406 research outputs found
Markov Chains and reliability analysis for reinforced concrete structure service life
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
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- Adye T
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- Afik Y
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- Akesson TPA
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- Alberghi GL
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- Vukotic I
- Wagner P
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- Walker SD
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- Wang WT
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- White AS
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- Whitmore BW
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- Wolter MW
- Wolters H
- Wong VWS
- Woods NL
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- Wraight K
- Wu SL
- Wu X
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- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
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- Xiao X
- Xiotidis I
- Xu D
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- Xu Z
- Yabsley B
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- Yallup DP
- Yamaguchi N
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- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang HJ
- Yang HT
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- Yao W-M
- Yap YC
- Yasu Y
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- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
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- Yue X
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- Zahreddine J
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- Zakharchuk N
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- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
The Puf-Family RNA-Binding Protein Puf2 Controls Sporozoite Conversion to Liver Stages in the Malaria Parasite
- Author
- AK Mueller
- Anne Charlotte Gruner
- AP Gerber
- AS Aly
- B Zhang
- BI Coleman
- BR Joyce
- C Fennell
- CJ Janse
- CJ Janse
- ED Putrianti
- EK De Silva
- GR Mair
- J Miao
- JA Braks
- JC Hafalla
- K Kaiser
- K Matuschewski
- Kai Matuschewski
- Katja Müller
- KG Le Roch
- L Cui
- LB Lamont
- M Tsuji
- M Wickens
- M Yuda
- M Yuda
- M Zhang
- N Hall
- O Silvie
- O Silvie
- O Silvie
- Olivier Silvie
- P Potocnjak
- PD Zamore
- Q Fan
- R Amino
- R Amino
- R Menard
- RC Wek
- S Balaji
- S Hegge
- SM Gantt
- T Ishino
- T Ishino
- T Quenault
- U Frevert
- X Wang
- Y Murata
- Y Wang
- YY Koh
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Malaria is a vector-borne infectious disease caused by unicellular, obligate intracellular parasites of the genus Plasmodium. During host switch the malaria parasite employs specialized latent stages that colonize the new host environment. Previous work has established that gametocytes, sexually differentiated stages that are taken up by the mosquito vector, control expression of genes required for mosquito colonization by translational repression. Sexual parasite development is controlled by a DEAD-box RNA helicase of the DDX6 family, termed DOZI. Latency of sporozoites, the transmission stage injected during an infectious blood meal, is controlled by the eIF2alpha kinase IK2, a general inhibitor of protein synthesis. Whether RNA-binding proteins participate in translational regulation in sporozoites remains to be studied. Here, we investigated the roles of two RNA-binding proteins of the Puf-family, Plasmodium Puf1 and Puf2, during sporozoite stage conversion. Our data reveal that, in the rodent malaria parasite P. berghei, Puf2 participates in the regulation of IK2 and inhibits premature sporozoite transformation. Inside mosquito salivary glands puf2(-) sporozoites transform over time to round forms resembling early intra-hepatic stages. As a result, mutant parasites display strong defects in initiating a malaria infection. In contrast, Puf1 is dispensable in vivo throughout the entire Plasmodium life cycle. Our findings support the notion of a central role for Puf2 in parasite latency during switch between the insect and mammalian hosts
