11 research outputs found
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni Frascà
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
- Hitoshi Akiyama
- Holly Wang
- Hong Mao
- Hong Zhang
- Hongguang Zheng
- Hongli Lin
- Horacio Sessa
- Hugo Colombo
- Hugo Laviada Molina
- Hugo Roberto Kurtz Lisboa
- Humberto Pavon
- Hyuk-Sang Kwon
- Iain MacDougall
- Ian Fraser
- Idalia Acosta
- Ildiko Halmagyi
- In-Kyung Jeong
- Ines Bartolacci
- Ingrid Abrahamsen
- Ingrid Buganova
- Inna Kolesnyk
- Ioana Emilia Ferariu
- Irene Noronha
- Irina Glinkina
- Irina Osipova
- Iryna Dudar
- Isabel Erika Rucker Joerg
- Isabel Garcia
- Isam Marar
- Israel Hartman
- Iuliia Komisarenko
- Ivan Fushtey
- Ivan Ory
- Ivan Rychlik
- Ivan Rychlík
- Ivan Smirnov
- Ivan Topchii
- Ivan Villegas
- Iveta Smatanova
- Jaco Jurgens
- Jakkidi Reddy
- Jamal Hammoud
- James Conway
- James Januzzi
- James Welker
- Jan Culak
- Jana Babikova
- Jana Belobradkova
- Jana Dzuponova
- Janos Mucsi
- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
- Javier Nieto Iglesias
- Jayameena Peringat
- Jayant Kumar
- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
- Jeffrey Stephens
- Jeimeen Agra
- Jelena Ignjatovic
- Jesus Cuadrado
- Jesus Egido de Los Rios
- Jian Liu
- Jiao Sun
- Jinkui Yang
- Jiri Lastuvka
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- Joseph Abdallah
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- JungEun Lee
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- Kazunori Koyama
- Kazuyuki Mizuyama
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- Lawrence Leiter
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- Leslie Spry
- Levin A.
- Li Yuan Lee
- Lidia Bermudez
- Ligia Petrica
- Lilia Beatriz Schiavi
- Liliana Monica Angelescu
- Liliia Zub
- Liliya Martynyuk
- Lin Sun
- Lincoln Chapin
- Linong Ji
- Lisa Rich
- Liudmila Kvitkova
- Lori Yost
- Luca Chiovato
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- Lucas Rista
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- Ludger Rose
- Luigi Gnudi
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- Luis Asmarats Mercadal
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- Luis Enrique Herrera Jimenez
- Luis Fernando Flota Cervera
- Luis Henrique Canani
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- Meg Jardine
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- Ping Tu
- Pollock C.
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- Rangel Rangelov
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- Ravendran Govender
- Ravi Sarin
- Reddy Sreedhar
- Reginald Parker
- Rehan Symonds
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- Renata Bijata-Bronisz
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- Roberto Pecoits-Filho
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- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
- Rolando Zamarripa Escobedo
- Ronald Goldenberg
- Ronald Harris
- Ronald Watts
- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- Rosângela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
- Sailaja Ventrapragada
- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
- Sandor Keresztesi
- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
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- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.
- Author
- Aberson Christopher
- Aczel Balazs
- Adamkovic Matus
- Adamus Sylwia
- Adetula Adeyemi
- Adetula Gabriel Agboola
- Adiguzel Arca
- Adoric Vera Cubela
- Afhami Reza
- Agadullina Elena
- Agesin Bamikole Bamikole
- Ahlgren Lina
- Ahmed Afroja
- Ahn El Rim
- Akgoz Aysegul
- Akkas Handan
- Alaei Ravin
- Albayrak-Aydemir Nihan
- Allred Tara Bulut
- Almeida Inês
- Alper Sinan
- Alvarez Daniela Serrato
- Alves Sara
- Andreychik Michael
- Anjum Gulnaz
- Ankushev Vladislav
- Anne Michele
- Antazo Benedict
- Antfolk Jan
- Anton-Boicuk Lisa
- Antoniadi Maria
- Anvari Farid
- Arinze Azuka Ikechukwu
- Arinze Nwadiogo
- Arinze Nwadiogo Chisom
- Ariyabuddhiphongs Kris
- Armstrong Marie
- Arnal Jack
- Arriaga Patrícia
- Artner Richard
- Aruta John Jamir Benzon
- Arvanitis Alexios
- Ashworth Logan
- Ask Karl
- Askelund Adrian Dahl
- Atari Mohammad
- Azab Habiba
- Azevedo Flavio
- Azouaghe Soufian
- Babincak Peter
- Badidi Touhami
- Bai Hui
- Baklanova Ekaterina
- Balas Benjamin
- Balci Busra Bahar
- Ballada Christine Joy
- Ballantyne Tonia
- Balt Nina
- Baník Gabriel
- Barba-Sánchez Alan
- Barbosa Sergio
- Barzykowski Krystian
- Basabe Nekane
- Baskin Ernest
- Basnight-Brown Dana
- Batres Carlota
- Bavolar Jozef
- Beaudry Jennifer
- Becker Maja
- Behzadnia Behzad
- Beitner Julia
- Belaus Anabel
- Belhaj Abdelkarim
- Bennett-Day Brooke
- Berkessel Jana
- Bernardo Márcia
- Beshears Julie
- Betlehem Ruben
- Bhushan Braj
- Bialek Michal
- Bialobrzeska Olga
- Białek Michał
- Bijlstra Gijsbert
- Blake Khandis
- Blaut Agata
- Bloxsom Nicholas
- Bobowik Magdalena
- Bogatyreva Natalia
- Bokkour Ahmed
- Bonick Judson
- Borras-Guevara Martha Lucia
- Bosch Jasmijn
- Bosma Minke Jasmijn
- Boucher Leanne
- Boudesseul Jordane
- Bozdoc Andreea Ioana
- Bradford Maria
- Bran Alexandre
- Brandt Mark
- Bravo Olalla Niño
- Brohmer Hilmar
- Buchanan Erin
- Bundt Carsten
- Burak Elif Gizem Demirag
- Burin Debora
- Butt Muhammad Mussaffa
- Bylinina Lisa
- Caballero Amparo
- Cai Sun Jun
