Treating treatment-resistant patients with panic disorder and agoraphobia: A randomized controlled switching trial

Background: Nonresponsiveness to therapy is generally acknowledged, but only a few studies have tested switching to psychotherapy. This study is one of the first to examine the malleability of treatment-resistant patients using acceptance and commitment therapy (ACT). Methods: This was a randomized controlled trial that included 43 patients diagnosed with primary panic disorder and/or agoraphobia (PD/A) with prior unsuccessful state-of-the-art treatment (mean number of previous sessions = 42.2). Patients were treated with an ACT manual administered by novice therapists and followed up for 6 months. They were randomized to immediate treatment (n = 33) or a 4-week waiting list (n = 10) with delayed treatment (n = 8). Treatment consisted of eight sessions, implemented twice weekly over 4 weeks. Primary outcomes were measured with the Panic and Agoraphobia Scale (PAS), the Clinical Global Impression (CGI), and the Mobility Inventory (MI). Results: At post-treatment, patients who received ACT reported significantly more improvements on the PAS and CGI (d = 0.72 and 0.89, respectively) than those who were on the waiting list, while improvement on the MI (d = 0.50) was nearly significant. Secondary outcomes were consistent with ACT theory. Follow-up assessments indicated a stable and continued improvement after treatment. The dropout rate was low (9%). Conclusions: Despite a clinically challenging sample and brief treatment administered by novice therapists, patients who received ACT reported significantly greater changes in functioning and symptomatology than those on the waiting list, with medium-to-large effect sizes that were maintained for at least 6 months. These proof-of-principle data suggest that ACT is a viable treatment option for treatment-resistant PD/A patients. Further work on switching to psychotherapy for nonresponders is clearly needed. © 2015 S. Karger AG, Basel

Avaliação de ionóforos pela técnica da perda do potássio celular e produção de gases in vitro.

Dois estudos foram realizados com vacas lactantes utilizadas como unidade experimental e doadoras de líquido ruminal, sendo as populações de bactérias utilizadas para avaliar a ação de níveis crescentes de lasalocida e monensina na resistência à perda de potássio intracelular, e para produção de gases in vitro. A perda de potássio (Kmax) da lasalocida foi menor para a população de bactérias obtidas do líquido de rúmen de vacas submetidas a dietas com monensina, óleo de soja e monensina mais óleo de soja (19,4 a 25,4%) quando comparada com a perda de potássio em vacas submetidas a dietas sem ionóforo e óleo de soja (30,1%). O mesmo ocorreu para a perda de potássio da monensina, em que o menor valor foi de 6,5% para monensina mais óleo e o maior, de 29,5%, para o controle. Necessita-se de alta concentração de monensina (Kd= 2,3µM), porém baixa de lasalocida (Kd= 0,2µM) para causar a metade da perda máxima de potássio intracelular da população de bactérias do rúmen de vacas submetidas a dietas com monensina. As populações de bactérias de vacas submetidas às dietas com monensina foram sensíveis à lasalocida. As amostras incubadas com própolis produziram menor volume de gases (12,9ml/100g de MS)

Secagem, beneficiamento e armazenamento de grãos.

