claudio
- Guerrero MariÌa Alejandra
- Guevara Jenny
- Guitart Marc PeÌrez
- Gulcu Baris
- Guler Mert
- Gulmez Mehmet
- Gunay Emre
- Gupta Amit
- Gupta Ashish
- Gussago Stefano
- GuÌlcuÌ Barış
- GuÌngoÌr Mert
- Hailemariam Dagnachew H.
- Halder Subhadip
- Hale Lyman Lansing
- Harvitkar Rafique Umer
- Hassen Khalid Arebo
- Hernandez-Garcia Miguel
- HernaÌndez Edgard EfreÌn Lozada
- Horesh Nir
- Iacobone Maurizio
- Iannone Immacolata
- IbaÌnÌez Noelia
- Ibrahim Aini Fahriza
- Idiz Ufuk Oguz
- Ielpo Benedetto
- Ielpo Benedetto
- Imana Ruhama Yoseph
- Inama Marco
- Ingallinella Sara
- Ingallinella Sara
- Ioannidis Argyrios
- Ioannidis Orestis
- Iodice Alessandra
- Ioia Giovanna
- Iordache-Petrescu Madalina Ionela
- Iossa Angelo
- Iqbal Muhammad Rafaih
- Iranzo Marina AlarcoÌn
- Isik Arda
- Izzo Giuliano
- Jamiri Al-Radjid
- Jansson Hannes
- Johnson Benjamin E.
- JordaÌo Daniel Filipe Martins
- Juloski Jovan
- Junior Marcelo A. F. Ribeiro
- Kampouroglou Georgios
- Kapsampelis Panagiotis
- Kara Yasin
- Karamarkovic Aleksandar
- Karamarkovic Aleksandar
- Karamarkovic Aleksandar
- Kaur Mandeep
- Kchaou Ali
- Kebede Kirubel Abebe
- Keci Laura
- Keller Deborah S.
- Kelly Michael E.
- Khan Huma Ahmed
- Khan Jan Sher
- Khan Mansoor
- Khobragade Krunal H.
- Kiros Samuel
- Klib Mohamad
- Klimczak Tomasz Jerzy
- Knickerbocker Chase Barrett
- Kobe Yoshiro
- KoeÌter Tijmen
- Koh Peng Soon
- Komaei Iman
- Koneti Akshadhar J.
- Konstantoudakis Georgios
- Koppel Darren
- Korkoman Mohammed J.
- Kosir Jurij A.
- Kovacevic Bojan
- Krsicka Petr
- Kucuk Gultekin Ozan
- Kucukarslan Rabia
- Kykalos Stylianos
- La Vaccara Vincenzo
- Labat Miriam Cazador
- Lafranceschina Stefano
- Lancellotti Francesco
- Landaluce-Olavarria Aitor
- Lapolla Pierfrancesco
- Laracca Giovanni Guglielmo
- Lasarte Mateusz PJeÌšckowski Aingeru Sarriuga
- Lasithiotakis Konstantinos
- Lauricella Sara
- Lee Lee Yeong Sing
- Lenz Jorge Godoy
- Leo Cosimo Alex
- Lesko Dusan
- Leventoglu Sezai
- Levi Sandri Giovanni Battista
- Lianos Georgios D.
- Licardie Eugenio
- Lichliter Warren E.
- Linares Neiling Massiel Oviedo
- Lisi Giorgio
- Lisi Giorgio
- Litta Francesco
- Litvin Andrey
- Locci Eleonora
- Lolis Evangelos
- Lopez Maria Martinez
- Lorente-Poch Leyre
- Lorenzo Irving
- Lostoridis Eftychios
- Low Juin
- LoÌpez MariÌa MartiÌnez
- LoÌpez-LoÌpez Victor
- LoÌpez-Soler Guillermo
- Luberto Antonio
- Luglio Gaetano
- Lukmonov Saidrakhim
- Luque Eduardo J.
- Luzzi Andrea Pierre
- Machairas Nikolaos
- Madrid Fausto A.
- Maggi Giulia
- Major Piotr
- Malerba Michele
- Malerba Michele
- Mambrilla Sara
- Mambrilla Sara
- Manatakis Dimitrios K.
