271 research outputs found
Cervical dystonia: clinical and therapeutic features in 85 patients
- Author
- Albanese A
- Barbosa ER
- Berardelli A
- Burke RE
- Cardoso F
- Carlos Henrique F. Camargo
- Chan J
- Deuschl G
- Dressler D
- Ertekin C
- Fahn S
- Fahn S
- Ferraz HB
- Ferraz HB
- Friedman A
- Hilker R
- Hélio A.G. Teive
- Jahanshahi M
- Jahanshahi M
- Jankovic J
- Jankovic J
- Jankovic J
- Kutvonen O
- Lineu César Werneck
- Lowenstein DH
- Maria Helena Herdoíza Baran
- Molho ES
- Müller J
- Müller J
- Nilson Becker
- Németh AH
- O'Riordan S
- Rosana Hermínia Scola
- Tsui JK
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Head tremor in patients with cervical dystonia: different outcome?
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Rural or urban living and Parkinson's disease
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Cytokine Gene Polymorphisms across Tuberculosis Clinical Spectrum in Pakistani Patients
- Author
- A Moran
- A O'Garra
- AC Lemos
- Adam J. Ratner
- AG Pacheco
- Ambreen Ansari
- B Jamil
- Bushra Jamil
- C Perrey
- D Guwatudde
- D Lio
- D Lopez-Maderuelo
- D Maher
- DM Turner
- E Sahiratmadja
- F Altare
- G Comstock
- G Etokebe
- Ghaffar Dawood
- GS Cooke
- HB Oral
- HD Shin
- HE Takiff
- HW Tso
- JC Delgado
- JC Ferraz
- JH Oh
- JL Flynn
- L Scola
- LE Rees
- M Bagheri
- M Rossouw
- M Vidyarani
- MI Henao
- N Sallakci
- Najeeha Talat
- O Ates
- PO Flores-Villanueva
- R Bellamy
- R Hussain
- R Hussain
- Rabia Hussain
- S Akhtar
- SE Dorman
- SQ Mehdi
- Tashmeem Razzaki
- V Pravica
- VK Dhingra
- Zahra Hasan
- Publication venue
- Public Library of Science
- Publication date
- 10/03/2009
- Field of study
BACKGROUND: Pakistan ranks 7(th) globally in terms of tuberculosis (TB) disease burden (incidence 181/100000 pop./yr; prevalence of 329/pop./yr). Reports from different populations show variable associations of TB susceptibility and severity with cytokine gene polymorphisms. Tuberculosis clinical severity is multi-factorial and cytokines play a pivotal role in the modulation of disease severity. We have recently reported that the ratio of two key cytokines (IFNgamma and IL10) show significant correlation with the severity spectrum of tuberculosis. The objective of the current study was to analyze the frequency of cytokine gene polymorphisms linked to high and low responder phenotypes (IFNgamma +874 T(hi)-->A(lo) and IL10 -1082 G(lo)-->A(hi)) in tuberculosis patients. METHODS AND FINDINGS: STUDY GROUPS WERE STRATIFIED ACCORDING TO DISEASE SITE AS WELL AS DISEASE SEVERITY: Pulmonary N = 111 (Minimal, PMN = 19; Moderate, PMD = 63; Advance, PAD = 29); Extra-pulmonary N = 67 (Disseminated DTB = 20, Localized LTB = 47) and compared with healthy controls (TBNA = 188). Genotype analyses were carried out using amplification refractory mutation system-PCR (ARMS-PCR) and stimulated whole blood (WB) culture assay was used for assessing cytokine profiles. Our results suggest that the IFNgamma +874 TT genotype and T allele was overrepresented in PMN (p = 0.01) and PMD (p = 0.02). IFNgamma +874 TT in combination with IL10 GG(lo) genotypes showed the highest association (chi(2) = 6.66, OR = 6.06, 95% CI = 1.31-28.07, p = 0.01). IFNgamma AA(lo) on the other hand in combination with IL10 GG(lo) increased the risk of PAD (OR = 5.26; p = 0.005) and DTB (OR = 3.59; p = 0.045). CONCLUSION: These findings are consistent with the role of IL10 in reducing collateral tissue damage and the protective role of IFNgamma in limiting disease in the lung
