315 research outputs found
Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury
- Author
- AJ Wardlaw
- C Kuhn
- CD Funk
- DJ Dupre
- DO Slosman
- E Fireman
- E Mazzon
- FH Green
- GL Snider
- GS Warshamana
- H Mensing
- J Wijnholds
- J Wilborn
- JF Blain
- KD Rainsford
- L Chilton
- LH Pan
- M Kolb
- M Peters-Golden
- M Selman
- MJ Coffey
- PF Piguet
- PF Piguet
- PF Piguet
- PI Latsi
- RP Charbeneau
- S Cuzzocrea
- S Maeba
- S Prechtl
- SH Phan
- SH Phan
- SP Cole
- T Ashcroft
- T Nagase
- T Ozaki
- T Ozaki
- T Schaub
- TC Beller
- TC Beller
- V Gekeler
- VA Ziboh
- WJ Van
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
Leukotrienes are increased locally in idiopathic pulmonary fibrosis. Furthermore, a role for these arachidonic acid metabolites has been thoroughly characterized in the animal bleomycin model of lung fibrosis by using different gene knock-out settings. We investigated the efficacy of pharmacological inhibition of leukotrienes activity in the development of bleomycin-induced lung injury by comparing the responses in wild-type mice with mice treated with zileuton, a 5-lipoxygenase inhibitor and MK-571, a cys-leukotrienes receptor antagonist. Mice were subjected to intra-tracheal administration of bleomycin or saline and were assigned to receive either MK-571 at 1 mg/Kg or zileuton at 50 mg/Kg daily. One week after bleomycin administration, BAL cell counts, lung histology with van Gieson for collagen staining and immunohistochemical analysis for myeloperoxidase, IL-1 and TNF-α were performed. Following bleomycin administration both MK-571 and zileuton treated mice exhibited a reduced degree of lung damage and inflammation when compared to WT mice as shown by the reduction of:(i) loss of body weight, (ii) mortality rate, (iii) lung infiltration by neutrophils (myeloperoxidase activity, BAL total and differential cell counts), (iv) lung edema, (v) histological evidence of lung injury and collagen deposition, (vi) lung myeloperoxidase, IL-1 and TNF-α staining. This is the first study showing that the pharmacological inhibition of leukotrienes activity attenuates bleomycin-induced lung injury in mice. Given our results as well as those coming from genetic studies, it might be considered meaningful to trial this drug class in the treatment of pulmonary fibrosis, a disease that still represents a major challenge to medical treatment
Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives
- Author
- AH Keenan
- AL Groeger
- AR Heller
- AS Cowburn
- B Xue
- BK Itariu
- Bruce A. Freeman
- CA Rouzer
- Chiara Cipollina
- CN Serhan
- DA Healy
- DS Straus
- E Mas
- ES Musiek
- FH Chilton
- FJ Schopfer
- Francisco J. Schopfer
- GC Shearer
- Giuseppe Danilo Norata
- HG Rose
- I Vedin
- JC McDaniel
- JH Wu
- JK Yao
- JT Dodge
- JT O'Flaherty
- K Ichihara
- KF Schulz
- KL Weaver
- L Tavazzi
- M Bouwens
- Matthew F. Muldoon
- ME Turini
- miocardico Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto
- MS Nielsen
- OD Rangel-Huerta
- P Patel
- P Saravanan
- P Singer
- PC Calder
- PC Norris
- SK Gebauer
- Sonia R. Salvatore
- T Cui
- T Maaloe
- T Strasser
- TH Lee
- U Martin
- VJ Hammond
- WS Powell
- WS Powell
- Y Lu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/04/2014
- Field of study
Dietary ω-3 polyunsaturated fatty acids (PUFAs) decrease cardiovascular risk via suppression of inflammation. The generation of electrophilic α,β-unsaturated ketone derivatives of the ω-3 PUFAs docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) in activated human macrophages is catalyzed by cyclooxygenase-2 (Cox-2). These derivatives are potent pleiotropic anti-inflammatory signaling mediators that act via mechanisms including the activation of Nrf2- dependent phase 2 gene expression and suppression of pro-inflammatory NF-κB-driven gene expression. Herein, the endogenous generation of ω-3 PUFAs electrophilic ketone derivatives and their hydroxy precursors was evaluated in human neutrophils. In addition, their dietary modulation was assessed through a randomized clinical trial. Methods: Endogenous generation of electrophilic omega-3 PUFAs and their hydroxy precursors was evaluated by mass spectrometry in neutrophils isolated from healthy subjects, both at baseline and upon stimulation with calcium ionophore. For the