The Impact of 4-H Public Speaking Programs

Do 4-H programs that focus on oral presentations help youth develop academic or workforce-readiness skills such as planning, organization, leadership, and communication? Bottom Line Preliminary evidence suggests some possible positive outcomes from youth participation in public speaking programs, but more rigorous research is needed to confirm these findings

Navigating the Global Economy: A Comprehensive Analysis of the Massachusetts Maritime Economy

The Massachusetts Maritime Economy is comprised of 5,555 establishments that employ 90,482 workers, pay $3.4 billion in total wages, and account for$6.4 billion in gross state product. These businesses are a significant economic driver in Massachusetts, representing 2.6 percent of the Commonwealth’s direct employment and 1.3 percent of its direct gross state product. 5,555 establishments 90,482 employees $3.4 billion total wages$6.4 billion gross state product Employment in the industry compares favorably with other major sectors of the state’s economy, including the Information and Manufacturing sectors. Growth in the Massachusetts Maritime Economy Was More Robust Than the Statewide Industry Total Growth in Massachusetts’ Maritime Economy was generally more robust than the state as a whole from 2005 to 2015; employment grew by 18.2 percent from 2005 to 2015, compared to 8.4 percent for the statewide industry total. Gross State Product (48.0% vs. 32.1%) and Real Gross State Product (36.7% vs. 11.4%) also increased significantly more than the state total, although the number of establishments grew at a slower pace. The Maritime Economy Grew Through the Great Recession The Massachusetts Maritime Economy exhibited fairly consistent employment and real GSP growth throughout the economic cycle. While the Maritime Economy experienced a slight downturn in employment and real GSP in 2009, both indicators returned to an upward trajectory just a year later and this trend continued through 2014 and 2015. The Massachusetts Maritime Economy Is a Significant Economic Driver The Massachusetts Maritime Economy generated a total statewide economic impact of $17.336 billion in output (sales), 135,924 jobs, and$6.839 billion in labor income in 2015. Or put another way, with $9.828 billion in output, 90,482 workers, and$3.924 billion in labor income (direct impacts), maritime related businesses supported an additional $7.508 billion in output, 45,442 jobs, and$2.915 billion in labor income in the Massachusetts economy (indirect and induced impacts). Tourism & Recreation is the Largest Maritime Economy Sector There are six major sectors in the Massachusetts Maritime Economy: Living Resources Marine Construction Offshore Minerals Ship & Boat Building & Repair Tourism & Recreation (Coastal) Transportation Tourism & Recreation is by far the largest sector in terms of employment, although it accounts for a smaller share of total wages and gross state product. Conversely, the Marine Transportation sector, which includes Marine Technology, accounts for only 13 percent of employment, yet 35 percent of total wages and 35 percent of GSP, is primarily due to the high value of the products and services the sector provides. The Living Resources sector accounts for six percent of Maritime Economy employment. Employment in the sector has been declining since 2009, particularly in the fishing industry. Ship & Boat Building & Repair accounts for only small portions of employment and GSP due to the almost total absence of major ship and boat builders in the Commonwealth. (One portion of executive summary--much more in total summary, see PDF

Practical Guidance for the Management of Adverse Events in Patients with KRASG12C-Mutated Non-Small Cell Lung Cancer Receiving Adagrasib