- Manfredelli Simone
- Manfredelli Simone
- Mangana Orsalia
- Manigrasso Michele
- Manrique Mario Montes
- Manrique Mario Montes
- Mansour Ahmed Mohammed Farid Mahmoud
- Manto Ottavia
- Manzo Carlo Alberto
- Marafante Chiara
- Marano Alessandra
- Marano Luigi
- Maraska Fatlum
- Marchegiani Francesco
- Marin Jacopo NicoloÌ
- Marinis Athanasios
- Marino Fabio
- Marino Marco V.
- Maroni Norvana
- Marra Angelo Alessandro
- Marra Ester
- Marrano Enrico
- Marsanic Patrizia
- Marsella Valentina Enrica
- Martines Gennaro
- Martini Francesco
- MartiÌn-PeÌrez Beatriz
- MartiÌnez Isidro
- Maruccia Michele
- Marwat Muhammad Ibrahim
- Marziali Irene
- Mascherini Matteo
- MascianaÌ Gianluca
- Masetti Michele
- Masior Ćukasz
- Massaro Daniele
- Massey Lisa H.
- Mastella Federica
- Mastronardi Manuela
- Materazzo Marco
- Materazzo Marco
- Mattioli Marco
- Mazzarella Gennaro
- Mc Farlane Sebastian Jeri
- Mccawley Niamh
- Medappil Noushif
- Medas Fabio
- Melberga Liene
- Mendes Beatriz ISilva
- Meneghini Simona
- Menegozzo Carlos Augusto Metidieri
- MeneÌndez Jaime Iturbe
- Menna Maria Paola
- Menna Maria Paola
- Mercado Octavio Avila
- Merlini David
- Merlini David A.
- Merlini Ilenia
- Merlo Ignacio Guillermo
- Meyer Jeremy
- Michael Michael
- Mifsut Patricia
- Miggino Marco
- Miguel Gustavo Machain
- MiguelaÌnÌez Isabel Pascual
- Mihailescu Andrei
- Mihailescu Andrei
- Milana Flavio
- Milana Flavio
- Milanesi Maria
- Milito Pamela
- Milne David M.
- Mineccia Michela
- Miotto Marco
- Mitul Ashrarur Rahman
- Moeckli Beat
- Moggia Elisabetta
- Mohamad Mohamad Ikhwan Sani
- Mohammed Abdullahi Ibrahim
- Mohammed Mohammed Mustafa
- Moletta Lucia
- Moncada-Ortega Augusto
- Mondi Isabella
- MontcusiÌ Blanca
- Montiel Carmen Galiana
- Montuori Mauro
- Morales Emilio J.
- Morales Emilio J.
- Morales-Conde Salvador
- Morelli Luca
- Morini Andrea
- Moro-Valdezate David
- Mosca Vinicio
- Mukherjee Indraneil
- Mulita Francesk
- Mulpuri Venu Bhargava
- MunÌoz-Cruzado Virginia DuraÌn
- Muriel Maria Emilia
- Murillo Gabriela Aracelly Arroyo
- Murzi Valentina
- Mutlu Arda Ulaş
- Muttillo Edoardo Maria
- Nacion Aeris Jane D.
- Naeem Awais
- Nagarajan Prasanth
- Naik Prashant
- Napetti Sara
- Nardo Bruno
- Nari Gustavo Adrian
- Natalia Savvala N.
- Nava Andrea Kazemi
- Navarro-SaÌnchez Antonio
- Nazir Fozia
- Nazir Fozia
- Neary Peter M.
- Negasa Tolera A.
- Negoi Ionut
- Neri Ignacio
- Neves Fernanda V. S.
- Newton Carla Joyce
- Nicolaescu Diana C.
- Nicolazzi Marco
- Nidaw Melkamu Kibret
- Nigri Giuseppe
- Nigri Giuseppe
- NL Harish
- Ntomi Vasileia
- null null
- Nunziante Marco
- Obiagwu Ndubuisi K.
- Oddis Lidia
- Oddis Lidia
- Oliva Alba
- Olivier James B.