Por que o grão/semente de feijão deve ser secado? Como pode ser executada a secagem do feijão colhido manualmente? O que deve ser feito nas pequenas propriedades, após a debulha, quando o feijão estiver muito úmido para ser ensacado ou beneficiado? O feijão colhido manualmente pode ser secado no campo? Que fatores podem afetar a secagem do feijão no campo? É verdade que o feijão colhido à mão pode ser enleirado no campo para secar até atingir o ponto de trilha? É verdade que, no campo, o número de fileiras que compõem as leiras de plantas de feijoeiro tem influência no tempo de secagem? Quando se deve proceder à secagem artificial do feijoeiro utilizando secadores estacionários? É aconselhável secar excessivamente o feijão? A semente de feijão pode sofrer injúrias térmicas durante a secagem? Que fatores são importantes para evitar injúrias às sementes de feijão durante a secagem? Qual deve ser a temperatura de secagem quando o feijão se destina à produção (semente)? Qual deve ser a temperatura de secagem quando o feijão se destina ao consumo (grãos)? Para climas muito secos, que alternativa pode ser adotada para secar grãos/sementes de feijão? É aconselhável a execução de uma pré-limpeza do feijão antes de submetê-lo à secagem artificial? Em que consiste o beneficiamento do feijão? Por que é importante realizar a classificação (padronização) do feijão no processo de beneficiamento? Quantas e quais são as principais máquinas utilizadas no beneficiamento do feijão? Existe algum equipamento que seleciona grãos de feijão pela cor do tegumento? É verdade que a máquina de pré-limpeza substitui a máquina de ar e peneira no beneficiamento do feijão? Existe alguma máquina que abane (limpa) o feijão colhido nas pequenas propriedades? Qual é o rendimento da abanadora manual? A abanadora manual serve apenas para limpar grãos de feijão? É verdade que a mesa gravitacional é eficaz na separação de sementes contaminadas por fungos? O que fazer durante o beneficiamento para reduzir danos fisiológicos à semente do feijoeiro? Nas pequenas propriedades, além do uso da abanadora, como o produtor pode fazer o beneficiamento das sementes de feijão? É verdade que o feijão destinado ao consumo necessita ser lavado para adquirir uma aparência limpa e atraente? Existe alguma relação entre tempo de cozimento e período de armazenamento do feijão? Quais são as condições de temperatura mais favoráveis para a armazenagem do feijão por um período de 6 meses? Qual é a recomendação da pesquisa quanto ao teor de umidade do feijão a ser armazenado por um curto período? É verdade que a textura (grau de maciez ou dureza) do feijão varia conforme o período de armazenagem? Há alteração no sabor se o feijão ficar armazenado por um período de 12 meses? É verdade que as condições e o período de armazenagem do feijão podem afetar o valor nutritivo do produto? Em que consiste a operação de expurgo ou fumigação? Quais são os métodos de armazenamento de feijão e qual é o mais eficiente? Existe algum método caseiro e eficiente para combater as pragas dos grãos de feijão armazenado? De que forma a qualidade do feijão pode ser afetada durante o armazenamento? O que pode ser feito para minimizar a perda de qualidade do feijão no período de armazenagem?bitstream/item/123680/1/p223.pd

Defect-control of conventional and anomalous electron transport at complex oxide interfaces

Using low-temperature electrical measurements, the interrelation between electron transport, magnetic properties, and ionic defect structure in complex oxide interface systems is investigated, focusing on NdGaO3/SrTiO3 (100) interfaces. Field-dependent Hall characteristics (2–300 K) are obtained for samples grown at various growth pressures. In addition to multiple electron transport, interfacial magnetism is tracked exploiting the anomalous Hall effect (AHE). These two properties both contribute to a nonlinearity in the field dependence of the Hall resistance, with multiple carrier conduction evident below 30 K and AHE at temperatures ≲10  K. Considering these two sources of nonlinearity, we suggest a phenomenological model capturing the complex field dependence of the Hall characteristics in the low-temperature regime. Our model allows the extraction of the conventional transport parameters and a qualitative analysis of the magnetization. The electron mobility is found to decrease systematically with increasing growth pressure. This suggests dominant electron scattering by acceptor-type strontium vacancies incorporated during growth. The AHE scales with growth pressure. The most pronounced AHE is found at increased growth pressure and, thus, in the most defective, low-mobility samples, indicating a correlation between transport, magnetism, and cation defect concentratio

Compactação e inseticidas no controle de cupins em arroz de terras altas, em plantio direto.

O objetivo do estudo foi determinar o efeito da compactação de sulco combinada com inseticidas, aplicados via tratamento de sementes, no ataque de cupins na cultura do arro

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations

Evidence for the Higgs-boson Yukawa coupling to tau leptons with the ATLAS detector

Results of a search for H → τ τ decays are presented, based on the full set of proton-proton collision data recorded by the ATLAS experiment at the LHC during 2011 and 2012. The data correspond to integrated luminosities of 4.5 fb−1 and 20.3 fb−1 at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV respectively. All combinations of leptonic (τ → `νν¯ with ` = e, µ) and hadronic (τ → hadrons ν) tau decays are considered. An excess of events over the expected background from other Standard Model processes is found with an observed (expected) significance of 4.5 (3.4) standard deviations. This excess provides evidence for the direct coupling of the recently discovered Higgs boson to fermions. The measured signal strength, normalised to the Standard Model expectation, of µ = 1.43 +0.43 −0.37 is consistent with the predicted Yukawa coupling strength in the Standard Model

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011