clinical trial, participants were healthy adults 30-55 years of age with a reported EPA+DHA consumption of ≤ 300 mg/day randomly assigned to parallel groups receiving daily oil capsule supplements for a period of 4 months containing either 1.4 g of EPA+DHA (active condition, n = 24) or identical appearing soybean oil (control condition, n = 21). Participants and laboratory technicians remained blinded to treatment assignments. Results: 5-lypoxygenase-dependent endogenous generation of 7-oxo-DHA, 7-oxo-DPA and 5-oxo-EPA and their hydroxy precursors is reported in human neutrophils stimulated with calcium ionophore and phorbol 12-myristate 13-acetate (PMA). Dietary EPA+DHA supplementation significantly increased the formation of 7-oxo-DHA and 5-oxo-EPA, with no significant modulation of arachidonic acid (AA) metabolite levels. Conclusions: The endogenous detection of these electro.©2014 Cipollina et al
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
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- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
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- Avolio G
- Ayoub MK
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- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
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- Bakker PJ
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- Baldin EM
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- Bannoura AAE
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- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
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- Zimmermann S
- Zinonos Z
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
- Author
- AJ Morris
- AM Tager
- B Saatian
- C Bonnans
- C Vancheri
- CW Lee
- D He
- D He
- DR Cerutis
- DS Im
- EJ van Corven
- F Hao
- FH Chilton
- FN van Leeuwen
- FR Postma
- G Tigyi
- GB Mills
- GM Gauvreau
- H Fan
- J Aoki
- J Aoki
- J Chun
- J Tong
- JH Newman
- JJ Contos
- JJ Contos
- JJ Ryan
- JL Cannon
- K Noguchi
- K Tabata
- M Averbeck
- M Idzko
- M Peters-Golden
- ML Toews
- MY Xu
- N Fukushima
- PA Padrid
- PX Elsas
- R Cummings
- RF Duff
- S An
- S Kalari
- S Li
- S Sammi
- SN Georas
- SY Lee
- T Doherty
- T Hashimoto
- T Hashimoto
- T Oguma
- T Sano
- Y Zhao
- Y Zhao
- Y Zhao
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Lysophosphatidic acid (LPA) plays a critical role in airway inflammation through G protein-coupled LPA receptors (LPA<sub>1-3</sub>). We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation.</p> <p>Methods</p> <p/> <p>Wild type, LPA<sub>1 </sub>heterozygous knockout mice (LPA<sub>1</sub><sup>+/-</sup>), and LPA<sub>2 </sub>heterozygous knockout mice (LPA<sub>2</sub><sup>+/-</sup>) were sensitized with inactivated <it>Schistosoma mansoni </it>eggs and local antigenic challenge with <it>Schistosoma mansoni </it>soluble egg Ag (SEA) in the lungs. Bronchoalveolar larvage (BAL) fluids and lung tissues were collected for analysis of inflammatory responses. Further, tracheal epithelial cells were isolated and challenged with LPA.</p> <p>Results</p> <p>BAL fluids from <it>Schistosoma mansoni </it>egg-sensitized and challenged wild type mice (4 days of challenge) showed increase of LPA level (~2.8 fold), compared to control mice. LPA<sub>2</sub><sup>+/- </sup>mice, but not LPA<sub>1</sub><sup>+/- </sup>mice, exposed to <it>Schistosoma mansoni </it>egg revealed significantly reduced cell numbers and eosinophils in BAL fluids, compared to challenged wild type mice. Both LPA<sub>2</sub><sup>+/- </sup>and LPA<sub>1</sub><sup>+/- </sup>mice showed decreases in bronchial goblet cells. LPA<sub>2</sub><sup>+/- </sup>mice, but not LPA<sub>1</sub><sup>+/- </sup>mice showed the decreases in prostaglandin E2 (PGE2) and LPA levels in BAL fluids after SEA challenge. The PGE2 production by LPA was reduced in isolated tracheal epithelial cells from LPA<sub>2</sub><sup>+/- </sup>mice. These results suggest that LPA and LPA receptors are involved in <it>Schistosoma mansoni </it>egg-mediated inflammation and further studies are proposed to understand the role of LPA and LPA receptors in the inflammatory process.</p
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aesky S
- Agar-Savedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