- Olivieri Laura
- Olmi Stefano
- Ortega Irene
- Ortega Nuria
- Ortenzi Monica
- Ossola Paolo
- Pach Radoslaw
- Pachajoa Diana Alejandra Pantoja
- Pacilli Mario
- Palmisano Silvia
- Palomba Giuseppe
- Panaccio Paolo
- Pandanaboyana Sanjay
- Pangeni Anang
- Paniagua-Garcia-SenÌorans Marta
- Panyko ArpaÌd
- PanÌella Clara
- Papadopoulos Aristeidis
- Papatheodorou Panayiotis
- Paradiso Giulia
- Paramasvaran Ganendra
- Paranyak Mykola
- ParrenÌo-Manchado Felipe Carlos
- Pascale Marco Maria
- Pascual Franco
- Pasculli Alessandro
- Paspala Anna
- Pata Francesco
- Pata Francesco
- Pattacini Gianmaria Casoni
- Pavlovic Mladen
- Pavone Giovanna
- Pazos Natalia SuaÌrez
- Pecorelli NicoloÌ
- Pedrazzani Corrado
- Pelegrina Amalia
- Pellicciaro Marco
- Pellino Gianluca
- Pellino Gianluca
- Peloso Andrea
- Pennisi Damiano
- Perez Guillermo
- Perez-Sanchez Luis E.
- Perfecto Arkaitz
- Perotti Bruno
- Perra Teresa
- Perrone Gennaro
- Pesce Antonio
- Petagna Lorenzo
- Peters Paul Adewunmi
- Petrakis Georgios
- Petropoulou Thalia
- Petrucciani Niccolo
- PeÌrez Raquel Escalera
- PeÌrez-BertoÌlez Sonia
- Pham Thuy Vy
- Picardi Biagio
- Picchetto Andrea
- Piccoli Micaela
- Piccolo Gaetano
- Pierobon Elisa Sefora
- Pilia Tiziana
- Pinotti Enrico
- Pio Luca
- Piozzi Guglielmo N.
- Piras Carla
- Pisaniello Donatella
- Pisano Marcello
- Pisano Michele
- Pisanu Adolfo
- Podda Mauro
- Podda Mauro
- Poillucci Gaetano
- Police Andrea
- Porcellini Iride
- Porcu Alberto
- Potkonjak Dario
- Poto Gianmario Edoardo
- Pouwels Sjaak
- Pozza Gioia
- Pradelle Irene
- Prieto Mikel
- Puccioni Caterina
- Puglisi Silvana Bernadetta
- Queffurus Michael
- Quiroga-Garza Alejandro
- Qureshi Ahmad Uzair
- Rachadell Juan JoseÌ
- Ramos-De la Medina Antonio
- Rasheed Faaiz
- Rashid Arshad
- Reccia Isabella
- Reid Rebecca
- Reitano Elisa
- Reiti Andrian
- Richards Chris B.
- Rico Douglas
- Rida Khaled
- Ridolfi Cristina
- Rizzuto Antonia
- Roat Rajesh
- Rocca Aldo
- Rodas Edgar B.
- Rodriguez Agustin E.
- Rodriguez-Lopez Mario
- Roesel Raffaello
- Roesel Raffaello
- Rojas-Bonet Noel
- Romano Angela
- Romano Fabrizio
- Romano Francesco Maria
- Romanzi Andrea
- Rompianesi Gianluca
- Ros Emilio PenÌa
- Rosa Fausto
- Rosa Fausto
- Roscio Francesco
- RoseÌs Helena Salvador
- Rossi Stefano
- Rosso Edoardo
- Rottoli Matteo
- Rubio Ainhoa Valle
- Rueda Erick
- Rusli Siti Mayuha
- Russo Alfio Alessandro
- Russo Iris Shari
- RutegaÌrd Martin
- Sabbatini Sonia
- Sabia Domenico
- Saeidi Sara
- Sahid Saidah
- Sahnan Kapil
- Sahnan Kapil
- Saladino Edoardo
- Salamea Juan C.