Expression of P. falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter
- Author
- A Barski
- A Scherf
- A van Daal
- A van Daal
- AA Thambirajah
- AJ Marty
- Alan F. Cowman
- AM Gopalakrishnan
- AM Salcedo-Amaya
- B Guillemette
- BA Biggs
- BA Biggs
- BA Biggs
- BK Chaal
- BO Zhou
- C Epp
- C Flueck
- C Flueck
- C Jin
- C Jin
- CB Millar
- Chin Chin Lee
- CJ Merrick
- CJ Tonkin
- CJ Tonkin
- CK Lee
- D Dryhurst
- D Rangasamy
- D Rangasamy
- DE Schones
- DG Brickner
- DI Baruch
- DJ Roberts
- DK Pokholok
- DW Chung
- E Bischoff
- E Sarcinella
- EK De Silva
- G Mizuguchi
- GR Mair
- GR Mair
- Graham V. Brown
- H Zhang
- IK Greaves
- IY Chen
- J Miao
- J Ouyang
- J Swaminathan
- JA Eisen
- JD Smith
- JE Lowell
- Jennifer Volz
- JG Beeson
- JJ Lopez-Rubio
- JJ Lopez-Rubio
- JY Fan
- JY Fan
- K Brick
- K Bruce
- K Cui
- K Perez-Toledo
- Katja E. Boysen
- KG Le Roch
- Kirk Deitsch
- KW Deitsch
- L Cui
- L Cui
- L Gannoun-Zaki
- LH Freitas-Junior
- LH Freitas-Junior
- M Adam
- M Frank
- M Iizuka
- M Larochelle
- M Petter
- M Yuda
- MB Trelle
- MC Dalmasso
- MD Meneghini
- MF Duffy
- MF Duffy
- Michael F. Duffy
- Michaela Petter
- MJ Clarkson
- MJ Gardner
- MM Wong
- MS Calderwood
- MS Kobor
- MS Santisteban
- MT Duraisingh
- N Iouzalen
- N Issar
- N Issar
- N Ponts
- NJ Krogan
- PB Talbert
- Q Ren
- R Dzikowski
- R Dzikowski
- R Faast
- R Hernandez-Rivas
- R Noviyanti
- RK Suto
- RM Coulson
- RM Raisner
- RR Adams
- S Balaji
- S Hardy
- S Kyes
- SA Ralph
- SJ Westenberger
- Stuart A. Ralph
- SV Kumar
- T Lavstsen
- Timothy J. Byrne
- TJ Templeton
- TN Mavrich
- TN Siegel
- TS Voss
- X Liu
- XZ Su
- Z Bozdech
- Publication venue
- Public Library of Science
- Publication date
- 01/02/2011
- Field of study
Plasmodium falciparum employs antigenic variation to evade the human immune response by switching the expression of different variant surface antigens encoded by the var gene family. Epigenetic mechanisms including histone modifications and sub-nuclear compartmentalization contribute to transcriptional regulation in the malaria parasite, in particular to control antigenic variation. Another mechanism of epigenetic control is the exchange of canonical histones with alternative variants to generate functionally specialized chromatin domains. Here we demonstrate that the alternative histone PfH2A.Z is associated with the epigenetic regulation of var genes. In many eukaryotic organisms the histone variant H2A.Z mediates an open chromatin structure at promoters and facilitates diverse levels of regulation, including transcriptional activation. Throughout the asexual, intraerythrocytic lifecycle of P. falciparum we found that the P. falciparum ortholog of H2A.Z (PfH2A.Z) colocalizes with histone modifications that are characteristic of transcriptionally-permissive euchromatin, but not with markers of heterochromatin. Consistent with this finding, antibodies to PfH2A.Z co-precipitate the permissive modification H3K4me3. By chromatin-immunoprecipitation we show that PfH2A.Z is enriched in nucleosomes around the transcription start site (TSS) in both transcriptionally active and silent stage-specific genes. In var genes, however, PfH2A.Z is enriched at the TSS only during active transcription in ring stage parasites. Thus, in contrast to other genes, temporal var gene regulation involves histone variant exchange at promoter nucleosomes. Sir2 histone deacetylases are important for var gene silencing and their yeast ortholog antagonises H2A.Z function in subtelomeric yeast genes. In immature