- Calin-Jageman Robert
- Calvillo Dustin
- Campos Olatz
- Capizzi Mariagrazia
- Carpentier Joelle
- Carrera Pilar
- Carvalho Lilian
- Ceary Chris
- Cellini Nicola
- Chandel Priyanka
- Chartier Christopher
- Charyate Abdelilah
- Chatard Armand
- Chen Sau-Chin
- Chen Zhang
- Chevallier Coralie
- Chittham Phakkanun
- Chiu Faith
- Choi Eunsoo
- Chopik William
- Chou Weilun
- Christopherson Cody
- Chuan-Peng Hu
- Coelho Gabriel Lins de Holanda
- Coetzee Vinet
- Cohen Noga
- Coles Nicholas
- Collins W. Matthew
- Colloff Melissa
- Cook Corey
- Corral-Frías Nadia
- Correa Pablo Sebastián
- Correia Rita
- Crawford Matthew
- Cruz Vásquez Julio
- Cubillas Carmelo
- Cyrus-Lai Wilson
- Czamanski-Cohen Johanna
- Czarnek Gabriela
- Cárcamo Rodrigo
- Daches Shimrit
- Dalgar Ilker
- Damnjanović Kaja
- Daniels Judith
- Danvers Alexander
- Davis William
- Day Chris
- De La Rosa-Gómez Anabel
- de Lima Tiago Jessé Souza
- de Souza Luana Elayne Cunha
- DeBruine Lisa
- del Carmen Espinoza Maria
- Delgado Lady Grey Javela
- Desai Kermeka
- Dixson Barnaby
- Dixson Barnaby James Wyld
- Djamai Ikhlas
- Djordjevic Jasna Milosevic
- Dodaj Arta
- Domurat Artur
- Dorison Charles
- Doğan Uğur
- Drexler Shira Meir
- Du Hongfei
- Du Xinkai
- Dubrov Dmitrii
- Dujols Olivier
- Dumont Kitty
- Dunham Yarrow
- Dunleavy Daniel
- Dursun Pinar
- Ebersole Charles
- Ebert Tobias
- El Arabi Kanza Ait
- Elouafa Jamal
- Escobar María Josefina
- Espinoza Barría Mauricio
- Esteban-Serna Celia
- Estrada-Mejia Catalina
- Etabari Zahra
- Eudave Luis
- Evans Kortnee
- Evans Thomas
- Eşkisu Mustafa
- FatahModarres Saiedeh
- Fedotov Maksim
- Feinberg David
- Feldman Gilad
- Fernandez Ana Maria
- Ferreira Ana
- Ferreira Diogo
- Ferreira Paulo
- Filip Katarzyna
- Findor Andrej
- Flake Jessica
- Floerke Victoria
- Flowe Heather
- Forbes Paul
- Foroni Francesco
- Forscher Patrick
- Freeman Jonathan
- Friedemann Maja
- Frizzo Thomas
- Frohlich Brooke
- Frías-Armenta Martha
- Galindo-Caballero Oscar
- Garcia Adolfo
- Garcia Elkin Oswaldo Luis
- Gardiner Gwendolyn
- Gawryluk Katarzyna
- Geiger Sandra
- Geniole Shawn
- Gialitaki Zoi
- Gilboa-Schechtman Eva
- Gilead Michael
- Gill Tripat
- Giolla Erik Mac
- Gjoneska Biljana
- Godbersen Hendrik
- Gogan Taylor
- Goldenberg Amit
- Golik Karolina
- González-Santoyo Isaac
- Gordon-Finlayson Alasdair
- Gourdon-Kanhukamwe Amélie
- Grano Caterina
- Gračanin Asmir
- Greenburgh Anna
- Grigoryev Dmitry
- Grinberg Maurice
- Gross James
- Groyecka-Bernard Agata
- Grzech Karolina
- Götz Friedrich
- Gülgöz Sami
- Habib Sumaiya
- Hahn Amanda
- Hajdu Nandor
- Hanel Paul
- Haque Shamsul
- Hareli Shlomo
- Hartanto Andree
- Harutyunyan Mikayel
- Hatami Javad
- Hedgebeth Mattie
- Hehman Eric
- Hofer Gabriela
- Holford Dawn Liu
- Hostler Thomas
- House Thea
- Hoyer Karlijn
- Hricova Monika
- Hristova Evgeniya
- Hruška Matej
- Hsu Rafael
- Hsu Tsuyueh
- Hu Chuan-Peng
- Hubena Barbora
- Ibanez Agustin
- Idzikowska Katarzyna
- Ihaya Keiko
- IJzerman Hans
- Inzlicht Michael
- Irrazabal Natalia
- Isager Peder Mortvedt
- Ishii Tatsunori
- Ishkhanyan Byurakn
- Ito Kenichi
- Ivanov Aleksandr
- Ivory James
- Iyer Aishwarya
- Izquierdo Sara Morales
- Jackson Emily
- Jaeger Bastian
- Janak Allison
- Jang Chaning
- Janjić Kristina
- Janssen Steve
- Jaremka Lisa
- Jarukasemthawee Somboon
- Jaworska Katarzyna
- Jernsäther Teodor
- Jiang Zhongqing
- Jimenez-Leal William
- Johannes Niklas
- Jones Benedict
- Jones Marc
- Jose Paul
- Joy-Gaba Jennifer
- Jurković Anita Penić
- Jzerman Hans
- Kadreva Veselina Hristova
- Kaliska Lada
- Kamburidis Julia
- Kaminski Gwenaël
- Kappes Heather
- Kapucu Aycan
- Karaarslan Cemre
- Karaaslan Aslan
- Karababa Alper
- Karashiali Christiana
- Kardum Igor
- Karekla Maria
- Karsten Julie
- Kassianos Angelos
- Kačmár Pavol
- Khaoudi Ahmed
- Khosla Meetu
- Kielińska Julita
- Kirgizova Komila
- Klein Richard
- Klevjer Kristoffer
- Kocalar Halil Emre
- Kocsel Natália
- Kocsor Ferenc
- Koehn Monica
- Kohlová Markéta Braun
- Kolen Anouk
- Konova Irina
- Koptjevskaja-Tamm Maria
- Korbmacher Max
- Kossowska Małgorzata
- Kovic Vanja
- Kowal Marta
- Kozma Luca
- Kołodziej Sabina
- Krafnick Anthony
- Kraus Sue
- Kremer Inbal
- Križanić Valerija
- Krupić Dajana
- Krupić Dino
- Kruse Elliott
- Kujur Pratibha
- Kung Chun-Chia
- Kung Franki
- Kunisato Yoshihiko
- Kunst Jonas
- Kurfali Merve
- Kurfalı Murathan
- Kushnir Elizaveta
- Kuzminska Anna
- Kácha Ondřej
- Kökönyei Gyöngyi
- Körner Anita
- Lamm Claus
- Landry Anais Thibault
- Law Wilbert
- Lazarevic Ljiljana
- Lee Ai-Suan
- Lee Jeong Min
- Lee Kean Mun
- Legate Nicole
- Lekkou Eleimonitria
- Leongómez Juan David
- Leonis Trinity
- Lerner Jennifer
- Levitan Carmel
- Levy Neil
- Lewis David
- Lewis Neil
- Lewis Savannah
- Li Manyu
- Li Ranran
- Li Yansong
- Lima Tiago
- Lin Hause
- Lin Yijun
- Lindemans Jan
- Lins Samuel
- Liu Qing-Lan
- Liuzza Marco Tullio
- Lu Jackson
- Lucas Marc
- Lutz Johannes
- Macapagal Paulo Manuel
- Maeura Nao
- Majeed Nadyanna
- Maldonado Mónica Alarcón
- Malik Sadia
- Mallik Peter
- Manavalan Mathi
- Manley Harry
- Manunta Efisio
- Marcu Gabriela
- Marcu Gabriela Mariana
- Marinova Evelina
- Markiewicz Łukasz
- Marko Dafne
- Marszalek Magdalena
- Martinez-Zelaya Gonzalo
- Martins Diogo
- Martončik Marcel
- Massoni Sébastien
- Mateo Nino Jose
- Maturan Princess Lovella G.