Adagrasib (MRTX849) is a KRASG12C inhibitor with favorable properties, including long half-life (23 h), dose-dependent pharmacokinetics, and central nervous system (CNS) penetration. As of September 1, 2022, a total of 853 patients with KRASG12C-mutated solid tumors, including patients with CNS metastases, had received adagrasib (monotherapy or in combination). Adagrasib-related treatment-related adverse events (TRAEs) are generally mild to moderate in severity, start early in treatment, resolve quickly with appropriate intervention, and result in a low rate of treatment discontinuation. Common TRAEs seen in clinical trials included gastrointestinal-related toxicities (diarrhea, nausea, and vomiting); hepatic toxicities (increased alanine aminotransferase/aspartate aminotransferase) and fatigue, which can be managed through dose modifications, dietary modifications, concomitant medications (such as anti-diarrheals and anti-emetics/anti-nauseants) and the monitoring of liver enzymes and electrolytes. To manage common TRAEs effectively, it is imperative that clinicians are informed, and patients are fully counseled on management recommendations at treatment initiation. In this review, we provide practical guidance on the management of adagrasib TRAEs and discuss some best practices for patient and caregiver counseling to facilitate optimal outcomes for patients. Safety and tolerability data from the phase II cohort of the KRYSTAL-1 study will be reviewed and presented with practical management recommendations based on our experience as clinical investigators

Groups of Galaxies in AEGIS: The 200 ksec Chandra Extended X-ray Source catalogue

We present the discovery of seven X-ray emitting groups of galaxies selected as extended X-ray sources in the 200 ksec Chandra coverage of the All-wavelength Extended Groth Strip International Survey (AEGIS). In addition, we report on AGN activity associated to these systems. Using the DEEP2 Galaxy Redshift Survey coverage, we identify optical counterparts and determine velocity dispersions. In particular, we find three massive high-redshift groups at z>0.7, one of which is at z=1.13, the first X-ray detections of spectroscopically selected DEEP2 groups. We also present a first look at the the L_X-T, L_X-sigma, and sigma-T scaling relations for high-redshift massive groups. We find that the properties of these X-ray selected systems agree well with the scaling relations of similar systems at low redshift, although there are X-ray undetected groups in the DEEP2 catalogue with similar velocity dispersions. The other three X-ray groups with identified redshifts are associated with lower mass groups at z~0.07 and together form part of a large structure or "supergroup" in the southern portion of the AEGIS field. All of the low-redshift systems are centred on massive elliptical galaxies, and all of the high-redshift groups have likely central galaxies or galaxy pairs. All of the central group galaxies host X-ray point sources, radio sources, and/or show optical AGN emission. Particularly interesting examples of central AGN activity include a bent-double radio source plus X-ray point source at the center of a group at z=0.74, extended radio and double X-ray point sources associated to the central galaxy in the lowest-redshift group at z=0.066, and a bright green valley galaxy (part of a pair) in the z=1.13 group which shows optical AGN emission lines.Comment: accepted to MNRAS, 15 pages, 11 figures, for version with full resolution figures see http://www.ucolick.org/~tesla/aegis_groups.ps.g

AEGIS: Demographics of X-ray and Optically Selected AGNs

We develop a new diagnostic method to classify galaxies into AGN hosts, star-forming galaxies, and absorption-dominated galaxies by combining the [O III]/Hbeta ratio with rest-frame U-B color. This can be used to robustly select AGNs in galaxy samples at intermediate redshifts (z<1). We compare the result of this optical AGN selection with X-ray selection using a sample of 3150 galaxies with 0.3<z<0.8 and I_AB<22, selected from the DEEP2 Galaxy Redshift Survey and the All-wavelength Extended Groth Strip International Survey (AEGIS). Among the 146 X-ray sources in this sample, 58% are classified optically as emission-line AGNs, the rest as star-forming galaxies or absorption-dominated galaxies. The latter are also known as "X-ray bright, optically normal galaxies" (XBONGs). Analysis of the relationship between optical emission lines and X-ray properties shows that the completeness of optical AGN selection suffers from dependence on the star formation rate and the quality of observed spectra. It also shows that XBONGs do not appear to be a physically distinct population from other X-ray detected, emission-line AGNs. On the other hand, X-ray AGN selection also has strong bias. About 2/3 of all emission-line AGNs at L_bol>10^44 erg/s in our sample are not detected in our 200 ks Chandra images, most likely due to moderate or heavy absorption by gas near the AGN. The 2--7 keV detection rate of Seyfert 2s at z~0.6 suggests that their column density distribution and Compton-thick fraction are similar to that of local Seyferts. Multiple sample selection techniques are needed to obtain as complete a sample as possible.Comment: 24 pages, 14 figures, submitted to ApJ. Version 2 matches the ApJ accepted version. Sec 3 was reorganized and partly rewritten with one additional figure (Fig.3