- Salido Andrea JimeÌnez
- Salimian Nick
- Salinas Roberto PauÌl Andrade
- Saliu Fatmir
- Salvador Alan Francisco Alfaro
- Salvans Silvia
- Salvetti Francesco
- Samadov Elgun
- Sammartano Fabrizio
- Santocchi Pietro
- Santoliquido Matteo
- Santos BaÌrbara Ribeiro
- Saracoglu Can
- Saraiya Swapnil Mukesh
- Sarmiento Ray Inocencio
- Saroglu Azize
- Sartori Alberto
- Sasia Diego
- Saumtally Mohammad Saad
- SaÌnchez Tatiana GoÌmez
- SaÌnchez-CabuÌs Santiago
- SaÌnchez-GuilleÌn Luis
- Sbacco Valentina
- Scabini Stefano
- Scaringi Stefano
- Scaringi Stefano
- Schena Carlo Alberto
- Schiavo Ciro
- Schiltz Boris
- Schizas Dimitrios
- Schlottmann Francisco
- Sciaudone Guido
- Scopelliti Michele
- Scotti Mauro Alessandro
- Scotti Mauro Alessandro
- Scotto Bruno
- Segura-Sampedro Juan J.
- Selvaggi Francesco
- Selvaggi Lucio
- Sensi Bruno
- Serena De Fatico Gilda
- Seretis Charalampos
- Sergeant Gregory
- Serrablo Alejandro
- Serradilla-MartiÌn Mario
- Serrano-Navidad Monica
- Sevik Husnu
- Seyfried Steffen
- Shalaby Mostafa
- Shiferaw Desta
- Siagian Dumaria Ketty
- Sibaja-Matamoros Dauber A.
- Sica Giuseppe S.
- Sidiropoulou Zacharoula
- Silvestro Roberto
- Singares Eduardo Smith
- Singh-Ranger Gurpreet
- Siragusa Leandro
- Slesser Alistair A. P.
- Sliwinski Svenja Christin
- Smerieri Elia
- Smerieri Nazareno
- Soares Antonio S.
- Soldini Gabriele
- Sotiropoulou Maria
- Sotiropoulu Maria
- Souadka Amine
- Sousa Xavier
- Souza Hamilton Petry
- Spampinato Marcello Giuseppe
- Sparavigna Marco
- Spartalis Eleftherios
- Spartalis Michael
- Sperotto Beatrice
- Spiezio Giovanni
- Spoletini Gabriele
- Stecca Tommaso
- Stijns Jasper
- Stocco Alberto
- Stringfield Sarah Beth
- Stubbs Benjamin M.
- Subramaniam Ravichandran
- Supit Tommy
- Syed Syed Muhammad Ali
- Syn Nicholas L.
- Synekidou Eirini
- Tadesse Robel
- Taeme Mulugeta
- Taffese Abebe
- Takkenberg Marijn
- Tallon-Aguilar Luis
- Tamini NicoloÌ
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Jessica J.
- Tan Jih Huei
- Tandoi Francesco
- Tantravahi Umasankar
- Tarallo Mariarita
- Tartaglia Nicola
- Tasselli Francesco Menegon
- Tasselli Francesco Menegon
- Tatar Cihad
- Tayeh Salim
- Taylor John Vincent
- Ted Tedla Gebretsadik
- Teddy Tewodros Abule Bilata
- Tegegn Ayenachew Getachew
- Tejedor Patricia
- Tekin Oguzhan
- Tellez Clara
- Tenconi Silvia Maria
- Tense Tadesse H.
- Tepelenis Kostas
- Teran Alfonso Ivan Sanchez
- TereÌs Lara Blanco
- Terwes Natasha Loria
- Tesfay Goytom Knfe
- Thambi Prem
- Tita AgustiÌn
- Tolla Ashenafi Negash
- Tolonen Matti
- Tomada Elisa Paoluzzi
- Tomasicchio Giovanni
- Toscano Marta JimeÌnez
- Toti Johannes M. A.
- Travers Lawrence Albert Salter
- Tropeano Francesca Paola
- Tryliskyy Yegor
- Tsouknidas Ioannis
- Tufo Andrea
- Tur-Martinez Jaume
- Tur-Martinez Jaume
- Tura Marina Vila
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Uccelli Matteo
- Uggeri Fabio
- Uzunoglu Mustafa Yener
- Uzzau Alessandro
- Uzzau Alessandro
- Vailas Michail
- Vailas Michail
- Valadez Michel Hernandez
- Valdivieso Xavier HGarciÌa
- Valinoti AgustiÌn
- Van Doorn Berend
- van Ramshorst Gabrielle
- Vanerio Patricio
- Vannelli Alberto
- Vanni Gianluca
- Vanni Gianluca
- Varela Cristopher
- Varela Cristopher L.