- Mburu Georgina
- McCarthy Randy
- Mefoh Philip
- Menon Madhavi
- Mensink Michael
- Mentser Sari
- Messerschmidt Johanna
- Metin-Orta Irem
- Michalak Nicholas
- Micheli Leticia
- Miller Jeremy
- Mioni Giovanna
- Miranda Jacob
- Misiak Michal
- Mokady Aviv
- Mola Débora
- Monajem Arash
- Monteiro Renan
- Moon Karis
- Moreau David
- Morey Richard
- Morvinski Coby
- Mosannenzadeh Farnaz
- Moshontz Hannah
- Muchembled Fany
- Mues Chiel
- Muminov Abdumalik
- Musser Erica
- Muñoz-Reyes Jose Antonio
- Nadif Khaoula
- Nakayama Masataka
- Nauman Rafia
- Ndukaihe Izuchukwu
- Nedelcheva-Datsova Mina
- Neyroud Lison
- Ng Wee Qin
- Nielsen Tonje
- Nilsonne Gustav
- Nock Nora
- Noone Chris
- Norton James
- Novak Sarah
- Nussinson Ravit
- Ogbonnaya Chisom Esther
- Oh Dong Won
- Okan Ceylan
- Oldmeadow Julian
- Oliveira Raquel
- Olofsson Jonas
- Olsen Jerome
- Ong Chew Wei
- Oosterlinck Marlies
- Orjiakor Charles
- Ortiz Manuel
- Ortiz María Victoria
- Ostermann Thomas
- Ouherrou Nihal
- Owsley Nicholas
- Ozery Daphna Hausman
- Očovaj Sanja Batić
- O’Mara Kunz Erin
- Pande Babita
- Pantazi Myrto
- Papachristopoulos Konstantinos
- Papadatou-Pastou Marietta
- Parashar Neha
- Parganiha Arti
- Paris Bastien
- Paruzel-Czachura Mariola
- Parveen Noorshama
- Parzuchowski Michal
- Pati Atanu Kumar
- Pavlacic Jeffrey
- Peltola Henna-Riikka
- Perillo Jennifer
- Peters Kim
- Pfuhl Gerit
- Philipp Michael
- Pich Olivia
- Pilecka Natalia
- Pineda Lina Maria Sanabria
- Pinto Isabel
- Pit Ilse
- Pizarro José
- Polo Pablo
- Pourafshari Razieh
- Pradhan Sraddha
- Primbs Maximilian
- Pronizius Ekaterina
- Protzko John
- Prusova Irina
- Przybylski Andrew
- Putz Ádám
- Páez Darío
- Pálfi Bence
- Pérez Laura Calderón
- Pöntinen Sara
- Qi Yue
- Quirin Markus
- Rachev Nikolay
- Radtke Theda
- Rahal Rima-Maria
- Rana Kafeel
- Razza Timothy
- Reeck Crystal
- Reggev Niv
- Reips Ulf-Dietrich
- Ren Dongning
- Rentfrow Peter
- Reyna Cecilia
- Ribeiro Gianni
- Ribeiro Matheus Fernando Felix
- Ribeiro Rafael
- Ricaurte Danilo Zambrano
- Richard Karley
- Ritchie Kay
- Ritchie Stuart
- Roczniewska Marta
- Rojas-Berscia Luis Miguel
- Romanova Marina
- Ropovik Ivan
- Rosa Anna Dalla
- Ross Robert
- Ruiz-Dodobara Fernando
- Ruiz-Fernández Susana
- Rule Nicholas
- Röer Jan Philipp
- Sacakli Asli
- Samojlenko Lara
- Sampaio Waldir
- Santos Anabela Caetano
- Santos Diana
- Sarda Elisa
- Saribay S. Adil
- Sarieva Irena
- Sarıoğuz Eylül
- Sato Wataru
- Saunders Blair
- Sawicki Przemysław
- Say Nicolas
- Schei Vidar
- Schild Christoph
- Schmid Irina
- Schmidt Kathleen
- Schmidt Nadya-Daniela
- Schorch Sebastian
- Schrover Elke
- Schrötter Jana
- Schubert Thomas
- Schwerdtfeger Andreas
- Schönefeld Victoria
- Schütz Astrid
- Searston Rachel
- Seehuus Martin
- Sesar Kristina
- Shani Yaniv
- Shankland Rebecca
- Sharifian MohammadHasan
- Sharman Leah
- Shiramazu Victor
- Sikka Pilleriin
- Silan Miguel
- Silva Jaime
- Simchon Almog
- Simonovic Nicolle
- Singer Gage
- Singh Margaret
- Sinkolova Sladjana
- Sirota Miroslav
- Sleegers Willem
- Sloane Guyan
- Solas Sara Álvarez
- Solorzano Claudio Singh
- Song Xin
- Sorokowska Agnieszka
- Sorokowski Piotr
- Soto Jose
- Sousa Daniela
- Sparacio Alessandro
- Stadel Marie
- Stanke Franziska
- Steffens Niklas
- Stephen Ian
- Stern Julia
- Sternglanz R. Weylin
- Stevens Laura
- Stewart Suzanne L.K.
- Stieger Stefan
- Stojanovska Dragana
- Stojanovska Marija
- Stolier Ryan
- Storage Daniel
- Stoyanova Alina
- Studzinska Anna
- Su-May Terri Tan
- Suavansri Panita
- Suchow Jordan
- Sullivan Gavin Brent
- Sunami Naoyuki
- Suter Lilian
- Sutherland Clare
- Sverdrup Therese
- Szabelska Anna
- Szala Anna
- Szaszi Barnabas
- Szecsi Peter
- Szwed Paulina
- Sánchez Oscar
- Taber Jennifer
- Taephant Nattasuda
- Tajchman Zuzanna
- Tamnes Christian
- Tan Chrystalle
- Tan Kok Wei
- Tatachari Srinivasan
- Tcherkassof Anna
- Tejada Rivera María del Carmen M. C.
- Terskova Maria
- Theodoropoulou Andriana
- Thirkettle Martin
- Thomas Andrew
- Thommesen Katrine Krabbe
- Thorstenson Christopher
- Tiantian Dong
- Tidwell Natasha
- Todsen Anna Louise
- Topor Marta
- Tops Mattie
- Toro Mónica
- Torres Adriana Olaya
- Torunsky Nathan
- Tran Ulrich
- Travaglino Giovanni
- Tressoldi Patrizio
- Tullett Alexa
- Turiegano Enrique
- Tümer Murat
- Uchida Yukiko
- Uittenhove Kim
- Urban Jan
- Urooj Anum
- Urry Heather
- Uttley Jim
- Uusberg Andero
- Vadillo Miguel
- Vaidis David
- Valderrama Eugenio
- Valentova Jaroslava
- Valentova Jaroslava Varella
- Vally Zahir
- van de Ven Niels
- Van der Linden Nicolas
- Van Doren Natalia
- van Schie Kevin
- van Steenkiste I.