P. falciparum parasites lacking Sir2A or Sir2B high var transcription levels correlate with enrichment of PfH2A.Z at the TSS. As Sir2A knock out parasites mature the var genes are silenced, but PfH2A.Z remains enriched at the TSS of var genes; in contrast, PfH2A.Z is lost from the TSS of de-repressed var genes in mature Sir2B knock out parasites. This result indicates that PfH2A.Z occupancy at the active var promoter is antagonized by PfSir2A during the intraerythrocytic life cycle. We conclude that PfH2A.Z contributes to the nucleosome architecture at promoters and is regulated dynamically in active var genes
Macrosomia and large for gestational age in Asia:One size does not fit all
- Author
- Ahkter J
- Alexander GR
- Anderson NH
- Aris IM
- Aziz N
- Balaji V
- Bao C
- Bhavadharini B
- Bhavadharini B
- Black RE
- Boo NY
- Boulet SL
- Cai L
- Chaemsaithong P
- Chattrapiban T
- Chen C
- Chen S
- Cheng YK
- Cho EH
- Cho GJ
- Cho HW
- Choi SK
- Dai L
- Druet C
- Enomoto K
- Fall CH
- Farrar D
- Feng H
- Fok TF
- Gairdner D
- Ganeshan M
- Gaudet L
- Gu S
- Harder T
- Harder T
- He JR
- He XJ
- Hirst JE
- Ho TC
- Hod M
- Hong JS
- Hou L
- Hua XG
- Huang X
- Hung TH
- Hung TH
- Hung TH
- International Association of Diabetes and Pregnancy Study Groups Consensus Panel
- Ishihara O
- James‐Todd TM
- Jeyaseelan L
- Kabeya Y
- Kandraju H
- Kolcic I
- Koyanagi A
- Kramer MS
- Leddy MA
- Lee JW
- Lenoir‐Wijnkoop I
- Leung TY
- Li G
- Li N
- Liu H
- Liu Y
- Lu MC
- Lu Y
- Luo XL
- Margetts BM
- Matsuda Y
- Mikolajczyk RT
- Mocarski M
- Morikawa M
- Najmi RS
- Nguyen CL
- Oawada N
- Oken E
- Ota E
- Ott R
- Pan L
- Pang MW
- Park JH
- Pei L
- Rao J
- Rossi AC
- Saereeporncharenkul K
- Schellong K
- Shan X
- Shi P
- Shigemi D
- Sinclair BA
- Song IG
- Srichumchit S
- Sun CC
- Sun L
- Sunsaneevithayakul P
- Surkan PJ
- Takagi K
- Takata N
- Takimoto H
- Tan M
- Tian C
- Toma R
- Tu S
- Villar J
- Wang C
- Wang D
- Wang H
- Wang Q
- Wang Y
- Wei YM
- Weng YH
- Weng YH
- Wie JH
- Wu L
- Wu Y
- Xu H
- Yan J
- Yang S
- Yang W
- Yokomichi H
- Yuan X
- Zhang CH
- Zhang L
- Zheng W
- Publication venue
- 'Wiley'
- Publication date
- 01/06/2021
- Field of study
Macrosomia, usually defined as infant birth weight of >= 4000 g, does not consider gestational age, sex, or country/region-specific differences in mean birth weight and maternal body weight. This issue is particularly relevant for Asia, where 60% of the world's population lives, due to variations in maternal size and birth weights across populations. Large for gestational age (LGA), defined as birth weight > 90th centile, is a more sensitive measure as it considers gestational age and sex, though it is dependent on the choice of growth charts. We aimed to review reporting of macrosomia and LGA in Asia. We reviewed the literature on prevalence and risk of macrosomia and LGA in Asia over the last 29 years. Prevalence of macrosomia ranged from 0.5% (India) to 13.9% (China) while prevalence of LGA ranged from 4.3% (Korea) to 22.1% (China), indicating substantial variation in prevalence within and between Asian countries. High pre-pregnancy body mass index, excessive gestational weight gain, and impaired glucose tolerance conferred risk of macrosomia/LGA. Incidence of macrosomia and LGA varies substantially within and between Asian countries, as do the growth charts and definitions. The latter makes it impossible to make comparisons but suggests differences in intrauterine growth between populations. Reporting LGA, using standardized country/regional growth charts, would better capture the incidence of high birth weight and allow for comparison and identification of contributing factors. Better understanding of local drivers of excessive intrauterine growth could enable development of improved strategies for prevention and management of LGA
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.