- Vargas Luis Felipe Cabrera
- Vellei Samantha
- Verdi Daunia
- Veroux Massimiliano
- Veroux Massimiliano
- Vescio Francesca
- Vigorita Vincenzo
- Vilallonga Ramon
- Vincenzi Paolo
- Vinci Danilo
- Vinci Danilo
- Violante Tommaso
- Visag-Castillo Victor
- Voon Kelvin
- WaleÌšdziak Maciej
- Wani Ajaz
- Wani Ishfaq Ahmad
- Wani Rauf
- Wassie Chekol
- Wilkins Alex
- Wyroslak-Najs Justyna
- Yallew Gebeyaw Mengist
- Yang Wah
- Yildirim Ali Cihat
- Yildiz Ishak
- Yiu Andrew
- Yiu Andrew
- Younis Muhammad Umar
- Yusoff Ahmad Ramzi
- Zacharis Georgios
- Zafra David Ambrona
- Zaghloul Tarek M.
- Zambon Martina
- Zanus Giacomo
- Zarnescu Narcis Octavian
- Zeb Muhammad
- Zena Alemayehu Shanko
- Zerbo Domenico
- Zuchini AndreÌs Mendoza
- Zullo Alessia
- Publication venue
- Publication date
- 29/04/2024
- Field of study
: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSSŸ v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI
Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: Aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon
- Author
- Adebayo JO
- Adebayo JO
- Aguiar AAC
- Aguiar AAC
- Ames BN
- Andrade VF
- Andrade VF
- Andrade VF
- Anna Caroline Campos Aguiar
- Antoniana Ursine Krettli
- Antonio Euzebio Goulart Santana
- Bourdy G
- BrandĂŁo MGL
- BĂ©zivin C
- Carlos Leomar Zani
- Carvalho LH
- Cunha AC
- de Oliveira DR
- Denizot F
- Desjardins R
- Dolabela MF
- Ferreira ICP
- Garavito G
- GuimarĂŁes HA
- Joaquim Corsino Lima
- Julia Penna Coutinho
- Krettli AU
- Krettli AU
- Krettli AU
- Krettli AU
- Lambros C
- LĂłpez ML
- Madureira MC
- Maria de Meneses Pereira
- Maria Gabrielle Lima Rocha
- Marques MFS
- Meneses-Pereira M
- Mota ML
- Muñoz V
- Noedl H
- Oduola AM
- Oliveira AB
- Pereira MM
- Peters W
- Pierre Alexandre dos Santos
- Rieckmann K
- Sachs J
- Tanaka JC
- Tania Maria Almeida Alves
- Trager W
- Uchoa VT
- Weniger B
- Willcox M
- Willcox M
- Zalis MG
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
- Author
- Abecasis Goncalo R.
- Absher Devin
- Albrecht Eva
- Amin Najaf
- Anderson Denise
- Arveiler Dominique
- Assimes Themistocles L.
- Atalay Mustafa
- Attwood Antony Paul
- Bakker Stephan J. L.
- Barlassina Cristina
- Barroso Ine S.
- Basart Hanneke
- Bauer Sabrina
- Beckmann Jacques S.
- Beilby John P.
- Berndt Sonja I.
- Boehm Bernhard O.
- Boehnke Michael
- Bolton Jennifer L.
- Bonnefond Amelie
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boucher Gabrielle
- Buechler Christa
- Campbell Harry
- Caulfield Mark J.
- Cesana Giancarlo
- Chanock Stephen J.
- Chasman Daniel I.
- Chen Yii-Der Ida
- Chines Peter S.
- Clegg Deborah J.
- Collins Francis S.
- Consortium DIAGRAM
- Croteau-Chonka Damien C.
- Cupples L. Adrienne
- Day Felix R.
- de Faire Ulf
- Dedoussis George
- Deloukas Panos
- den Heijer Martin
- Dermitzakis Emmanouil T.
- Dimas Antigone S.
- Dimitriou Maria
- Edkins Sarah
- Eisinger Kristina
- Eklund Niina
- Erbel Raimund
- Erdmann Jeanette
- Eriksson Johan G.