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
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- Andeen T
- Anders CF
- Anders JK
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- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
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- Antel C
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- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
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- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
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- Asimakopoulou EM
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- Wagner P
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- Yamazaki T
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- Yao W-M
- Yap YC
- Yasu Y
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- Ye H
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- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
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- Yu J
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- Yue X
- Zaazoua M
- Zabinski B
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- Zahreddine J
- Zaitsev AM
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- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
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- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Antimicrobial susceptibility patterns and characterization of clinical isolates of Staphylococcus aureus in KwaZulu-Natal province, South Africa
- Author
- A Hoefnagels-Schuermans
- A Norazah
- A Schwarzkopf
- A Van Belkum
- AC Fluit
- Adebayo O Shittu
- AM Hanssen
- American Society for Microbiology
- AO Shittu
- B Matynia
- B Shopsin
- BJ Kopp
- BP Howden
- C Annemuller
- C Kesah
- C Lawrence
- C Rayner
- CS Zinn
- DC Shanson
- DJ Diekema
- E Petinaki
- EE Udo
- EF Peddie
- F Amod
- FC Tenover
- FD Lowy
- FJ Schmitz
- FJ Schmitz
- G Duckworth
- GE Bignardi
- H-J Yun
- HB Kim
- HM Aucken
- I Montesinos
- I Tosun
- IS Santos Sanches
- J Lin
- J Lin
- J Turnidge
- J Van den Ende
- JJ Engemann
- JM Bell
- JM Boyce
- JN Scragg
- Johnson Lin
- JR Johnson
- JV Hookey
- JV Hookey
- K Hiramatsu
- KJ Christiansen
- KR Fiebelkorn
- M Barber
- M Kuroda
- M Melzer
- MP Jevons
- N Kobayashi
- N Maniatis
- N Woodford
- National Committee for Clinical Laboratory Standards
- National Committee for Clinical Laboratory Standards (now CLSI)
- National Nosocomial Infections Surveillance (NNIS) System Report
- OG Brakstad
- PAC Maple
- PE Carter
- R Skov
- S Fokas
- S Murchan
- S Subedi
- S-H Goh
- SE Cosgrove
- SE Cosgrove
- SI Blot
- SK Bouchillon
- T Gottlieb
- T Nada
- TA Leski
- TA Wichelhaus
- TP Levin
- TP Lodise
- TTR Walsh
- V Ferraz
- W Brumfitt
- WE Kloos
- Y Gardee
- Publication venue
- BioMed Central
- Publication date
- 01/07/2006
- Field of study