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming

BACKGROUND: Although chronic morbidity in humans from soil transmitted helminth (STH) infections can be reduced by anthelmintic treatment, inconsistent diagnostic tools make it difficult to reliably measure the impact of deworming programs and often miss light helminth infections. METHODS: Cryopreserved stool samples from 796 people (aged 2-81 years) in four villages in Bungoma County, western Kenya, were assessed using multi-parallel qPCR for 8 parasites and compared to point-of-contact assessments of the same stools by the 2-stool 2-slide Kato-Katz (KK) method. All subjects were treated with albendazole and all Ascaris lumbricoides expelled post-treatment were collected. Three months later, samples from 633 of these people were re-assessed by both qPCR and KK, re-treated with albendazole and the expelled worms collected. RESULTS: Baseline prevalence by qPCR (n = 796) was 17 % for A. lumbricoides, 18 % for Necator americanus, 41 % for Giardia lamblia and 15% for Entamoeba histolytica. The prevalence was <1% for Trichuris trichiura, Ancylostoma duodenale, Strongyloides stercoralis and Cryptosporidium parvum. The sensitivity of qPCR was 98% for A. lumbricoides and N. americanus, whereas KK sensitivity was 70% and 32%, respectively. Furthermore, qPCR detected infections with T. trichiura and S. stercoralis that were missed by KK, and infections with G. lamblia and E. histolytica that cannot be detected by KK. Infection intensities measured by qPCR and by KK were correlated for A. lumbricoides (r = 0.83, p < 0.0001) and N. americanus (r = 0.55, p < 0.0001). The number of A. lumbricoides worms expelled was correlated (p < 0.0001) with both the KK (r = 0.63) and qPCR intensity measurements (r = 0.60). CONCLUSIONS: KK may be an inadequate tool for stool-based surveillance in areas where hookworm or Strongyloides are common or where intensity of helminth infection is low after repeated rounds of chemotherapy. Because deworming programs need to distinguish between populations where parasitic infection is controlled and those where further treatment is required, multi-parallel qPCR (or similar high throughput molecular diagnostics) may provide new and important diagnostic information

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

A high-precision near-infrared survey for radial velocity variable low-mass stars using CSHELL and a methane gas cell

We present the results of a precise near-infrared (NIR) radial velocity (RV) survey of 32 low-mass stars with spectral types K2-M4 using CSHELL at the NASA InfraRed Telescope Facility in the K band with an isotopologue methane gas cell to achieve wavelength calibration and a novel, iterative RV extraction method. We surveyed 14 members of young (≈25-150 Myr) moving groups, the young field star ϵ Eridani, and 18 nearby (&lt;25 pc) low-mass stars and achieved typical single-measurement precisions of 8-15 m s-1with a long-term stability of 15-50 m s-1 over longer baselines. We obtain the best NIR RV constraints to date on 27 targets in our sample, 19 of which were never followed by high-precision RV surveys. Our results indicate that very active stars can display long-term RV variations as low as ∼25-50 m s-1 at ≈2.3125 μm, thus constraining the effect of jitter at these wavelengths. We provide the first multiwavelength confirmation of GJ 876 bc and independently retrieve orbital parameters consistent with previous studies. We recovered RV variabilities for HD 160934 AB and GJ 725 AB that are consistent with their known binary orbits, and nine other targets are candidate RV variables with a statistical significance of 3σ-5σ. Our method, combined with the new iSHELL spectrograph, will yield long-term RV precisions of ≲5 m s-1 in the NIR, which will allow the detection of super-Earths near the habitable zone of mid-M dwarfs

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.Peer reviewe