- Esko Tonu
- Estrada Karol
- Fall Tove
- Farrall Martin
- Feitosa Mary F.
- Ferreira Teresa
- Fischer Krista
- Fowkes Gerry
- Fox Caroline S.
- Franks Paul W.
- Fraser Ross M.
- Frayling Timothy
- Froguel Philippe
- Ganna Andrea
- Gejman Pablo V.
- Gieger Christian
- Gigante Bruna
- Goel Anuj
- Grallert Harald
- Gronberg Henrik
- Groop Leif C.
- Gustafsson Stefan
- Gyllensten Ulf
- Hall Alistair S.
- Hall Per
- Hallmans Goran
- Hamsten Anders
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heard-Costa Nancy L.
- Heid Iris M.
- Hengstenberg Christian
- Hicks Andrew A.
- Hingorani Aroon
- Hirschhorn Joel N.
- Hofman Albert
- Hottenga Jouke-Jan
- Hovingh Kees G.
- Hui Jennie
- Huikuri Heikki
- Humphries Steve E.
- Hung Joseph
- Hunter David
- Hveem Kristian
- Hyppoenen Elina
- Illig Thomas
- Ingelsson Erik
- Investigators MAGIC
- Iribarren Carlos
- Jackson Anne U.
- Jacobs Kevin B.
- Jarvelin Marjo-Riitta
- Johansson Asa
- Johnson Toby
- Jolley Jennifer
- Jula Antti
- Kanoni Stavroula
- Kaplan Robert
- Kaprio Jaakko
- Karpe Fredrik
- Kathiresan Sekar
- Keinanen-Kiukaanniemi Sirkka M.
- Khaw Kay-Tee
- Kiemeney Lambertus A.
- Kilpelaeinen Tuomas O.
- KivimÀki Mika
- Kleber Marcus E.
- Koenig Wolfgang
- Kolovou Genovefa
- Kovacs Peter
- Kraja Aldi T.
- Kristiansson Kati
- KrjutAikov Kaarel
- Krohn Jon P.
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuulasmaa Kari
- Kuusisto Johanna
- Laakso Markku
- Lakka Timo A.
- Lamina Claudia
- Langenberg Claudia
- Leach Irene Mateo
- Lehtimaki Terho
- Li Guo
- Li Shengxu
- Liang Liming
- Lind Lars
- Lindgren Cecilia M.
- Lindstrom Jaana
- Locke Adam E.
- Lokki Marja-Liisa
- Loley Christina
- Loos Ruth J. F.
- Lorentzon Mattias
- Luan Jian'an
- Maegi Reedik
- Maerz Winfried
- Magnusson Patrik K. E.
- Mangino Massimo
- Martin Nicholas G.
- Maschio Andrea
- Mathieson Iain
- McArdle Wendy L.
- McCarthy Mark I.
- Medina-Gomez Carolina
- Medland Sarah E.
- Metspalu Andres
- Mihailov Evelin
- Min Josine L.
- Moebus Susanne
- Mohlke Karen L.
- Monda Keri L.
- Montgomery Grant W.
- Morris Andrew David
- Mueller-Nurasyid Martina
- Munroe Patricia B.
- Narisu Narisu
- Navis Gerjan
- Nicholson George
- Njolstad Inger
- Noethen Markus M.
- Nolte Ilja M.
- North Kari E.
- O'Connell Jeffrey R.
- Ohlsson Claes
- Ong Ken K.
- Oostra Ben A.
- Palmer Colin N. A.
- Palmer Lyle J.
- Pechlivanis Sonali
- Pedersen Nancy L.
- Penninx Brenda
- Perola Markus
- Person Thomas
- Peters Annette
- Power Chris
- Pramstaller Peter P.
- Price Jackie F.
- Prokopenko Inga
- Province Michael A.
- Qi Lu
- Raitakari Olli
- Randall Joshua C.
- Rauramaa Rainer
- Rehnberg Emil
- Ridker Paul M.
- Ripatti Samuli
- Rivadeneira Fernando
- Rivolta Carlo
- Rose Lynda M.
- Rudan Igor
- Saaristo Timo E.
- Sager Hendrik
- Salomaa Veikko
- Samani Nilesh J.
- Sambrook Jennifer G.