BACKGROUND: Antimicrobial resistance of Staphylococcus aureus especially methicillin-resistant S. aureus (MRSA) continues to be a problem for clinicians worldwide. However, few data on the antibiotic susceptibility patterns of S. aureus isolates in South Africa have been reported and the prevalence of MRSA in the KwaZulu-Natal (KZN) province is unknown. In addition, information on the characterization of S. aureus in this province is unavailable. This study investigated the susceptibility pattern of 227 S. aureus isolates from the KZN province, South Africa. In addition, characterization of methicillin-sensitive S. aureus (MSSA) and MRSA are reported in this survey. METHODS: The in-vitro activities of 20 antibiotics against 227 consecutive non-duplicate S. aureus isolates from clinical samples in KZN province, South Africa were determined by the disk-diffusion technique. Isolates resistant to oxacillin and mupirocin were confirmed by PCR detection of the mecA and mup genes respectively. PCR-RFLP of the coagulase gene was employed in the characterization of MSSA and MRSA. RESULTS: All the isolates were susceptible to vancomycin, teicoplanin and fusidic acid, and 26.9% of isolates studied were confirmed as MRSA. More than 80% of MRSA were resistant to at least four classes of antibiotics and isolates grouped in antibiotype 8 appears to be widespread in the province. The MSSA were also susceptible to streptomycin, neomycin and minocycline, while less than 1% was resistant to chloramphenicol, ciprofloxacin, rifampicin and mupirocin. The inducible MLS(B )phenotype was detected in 10.8% of MSSA and 82% of MRSA respectively, and one MSSA and one MRSA exhibited high-level resistance to mupirocin. There was good correlation between antibiotyping and PCR-RFLP of the coagulase gene in the characterization of MRSA in antibiotypes 1, 5 and 12. CONCLUSION: In view of the high resistance rates of MRSA to gentamicin, erythromycin, clindamycin, rifampicin and trimethoprim, treatment of MRSA infections in this province with these antibacterial agents would be unreliable. There is an emerging trend of mupirocin resistance among S. aureus isolates in the province. PCR-RFLP of the coagulase gene was able to distinguish MSSA from MRSA and offers an attractive option to be considered in the rapid epidemiological analysis of S. aureus in South Africa. Continuous surveillance on resistance patterns and characterization of S. aureus in understanding new and emerging trends in South Africa is of utmost importance
Forest landscape ecology and global change: an introduction
- Author
- A Alignier
- A Hansen
- AD Chalfoun
- AH Perera
- AH Perera
- AJ Hansen
- AL Westerling
- AW King
- BW Brook
- C Cossalter
- C Keenleyside
- CD Oliver
- CJ Walters
- CJA Bradshaw
- D Armenteras
- D Bachelet
- D Lamb
- D Schroter
- D Skole
- DA Saunders
- DB Lindenmayer
- DB Lindenmayer
- DB Lindenmayer
- DG Sprugel
- DJ Mladenoff
- DJ Mladenoff
- DJ Mladenoff
- DJ Mladenoff
- DO Wallin
- E Baskent
- EF Lambin
- EG Brockerhoff
- EJ Gustafson
- EJ Gustafson
- EJ Gustafson
- EP Farrell
- ES Weng
- F Moreira
- F Moreira
- FAO
- FAO
- FAO
- FH Bormann
- FSC
- G Williams-Linera
- GJ Cary
- HB Li
- HM Rauscher
- HR Akcakaya
- HR Delcourt
- HS He
- I Numata
- IS Zonneveld
- J Barlow
- J Brunet
- J Burley
- J Lubchenco
- JC Azevedo
- JC Azevedo
- JF Franklin
- JF Franklin
- JF Franklin
- JG Wu
- JH Cissel
- JK Hill
- JM Hagan
- JMR Benayas
- JP Metzger
- JQ Chen
- JQ Chen
- JQ Chen
- KA Harper
- KA Kohm
- KA With
- KA With
- KH Riitters
- L Bélanger
- L Fahrig
- L Hannah
- L Hannah
- L Navarro
- L Ries
- L Willemen
- L Zanella
- M Hanewinkel
- M Kelly
- M Tabarelli
- MA Larson
- MA Zavala
- MB Araujo
- MG Turner
- MG Turner
- MG Turner
- MG Turner
- MG Turner
- MJ Groom
- ML Hunter
- Montréal Process
- MP North
- MV Lantschner
- MVF Amaral
- NE Heller
- NL Christensen
- P August
- P Leadley
- P Opdam
- PD Taylor
- PK Lira
- R Hassan
- R Lafortezza
- R Loyn