- Author
- Abdulhakim E
- Agous I
- Allegar N
- Alvarado O
- Amalyan W
- Andersen J
- Andor M
- Andrei L
- Anspach R
- Asbill B
- Averna M
- Averna M
- Awasty V
- Balaji H
- Balthazar Y
- Barna O
- Basart D
- Becher P
- Beke E
- Bellingar B
- Bergeron J
- Bergeron J
- Biro J
- Blach E
- Black R
- Blair Britt L
- Blumberg V
- Bolster E
- Bondarchuk O
- Bonnet J
- Borgencrantz B
- Boye A
- Breedt J
- Briones Ir
- Broker R
- Bruckert E
- Bucci M
- Butuk D
- Caccavo A
- Cadinot D
- Caixas A
- Campos Pf
- Capiau L
- Cardenas Sp
- Carvalho D
- Casanova R
- Cañon Co
- Cesar M
- Ceska R
- Chaudhari U
- Chaykin L
- Cheung D
- Chizhov P
- Chuang R
- Chumakova G
- Codutti O
- Cohen K
- Cohen L
- Collins G
- Collins H
- Conrad G
- Constance C
- Contzen C
- Cure Cc
- D'Ignazio G
- da Silva Pm
- Dabrowska M
- David W
- Davis B
- De Cesare N
- De Pellegrin Am
- de Salazar Dm
- Degtyareva E
- Derezinski T
- Devedzhiev T
- Dimov B
- Dohad S
- Doig F
- Donnachie H
- Dunn F
- Dyadyk O
- Dzongowski P
- East C
- Ebrahim I
- Egelhof R
- Egstrup K
- El Shahawy M
- El Shahawy M
- Elias M
- Elkin G
- Elle S
- Ellery A
- Elliott T
- Ellis G
- Eriksson M
- Espinosa Ev
- Farnier M
- Farnier M
- Feld L
- Fernandez Cruz A
- Fraile B
- Francis A
- Fuentes F
- Fulat M
- Fuller G
- Furusho Lc
- García Lr
- Gatien L
- Gavish D
- Gawron A
- Gelersztein E
- Gen M
- Gerber J
- Ghitis A
- Gil Extremera B
- Gislason G
- Glover R
- Golden G
- Goloschekin B
- Gomez Ji
- Gotchev D
- Graff A
- Greenwald J
- Grijalvo Om
- Gronkova N
- Gunstone A
- Hart R
- Harvey P
- Hassanin H
- Haught H
- Heaton K
- Heitner J
- Henderson D
- Herrman J
- Herrod J
- Himpel Boenninghoff Aa
- Hoag G
- Hoivik H
- Hoogendijk J
- Horacek T
- Horvathova V
- Huffman C
- Hunter J
- Høivik Ho
- Isermann B
- Jain R
- Jansky P
- Junggeburth J
- Kadr H
- Kanakaridisz N
- Kantaros L
- Karpenko O
- Kassas S
- Kastelein Jj
- Kaye W
- Kekki S
- Kentgens S
- Kerrane J
- Khan N
- Kimmel M
- Kinzfogl G
- Kivitz A
- Klausen Ib
- Kolettis E
- Kondagunta V
- Konieczny M
- Kooy A
- Koren M
- Koren Mj
- Kotzé H
- Koval O
- Kovalyov O
- Koziolova N
- Krempf M
- Krempf M
- Krolick M
- Kumar M
- Kushnir M
- Kuusela M
- König Hj
- Köse V
- Lakin G
- Landman C
- Langslet G
- Langslet G
- Lappo M
- Larnefeldt H
- Lebeis M
- Lejay D
- Lembo G
- Lepor N
- Lepor Ne
- Levinsky D
- Libov I
- Lingan Gr
- Lip G
- Lo E
- Loayza Ms
- Lomholdt J
- Lopez Rb
- Lorch D
- Lorenzato C
- Luc G
- Luc G
- Madder R
- Majul C
- Malik A
- Marple R
- Marten I
- Martinho V
- Massalski W
- Matias F
- Matoltsy A
- Maus O
- Maw K
- Mccullough P
- Mcknight T
- Meissner G
- Meli J
- Mendonca I
- Mendoza Ja
- Mezzetti A
- Miekus P
- Mincheva V
- Mollod M
- Moriarty P
- Moulin P
- Murray A
- Naccarato T
- Nadar V
- Nagy K
- Narvaez Nc
- Nevins B
- Nieminen S
- Nikolaeva A
- Norheim P
- Nseir W
- Nyirati G
- O'Dea D
- O'Mahony M
- Ogorek M
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- Oyesile B
- Paillard F
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- Paltsman Z
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- RUBBA PAOLO OSVALDO FEDERICO
- Rubino J
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- Talreja D
- Tashchuk V
- Tayob M
- Tellier G
- Tengmark Bo
- Theis E
- Thew S
- Thomas H
- Thompson P.