- Saramies Jouko
- Scherag Andre
- Schlessinger David
- Schunkert Heribert
- Schwarz Peter E. H.
- Shi Jianxin
- Shuldiner Alan R.
- Shungin Dmitry
- Sinisalo Juha-Pekka
- Smith Albert Vernon
- Snieder Harold
- Spector Tim D.
- Speliotes Elizabeth K.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Strachan David P.
- Strawbridge Rona J.
- Surakka Ida
- Swift Amy J.
- Teder-Laving Maris
- Teumer Alexander
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Toenjes Anke
- Tremoli Elena
- Tuomilehto Jaakko
- Tyrer Jonathan
- Uitterlinden Andre G.
- Uusitupa Matti
- van der Harst Pim
- Van der Klauw Melanie M.
- van Duijn Cornelia M.
- Van Vliet-Ostaptchouk Jana V.
- Vedantam Sailaja
- Virtamo Jarmo
- Voelzke Henry
- Waite Lindsay L.
- Wang Zhaoming
- Wareham Nicholas J.
- Wichmann H. Erich
- Wilsgaard Tom
- Wilson James F.
- Winkelmann Bernhard R.
- Winkler Thomas W.
- Wong Andrew
- Wood Andrew R.
- Workalemahu Tsegaselassie
- Yang Jian
- Yarnell John W. G.
- Zhao Jing Hua
- Zillikens M. Carola
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Peer reviewe
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Ellis Yvette
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazla Fathima
- Featherstone Peter
- Felton Tim
- Fennessy Gerard
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernandes Edna
- Fernandez Maria
- Fernando Gloria
- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
- Fesz Jessica
- Fierens Jan
- Finch Cheryl
- Finn André
- Finn Stephanie
- Finnis Mackenzie
- Fiouni Sofia
- Fischer Roy
- Fitzgerald Mark
- Fitzpatrick Meghan
- Fletcher Simon
- Flint Neil
- Flor Thomas
- Florescu Simin
- Fluher Jure
- Flynn Gordon
- FocĂ Emanuele
- Folci Marco
- Forbes Andrew
- Ford Megan
- Forster Elliot
- Foster Tracy
- Fottrell-Gould Deirdre
- Foulds Angela
- Fowler Rob
- Fowler Robert
- Fox Claire
- Fox Eleonore
- Fragner Gertrud
- Frakking Thuy
- Franch-LLasat Diego
- Francis Olesya
- Francoeur François
- Francois Bruno
- Frankfurter Claudia
- Franz Christopher
- François Bourgerol
- Fraser Catherine
- Frater Alasdair
- French Craig
- Frey Anna
- Frey Christian
- Frise Matthew
- Frost Victoria
- Fuchs Ralph
- Fujitani Shigeki
- Fysh Ed
- Gachet Alexandre
- Galbiati Carola
- Galea James
- Ganesan Arunkumar
- Ganesan Manisha
- Ganguly Saibal
- Garcia Sara
- Gardiner-Hill Caroline
- Garot Denis
- Garrard Hywel
- Garrard William
- Garrett Peter
- Garrier Ludivine
- Garrod Esther
- Garton Mark
- Garvey James
- Gascoyne Rachel
- Gattas David
- Gauli Basanta
- Gay Alexandra
- Gaylard Jane
- Gellamucho Minerva
- Gemmell Lisa
- Gendall Emma
- Geng Wenli
- Geoghegan Pierce
- Geri Guillaume
- Geurts Heidi
- Ghaffari Mehrdad
- Ghamraoui Ali
- Ghattaoraya Amardeep
- Ghosh Alison
- Giardina Giuseppe
- Gibbins Alexandra
- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
- Girard Timothy
- Girijadevi Dinuraj
- Gladas Kirsty
- Glasby Kathleen
- Gledhill Lisa
- Glister Georgina
- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
- Grady Bart
- Graham Cheryl
- Graham Libby
- Graniewski Jaroslaw
- Grant Caroline
- GrauNovellas Neus
- Greco Massimiliano
- Grecu Irina
- Green Cameron
- Green Jackie
- Greene Emma
- Greener Danni
- Gregory Jane
- Gresham Rebecca
- Greven Frances
- Grieve Richard
- Grimm Patrick
- Grimmer Lisa
- Groeneveld Erika
- Gross Jamie
- GrĂŒnewaldt Achim
- Guanco Mark
- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
- Gupta Abhinav
- Gurung Anita
- Guérin Emmanuelle