- R Schlaepfer
- RC Szaro
- RE Grumbine
- RF Zhao
- RS DeFries
- RTT Forman
- RTT Forman
- S Fraver
- S Saura
- S Saura
- SFB Ferraz
- SG Boyce
- SG Cumming
- SM Carvalho-Ribeiro
- SR Freitas
- SR Shifley
- SR Shifley
- SX Cao
- TA Burton
- TA Spies
- TM Donovan
- TR Crow
- TR Crow
- UN
- V Proença
- V Sahin
- VC Radeloff
- VH Dale
- W Xi
- WA Kurz
- WB Kessler
- WB Meyer
- WB Meyer
- WF Laurance
- WF Laurance
- Z Naveh
- ZH Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Forest landscape ecology examines broad-scale patterns and processes and their interactions in forested systems and informs the management of these ecosystems. Beyond being among the richest and the most complex terrestrial systems, forest landscapes serve society by providing an array of products and services
and, if managed properly, can do so sustainably. In this chapter, we provide an overview of the field of forest landscape ecology, including major historical and present topics of research, approaches, scales, and applications, particularly those concerning edges, fragmentation, connectivity, disturbance, and biodiversity. In addition, we discuss causes of change in forest landscapes, particularly land-use and management changes, and the expected structural and functional consequences that may result from these drivers. This chapter is intended to set the context and provide an overview for the remainder of the book and poses a broad set of questions related to forest landscape ecology and global change that need answers
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouzeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlas Collaboration
- Atlay NB
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Baines JT
- Bajic M
- Bakalis C
- Baker OK
- Bakker PJ
- Bakshi Gupta D
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barlow N
- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimarães Da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batlamous S
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
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- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
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- Abdullakutty J
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- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
- Koba M
- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
- Koldas N
- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- Kopczyńska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
- Lal S
- Lamance J
- Lamas G
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- Lambert J
- Lameira A
- Lamontagne C
- Landers B
- Landolfi A
- Landzberg J
- Lang C
- Langdon J
- Laniec M
- Lappo M
- Lardinois R
- Laszlo Z
- Latheef K
- Laube S
- Lauzon C
- Lavoie W
- Lazov P
- Ledger G
- Lee Hn
- Lee J
- Lee Jh
- Lee K
- Lee K
- Lee Kr
- Lee Sc
- Lee Sh
- Lee T
- Leggewie S
- Lehman Kf
- Lehman R
- Lehmann D
- Leimbach W
- Lekakis J
- Lembo G
- Lenderink T
- Lennard M
- Lenner E
- Lennerova J
- Leon S
- Lepage S
- Lepor N
- Lepp H
- Lester F
- Levin P
- Levine D
- Lewis D
- Li W
- Li X
- Li Y
- Li Y
- Li Y
- Li Yh
- Li Z
- Libby P
- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
- Lindholm Cj
- Lindner C
- Liniado G
- Lino E
- Lipchenko A
- Liu B
- Liu B
- Liu Hm
- Liu P
- Liu S
- Liu Y
- Liviu C
- Lock E
- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
- Mody F
- Moehring B
- Moen S
- Moffat J
- Mohan K
- Molina Di
