13 research outputs found
Cinacalcet for hypercalcaemic secondary hyperparathyroidism after renal transplantation: a multicentre, retrospective, 3-year study
Mineral metabolism in renal transplant recipients discontinuing cinacalcet at the time of transplantation: a prospective observational study
Knowledge, attitude and practice of family planning amongst community health extension workers in Kaduna State, Nigeria
Parvovirus B19 (B19) and cytomegalovirus (CMV) infections and anti-erythropoietin (anti-EPO) antibodies in patients on dialysis hyporesponsive to erythropoietin therapy
The calcium-sensing receptor
Cell surface sensors for extracellular Ca2+ and Mg2+51 provide an important mechanism for the regulation of diverse physiological processes by extracellular divalent mineral ions.53, 190 and 402 These ion sensors function as “calciostats” for Ca2+ and/or Mg2+ that not only regulate divalent mineral metabolism at the level of the whole organism but also control a variety of other cellular processes (e.g., salt and water handing in various epithelia and cell proliferation-differentiation) in terrestrial and aquatic animals, as well as in plants. This chapter will focus on the role of the extracellular calcium-sensing receptor (CaSR) in the mammalian parathyroid, kidney, and other tissues participating in divalent mineral ion homeostasis. The unique properties of the mammalian CaSR include: (1) Having extracellular Ca2+ and Mg2+ as its primary physiological ligands, establishing that ions can function as first messengers. (2) Responding with a millimolar EC50, close to the normal plasma ionized Ca2+ concentration, but several orders of magnitude higher than that for ligands of other G protein–coupled receptors. (3) Possessing a remarkable ability to detect small deviations from the normal ionized calcium concentration of 1.1–1.3 mM, making it an ideal sensor for Ca2+, functioning as a “calciostat.”
The identification of inherited disorders due to activating or inactivating mutations of the CaSR, basic research in CaSR biology, the development of CaSR-active compounds (calcimimetics), and the results from clinical trials of calcimimetics have established the biological roles of this receptor in mineral ion homeostasis and have suggested roles of the CaSR in several non-Ca2+ homeostatic processes. The reader is referred to Chapter 65 and other chapters in the section, “Regulation and Disorders of Calcium Homeostasis,” for additional information and background