- GĂłmez Francisco
- Göpel Siri
- Habeichi Wadih
- Habraken Hannah
- Hadebe Bernard
- Haffiane Abdelmagid
- Hagel Stefan
- Haghi Theerata
- Haiba Khalid
- Haidar Ghady
- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
- Hanisch Alexis
- Hanley Joanne
- Hansen Dan
- Hanson Helen
- Hanson Jane
- Harden Lesley
- Harding Daniel
- Hardy Chloe
- Harford Rachel
- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
- Hassan Noor
- Hausermann Marie-Helene
- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
- Hayes Leanne
- HC Ooi
- Headdon William
- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
- Henning Jeremy
- Henri-Lagarrigue Matthieu
- Henry Joanne
- Henry Lavinia
- Hensley Joseph
- Heritier Stephane
- Hernandez Erik
- Hewitt Claire
- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
- Hills Thomas
- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
- Hird Clare
- Hodge Christopher
- Hodgson Carol
- Hodgson Helen
- Hoff Uwe
- Hoiting Oscar
- Holbrook Catherine
- Holland Andrew
- Holland Nicky
- Holland Susan
- Hollos Laszlo
- Homes Jennifer
- Honda Hitoshi
- Hope David
- Hopkins Phil
- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
- Humphrey Charlotte
- Hunt Beverley
- Hunter Stephanie
- Hurford Sally-Anne
- Hussain Mahwish
- Hussain Sajid
- Hutchinson Christina
- Hutton Paula
- HĂŒning Vanessa
- Ichihara Nao
- Ijaz Nazia
- Ikhena Ikhuemose
- Inskip Deborah
- Irving Ben
- Isgro Graziella
- Isguzar Agah
- Ishani Pramodya
- Ivatt Helen
- Jackson Carolyn
- Jackson Shane
- Jackson Susan
- Jacob Reni
- Jacquier Sophie
- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
- Jennings Stacey
- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
- Jin Xia
- Jindai Kazuaki
- John Maya
- Johns Magaret
- Johnson David
- Johnson Paul
- Johnson Rebekah
- Johnson Toby
- Johnston Brian
- Jones Andrea
- Jones Cathy
- Jones Dawn
- Jones Emily
- Jones Jessica
- Jones Samantha
- Jongebloed Katherine
- Joseph Sibet
- Joseph Treesa
- Joyce Kirsten
- Juffermans Nicole
- Juhaz Vera
- Kadam Umesh
- Kalamar ?iga
- Kalchko-Veyssal Selver
- Kalchthaler Kyle
- Kaliappan Agilan
- Kalla Ismail
- Kalogirou Michael
- Kamata Kazuhiro
- Kamel Toufik
- Kampschreur Linda
- Kamra Maneesha
- Kandeepan Revathi
- Kannan Santhana
- Kannan Thogulava
- Kanwal Darakhshan
- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kassir Sandy
- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
- Kaye Callum
- Kazi Aayesha
- KC Shirish
- KC Shirsh
- Keating Liza
- Keatley Claire
- Keeler Sheryl
- Keen Alexandra
- Keen Sherbrina
- Keijzer-Timmers Nicole
- Kell Kay
- Kelly Martin
- Kelly Niamh
- Kelsall Olivia
- Kendrick Sara
- Kernan Maeve
- Kerslake Ian
- Kester Esmee
- Khade Reena
- Khalid Imrana
- Khan Meherunnisa
- Khanal Kishor
- Khanal Sushil
- Khare Divya
- Khoso Nasir
- Khoud Ahmed
- Khwaja Kosar
- Kidwai Aneela
- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirk Jill
- Kirk Rosemary
- Kirkby Amy
- Kirkham Simon
- Kit Barbara
- Kitsios Georgios
- Kittridge Lauren
- Klein Daniela
- Klop-Riehl Margreet
- Kluge Stefan
- Knowles Karen
- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
- Kolanos Steffi
- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
- Kunwar Puja
- Kunz Kevin
- Kurenda Catherine
- Kutsogiannis Demetrios
- Kuybida Yuriy
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- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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