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- Arguin J-F
- Argyropoulos S
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- Arik M
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- Artamonov A
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- Arutinov D
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- Asman B
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- Astbury A
- Atkinson M
- Aubert B
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- Aurousseau M
- Avolio G
- Axen A
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- Azuma Y
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- Baccaglioni G
- Bacci C
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- Bachas K
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- Backhaus M
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
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- Banerjee P
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- Banfi D
- Bangert A
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- Bansil HS
- Barak L
- Baranov SP
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- Barberio EL
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- Barbero N
- Bardin DY
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- Blair RE
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- Bobrovnikov VS
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- Boeriu OEV
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- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yagci KD
- Yamada N
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Preventive Effects of Omega-3 and Omega-6 Fatty Acids on Peroxide Mediated Oxidative Stress Responses in Primary Human Trabecular Meshwork Cells
- Author
- A Izzotti
- A Izzotti
- A Terman
- AA Ghanem
- AF Clark
- AF Clark
- AF Clark
- AL Yu
- AP Simopoulos
- AP Simopoulos
- AS Roman
- B Hallahan
- BT Gabelt
- D Galimberti
- D Lanneau
- E Lutjen-Drecoll
- FH Chilton
- Friedrich E. Kruse
- G Li
- G Tezel
- H Ishikawa
- HM Den Ruijter
- JH Kang
- JL Walgren
- JP SanGiovanni
- K Wilson
- Kaustubh Datta
- Kerstin Birke
- KK Abu-Amero
- L Zhou
- M Ebrahimi
- M Pache
- M Tanwar
- Marco T. Birke
- MD Temple
- MS Filla
- P Bougnoux
- P Dumont
- PB Liton
- PB Liton
- PC Calder
- R Fuchshofer
- R Wall
- RJ Wordinger
- S Joachim
- SC Sacca
- SC Sacca
- SM Ferreira
- Theofilos Tourtas
- U Welge-Lussen
- Ulrich-Christoph Welge-Lüssen
- V Zanon-Moreno
- Y He
- Y He
- Y Lin
- Y Yoshida
- YR Lou
- Publication venue
- Public Library of Science
- Publication date
- 03/02/2012
- Field of study
Pathologic processes in glaucoma include increased apoptosis, accumulation of extracellular material in the trabecular meshwork and optic nerve, condensations of the cytoskeleton and precocious cellular senescence. Oxidative stress was shown to generate these alterations in primary ocular cells. Fatty acids omega-3 and -6 are alleged to constitute a prophylaxis against these deleterious effects. Here, we tested actual preventive effects omega-3 and -6 against peroxide induced stress responses in primary human trabecular meshwork cells. Changes of mitochondrial activity, proliferation, heat shock proteins, extracellular matrix components, and inflammatory markers were evaluated. Alterations of the cytoskeleton were evaluated by phalloidin labeling. Here we report a repressive effect of omega-6 on metabolic activity and proliferation, which was not detected for omega-3. Both agents were able to prevent the anti-proliferative effect of H2O2, but only omega-3 prevented metabolic repression. Expression of heat shock protein 27 was unaltered by both fatty acids, whereas heat shock protein 90 was significantly induced by both. Omega-6 increased fibronectin and connective tissue growth factor synthesis, as well as the amount of secreted fibronectin. Omega-3, instead, induced plasminogen activator inhibitor 1 synthesis. H2O2 further increased fibronectin production in omega-6 supplemented cells, which was not the case in omega-3 treated cells. H2O2 stimulation of plasminogen activator inhibitor 1 and connective tissue growth factor was repressed by both fatty acids. Both fatty acids appeared to abolish H2O2 mediated stimulation of nuclear factor κB and IL-6, but not IL-1α and IL-8. H2O2 induced formation of cross-linked actin networks and stress fibers, which was reduced by preemptive application of omega-3. Omega-6, in contrast, had no protective effect on that, and even seemed to promote condensation. Based on the observed side effects of omega-6, omega-3 appears to be the more beneficial fatty acid in respect of prophylactic intake for prevention of a glaucomatous disease