- van Zyl Casper
- Vanman Eric
- Vanpaemel Wolf
- Varella Marco
- Vargas-Nieto Juan Camilo
- Vasilev Martin
- Vatakis Argiro
- Vaughn Leigh Ann
- Vazire Simine
- Vdovic Milica
- Vega Diego
- Verbruggen Frederick
- Vergauwe Evie
- Verharen Jeroen
- Verschuere Bruno
- Vezirian Kevin
- Vianello Michelangelo
- Vieira Luc
- Vilar Roosevelt
- Vilares Iris
- Villar Sergio
- Vilsmeier Johannes
- Vingerhoets Ad
- Vintr Jáchym
- Volz Leonhard
- von Bastian Claudia
- Voracek Martin
- Vranka Marek
- Vuoskoski Jonna
- Vásquez-Amézquita Milena
- Wagemans Fieke
- Walczak Radoslaw
- Wang Chunhui
- Wang Hsiao-Hsin
- Wang Ke
- Warmelink Lara
- Weinstein Netta
- Weissgerber Sophia
- Westerlund Minja
- Westgate Erin
- White David
- Whitt Cassie
- Wichman Aaron
- Wielgus Magdalena
- Willis Megan
- Wilson John
- Wilson John Paul
- Wissink Joeri
- Wlodarczyk Anna
- Wolf Daniel
- Wolfe Kelly
- Wu Qi
- Wu Yang
- Xiao Qinyu
- Xie Sally
- Yamada Yuki
- Yan Wen-Jing
- Yang Xin
- Yao Elvin
- Yeung Siu Kit
- Yu Karen
- Zabel Chelsea
- Zakharov Ilya
- Zdybek Przemysław
- Zettler Ingo
- Zheng Michelle Xue
- Ziano Ignazio
- Zickfeld Janis
- Zorjan Saša
- Zrimsek Miha
- Zsido Andras
- Álvarez-Solas Sara
- Çoksan Sami
- Çolak Tuğba Seda
- Özdoğru Asil
- Özdoğru Asil Ali
- Čadek Martin
- Ścigała Karolina
- Śmieja Magdalena
- Šakan Dušana
- Šebeňa René
- Štrukelj Eva
- Žuro Barbara
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world
Vitamin D-modulated dendritic cells delay lethal graft-versus-host disease through induction of regulatory T cells
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2019
- Field of study
Graft-versus-host disease (GVHD) is the most lethal complication after allogeneic bone marrow transplantation (allo-BMT). Current approaches to prevent GVHD rely on donor lymphocyte/T cell depletion or general immunosuppression, leading to opportunistic infections and cancer relapse. Tolerogenic dendritic cells can induce regulatory T cells (Tregs) with the ability to suppress inflammation and prevent transplant rejection, making them an attractive cellular therapy to control GVHD. Active vitamin D (1α,25-dihydroxyvitamin D3; 1α,25(OH)2D3) promotes the generation of tolerogenic dendritic cells (1,25D3-DCs). This study aimed to determine the ability of ex vivo generated 1,25D3-DCs to trigger the expansion of Tregs that are able to control lethal xenogeneic GVHD in humanized NOD/LtSz-PrkdcscidIL2rγtm1Wjl (NSG) mice. We demonstrate that 1,25D3-DCs express lower levels of HLA-DR and costimulatory molecules, such as CD80 and CD86, and produce higher levels of IL-10 and TNF-α and lower amounts of IL-12, compared to vehicle-treated DCs. Moreover, these cells express increased levels of various co-inhibitory molecules such as PD-L1 and ILT-3 and the glycoprotein CD52 that is known to suppress T cell activation. Consequently, 1,25D3-DCs are poor stimulators of alloantigen-primed T cells, but foster the generation of antigen-specific suppressive Tregs. When adoptively transferred in humanized NSG mice, these 1,25D3-DC-induced Tregs delayed GVHD caused by the co-transferred autologous human peripheral blood mononuclear cells (PBMCs). These results indicate that 1,25D3-DC-induced Tregs can inhibit xenogeneic GVHD and maintain their immunomodulatory function under conditions of inflammation.status: publishe
Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells
- Author
- Publication venue
- 'American Diabetes Association'
- Publication date
- 08/11/2016
- Field of study
The introduction of β-cell autoantigens via the gut through Lactococcus lactis (L. lactis) has been demonstrated to be a promising approach for diabetes reversal in NOD mice. Here we show that a combination therapy of low-dose anti-CD3 with a clinical-grade self-containing L. lactis, appropriate for human application, secreting human proinsulin and interleukin-10, cured 66% of mice with new-onset diabetes, which is comparable to therapy results with plasmid-driven L. lactis Initial blood glucose concentrations (<350 mg/dL) and insulin autoantibody positivity were predictors of the stable reversal of hyperglycemia, and decline in insulin autoantibody positivity was an immune biomarker of therapeutic outcome. The assessment of the immune changes induced by the L. lactis-based therapy revealed elevated frequencies of CD4(+)Foxp3(+) T cells in the pancreas-draining lymph nodes, pancreas, and peripheral blood of all treated mice, independent of metabolic outcome. Neutralization of cytotoxic T-lymphocyte antigen 4 and transforming growth factor-β partially abrogated the suppressive function of therapy-induced regulatory T cells (Tregs). Ablation or functional impairment of Foxp3(+) Tregs in vivo at the start or stop of therapy impaired immune tolerance, highlighting the dependence of the therapy-induced tolerance in mice with new-onset diabetes on the presence and functionality of CD4(+)Foxp3(+) T cells. Biomarkers identified in this study can potentially be used in the future to tailor the L. lactis-based combination therapy for individual patients
Effects of repeated infections with non-typeable Haemophilus influenzae on lung in vitamin D deficient and smoking mice.
