9 research outputs found

    The effect of phospholipid composition of reconstituted HDL on its cholesterol efflux and anti-inflammatory properties

    Get PDF
    goal of this study was to understand how the reconstituted HDL (rHDL) phospholipid (PL) composition affects its cholesterol efflux and anti-inflammatory properties. An ApoA-I mimetic peptide, 5A, was combined with either SM or POPC. Both lipid formulations exhibited similar in vitro cholesterol efflux by ABCA1, but 5A-SM exhibited higher ABCG1- and SR-BI-mediated efflux relative to 5A-POPC (P < 0.05). Injection of both rHDLs in rats resulted in mobilization of plasma cholesterol, although the relative potency was 3-fold higher for the same doses of 5A-SM than for 5A-POPC. Formation of pre HDL was observed following incubation of rHDLs with both human and rat plasma in vitro, with 5A-SM inducing a higher extent of pre formation relative to 5A-POPC. Both rHDLs exhibited anti-inflammatory properties, but 5A-SM showed higher inhibition of TNF-, IL-6, and IL-1 release than did 5A-POPC (P < 0.05). Both 5A-SM and 5A-POPC showed reduction in total plaque area in ApoE(-/-) mice, but only 5A-SM showed a statistically significant reduction over placebo control and baseline (P < 0.01). The type of PL used to reconstitute peptide has significant influence on rHDL's anti-inflammatory and anti-atherosclerosis properties

    Measurement of event-shape observables in Z→ℓ+ℓ− events in pp collisions at √ s=7 TeV with the ATLAS detector at the LHC

    Get PDF
    Event-shape observables measured using charged particles in inclusive ZZ-boson events are presented, using the electron and muon decay modes of the ZZ bosons. The measurements are based on an integrated luminosity of 1.1fb−11.1 {\rm fb}^{-1} of proton--proton collisions recorded by the ATLAS detector at the LHC at a centre-of-mass energy s=7\sqrt{s}=7 TeV. Charged-particle distributions, excluding the lepton--antilepton pair from the ZZ-boson decay, are measured in different ranges of transverse momentum of the ZZ boson. Distributions include multiplicity, scalar sum of transverse momenta, beam thrust, transverse thrust, spherocity, and F\mathcal{F}-parameter, which are in particular sensitive to properties of the underlying event at small values of the ZZ-boson transverse momentum. The Sherpa event generator shows larger deviations from the measured observables than Pythia8 and Herwig7. Typically, all three Monte Carlo generators provide predictions that are in better agreement with the data at high ZZ-boson transverse momenta than at low ZZ-boson transverse momenta and for the observables that are less sensitive to the number of charged particles in the event.Comment: 36 pages plus author list + cover page (54 pages total), 14 figures, 4 tables, submitted to EPJC, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2014-0

    Search for a heavy Standard Model Higgs boson in the channel H→ZZ→l+l−qqˉH\rightarrow ZZ\rightarrow l^{+}l^{-} q\bar{q} using the ATLAS detector

    Get PDF
    A search for a heavy Standard Model Higgs boson decaying via H->ZZ->llqq, where l=e,mu, is presented. The search is performed using a data set of pp collisions at sqrt(s)=7 TeV, corresponding to an integrated luminosity of 1.04 fb^-1 collected in 2011 by the ATLAS detector at the CERN LHC collider. No significant excess of events above the estimated background is found. Upper limits at 95% confidence level on the production cross section (relative to that expected from the Standard Model) of a Higgs boson with a mass in the range between 200 and 600 GeV are derived. Within this mass range, there is at present insufficient sensitivity to exclude a Standard Model Higgs boson. For a Higgs boson with a mass of 360 GeV, where the sensitivity is maximal, the observed and expected cross section upper limits are factors of 1.7 and 2.7, respectively, larger than the Standard Model prediction.Comment: 11 pages plus author list (26 pages total), 4 figures, 1 table, final version to appear in Physics Letters

    Charged-particle multiplicities in <i>pp</i> interactions at &#8730;s = 900 GeV measured with the ATLAS detector at the LHC

    No full text
    The first measurements from proton–proton collisions recorded with the ATLAS detector at the LHC are presented. Data were collected in December 2009 using a minimum-bias trigger during collisions at a centre-of-mass energy of 900 GeV. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity, and the relationship between mean transverse momentum and charged-particle multiplicity are measured for events with at least one charged particle in the kinematic range |η|&#60;2.5 and pT&#62;500 MeV. The measurements are compared to Monte Carlo models of proton–proton collisions and to results from other experiments at the same centre-of-mass energy. The charged-particle multiplicity per event and unit of pseudorapidity at η=0 is measured to be1.333&#177;0.003(stat.)&#177;0.040(syst.), which is 5–15% higher than the Monte Carlo models predict

    Measurement of the isolated diphoton cross section in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

    No full text
    15 pages plus author list (27 pages total), 9 figures, 2 tables, submitted to Phys. Rev. DThe ATLAS experiment has measured the production cross-section of events with two isolated photons in the final state, in proton-proton collisions at sqrt(s) = 7 TeV. The full data set acquired in 2010 is used, corresponding to an integrated luminosity of 37 pb-1. The background, consisting of hadronic jets and isolated electrons, is estimated with fully data-driven techniques and subtracted. The differential cross-sections, as functions of the di-photon mass, total transverse momentum and azimuthal separation, are presented and compared to the predictions of next-to-leading-order QCD

    The ATLAS experiment at the CERN Large Hadron Collider

    Get PDF
    The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented
    corecore