What Electrophysiology Tells Us About Alzheimer’s Disease::A Window into the Synchronization and Connectivity of Brain Neurons

Electrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic (EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in patients with Alzheimer’s disease (AD), despite a surge in recent validated evidence. This Position Paper of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational electrophysiological techniques applied to both experimental animal models of AD and patients, to probe the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as well as brain network dynamics, synchronization, and functional connectivity reflecting thalamocortical and cortico-cortical residual capacity. Converging evidence shows relationships between abnormalities in EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting evidence for the application of electrophysiology in AD clinical research as well as drug discovery pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main multicentric projects planned in AD patients, to produce conclusive findings challenging the present regulatory requirements and guidelines for AD studies

Codes, Patterns and Shapes of Contemporary Online Antisemitism and Conspiracy Narratives – an Annotation Guide and Labeled German-Language Dataset in the Context of COVID-19

Over the course of the COVID-19 pandemic, existing conspiracy theories were refreshed and new ones were created, often interwoven with antisemitic narratives, stereotypes and codes. The sheer volume of antisemitic and conspiracy theory content on the Internet makes data-driven algorithmic approaches essential for anti-discrimination organizations and researchers alike. However, the manifestation and dissemination of these two interrelated phenomena is still quite under-researched in scholarly empirical research of large text corpora. Algorithmic approaches for the detection and classification of specific contents usually require labeled datasets, annotated based on conceptually sound guidelines. While there is a growing number of datasets for the more general phenomenon of hate speech, the development of corpora and annotation guidelines for antisemitic and conspiracy content is still in its infancy, especially for languages other than English. To address this gap, we have developed an annotation guide for antisemitic and conspiracy theory online content in the context of the COVID-19 pandemic that includes working definitions, e.g. of specific forms of antisemitism such as encoded and post-Holocaust antisemitism. We use the guide to annotate a German-language dataset consisting of $\sim \! 3,700$ Telegram messages sent between 03/2020 and 12/2021