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
In chronic obstructive pulmonary disease (COPD), exacerbations cause acute inflammatory flare-ups and increase the risk for hospitalization and mortality. Exacerbations are common in all disease stages and are often caused by bacterial infections e.g., non-typeable Heamophilus influenzae (NTHi). Accumulating evidence also associates vitamin D deficiency with the severity of COPD and exacerbation frequency. However, it is still unclear whether vitamin D deficiency when combined with cigarette smoking would worsen and prolong exacerbations caused by repeated infections with the same bacterial strain. Vitamin D sufficient (VDS) and deficient (VDD) mice were exposed to nose-only cigarette smoke (CS) for 14 weeks and oropharyngeally instilled with NTHi at week 6, 10 and 14. Three days after the last instillation, mice were assessed for lung function, tissue remodeling, inflammation and immunity. The impact of VDD and CS on inflammatory cells and immunoglobulin (Ig) production was also assessed in non-infected animals while serum Ig production against NTHi and dsDNA was measured in COPD patients before and 1 year after supplementation with Vitamin D3. VDD enhanced NTHi eradication, independently of CS and complete eradication was reflected by decreased anti-NTHi Ig's within the lung. In addition, VDD led to an increase in total lung capacity (TLC), lung compliance (Cchord), MMP12/TIMP1 ratio with a rise in serum Ig titers and anti-dsDNA Ig's. Interestingly, in non-infected animals, VDD exacerbated the CS-induced anti-NTHi Ig's, anti-dsDNA Ig's and inflammatory cells within the lung. In COPD patients, serum Ig production was not affected by vitamin D status but anti-NTHi IgG increased after vitamin D3 supplementation in patients who were Vitamin D insufficient before treatment. During repeated infections, VDD facilitated NTHi eradication and resolution of local lung inflammation through production of anti-NTHi Ig, independently of CS whilst it also promoted autoantibodies. In COPD patients, vitamin D supplementation could be protective against NTHi infections in vitamin D insufficient patients. Future research is needed to decipher the determinants of dual effects of VDD on adaptive immunity. ClinicalTrials, NCT00666367. Registered 23 April 2008, https://www.clinicaltrials.gov/ct2/show/study/NCT00666367
Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis
- Author
- Publication venue
- 'American Diabetes Association'
- Publication date
- Field of study
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis
- Author
- (Jay) Kropp Jeffrey
- Abdul Kadir Khalid
- Abdullah Raied
- Abraham Oomman India:
- Abramowitz Matthew
- Acosta Idalia
- Africa: Fayzal Ahmed South
- Agra Jeimeen
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alappan Rajendran
- Alberto Andreotti Turatti Luiz
- Alberto Berli Mario
- Alberto Cuneo Carlos
- Alberto Cunha V\ueancio S\ue9rgio
- Alberto Ramirez Roca Luis
- Alexandra Terront Lozano Monica
- Alfonso Leon de la Fuente Ricardo
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Alina Agafyina Russia:
- Alpizar Salazar Melchor
- Alva Hansraj
- Alvarisqueta Andres
- Amodeo Celso
- Andres Ahuad Guerrero Rodolfo
- Angel Reyes Rosano Miguel
- Angelova Angelina
- Anghel Veronica
- Angustias Quesada Sim\uf3n Mar\ueda
- Ant\uf4nio Pereira M\ue1rcio
- Antonia Munar Vila Maria
- Antonio Novoa Pablo
- Antonio S\ue1nchez Arenales Jose
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Archibaldo Glenny Jorge
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Asmarats Mercadal Luis
- Atray Naveen
- Augusto Alves da Costa Fernando
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Baas Cruz Juan
- Badat Aysha
- Bajaj Harpreet
- Bakris George
- Barbarash Olga
- Barnard Maria
- Barnhill Peggy
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Beatrice Zanata Petry Tarissa
- Beatriz Schiavi Lilia
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berenice Saavedra Sanchez Sandra
- Bermudez Lidia
- Bernardo Marializa
- Bhajan Manocha Anita
- Bhushan Raju Sree
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bordonava Anselmo
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brusco Osvaldo
- Buganova Ingrid
- Burgos Soto Mario
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calella Pedro
- Canaan Yamil
- Caringal Clodoaido
- Cariou Bertrand
- Carlo Sasso Ferdinando
- Carlo Tibes Hachmann Jean
- Carlos Santos Juan
- Castellino Pietro
- Cecilia Cantero Maria
- Cecilia Coloma Gabriela
- Cercos Esteban
- Cereto Castro Fernando
- Ceriello Antonio
- Chandra Vyasam Ramesh
- Chen Qinkai
- Cherney David
- Chevaile Ramos Jose
- Chew Wong Alfredo
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Chwen-Tzuei Chang Taiwan:
- Cif Adriana
- Cigarran Guldris Secundino
- Cohen Kenneth
- Cohen Robert
- Cohen- Stein Debbie
- Colombo Hugo
- Commendatore Victor
- Conway James
- Cook Charles
- Cosma Dana
- Cournoyer Serge
- Coyne Daniel
- Crawford Allison Dale
- Crisan Carmen
- Cristian Greloni Gustavo
- Cristina Camelo Sanches Fernanda
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- d'Avila Domingos
- Daboul Nizar
- Danos Peter
- Dario Dran Ricardo
- Dario Vargas Alonso Ruben
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- Daud Che Yusof Mohd
- David Gomez Rangel Jose
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- De Cosmo Salvatore
- De Nicola Luca
- De Serres Sacha
- de Souza Portes Evandro
- de Souza Pedro
- Deak Laszlo
- Deck Kenneth
- del Carmen Gonzalez Colaso Patricia
- Delos Santos Lalaine
- Derosa Giuseppe
- Desouza Cyrus
- Despina Demian Luiza
- Dev Devasmita
- Dewan Deepak
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Diaz Escalante Tonatiu
- Diego Higuera Juan
- Dimitrov Stefan
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Dominguez Lopez Marta
- Dovie Lallaine Ygpuara Ma.
- Drasnar Tomas
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
- Dub\ue9 Fran\ue7ois
- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- Eder Frank
- Edmundo Enriquez Sosa Favio
- Edwin Fernando M.