PGH1, the Precursor for the Anti-Inflammatory Prostaglandins of the 1-series, Is a Potent Activator of the Pro-Inflammatory Receptor CRTH2/DP2
- Author
- A Fraile-Ramos
- A Heinemann
- A Rossi
- A Sorkin
- AK Mandal
- Akos Heinemann
- AN Hata
- BR Conklin
- CA Rouzer
- CD Funk
- D Irikura
- E Böhm
- E Kostenis
- E Kostenis
- E Ricciotti
- EM Smyth
- EM Sturm
- Evi Kostenis
- FG Gervais
- FH Chilton
- G Clarke
- G de Gaetano
- G Levin
- G Monneret
- G Monneret
- GA FitzGerald
- GJ Sturm
- H Hirai
- H Hirai
- H Murota
- H Sandig
- HY Kim
- I Kompauer
- I Sabroe
- J Svensson
- JA Mitchell
- Jennifer L. Whistler
- JG Bell
- JL Whistler
- K Aritake
- K Nagata
- KJ Stebbins
- L Gazi
- L Hein
- L Uller
- L Xue
- Lene Martini
- Luzheng Xue
- M Camacho
- M Hamberg
- M Hohwy
- M Saito
- M Shichijo
- M Soler
- M Soler
- MW Buczynski
- N Sawyer
- Nora Kampitsch
- NW Lukacs
- R Nomiya
- R Pettipher
- R Salvatori
- R Schröder
- R Schröder
- R Schröder
- R Schuligoi
- Ralf Schröder
- RB Zurier
- RB Zurier
- RJ Flower
- RK Woods
- Roland Seifert
- Roy Pettipher
- S Demyanets
- S Kakutani
- SL Kunkel
- SS Ferguson
- T Inoue
- T Shimizu
- T Ulven
- Trond Ulven
- TW Ly
- V Konya
- V Konya
- Viktoria Konya
- WS Powell
- Y Kanaoka
- Y Kanaoka
- Y Shiraishi
- Y Shiraishi
- Y Urade
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Prostaglandin H1 (PGH1) is the cyclo-oxygenase metabolite of dihomo-γ-linolenic acid (DGLA) and the precursor for the 1-series of prostaglandins which are often viewed as “anti-inflammatory”. Herein we present evidence that PGH1 is a potent activator of the pro-inflammatory PGD2 receptor CRTH2, an attractive therapeutic target to treat allergic diseases such as asthma and atopic dermatitis. Non-invasive, real time dynamic mass redistribution analysis of living human CRTH2 transfectants and Ca2+ flux studies reveal that PGH1 activates CRTH2 as PGH2, PGD2 or PGD1 do. The PGH1 precursor DGLA and the other PGH1 metabolites did not display such effect. PGH1 specifically internalizes CRTH2 in stable CRTH2 transfectants as assessed by antibody feeding assays. Physiological relevance of CRTH2 ligation by PGH1 is demonstrated in several primary human hematopoietic lineages, which endogenously express CRTH2: PGH1 mediates migration of and Ca2+ flux in Th2 lymphocytes, shape change of eosinophils, and their adhesion to human pulmonary microvascular endothelial cells under physiological flow conditions. All these effects are abrogated in the presence of the CRTH2 specific antagonist TM30089. Together, our results identify PGH1 as an important lipid intermediate and novel CRTH2 agonist which may trigger CRTH2 activation in vivo in the absence of functional prostaglandin D synthase
Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya S Tapia
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkin RJ
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Bakker PJ
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee Sw
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo JT
- Barklow T
- Barlow N
- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimaraes da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Bell AS
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertram IA
- Bertsche C
- Besjes GJ
- Bessner M
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan AJ
- Beyer J
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Bisanz T
- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blunier Dr
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Bock C
- Boeriu OE Vickey
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bolz AE
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
- Boscherini D
- Bosman M
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt A
- Brandt G
- Brandt O
- Braren F
- Bratzler U
- Brau B
- Brau JE
- Brendlinger K
- Brennan AJ
- Brenner L
- Brenner R
- Bressler S
- Bret M Cano
- Briglin DL
- Bristow TM