- Molk B
- Molter D
- Monroe T
- Montana O
- Montenegro E
- Montenegro P
- Montero H
- Montgomery R
- Monti L
- Moodh J
- Mooe T
- Mookherjee D
- Moon K
- Moraes J Jr
- Moran J
- Moreira L
- Morell Y
- Moriarty P
- Morii I
- Morinaga Y
- Morisawa T
- Morozov E
- Morrison J
- Morton D
- Mos L
- Moshayedi P
- Mosley J
- Motiejuniene R
- Muehlhaus J
- Mueller S
- Muenter Kc
- Muenzel T
- Mulder R
- Munoz N
- Munoz R
- Munshi K
- Muntaner J
- Mureddu V
- Murphy G
- Murray A
- Mustafa J
- Musumeci Mb
- Muñoz W
- Myslyaeva L
- Nadar V
- Nagai Y
- Nagele-Luse I
- Nagy Ac
- Naidu R
- Naka T
- Nakamura S
- Nakamura Y
- Nakayoshi K
- Nalley J
- Nanas J
- Nandy P
- Naumann R
- Navarrete S
- Navy S
- Nebel J
- Neil L
- Nema D
- Neumann J
- Neutel Jm
- Niblack P
- Nicely V
- Nicolai M
- Nicolau J
- Nijmeh G
- Nikas A
- Nikoletta P
- Nikolic L
- Nikyar A
- Nilsen V
- Ning M
- Nishibe A
- Nixon S
- Nociar J
- Noori E
- Norin V
- Norkiene S
- Norkute-Macijauske U
- Norman L
- Noto G
- Nour K
- Novo S
- Nuding S
- Nugent A
- Nugteren Skz
- Ocman B
- Odegard A
- Ogawa H
- Ogawa M
- Okada Y
- Okawa M
- Okeefe D
- Olenchock B
- Olmedo M
- Olofsson M
- Olsen S
- Olsson Gh
- Olympios Cd
- Ondrasik J
- Onuchina E
- Oomman A
- Ord M
- Ortiz-Carrasquillo R
- Ossino N
- Otasevic P
- Otava M
- Otis R
- Otterstad Je
- Ouimet F
- Overhoff U
- Ozcan It
- O’Neil G
- P Pais
- P Peters
- P Piatti
- P Poliacik
- P Povolny
- P Purnell
- Pacora Ff
- Paez H
- Paganini M
- Page A
- Pagett K
- Pagnan M
- Pai R
- Pai V
- Palaniswami N
- Palatkina T
- Palchick B
- Pales J
- Paliwal Y
- Palka J Jr
- Palubova L
- Pande R
- Pandey S
- Paniagua A
- Pannell R
- Panov A
- Pansheriya A
- Panzarino C
- Papke B
- Parekh N
- Parente A
- Parepa I
- Parfait V
- Park B
- Park C
- Parmon E
- Partridge J
- Patel B
- Patel J
- Patel M
- Patel R
- Patel R
- Patel S
- Patino Jm
- Patole T
- Patsilinakos S
- Paulweber B
- Pavlickova L
- Paysor C
- Paz S
- Peck C
- Pella D
- Pena A
- Pencz I
- Peng L
- Penzes J
- Pereira S
- Perez Manghi F
- Perez A
- Perez M
- Perkins H
- Perkins L
- Perlstein T
- Perotti M
- Perperis A
- Perry B
- Pesce F
- Petelina T
- Peter Y
- Peterka M
- Petrauskiene B
- Petrescu L
- Petrillo C
- Petrov D
- Petrova I
- Petrusheva T
- Pettersen Ki
- Peukert Am
- Phillippi C
- Phillips A
- Phillips A
- Piacente R
- Pieretti Hb
- Pinheiro L
- Pintado M
- Pirenne B
- Pish R
- Piskorz D
- Pitt W
- Planinc I
- Ploechl A
- Plotz M
- Podoleanu C
- Pogson A
- Pokorna B
- Polato C
- Poling T
- Pomposini D
- Ponce T
- Poock J
- Pool T
- Poor F
- Pop Cf
- Popa V
- Popescu E
- Popovic Z
- Potts J
- Poudrier R
- Poulimenos L
- Pradhan A
- Pramatarova I
- Praveen M
- Prenner A
- Price D
- Price R
- Prior J
- Priori S
- Pritchard C
- Procter K
- Pupic L
- Purighalla R
- Pye M
- Qing L
- Quddusi K
- Quinones J
- Quinton D
- R Rauch
- R Recoaro
- R Reyes
- R Roettges
- R Rummel
- Racca V
- Radde I
- Radeljic V
- Radhakrishnan V
- Radin M
- Radoi M
- Radojcsics B
- Radvan M
- Raev D
- Ragghianti B
- Raghu C
- Rajan B A
- Rajasekhar D
- Rajput B
- Raju Ss
- Rama B
- Ramdas S
- Ramos G
- Ramos M
- Rancane G
- Randvee L
- Ranjith N
- Rao M
- Rao Mb
- Rao Nm
- Rassi S
- Rathnavel S
- Rathore A
- Rathore Srs
- Ratnik E
- Rau T
- Rawat S
- Raynes K
- Reber Am
- Reddy J
- Reddy Nc
- Redfearn H
- Rees Dh
- Reeves M
- Regner S
- Reichenbach D
- Reilly K
- Reimand M
- Reimer D
- Reinmets S
- Reis G
- Reis H
- Ren L
- Renaud K
- Renda G
- Repin A
- Resende I
- Resnick H
