E-learning in a competitive firm setting

This paper explores the use of e‐learning technologies for organisational learning within a commercial environment. A model has been developed to represent those factors that determine organisational learning. This model has been embedded within a case study based on the use of an e‐learning program that was developed in order to enhance employees’ knowledge and endorse corporate values within a Norwegian company. The results of the study reflect the high performance of the e‐learning program. They also highlight critical issues concerning the successful implementation of e‐learning technologies to achieve the knowledge sharing that is required for organisational learning

Blogging about the End Times: Dealing with the Fringes of Archaeology

The 2012-phenomenon is based on the idea that something important was expected to occur on December 21, 2012, a date associated with the ancient Maya Long Count calendar. Even though the date has passed, the overall phenomenon is unlikely to disappear because the dominant themes of the end of the world and/or a transformation of consciousness can be found in other ‘alternative’ histories. These non-academic histories are ultimately apocalyptic in nature. The 2012-phenomenon is also an example of an ‘incorporeal hyperobject’, i.e. an object widely distributed and repeated. It is not anchored in a specific time-space unit but it is manifested in many different corporeal objects. The 2012-phenomenon is different from the academic Mayanist incorporeal hyperobject because each of them uses different distinctions of what exists or not. These different objects cannot communicate directly in different media ecologies since different distinctions have formed each one. Hence, there can never be a sincere understanding of each camp. Only by perturbing another object can information be translated into meaning. The blog is such a medium that can affect incorporeal hyperobjects. This article discusses the way one blog has interacted with the 2012-phenomenon

The role of endosymbionts in the evolution of haploid-male genetic systems in scale insects (Coccoidea)

There is an extraordinary diversity in genetic systems across species, but this variation remains poorly understood. In part, this is because the mechanisms responsible for transitions between systems are often unknown. A recent hypothesis has suggested that conflict between hosts and endosymbiotic microorganisms over transmission could drive the transition from diplodiploidy to systems with male haploidy (haplodiploidy, including arrhenotoky and paternal genome elimination [PGE]). Here, we present the first formal test of this idea with a comparative analysis across scale insects (Hemiptera: Coccoidea). Scale insects are renowned for their large variation in genetic systems, and multiple transitions between diplodiploidy and haplodiploidy have taken place within this group. Additionally, most species rely on endosymbiotic microorganisms to provide them with essential nutrients lacking in their diet. We show that species harboring endosymbionts are indeed more likely to have a genetic system with male haploidy, which supports the hypothesis that endosymbionts might have played a role in the transition to haplodiploidy. We also extend our analysis to consider the relationship between endosymbiont presence and transitions to parthenogenesis. Although in scale insects there is no such overall association, species harboring eukaryote endosymbionts were more likely to be parthenogenetic than those with bacterial symbionts. These results support the idea that intergenomic conflict can drive the evolution of novel genetic systems and affect host reproduction.Peer reviewe

Preasymptotic multiscaling in the phase-ordering dynamics of the kinetic Ising model

The evolution of the structure factor is studied during the phase-ordering dynamics of the kinetic Ising model with conserved order parameter. A preasymptotic multiscaling regime is found as in the solution of the Cahn-Hilliard-Cook equation, revealing that the late stage of phase-ordering is always approached through a crossover from multiscaling to standard scaling, independently from the nature of the microscopic dynamics.Comment: 11 pages, 3 figures, to be published in Europhys. Let

Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial Cells

Toll-like receptor (TLR)4 has recently been shown to reside in the Golgi apparatus of intestinal crypt epithelial m-ICcl2 cells, colocalizing with internalized lipopolysaccharide (LPS). Here we demonstrate that disruption of the integrity of the Golgi apparatus significantly reduced LPS-mediated nuclear factor κB activation. Also, the TLR4 adaptor protein MyD88 and the serine/threonine kinase IRAK-1 were rapidly recruited to the Golgi apparatus upon stimulation. LPS-mediated activation required lipid raft formation and intact clathrin-dependent internalization. In contrast to macrophages, prevention of ligand internalization by use of LPS-coated beads significantly impaired recognition by epithelial cells. The localization of TLR4 to the Golgi apparatus was abrogated by expression of a genetically modified form of the TLR4 binding chaperone gp96. Thus, our data provide evidence that in contrast to the situation in macrophages, LPS recognition in intestinal epithelial cells may occur in the Golgi apparatus and require LPS internalization

Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection

Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the predominant serotype 3 clone in much of the world, found most sampled isolates belonged to a clade affected by few diversifying recombinations. However, other isolates indicate significant genetic variation has accumulated over the clonal complex’s entire history. Two closely related genomes, one from the blood and another from the cerebrospinal fluid, were obtained from a patient with meningitis. The pair differed in their behaviour in a mouse model of disease and in their susceptibility to antimicrobials, with at least some of these changes attributable to a mutation that upregulated the patAB efflux pump. This indicates clinically important phenotypic variation can accumulate rapidly through small alterations to the genotype

Offering Urban Spaces for Community Gardens: Implementation, Development, and Resilience in Stockholm, Sweden

One way of using public green spaces is to allow cultivation by citizens. Community gardening has proven to have many social benefits and can undoubtedly contribute to a sustainable society in a variety of ways. Yet while being clearly attractive for both citizens and officials, it does not always flourish in practice. In this study we draw on interviews with park engineers working in the city of Stockholm to analyze why community gardening is not more prevalent, despite the clearly existing political and popular will to promote it. The study shows that there are significant differences between Stockholm City’s district administrations. Through applying implementation theory, we show that relatively small variations in local resources, expertise, and interests fundamentally shape the outcome of community gardening initiatives. It is also shown that unclear guidelines and a lack of horizontal and vertical communication constitute institutional barriers to the implementation, development, and resilience of community gardening in the districts of Stockholm