- Egido de los Rios Jesus
- Egle Gaupsiene Lithuania:
- El Kossi Mohsen
- El-Shahawy Mohamed
- Emilia Ferariu Ioana
- English Patrick
- Enrique Herrera Jimenez Luis
- Eric Alamartine France:
- Erika Rucker Joerg Isabel
- Ernesto Andres Diaz Ruiz Jorge
- Ervin John
- Esquenazi Alberto
- Esteban Jodar Gimeno Jose
- Esther Visco Virginia
- Ethel Yap Yvette
- Evans John
- Faghih Markus
- Farias Eduardo
- Faulmann Grit
- Fauvel Jean-Pierre
- Ferkl Richard
- Fernandez Fresnedo Gema
- Fernando Flota Cervera Luis
- Finkelstein Hernan
- Fishbane Steven
- Florencia Fernandez Maria
- Flores Lozano Fernando
- Fragale Guillermo
- Fraige Filho Fadlo
- Francisco Kerr Saraiva Jose
- Frasc\ue0 Giovanni
- Fraser Donald
- Fraser Ian
- Frenk Baron Paul
- Frias Juan
- Fuiano Giorgio
- Fulop Peter
- Fushtey Ivan
- Gabriela Onaca Adriana
- Galan Serrano Antonio
- Galindo-Ramos Eugenia
- Galphin Claude
- Gambaro Giovanni
- Gan Shenglian
- Garcia Ballesteros Cecilia
- Garcia Isabel
- Garibotto Giacomo
- Gastaldi Anibal
- Gelersztein Elizabeth
- Geloneze Neto Bruno
- Genadieva Veselka
- Genova-Hristova Gabriela
- Ghazi Adline
- Giorda Carlo
- Glinkina Irina
- Gnudi Luigi
- Godlevska Olga
- Goldenberg Ronald
- Golovchenko Oleksandr
- Gomes Marcus
- Gomez Olivert
- Gon Kim Sin
- Gonzalez Alexander
- Gonzalez Enrique
- Gonzalo Godoy Jorquera Juan
- Gopalakrishnan Natarajan
- Gorson David
- Gourdy Pierre
- Govender Ravendran
- Govender Vimladhevi
- Gowda Anupama
- Goycoa Claudia
- Gracious Noble
- Greco Barbara
- Grineva Elena
- Grubb Stephen
- Guillermo Douthat Walter
- Guinsburg Adrian
- Gulati Rakesh
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gyongyi Csecsei Hungary:
- Gyrina Olga
- H-H Sheu Wayne
- Halciakova Katarina
- Hall Timothy
- Haller Hermann
- Halmagyi Ildiko
- Hammoud Jamal
- Hancu Nicolae
- Handelsman Stuart
- Hanif Wasim
- Harcsa Eleonora
- Hartman Israel
- Hector Resk Jorge
- Hector Sanchez Mijangos Jose
- Henein Sam
- Henrique Canani Luis
- Hermida Sonia
- Hernandez Triana Eric
- Hernando Garcia Ortiz Luis
- Hershon Kenneth
- Hiser Daniel
- Hitoshi Akiyama Japan:
- Ho Yoon Kun
- Hon George
- Hoon Kim Yeong
- Horacio Garcia Nestor
- Hotlos Lucyna
- Hristozov Kiril
- Hsia Te-Lin
- Hsieh Chang-Hsun
- Hwang ShangJyh
- Iitsuka Tadashi
- Ilavska Adriana
- In\ue9s Molina de Salazar Dora
- Ines Orio Silvia
- Isabel Klyver Maria
- Isaias Juncos Luis
- Isela Luna Ceballos Rosa
- Ismail Mastura
- Jackson Alan
- Jacob Radu
- Jaime Maria
- Jain Dinesh
- Jamal Aamir
- Jana Babikova Slovakia:
- Januszewicz Andrzej
- Javier Gonzalez Martinez Francisco
- Javier Zaidman Cesar
- Jeong Kwon Min
- Jeong In-Kyung
- Jerwan-Keim Reinhold
- Jimenez Flores Fernando
- Jimeno Cecilia
- Johnson Andrew
- Johnson David
- Jorge da Silva Franco Roberto
- Jose Luis Accini Mendoza Colombia:
- Jose Tinahones Madueno Francisco
- Joseph Franklin
- Joshi Mukesh
- Jurgens Jaco
- Kaczmarek Barbara
- Kajiyama Shizuo
- Kaldun Nossuli A.
- Kamenov Zdravko
- Kaminska Anna
- Kashine Susumu
- Kaupke Charles
- Kawada Toshio
- Kazmirchuk Anatoliy
- Keightley Gerald
- Keiko Kohara Suely
- Keitel Elizete
- Keltai Katalin
- Kendereski Aleksandra
- Keresztesi Sandor
- Kern Elizabeth
- Keshavamurthy C. B.
- Khandwala Hasnain
- Khanna Rakhi
- Khirmanov Vladimir
- Khitan Zeid
- Khullar Dinesh
- Kim Sun
- Kingdom: Kamal Abouglila United
- Kiss Krisztian
- Klein Alexandre
- Klokocnikova Vera
- Kodera Takamoto
- Kolesnyk Mykola
- Kolmakova Elena
- Komisarenko Iuliia
- Kong Yaozhong
- Kono Hiroshi
- Konyves Laszlo
- Kopyt Nelson
- Korea: Dong-Wan Chae South
- Koroleva Tatiana
- Korzh Oleksii
- Koundurdjiev Atanas
- Kovar Richard
- Kovesdy Csaba
- Koyama Kazunori
- Kozloviene Dalia
- Kraft Florencia
- Kravchun Nonna
- Krishna Gopal
- Krishnan Singhan
- Krynski Fernando
- Kumar Amrendra
- Kumar Jayant
- Kumar Neil
- Kumeda Yasuro
- Kumwenda Mick
- Kun Lim Soo
- Kusnir Jorge
- Kvitkova Liudmila
- Kwon Hyuk-Sang
- Lalic Katarina
- Lalic Nebojsa
- Lane Wendy
- Lastuvka Jiri
- Latiff Gulam
- Laviada Molina Hugo
- Lawrence Mary
- Lazuka Lech
- Le Meur Yannick
- Lee Gan Chye
- Lee Byung-Wan
- Lee JungEun
- Lee Moon-Kyu
- Legun Oleg
- Lehrner Lawrence
- Leiter Lawrence
- Lentz John
- Levin Adeera
- Levinson Dennis
- Lewis Derek
- Li Detian
- Li Wenge
- Li Xuemei
- Liliana Monica Angelescu Romania:
- Lin Chih-Ching
- Lin Hongli
- Lindolfo Cunha Borges Jo\ue3o
- Liss Kenneth
- Liu Jian
- Lombard Landman
- Loong Loh Chek
- Lopez Mendoza Manuel