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks T
- Brooks WK
- Brost E
- Broughton JH
- Bruncko D
- Bruni A
- Bruni G
- Bruni LS
- Bruno S
- Brunt BH
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Buescher D
- Buescher V
- Bugge MK
- Bulekov O
- Bullock D
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burka K
- Burke S
- Burmeister I
- Burr JTP
- Buschmann E
- Bussey P
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund O Bessidskaia
- Cabras G
- Cabrera Urban S
- Caforio D
- Cai H
- Cairo VMM
- Cakir I Turk
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camarda S
- Camarri P
- Cameron D
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
- Cantero J
- Cao T
- Cao Y
- Caprini I
- Caprini M
- Capua M
- Carbone RM
- Cardarelli R
- Cardillo F
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carra S
- Carrillo-Montoya GD
- Casadei D
- Casado MP
- Casha AF
- Casolino M
- Casper DW
- Castelijn R
- Castillo Gimenez V
- Castillo LR Flores
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Ceradini F
- Cerda Alberich L
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chafaq A
- Chakraborty D
- Chan SK
- Chan WS
- Chan YL
- Chang P
- Chapman JD
- Charlton DG
- Chau CC
- Chavez Barajas CA
- Che S
- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen C
- Chen H
- Chen J
- Chen J
- Chen S
- Chen S
- Chen X
- Chen Y
- Chen Y-H
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chouridou S
- Chow YS
- Christodoulou V
- Chu MC
- Chudoba J
- Chuinard AJ
- Chwastowski JJ
- Chytka L
- Cinca D
- Cindro V
- Cioara IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Clark A
- Clark MR
- Clark PJ
- Clarke RN
- Clement C
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Colasurdo L
- Cole B
- Colijn AP
- Collaboration ATLAS
- Collot J
- Conde Muino P
- Coniavitis E
- Connell SH
- Connelly IA
- Constantinescu S
- Conventi F
- Cooper-Sarkar AM
- Corga K De Vasconcelos
- Cormier F
- Cormier KJR
- Cornell S Diez
- Corradi M
- Correia AM Henriques
- Corrigan EE
- Corriveau F
- Cortes-Gonzalez A
- Costa MJ
- Costanzo D
- Cottin G
- Cowan G
- Cox BE
- Crane J
- Cranmer K
- Crawley SJ
- Creager RA
- Cree G
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cukierman AR
- Curatolo M
- Cuth J
- Czekierda S
- Czodrowski P
- D'amen G
- D'Auria S
- D'eramo L
- D'Onofrio M
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dale O
- Dallaire F
- Dallapiccola C
- Dam M
- Damazio D Oliveira
- Dandoy JR
- Daneri MF
- Dang NP
- Dann NS
- Danninger M
- Dao V
- Darbo G
- Darmora S
- Dartsi O
- Dattagupta A
- Daubney T
- Davey W
- David C
- Davidek T
- Davis DR
- Dawe E
- Dawson I
- de Asmundis R
- De Benedetti A
- De Bruin PH Sales
- De Castro S
- De Cecco S
- De Groot N
- de Jong P
- De la Torre H
- de Lima DE Ferreira
- De Lorenzi F
- De Maria A
- De Pedis D
- De Regie JB De Vivie
- de Renstrom PA Bruckman
- De Salvo A
- De Sanctis U
- De Santo A
- De K
- Debenedetti C
- Dedovich DV
- Dehghanian N
- Del Gaudio M
- Del Peso J
- Delgove D
- Deliot F
- Delitzsch CM
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- della Volpe D
- Delmastro M
- Delporte C
- Delsart PA
- DeMarco DA
- Demers S
- Demichev M
- Denisov SP
- Denysiuk D
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Deterre C
- Dette K
- Devesa MR
- Deviveiros PO
- Dewhurst A
- Dhaliwal S
- Di Bello FA
- Di Ciaccio A
- Di Ciaccio L
- Di Clemente WK
- Di Donato C
- Di Girolamo A
- Di Micco B
- Di Nardo R
- Di Petrillo KF
- Di Simone A
- Di Sipio R
- Di Valentino D
- Diaconu C
- Diamond M
- Dias do Vale T
- Dias FA
- Diaz MA
- Dickinson J
- Diehl EB
- Dietrich J
- Dimitrievska A
- Dingfelder J
- Dittus F
- Djama F
- Djobava T
- Djuvsland JI
- do Vale MAB
- Dobre M
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Donadelli M
- Donini J
- Donszelmann T Cuhadar
- Dopke J
- Doria A
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Dris M
- Du Y
- Duarte-Campderros J
- Dubinin F
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducourthial A
- Ducu OA
- Duda D
- Dudarev A
- Dudder A Chr
- Duehrssen M
- Dueren M
- Duffield EM
- Duflot L
- Dulsen C
- Dumancic M
- Dumitriu AE
- Duncan AK
- Dunford M
- Duperrin A
- Durglishvili A
- Duschinger D
- Dutta B
- Duvnjak D
- Dyndal M
- Dziedzic BS
- Eckardt C
- Ecker KM
- Edgar RC