- Rewbury J
- Reznakova S
- Reznik I
- Rhudy Jm
- Richardson M
- Richert L
- Rickova Z
- Ridker Pm
- Riethof M
- Righini V
- Rinke A
- Risberg K
- Risenfors M
- Riser J
- Rivis L
- Robbins K
- Roberts-Thomson P
- Robinson S
- Rodero M
- Rodriguez Araya E
- Rodriguez A
- Rodriguez D
- Rodriguez J
- Rodriguez Lm
- Rodriguez Sm
- Roel A
- Romano A
- Romanski A
- Roos J
- Roper L
- Ross B
- Rossi Prf
- Rost N
- Roszkowska P
- Rotreklova M
- Roy A
- Roy C
- Roy M
- Rozeman P
- Ruder D
- Rudys A
- Ruffini L
- Rugo H
- Runev N
- Runquist L
- Rupka D
- Ruschel K
- Ryding A
- Rönndahl M
- Rønnevik P
- Rønnevik Td
- S Sarah
- S Sasaki
- S Sathe
- S Seki
- S Sharma
- S Shayani
- S Shetty
- S Shustov
- S Srivastava
- S Stadelmeier
- S Stoltz
- S Strand
- S Strugatsky
- S Such
- Sabo L
- Sack G
- Sahin M
- Sahin T
- Saini R
- Saint-Jacques H
- Saka B
- Sakamoto Y
- Sakurada M
- Salfity M
- Salinger M
- Salko T
- Sall N
- Saloustros I
- Salvador L
- Sam K
- Samal A
- Samer H
- Samkova D
- Sanchez Vallejo G
- Sanchez A
- Sanchez D
- Sang X
- Santiago J Jr
- Santosh Mj
- Sanuri M
- Saporito W
- Saraiva Jf
- Saravia Ma
- Sarbu I
- Sarcone M
- Sarjanovich R
- Sarma R
- Sarnighausen He
- Sarszegi Z
- Sattar N
- Saunders K
- Savard D
- Savignano C
- Saylor R
- Sazonova E
- Scaro G
- Scheffel M
- Scheibner T
- Schermaul Kh
- Schiavi Lb
- Schifferdecker B
- Schindler A
- Schindler A
- Schindler E
- Schlundt C
- Schmidt E
- Schmidt K
- Schnabel A
- Schneider P
- Schneider R
- Schnitzler R
- Schoen N
- Schorn K
- Schrager B
- Schroeder T
- Schulenburg D
- Schultz C
- Schulz M
- Schulze J
- Schulze U
- Schumacher M
- Schwartz A
- Schwerin G
- Schwerin M
- Schäfer B
- Sciborski R
- Scott J
- Scott R
- Seals A
- Senni M
- Sergienko T
- Seroqui M
- Servaes V
- Sesto I
- Seung Kb
- Shah A
- Shah Av
- Shah J
- Shaikh P
- Shanahan T
- Shaposhnik I
- Shapovalova Y
- Sharma K
- Sharma T
- Sharp A
- Shatsky K
- Shaw P
- Shealy N
- Sheets L
- Shelley J
- Shepard P
- Shetty P
- Shimokawa H
- Shimomura H
- Shinozaki T
- Shvarts Y
- Sidhu G
- Siemann M
- Sigurdadottir E
- Sigurdsson A
- Silva R
- Silver K
- Simay A
- Sime I
- Simon J
- Simon M
- Simons N
- Simpson H
- Singerling M
- Singh K
- Singh N
- Singh V
- Singhal A
- Sinnaeve P
- Siostrzonek P
- Sirakova-Taseva A
- Sirnes Pa
- Sizemore Bc
- Skalicka H
- Skatrud L
- Skjelvan G
- Skopets I
- Skubova K
- Skuladottir F
- Skuratova M
- Slanina M
- Slapikas R
- Slayton C
- Slechticka A
- Slimak V
- Sloane G
- Smallwood B
- Smeele F
- Smik R
- Smith B
- Smith G
- Smith J
- Smith J
- Smith M
- Smith M
- Smith P
- Smith T
- Smith W
- Smith W
- Smolenskaya O
- Soca Y
- Socoteanu E
- Socoteanu G
- Sofley C
- Sohi Gs
- Solares A
- Soler J
- Solovev O
- Song M
- Sopko K
- Soro E
- Sorodoc L
- Sosa-Padilla M
- Sotolongo R
- Sotomayor A
- Soucy D
- Spiridon M
- Sprinkle B
- Squire I
- Srdos V
- Srinath Vs
- St Amour E
- Stahl A
- Stahl Hd
- Stanciulescu G
- Starzec M
- Stefanescu M
- Steinhoff J
- Stelly L
- Steringer-Mascherbauer R
- Stern M
- Sternthal P
- Stinson J
- Stitova M
- Stockhausen G
- Stockhausen J
- Stoddard M
- Stoessel J
- Stofkova D
- Stokuca-Korac N
- Stolze K
- Stone B
- Stonkute K
- Storey R
- Stover T
- Strain J
- Stratmann M
- Strazdiene D
- Strbova J
- Stroes E
- Strohner-Kaestenbauer H
- Stys T
- Sugimoto N
- Suleman A
- Sullivan P
- Sun Z
- Sundelin R
- Suorra I
- Sutalo K
- Suzuki A
- Swart Hp
- Szacinski G
- Szakal I
- Szatmarine V
- Szocs A
- Szpajer M
- Szymanowski N