- Timmis H
- Todorov G
- Torp Pedersen C
- Torres D
- Toth P
- Treasure C
- Troquay R
- Tumbev H
- Tuomilehto J
- Tzekova M
- Uusinarkaus K
- Valdivielso P
- Vally T
- van den Berg R
- van der Walt E
- van Dyk C
- van Kempen W
- van Rensburg Dj
- Vardi G
- Velazquez F
- Vermeersch P
- Vico M
- Voors Pette C
- Voyce S
- Vrolix M
- Waxler A
- Wayne J
- Weinstein D
- Weiss D
- West J
- Wong Yk
- Zaidman C
- Zarich S
- Zidkova E
- Zilahi Z
- Zimlichman R
- Züchner D
- Zühlke M
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
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- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
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- Agaras MN
- Aggarwal A
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- Akesson TPA
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- Al Khoury K
- Alberghi GL
- Alberich LC
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Alfonsi A
- Alhroob M
- Ali B
- Alimonti G
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- Alkire SP
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- Alvarez Piqueras D
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- Cardillo FC
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carra S
- Carter JWS
- Casado MP
- Casha AF
- Casper DW
- Castelijn R
- Castillo Gimenez V
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chafaq A
- Chakraborty D
- Chan SK
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Chau CC
- Che S
- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
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- Chen Y-H
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalerias TJA
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
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- Choi K
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- Chu MC
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- Chytka L
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- Ciocio A
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- Costanza F
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- Cowley JW
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- Cranmer K
- Crawley SJ
- Creager RA
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cukierman AR
- Czekierda S
- Czodrowski P
- D'amen G
- D'Auria S
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- D'onofrio A
- D'Onofrio M
- da Costa JBG
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damazio DO
- Damp J
- Dandoy JR
- Daneri MF
- Dang NP
- Dann ND
- Danninger M
- Dao V
- Darbo G
- Dartsi O
- Dattagupta A
- Daubney T
- Davey W
- David C
- Davidek T
- Davis DR
- Dawe E
- Dawson I
- De Asmundis R
- De Benedetti A
- De Beurs M
- De Bruin PHS
- De Castro S
- De Cecco S
- De Groot N
- de Jong P
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- de Lima DEF
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- De Regie JBDV
- de Renstrom PAB
- De Salvo A
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- De K
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- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
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- Zhao P
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu CG
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
- Author
- Abdulhakim E
- Abraham P
- Abramov G
- Abu Hassan MR
- Adamson K
- Adawi F
- Adkins K
- Adler A
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- Zimmerman R
- Zinman B
- Śmiałowski A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events
Search for bottom-squark pair production in pp collision events at √s=13 TeV with hadronically decaying τ-leptons, b-jets, and missing transverse momentum using the ATLAS detector
- Author
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- Wang W
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- Weston TD
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- Whitmore BW
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- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams DM
- Williams HH
- Williams S
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- Yamamoto A
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- Yan J
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- Yao W-M
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- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yin P
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- Young C
- Young CJS
- Yu J
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- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
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- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang M
- Zhang R
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- Zhang X
- Zhang X
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhou M
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- Zhu C
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- Zhulanov V
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- Zimine N
- Zimmermann S
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- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 01/08/2021
- Field of study
A search for pair production of bottom squarks in events with hadronically decaying
τ
-leptons,
b
-tagged jets, and large missing transverse momentum is presented. The analyzed dataset is based on proton-proton collisions at
√
s
=
13
TeV
delivered by the Large Hadron Collider and recorded by the ATLAS detector from 2015 to 2018, and corresponds to an integrated luminosity of
139
fb
−
1
. The observed data are compatible with the expected Standard Model background. Results are interpreted in a simplified model where each bottom squark is assumed to decay into the second-lightest neutralino
˜
χ
0
2
and a bottom quark, with
˜
χ
0
2
decaying into a Higgs boson and the lightest neutralino
˜
χ
0
1
. The search focuses on final states where at least one Higgs boson decays into a pair of hadronically decaying
τ
-leptons. This allows the acceptance and thus the sensitivity to be significantly improved relative to the previous results at low masses of the
˜
χ
0
2
, where bottom-squark masses up to 850 GeV are excluded at the 95% confidence level, assuming a mass difference of 130 GeV between
˜
χ
0
2
and
˜
χ
0
1
. Model-independent upper limits are also set on the cross section of processes beyond the Standard Model
- …