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Kacimi M
- El Kosseifi R
- El Moursli R Cherkaoui
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Enari Y
- Ennis JS
- Epland MB
- Erdmann J
- Ereditato A
- Errede S
- Escalier M
- Escobar C
- Esposito B
- Estrada Pastor O
- Etienvre AI
- Etzion E
- Evans H
- Ezhilov A
- Ezzi M
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fang Y
- Fanti M
- Farbin A
- Farilla A
- Farina EM
- Farooque T
- Farrell S
- Farrington SM
- Farthouat P
- Fassi F
- Fassnacht P
- Fassouliotis D
- Favareto A
- Fawcett WJ
- Fayard L
- Fedin OL
- Fedorko W
- Feickert M
- Feigl S
- Feligioni L
- Feng C
- Feng EJ
- Feng M
- Fenton MJ
- Fenyuk AB
- Feremenga L
- Ferrando J
- Ferrari A
- Ferrari P
- Ferrari R
- Ferrer A
- Ferrere D
- Ferretti C
- Fiedler F
- Filipcic A
- Filthaut F
- Fincke-Keeler M
- Finelli KD
- Fiolhais MCN
- Fiorini L
- Fischer C
- Fischer J
- Fisher WC
- Flaschel N
- Fleck I
- Fleischmann P
- Fletcher RRM
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- Zhemchugov A
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level
Search for the direct production of charginos and neutralinos in final states with tau leptons in √s=13 TeV collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Albergh GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee Sw
- Bannoura AAE
- Barajas CA Chavez
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo JT
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
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- Becker K
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- Beddall A
- Beddall AJ
- Bednyakov VA
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- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behr JK
- Bell AS
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
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- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernardi G
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- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
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- Blum W
- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Bock C
- Boehler M
- Boeriu OE Vickey
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bolz AE
- Bomben M
- Bona M
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
- Boscherini D
- Bosman M
- Bossio Sola JD
- Boudreau J
- Bouffard J
- Bouhova-Thacker EV
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- Yigitbasi E
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
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- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
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- Zemaityte G
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
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- Zhang G
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- Zhang J
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- Zhang M
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- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fb−1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13TeV.Nosignificant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of ˜χ+1 ˜χ−1 pair production and of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the ˜ τL state is set to be halfway between the masses of the ˜χ±1 and the ˜χ01. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of ˜χ+1 ˜χ−1 for a massless ˜χ01. Common ˜χ±1 and ˜χ02 masses up to 760 GeV are excluded in the case of production of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 assuming a massless ˜χ01. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the ˜χ±1 and the ˜χ01 are also studied by varying the ˜ τL mass between the masses of the ˜χ±1 and the ˜χ01
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
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- Aad G
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- Abdinov O
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- Abhayasinghe DK
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- Zhemchugov A
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- Zobernig G
- Zoccoli A
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- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
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