- Loss de Carvalho Contieri Fabiana
- Lozanov Lachezar
- Lu Weiping
- Lu Yung-Chuan
- Luis David Abraira Munoz Mexico:
- Lukac Martin
- M\uf4nica Deboni Luciane
- Ma Portoles Perez Jose
- MacDougall Iain
- Maddux Andreas
- Madej Andrzej
- Madore Fran\ue7ois
- Maheshwari Hiralal
- Major Lajos
- Malaver Natalia
- Malberti Fabio
- Malek Marin Tamara
- Mandayam Sreedhar
- Mandreoli Marcora
- Mankovskyy Borys
- Mann Mah Peak
- Mannucci Edoardo
- Mao Hong
- Mar\ueda Alicia Fern\ue1ndez Montenegro Chile:
- Marar Isam
- Marasaev Viacheslav
- Marchetta Nora
- Margaritov Viktor
- Maria Cusumano Ana
- Maria Elosegui Ana
- Maria Veronelli Anna
- Martin del Campo Blanco Belia
- Martinka Emil
- Martynyuk Liliya
- Maxeiner Stephan
- Mazur Stanislaw
- Mc- Mahon Alan
- Medina Fari\uf1a Marcelo
- Mehta Bhasker
- Mele Pablo
- Melemadathil Sreelatha
- Middleton John
- Milagres Ros\ue2ngela
- Mileder Margit
- Min Cho Young
- Miyauchi Shozo
- Mizuyama Kazuyuki
- Mkrtumyan Ashot
- Mlodawska-Choluj Dorota
- Mohamed Railey United Arab Emirates: Salah Abusnana
- Molnar Marta
- Montenegro Junior Renan
- Mookadam Mohamed
- Morales Franco Guadalupe
- Morales Portillo Cristobal
- Mordujovich Jorge
- Moreda Ramon
- Moreira de Brito Claudia
- Morugova Tatiana
- Mostovoy Yuriy
- Moustafa Moustafa
- Mu\uf1oz Torres Manuel
- Mucsi Janos
- Muirhead Norman
- Mujica Trenche Samuel
- Munteanu Mircea
- Mustieles Rocha Cynthia
- Nagibovich Galina
- Nagibovich Oleg
- Nam Moon-Suk
- Nan Chen China:
- Narayanan Mohanram
- Naresh Aggarwal Canada:
- Narvarte Javier
- Nassar Tareq
- Nasser Hissa Miguel
- Navickas Antanas
- Nedogoda Sergei
- Negru Doru
- Newman George
- Ngai Wah Cheung Australia:
- Ngcakani Nomangesi
- Nichol Brian
- Nicholls Kathy
- Nicol Philip
- Nicolai Silvia
- Nieto Iglesias Javier
- Niiya Tetsuji
- Nisnisan Josier
- Nixon Paul
- Nonchev Boyan
- Noonan Paul
- Noronha Irene
- Nortje Hendrik
- Nowicki Michal
- Nur Fatnoon Nik Ahmad Nik
- O'Hare Joseph
- O'Shaughnessy Andrew
- Obialo Chamberlain
- Obrador Vera Gregorio
- Ochodnicka Zuzana
- Oh Kook-Hwan
- Oishi Hiroko
- Olelewe Sarah
- Olga Barna Ukraine:
- Oliver Michael
- Oosthuizen Helena
- Orlowska-Kowalik Grazyna
- Oroszlan Tamas
- Orozco Castellanos Ricardo
- Orsi Emanuela
- Ory Ivan
- Osipova Irina
- Osvaldo Fretes Jose
- Ota Satoshi
- Otreras Fabian
- Oviedo Alejandra
- Pablo Albisu Juan
- Pablo Gonzalez Joaquin
- Pablo Moreira Diaz Juan
- Packham David
- Padron John
- Panarotto Daniel
- Pankhaniya Rohit
- Pantoja Perez Jonay
- Paragh Gyorgy
- Park Cheol-Young
- Park Sun-Hee
- Parker Reginald
- Paschen Bj\uf6rn
- Pashkovska Nataliia
- Patel Devesh
- Patel Gnyandev
- Patel Nina
- Paul Haase Franklin
- Pavon Humberto
- Pecoits Filho Roberto
- Pella Daniel
- Penfornis Alfred
- Peralta Calcaneo Juan
- Pere Alvarez Garcia Spain:
- Pererva Larysa
- Perez Vera Merce
- Perez Armando
- Perez Carlos
- Peringat Jayameena
- Perlman Alan
- Pertseva Tetyana
- Pesickova Satu
- Peterfai Eva
- Peterka Karel
- Petrica Ligia
- Petro Gizella
- Pettis Karlton
- Pharr Walter
- Philip Sam
- Phillips Andrea
- Piatti Piermarco
- Pichette Vincent
- Pillay-Ramaya Larisha
- Plassmann Georg
- Popenda Grazyna
- Popovic-Radinovic Vesna
- Prasad Narayan
- Proietto Joseph
- Prozesky Hans
- Pumprla Jiri
- Purighalla Raman
- Quesada-Suarez Luis
- Rabasa-Lhoret Remi
- Raffaele Pablo
- Ramtoola Shenaz
- Ranetti Aurelian-Emil
- Rangelov Rangel
- Ranjan Rajiv
- Raskina Tatiana
- Rastogi Sanjeev
- Ratnasingam Vanassa
- Reddy Jakkidi
- Reddy Jeevren
- Reddy Sreedhar
- Regina Nazario Sabbag \uc2ngela
- Remus Popa Amorin
- Ren Yan
- Renata Bijata-Bronisz Poland:
- Rendell Marc
- Republic: Dagmar Bartaskova Czech
- Revesz Katalin
- Rewerska Barbara
- Rheeder Paul
- Ricardo Correa Rotter Jose
- Riccardo Bonadonna Italy:
- Rich Lisa
- Rista Lucas
- Roberto Abr\ue3o Raduan Brazil:
- Roberto Chacra Ant\uf4nio
- Roberto Kurtz Lisboa Hugo
- Roberts Anthony
- Robinson Michael
- Rodolfo Cartasegna Luis
- Rodriguez Papini Nelson
- Rodriguez Pattzi Hiromi
- Rodriguez Hector
- Roger Simon
- Rohana Abdul Ghani Malaysia:
- Ronaldo Arturo Gonzalez Orellana Guatemala:
- Rosa Ulla Maria
- Rosas Guzman Juan
- Rosas Sylvia
- Rose Ludger
- Rosero Ricardo
- Roussel Ronan
- Rychlik Ivan
- Saavedra Gajardo Victor
- Saba Fadi
- Sahay Manisha
- Sakakibara Terue
- Sala Jorgelina
- Samoylov Oleksandr
- Samoylova Yulia
- Sankaram Rallabhandi
- Santoro Domenico
- Santos Florence
- Saporito Wladmir
- Sarin Ravi
- Satyanarayana Rao K.
