Glycemic Control Protocol Comparison using Virtual Trials

DTM2011 handbook/programme is given in files and also available as a hard copyBackground: Several accurate glycemic control (AGC) protocols for critical care patients exist but making comparisons is very hard. Objective: This study uses clinically validated virtual patient methods to compare safety and performance for several published AGC protocols. Method: Clinically validated virtual trials were run on 371 patients (39,481 hours, 26,646 measurements) created from the SPRINT AGC cohort. For protocols that do not modulate feed rates enteral nutrition was held at 100% of ACCP goal (25kcal/kg/day) when the patients were clinically fed, and parenteral nutrition rates were matched to clinical data. Performance was defined as %BG within glycemic bands and BG measurement frequency. Safety was defined as the incidence of severe (number patients with BG<40mg/dL) and moderate (%BG<72mg/dL) hypoglycemia. Clinical data from SPRINT is also compared. Results: Clinical SPRINT performance data matched re-simulated SPRINT with 86% vs. 86% BG in 80-145mg/dL, 2.00% vs. 2.07% BG above 180mg/dL and 7.83% vs. 7.29% BG below 72mg/dL, with 14 measurements (over 8 patients) of BG<40mg/dL. Yale results were 83.5%, 3.20%, 5.18%, with 6 severe hypoglycemic patients, using 37,961 measurements (23.0/day). Glucontrol had 75.2%, 3.70%, 9.45%, 52 cases and 26,199 measurements (15.8/day). Braithwaite had 84.2%, 3.00%, 4.22%, 19 cases and 24,396 measurements (14.8/day). The STAR (Stochastic TARgeted) model-based method had 90.6%, 1.67%, 1.33%, 5 cases and 20,591 measurements (12.3/day). Conclusions: Virtual trials provided an effective comparison across protocols with different target bands/values and different clinical cohorts. The model-based STAR protocol provided the best management of patient variability yielding the best performance and safety

Validation and implementation of low-cost dynamic insulin sensitivity tests

DTM2011 handbook/programme is given in files and also available as a hard copyObjective: Insulin sensitivity (SI) tests can provide important information for type 2 diabetes risk assessment and investigations of metabolism or pre-diabetes. Our group previously presented the dynamic insulin sensitivity and secretion test (DISST) and the real-time quick DISST (DISTq) as low-cost, low-burden and accurate alternatives to established tests. The DISST provides concurrent SI and endogenous insulin secretion (UN) metrics, the DISTq does not require insulin or C-peptide assays for SI identification, but can return an immediate result. This study validates the DISST and DISTq in comparison to the euglycemic, hyperinsulinemic clamp (EIC) Method: Fifty participants (with 10 BMI>30; 10 BMI>25, <30; and 5 BMI<25 of each gender) underwent the EIC and DISST. The DISST protocol requires 5 samples from a 30 minute protocol similar to the IM-IVGTT. Data from the DISST protocol was sufficient to identify SI using both the DISST and DISTq parameter identification methods and UN from the DISST. Result: DISST and DISTq SI values correlated well to the EIC (R=0.81 and R=0.76, respectively) and each other (R=0.84). UN values obtained during the DISST showed clinically relevant distinctions between participants, and clearly differentiated the beta-cell function of impaired glucose tolerant participants who had the same EIC SI. Participant acceptance of the protocol was high with very minor reported adverse effects. Conclusion: The DISST and DISTq correlated well against the EIC compared to most established insulin sensitivity tests. The DISST can better differentiate patients as it provides UN metrics that the EIC does not. A computer program makes uptake and use of the model-based DISST and DISTq tests straightforward for clinicians and researchers

Semiclassical approach to calculating the influence of local lattice fluctuations on electronic properties of metals

We propose a new semiclassical approach based on the dynamical mean field theory to treat the interactions of electrons with local lattice fluctuations. In this approach the classical (static) phonon modes are treated exactly whereas the quantum (dynamical) modes are expanded to second order and give rise to an effective semiclassical potential. We determine the limits of validity of the approximation, and demonstrate its usefulness by calculating the temperature dependent resistivity in the Fermi liquid to polaron crossover regime (leading to `saturation behavior') and also isotope effects on electronic properties including the spectral function, resistivity, and optical conductivity, problems beyond the scope of conventional diagrammatic perturbation theories.Comment: 11 pages, 7 figure

Correlation gap in the heavy-fermion antiferromagnet UPd_2Al_3

The optical properties of the heavy-fermion compound UPd$_2$Al$_3$ have been measured in the frequency range from 0.04 meV to 5 meV (0.3 to 40 cm$^{-1}$) at temperatures $2 {\rm K}<T< 300$ K. Below the coherence temperature $T^*\approx 50$ K, the hybridization gap opens around 10 meV. As the temperature decreases further ($T\leq 20$ K), a well pronounced pseudogap of approximately 0.2 meV develops in the optical response; we relate this to the antiferromagnetic ordering which occurs below $T_N\approx 14$ K. The frequency dependent mass and scattering rate give evidence that the enhancement of the effective mass mainly occurs below the energy which is associated to the magnetic correlations between the itinerant and localized 5f electrons. In addition to this correlation gap, we observe a narrow zero-frequency conductivity peak which at 2 K is less than 0.1 meV wide, and which contains only a fraction of the delocalized carriers. The analysis of the spectral weight infers a loss of kinetic energy associated with the superconducting transition.Comment: RevTex, 15 pages, 7 figure

The Intentional Use of Service Recovery Strategies to Influence Consumer Emotion, Cognition and Behaviour

Service recovery strategies have been identified as a critical factor in the success of. service organizations. This study develops a conceptual frame work to investigate how specific service recovery strategies influence the emotional, cognitive and negative behavioural responses of . consumers., as well as how emotion and cognition influence negative behavior. Understanding the impact of specific service recovery strategies will allow service providers' to more deliberately and intentionally engage in strategies that result in positive organizational outcomes. This study was conducted using a 2 x 2 between-subjects quasi-experimental design. The results suggest that service recovery has a significant impact on emotion, cognition and negative behavior. Similarly, satisfaction, negative emotion and positive emotion all influence negative behavior but distributive justice has no effect