- T Tase
- T Tekten
- T Thuren
- T Tjaden
- Taguchi S
- Tahk S
- Tahon S
- Takahashi J
- Takase S
- Talliard C
- Tamburrini P
- Tamesby G
- Tamez W
- Tan M
- Tan R
- Tanabe K
- Tanaka A
- Tanaseanu C
- Tandon N
- Tani S
- Taqueti V
- Taran A
- Taverner P
- Tawfik R
- Teenan M
- Telekes P
- Teltser M
- Ten Holt W
- Terry K
- Terry Ps
- Tesak M
- Teschner Ab
- Teske A
- Tessmar C
- Thakkar B
- Thekkoott D
- Theunissen E
- Thiessen S
- Thomas D
- Thomas Dm
- Thomas H
- Thompson E
- Thompson J
- Thornton A
- Tijuneliene E
- Tinnirello V
- Tisheva-Gospodinova S
- Tobias C
- Todorova A
- Tomassi A
- Tomioka J
- Toom M
- Topper J
- Torgersruud M
- Torstensson I
- Torun A
- Toth P
- Townend J
- Tran A
- Treasure C
- Trenkamp P
- Trevelyan J
- Trevino M
- Trofimov V
- Troquay Rpt
- Tsai Mc
- Tsao Hm
- Tsioufis K
- Tsorbatzoglou K
- Tsou L
- Tsuboi H
- Tsuji M
- Tsujita K
- Tsujiyama S
- Tudoran M
- Tuholske C
- Turner F
- Tusek S
- Tzekova M
- Tzong L
- Ucar N
- Uecker C
- Ueng Kc
- Umesu A
- Unterkircher B
- Urbonas G
- Uresin S
- Urgeova L
- Urina M
- Urina-Triana M
- Uy W
- V Vahula
- V Vijan
- V Vora
- Vahtel M
- Vaid B
- Valenzuela M
- Valle M
- Vallejo Ma
- Vallone L
- Van Der Wal M
- Van Der Zwaan C
- Van Genechten G
- Van Kempen Ww
- Van Maarseveen M
- Van Stein I
- Vanagiene S
- Vance A
- Vandam J
- Vanhecke T
- Vanness WC Iii
- Vardas P
- Vargas R
- Varigos J
- Vasiliev M
- Vaz S
- Vazquez Tanus J
- Veerina K
- Vega J
- Vegsundvåg J
- Veit S
- Velusamy K
- Vento A
- Venturini C
- Vertes G
- Vervoort G
- Vesely J
- Vesely P
- Vesga B
- Vettus R
- Veze I
- Vezikova N
- Vezina M
- Vibert J
- Vicente C
- Vico Ml
- Vida-Simiti L
- Vieira N
- Viergever Ep
- Viezelis M
- Vijay N
- Villani Gq
- Vinanska D
- Vincelli G
- Vins P
- Viola Hg
- Visseren Flj
- Vissers C
- Vitovec M
- Vodnansky P
- Voelker F
- Voeller H
- Vogel M
- Vogt E
- Vold D
- Volpe M
- Voors C
- Vora K
- Vorster M
- Voyzey Ej
- Vozzhaev A
- Vranckx P
- Vrolix M
- Vuriya Ak
- W Wu
- Wade Rd
- Wadell C
- Wakeling J
- Waksman R
- Walker K
- Walker K
- Wallace K
- Walter I
- Walter J
- Walther I
- Walukiewicz P
- Wanderley Ff
- Wang Cp
- Wang Hc
- Wang J
- Wang Y
- Wang Yl
- Warren M
- Washam M
- Watson B
- Webel R
- Weber Hg
- Wei J
- Wei N
- Weimer J
- Weisnagel Sj
- Wells T
- West M
- Westberg Jc
- Whitaker J
- White A
- White A
- White C
- White J
- Wichterich K
- Wiebusch A
- Wilhoit G
- Wilkins M
- Wilkinson S
- William M
- Willingham K
- Willmerdinger M
- Willner C
- Wilson S
- Wilson V
- Winkelmann B
- Winkler J
- Wise J
- Wistuba T
- Woehrle J
- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Operation and performance of the ATLAS Tile Calorimeter in Run 1
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouelfadl 
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
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- Alconada Verzini MJ
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- Aleksa M
- Aleksandrov IN
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- Alkire SP
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- Zwalinski L
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeter’s performance during the years 2008–2012 using cosmic-ray muon events and proton–proton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fb−1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from proton–proton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report
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