- Saudek Frantisek
- Saul Irizar Santana Sergio
- Saulnier Pierre-Jean
- Saxena Manish
- Sazonova Olga
- Scafuto Scotton Antonio
- Schreiman Robert
- Schuch Tiago
- Scott David
- Scott Russell
- Seeber Mary
- Sekkarie Mohamed
- Sennik Davesh
- Sensenbrenner John
- Serafinceanu Cristian
- Serrano Sanson Pablo
- Serviddio Gaetano
- Sessa Horacio
- Severina Comia Rhea
- Shahrizal Bin Shudim Saiful
- Shakeel Muhammad
- Shamkhalova Minara
- Shanik Michael
- Shaw Sylvia
- Shinkov Alexander
- Shutemova Elena
- Shwartz Yuriy
- Sim\uf5es de Almeida Roberto
- Simo Canonge Rafael
- Simon Godwin
- Sing Ng Kee
- Singh Baldev
- Slobodan Antic Serbia:
- Slompo Ramos C\ue1ssio
- Smatanova Iveta
- Smirnov Ivan
- Smith Casabella Tomas
- Smith Stephen
- Soares Fel\uedcio Jo\ue3o
- Solomon Richard
- Song Weihong
- Soto Gonzalez Alfonso
- Sowinski Dariusz
- Sprague Amy
- Spry Leslie
- States: Joseph Abdallah United
- Steele Andrew
- Stella Andrea
- Stephens Jeffrey
- Strzelecka Anna
- Suchinda Pusadee
- Sudhakar Bhimavarapu
- Sultan Senan
- Sun Jiao
- Sun Lin
- Surampudi Prasanth
- Sussman Sherry
- Svyshchenko Yevgeniya
- Symonds Rehan
- Takacs Robert
- Takai Masahiko
- Tan Anjanette
- Tan Gerry
- Tangri Navdeep
- Tarsicio Moreno Loza Oscar
- Tellez Chavez Eloisa
- Temelkova Margarita
- Teresa Zanella Maria
- Terns Riera Manel
- Terrelonge Antonio
- Tesar Vladimir
- Thervet Eric
- Thom\ue9 Fernando
- Thompson Michael
- Toarba Cristina
- Tolentino Marsha
- Tomashkevych Halyna
- Tomonaga Osamu
- Topchii Ivan
- Torshizi Ali
- Trespalacios Fernando
- Trevisan Roberto
- Trippe Bruce
- Trueba Pilar
- Tryshchuk Nadiya
- Tsang Venessa
- Tseluyko Vira
- Tsujimoto Mitsuru
- Tu Ping
- Turcios Juarez Erick
- Turner Wayne
- Twahirwa Marcel
- Updegrove John
- Urbanaviciene Egle
- Uriasyev Oleg
- Valderrama Cometa Luis
- Valdes Cepeda Alejandro
- Valdez Maria
- Valenzuela Alex
- Valis Martin
- Vallejos Augusto
- Van Buren Peter
- Vangel Sandor
- Vannorsdall Mark
- Varghese Freemu
- Vasas Szilard
- Vejar Margarita
- Velasquez-Mieyer Pedro
- Velichkova Ekaterina
- Velo Plaza Mercedes
- Venegas Carrillo Luis
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vicente Sanchez Polo Jos\ue9
- Viktoria Andreeva Bulgaria:
- Villagordoa Mesa Juan
- Villarino Adriana
- Villegas Ivan
- Virginia Lanchiotti Paulina
- Vizir Vadym
- Vlasenko Maryna
- Volker Burst Germany:
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler David
- Williams Michael
- Williams Shelley
- Win Lam Swee
- Winocour Peter
- Woo Vincent
- y Orozco Juan Alfredo Tamayo
- Yakov Andrian
- Yamada Masayo
- Yamada S\ue9rgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yen Kong Wei
- Yin Aiping
- Yoiti Hayashida Cesar
- Young Simon
- Yu Xueqing
- Yuan Lee Li
- Yumita Wataru
- Yupanqui Hernan
- Zalunardo Nadia
- Zamarripa Escobedo Rolando
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zaynab Abejuela Philippines:
- Zealand: John Baker New
- Zemek Stanislav
- Zhao Minghui
- Zheng Hongguang
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
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- de Almeida Roberto Simões
- de Brito Claudia Moreira
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- De Nicola Luca
- De Nicola Luca
- de Salazar Dora Inés Molina
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- de Souza Pedro
- de Zeeuw Dick
- de Zeeuw Dick
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- Deepak Dewan
- del Campo Blanco Belia Martin
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- Derosa Giuseppe
- Desouza Cyrus
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- Di Carlo Alberto
- Di Cianni Graziano
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- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
- Distiller Larry
- Distiller Lawrence
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- Douthat Walter Guillermo
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- Egido de los Rios Jesus
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- Evans John
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- Farias Eduardo
- Fariña Marcelo Medina
- Faulmann Grit
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- Filho Roberto Pecoits
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- Heerspink Hiddo J. L.
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- Wada Takashi
- Wada Takashi
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- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
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- Watanabe Takayuki
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- Watson Henry
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- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler C.
- Wheeler David
- Wheeler David C.
- Wheeler David C.
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- Williams Shelley
- Winocour Peter
- Wong Alfredo Chew
- Woo Vincent
- Yakov Andrian
- Yamada Masayo
- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cesar Javier
- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A.
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahamed khader null
- Ahmad Azam Ummi Azmira
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Anizi Mashel
- Al hussaini Sabah
- Al'Amri Khalid
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alberto Lisi Zaheer Moolla
- AlbertoVolta Carlo
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alit Mahaalit Aribawa
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Antonina Webombesa
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Arkalaki Eleni
- Arlo whitehouse null
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam F Noorbhai M.
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Bai Yun
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balaji Packianathaswamy
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Baroselli Antonio
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
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- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benedikt Preckel Osne Kirzner
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
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- Beretta Luigi
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- Bergin Colin
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Bin Mustapha Mohd Tarmimi
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P.
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boereboom Catherine
- Boggiano Victoria
- Bogner Gerhard
- Bokkel-Andela Janneke ten
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
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- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
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- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
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- Cancho David
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- Cang Jing
- Cannavo' Maurizio
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- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- CarmenVaida Laura Aflori
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- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
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- Chaniotaki Fotini
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- Charlalampidoy Alexandra
- Charles Rob
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- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
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- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
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- Codita Anisoara
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- Colling Kerry
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- Diago Lorena Gómez
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- Dragoescu Nicoleta Alice
- Drake Matthew
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- Duca Alejandro
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- Durodola Adekunle
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- Durst Alexander
- Duttchen Kaylene
- Dutu Madalina
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- Dylst Dimitri
- Dzhamullaev Parvin
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- Farina Zane
- Farrell Helen
- Farrow Mehreen
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- Fatungase Oluwabunmi Motunrayo
- Faulds Matthew
- Fei Yue
- Fellinger Paul
- Feng Yunlin
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- Fernández Salvador
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- Filippopoulos Andreas
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- Foubert Luc
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- Fowler Alexander
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- Ganter Michael T.
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- Hamzah Zulkarnain
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- Hartmann Andreas
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- Hidayatullah Rahmat
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- Hosdurga Gurunath
- Hou Benchao
- Hou Jiabao
- Houston Kendra
- Houweling Peter
- Hove Mazvangu Onie
- Hovendal Claus
- Hu Chun hua
- Hu Liu
- Hu Na
- Hu Nianqiang
- Hu Rong
- Hu Shuangfei
- Hu Tingju
- Hu Xianwen
- Hu Xiaolan
- Hu Xuming
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- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeidan Lisa
- Zeng Qiuting
- Zerman Luiza
- Zettergren Jan
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- Zhang Shihai
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- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Xuekang
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Lili
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Åkring Irene
- Ögren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
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- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
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- Belda Margarita Tormo
- Bell Gillian
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- Bell Rachel
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- Bello Jibril
- Beloeil Helene
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- Beltran Anna Valle
- Ben-Menachem Erez
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- Benevento Angelo
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- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
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- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
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- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
- Bland Martin
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- Bodansky Daniella
- Bodger Phoebe
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- Boereboom Catherine
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- Bolaji Benjamin
- Bolton David
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- Bouris Vasilios
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- Bouwman Arthur
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- Buise Marc
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- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- Carmino Livio
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- Carr Adrienne
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- Carroll Jo
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- Castro Gabriel Isaac Pereira
- Cavanagh Sarah
- Cawthorn Louise
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- Chaddock Mark
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- Chandra Susilo
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
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- Chen Fumei
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- Chen Junping
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- Chen Lee-lynn
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- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
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- Mosxogiannidis Dimitris
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- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally