Delayed Self-Synchronization in Homoclinic Chaos

The chaotic spike train of a homoclinic dynamical system is self-synchronized by re-inserting a small fraction of the delayed output. Due to the sensitive nature of the homoclinic chaos to external perturbations, stabilization of very long periodic orbits is possible. On these orbits, the dynamics appears chaotic over a finite time, but then it repeats with a recurrence time that is slightly longer than the delay time. The effect, called delayed self-synchronization (DSS), displays analogies with neurodynamic events which occur in the build-up of long term memories.Comment: Submitted to Phys. Rev. Lett., 13 pages, 7 figure

Radiative Kaon Decays and the Penguin Contribution to the Delta I = 1/2 Rule

A consistent census of penguins in the Delta I = 1/2 rule is taken from the eta0 pole contribution to the radiative KL to gamma gamma, KS to pi0 gamma gamma and K+ to pi+ gamma gamma decay modes. We briefly comment on its impact for KL to pi0 pi0 gamma gamma, KL to pi+ pi- gamma and check its compatibility with the KL - KS mass difference and the CP violating epsilon-prime / epsilon parameter.Comment: 37 pages, 16 figure

Submarine sediment routing over a blocky mass-transport deposit in the Espírito Santo Basin, SE Brazil

The control of slide blocks on slope depositional systems is investigated in a high-quality 3D seismic volume from the Espírito Santo Basin, SE Brazil. Seismic interpretation and statistical methods were used to understand the effect of differential compaction on strata proximal to the headwall of a blocky mass-transport deposit (MTD), where blocks are large and undisturbed (remnant), and in the distal part of this same deposit. The distal part contains smaller rafted blocks that moved and deformed with the MTD. Upon their emplacement, the positive topographic relief of blocks created a rugged seafloor, confining sediment pathways and creating accommodation space for slope sediment. In parallel, competent blocks resisted compaction more than the surrounding debrite matrix during early burial. This resulted in differential compaction between competent blocks and soft flanking strata, in a process that was able to maintain a rugged seafloor for >5 Ma after burial. Around the largest blocks, a cluster of striations associated with a submarine channel bypassed these obstructions on the slope and, as a result, reflects important deflection by blocks and compaction-related folds that were obstructing turbidite flows. Log-log graphs were made to compare the width and height of different stratigraphic elements; blocks, depocentres, and channels. There is a strong correlation between the sizes of each element, but with each subsequent stage (block – depocentre – channel) displaying marked reductions in height. Blocky MTDs found on passive margins across the globe are likely to experience similar effects during early burial to those documented in this work

Familial Resemblance for Loneliness

Social isolation and loneliness in humans have been associated with physical and psychological morbidity, as well as mortality. This study aimed to assess the etiology of individual differences in feelings of loneliness. The genetic architecture of loneliness was explored in an extended twin-family design including 8,683 twins, siblings and parents from 3,911 families. In addition, 917 spouses of twins participated. The presence of assortative mating, genetic non-additivity, vertical cultural transmission, genotype–environment (GE) correlation and interaction was modeled. GE interaction was considered for several demographic characteristics. Results showed non-random mating for loneliness. We confirmed that loneliness is moderately heritable, with a significant contribution of non-additive genetic variation. There were no effects of vertical cultural transmission. With respect to demographic characteristics, results indicated that marriage, having offspring, more years of education, and a higher number of siblings are associated with lower levels of loneliness. Interestingly, these effects tended to be stronger for men than women. There was little evidence of changes in genetic architecture as a function of these characteristics. We conclude that the genetic architecture of loneliness points to non-additive genetic influences, suggesting it may be a trait that was not neutral to selection in our evolutionary past. Sociodemographic factors that influence the prevalence of loneliness do not affect its genetic architecture

The impact of family structure and disruption on intergenerational emotional exchange in Eastern Europe

Demographic trends across Europe involve a decrease in fertility and mortality rates, and an increase in divorce and stepfamily formation. Life courses and living arrangements have become less standardized and the structure of families has changed. In this article, we examine to what extent contemporary family structure and composition resulting from demographic changes affect emotional exchange between children and their parents, both from adult child to parent and from parent to child. Because the general level of well-being has been shown to be lower in Eastern Europe, thereby potentially affecting emotional exchange within families, we focus our research on Eastern Europe. We use the “conservation of resources theory” to derive hypotheses on how family structure may affect intergenerational emotional exchange. Family ties are assumed to be important resources of affection that people want to obtain and retain throughout their lives. Data from the Generations and Gender Survey (GGS) are used to test our hypotheses. In general, our data offer more support for the idea that families are resilient than for the often heard assumption that families are in decline as a consequence of the changed family structure and composition

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors in 597 single primary blood stem and progenitor cells isolated from mouse bone marrow. We demonstrate that different stem/progenitor populations are characterized by distinctive transcription factor expression states, and through comprehensive bioinformatic analysis reveal positively and negatively correlated transcription factor pairings, including previously unrecognized relationships between Gata2, Gfi1 and Gfi1b. Validation using transcriptional and transgenic assays confirmed direct regulatory interactions consistent with a regulatory triad in immature blood stem cells, where Gata2 may function to modulate cross-inhibition between Gfi1 and Gfi1b. Single-cell expression profiling therefore identifies network states and allows reconstruction of network hierarchies involved in controlling stem cell fate choices, and provides a blueprint for studying both normal development and human disease

A database solution for the quantitative characterisation and comparison of deep-marine siliciclastic depositional systems

In sedimentological investigations, the ability to conduct comparative analyses between deep-marine depositional systems is hindered by the wide variety in methods of data collection, scales of observation, resolution, classification approaches and terminology. A relational database, the Deep-Marine Architecture Knowledge Store (DMAKS), has been developed to facilitate such analyses, through the integration of deep-marine sedimentological data collated to a common standard. DMAKS hosts data on siliciclastic deep-marine system boundary conditions, and on architectural and facies properties, including spatial, temporal and hierarchical relationships between units at multiple scales. DMAKS has been devised to include original and literature-derived data from studies of the modern sea-floor, and from ancient successions studied in the sub-surface and in outcrop. The database can be used as a research tool in both pure and applied science, allowing the quantitative characterisation of deep-marine systems. The ability to synthesise data from several case studies and to filter outputs on multiple parameters that describe the depositional systems and their controlling factors enables evaluation of the degree to which certain controls affect sedimentary architectures, thereby testing the validity of existing models. In applied contexts, DMAKS aids the selection and application of geological analogues to hydrocarbon reservoirs, and permits the development of predictive models of reservoir characteristics that account for geological uncertainty. To demonstrate the breadth of research applications, example outputs are presented on: (i) the characterisation of channel geometries, (ii) the hierarchical organisation of channelised and terminal deposits, (iii) temporal trends in the deposition of terminal lobes, (iv) scaling relationships between adjacent channel and levee architectural elements, (v) quantification of the likely occurrence of elements of different types as a function of the lateral distance away from an element of known type, (vi) proportions and transition statistics of facies in elements and beds, (vii) variability in net-to-gross ratios among element types

Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)

A novel signaling cascade controlling actin polymerization in response to extracellular signals regulates filopodia formation and likely also neuronal synapse formation