Quantum Critical Kondo Quasiparticles Probed By Esr In β-ybalb 4

Electron spin resonance (ESR) can probe conduction electrons (CE) and local moment (LM) spin systems in different materials. A CE spin resonance (CESR) is observed in metallic systems based on light elements or with enhanced Pauli susceptibility. LM ESR can be seen in compounds with paramagnetic ions and localized d or f electrons. Here we report a remarkable and unprecedented ESR signal in the heavy-fermion superconductor β-YbAlB4 which behaves as a CESR at high temperatures and acquires characteristics of the Yb3 LM ESR at low temperature. This dual behavior strikes as an in situ unique observation of the Kondo quasiparticles in a quantum critical regime. The proximity to a quantum critical point may favor the appearance of this dual character of the ESR signal in β-YbAlB4. © 2011 American Physical Society.1072Tien, C., Yu, J., Duh, H., (1993) Jpn. J. Appl. Phys., 32, p. 2658. , JAPNDE 0021-4922 10.1143/JJAP.32.2658Sichelschmidt, J., (2003) Phys. Rev. Lett., 91, p. 156401. , PRLTAO 0031-9007 10.1103/PhysRevLett.91.156401Sichelschmidt, J., (2007) J. Phys. Condens. Matter, 19, p. 016211. , JCOMEL 0953-8984 10.1088/0953-8984/19/1/016211Krellner, C., Forster, T., Jeevan, H., Geibel, C., Sichelschmidt, J., Relevance of ferromagnetic correlations for the electron spin resonance in kondo lattice systems (2008) Physical Review Letters, 100 (6), p. 066401. , http://oai.aps.org/oai?verb=GetRecord&Identifier=oai:aps.org: PhysRevLett.100.066401&metadataPrefix=oai_apsmeta_2, DOI 10.1103/PhysRevLett.100.066401Abrahams, E., Wolfle, P., (2008) Phys. Rev. B, 78, p. 104423. , PRBMDO 1098-0121 10.1103/PhysRevB.78.104423Schlottmann, P., (2009) Phys. Rev. B, 79, p. 045104. , PRBMDO 1098-0121 10.1103/PhysRevB.79.045104Macaluso, R.T., Nakatsuji, S., Kuga, K., Thomas, E.L., Machida, Y., Maeno, Y., Fisk, Z., Chan, J.Y., Crystal structure and physical properties of polymorphs of LnAlB 4 (Ln = Yb, Lu) (2007) Chemistry of Materials, 19 (8), pp. 1918-1922. , DOI 10.1021/cm062244+Nakatsuji, S., (2008) Nature Phys., 4, p. 603. , NPAHAX 1745-2473 10.1038/nphys1002Duque, J.G.S., (2009) Phys. Rev. B, 79, p. 035122. , PRBMDO 1098-0121 10.1103/PhysRevB.79.035122Trovarelli, O., (2000) Phys. Rev. Lett., 85, p. 626. , PRLTAO 0031-9007 10.1103/PhysRevLett.85.626Gegenwart, P., (2002) Phys. Rev. Lett., 89, p. 056402. , PRLTAO 0031-9007 10.1103/PhysRevLett.89.056402Dyson, F.J., (1955) Phys. Rev., 98, p. 349. , PHRVAO 0031-899X 10.1103/PhysRev.98.349Tao, L.J., (1971) Phys. Rev. B, 4, p. 5. , PRBMDO 0556-2805 10.1103/PhysRevB.4.5Abragam, A., Bleaney, B., (1970) EPR of Transitions Ions, , Clarendon, OxfordSattler, J.P., Nemarich, J., (1970) Phys. Rev. B, 1, p. 4249. , PRBMDO 0556-2805 10.1103/PhysRevB.1.4249Rettori, C., (1981) Physica (Amsterdam), 107, p. 359. , PHYBE3 0378-4363 10.1016/0378-4363(81)90485-XHuber, D.L., (2004) Phys. Rev. B, 70, p. 125417. , PRBMDO 1098-0121 10.1103/PhysRevB.70.125417Oseroff, S.B., (1977) Phys. Rev. B, 15, p. 1283. , PRBMDO 0556-2805 10.1103/PhysRevB.15.1283Continetino, M., (2005) Braz. J. Phys., 35, p. 197. , BJPHE6 0103-9733 10.1590/S0103-97332005000100018Coleman, P., Pepin, C., Si, Q., Ramazashvili, R., How do Fermi liquids get heavy and die? (2001) Journal of Physics Condensed Matter, 13 (35), pp. R723-R738. , DOI 10.1088/0953-8984/13/35/202, PII S095389840124853XMonod, P., (1978) J. Phys. (Paris), 39, pp. 6-1472. , JOPQAG 0302-0738 10.1051/jphyscol:19786589Rettori, C., (1997) Phys. Rev. B, 55, p. 1016. , PRBMDO 0163-1829 10.1103/PhysRevB.55.1016Pagliuso, P.G., (1997) Phys. Rev. B, 56, p. 8933. , PRBMDO 0163-1829 10.1103/PhysRevB.56.8933Urbano, R.R., (2002) Phys. Rev. Lett., 89, p. 087602. , PRLTAO 0031-9007 10.1103/PhysRevLett.89.087602Likodimos, V., Koutandos, S., Pissas, M., Papavassiliou, G., Prassides, K., Conduction electron spin resonance in Mg1-xAl xB2 (2003) Europhysics Letters, 61 (1), pp. 116-121. , DOI 10.1209/epl/i2003-00257-1Sercheli, M.S., Kopelevich, Y., Ricardo Da Silva, R., Torres, J.H.S., Rettori, C., Evidence for internal field in graphite: A conduction electron spin-resonance study (2002) Solid State Communications, 121 (9-10), pp. 579-583. , DOI 10.1016/S0038-1098(01)00465-3, PII S0038109801004653Walmsley, L., Rettori, C., C-Axis resistivity in graphite-AlCl3 as found by CESR measurements (1990) Synthetic Metals, 36 (2), pp. 235-239. , DOI 10.1016/0379-6779(90)90056-QPfluger, P., (1983) Synth. Met., 8, p. 15. , SYMEDZ 0379-6779 10.1016/0379-6779(83)90004-8Nevidomskyy, A.H., Coleman, P., (2009) Phys. Rev. Lett., 102, p. 077202. , PRLTAO 0031-9007 10.1103/PhysRevLett.102.077202Si, Q., Rabello, S., Ingersent, K., Smith, J.L., Locally critical quantum phase transitions in strongly correlated metals (2001) Nature, 413 (6858), pp. 804-808. , DOI 10.1038/3510150

Search for heavy resonances decaying into a vector boson and a Higgs boson in final states with charged leptons, neutrinos, and b quarks

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Search for high-mass diphoton resonances in proton-proton collisions at 13 TeV and combination with 8 TeV search

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Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV

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Measurement of the mass difference between top quark and antiquark in pp collisions at root s=8 TeV

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