Sensitivity of Prescribing High-Intensity, Interval Training Using the Critical Power Concept

International Journal of Exercise Science 8(3): 202-212, 2015. The critical power (CP) concept enables the calculation of time to exhaustion (tLIM) for a given power output above CP using the equation of tLIM = W’/(power – CP), where W’ is the curvature constant, and CP is the asymptote for the power-tLIM relationship. The CP concept offers great promise for prescribing high-intensity interval training (HIIT); however, knowledge on the concept’s sensitivity is lacking (i.e., how much of a difference in W’ expenditure is needed to evoke different metabolic responses). We tested if two different power-tLIM configurations expending identical proportions of W’ would evoke different end-exercise oxygen uptake (VO2) and heart rate (HR) values. Five men and five women completed a graded exercise test, 3-min all-out exercise tests, and intervals prescribed to deplete either 70 or 80% of W’ on separate visits. Consistency statistics of intraclass correlation (ICC a), standard error of measure (SEM), and coefficient of variation (CV) were calculated on end-exercise values. End-exercise VO2 were similar for the 3.5- and 5-min bouts, depleting 70% of W’ (ICC a = 0.91, SEM = 3.23 mL·kg-1·min-1, CV = 8.1%) and similar for the 4- and 5-min bouts, depleting 80% of W’ (ICC a = 0.95, SEM = 2.34 mL·kg-1·min-1, CV = 8.1%). No VO2 differences were observed between trials or conditions (p = 0.58). Similarly, HR values (~181 b·min-1) did not differ between trials or conditions (p = 0.45). Use of the CP concept for HIIT prescriptions of different power-tLIM configurations evokes similar end-exercise VO2 values on a given day. Our findings indicate that \u3e10% W’ depletion is necessary to evoke different metabolic responses to HIIT

Monitoring interval-training responses for swimming using the 3-min all-out exercise test.

International Journal of Exercise Science 9(5): 545-553, 2016. The purpose of this study was to determine whether the 3-min all-out exercise test (3MT) could be applied to create an off-season high intensity, interval training (HIIT) program to improve performance, specifically critical velocity (CV), in the sport of swimming. We tested a group of competitive female swimmers (age = 19 ± 1 yrs, height = 169 ± 7 cm, body mass = 69 ± 9 kg) to determine their swimming CV and finite energy capacity \u3eCV (D’), and created a four week (2 d∙wk-1) personalized interval training program. Participants were divided in to two groups, a 150yd interval group (n =11) and a 250yd interval group (n =6). Each group completed a series of intervals designed to deplete a given percentage of D’ at velocities exceeding CV. A 3MT following the training period was administered to assess for any changes in CV, D’, average velocity during the first 150s of the test (V150s) and total distance traveled (D). Both groups improved their CV (+0.04 m∙s-1), V150s (+0.03 m∙s-1) and D (+8.64 m) (p \u3c 0.05), however, significant interactions for D’ between groups was not observed (p \u3e 0.05). We conclude that HIIT prescriptions based on a 3MT can improve swim performance over a four-week period. Future research on the fidelity of measuring CV and D’ using a swimming 3MT is needed to help aid practitioners in interpreting true training adaptations

Singular shell embedded into a cosmological model

We generalize Israel's formalism to cover singular shells embedded in a non-vacuum Universe. That is, we deduce the relativistic equation of motion for a thin shell embedded in a Schwarzschild/Friedmann-Lemaitre-Robertson-Walker spacetime. Also, we review the embedding of a Schwarzschild mass into a cosmological model using "curvature" coordinates and give solutions with (Sch/FLRW) and without the embedded mass (FLRW).Comment: 25 pages, 2 figure

Another Avenue for Anatomy of Income Comparisons : Evidence from Hypothetical Choice Experiments

September 2010, Revised December 2010, Secondly Revised November 2011, Thirdly Revised May 2012, Fourthly Revised March 2013

CD155/PVR plays a key role in cell motility during tumor cell invasion and migration

BACKGROUND: Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification and validation of candidate proteins necessary for invasion and migration. METHODS: We developed a functional proteomic screen to identify mediators of tumor cell invasion. This screen couples Fluorophore Assisted Light Inactivation (FALI) to a scFv antibody library to systematically inactivate surface proteins expressed by human fibrosarcoma cells followed by a high-throughput assessment of transwell invasion. RESULTS: Using this screen, we have identified CD155 (the poliovirus receptor) as a mediator of tumor cell invasion through its role in migration. Knockdown of CD155 by FALI or by RNAi resulted in a significant decrease in transwell migration of HT1080 fibrosarcoma cells towards a serum chemoattractant. CD155 was found to be highly expressed in multiple cancer cell lines and primary tumors including glioblastoma (GBM). Knockdown of CD155 also decreased migration of U87MG GBM cells. CD155 is recruited to the leading edge of migrating cells where it colocalizes with actin and αv-integrin, known mediators of motility and adhesion. Knockdown of CD155 also altered cellular morphology, resulting in cells that were larger and more elongated than controls when plated on a Matrigel substrate. CONCLUSION: These results implicate a role for CD155 in mediating tumor cell invasion and migration and suggest that CD155 may contribute to tumorigenesis

The global abundance of tree palms

Aim Palms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree palm relative abundance to help improve understanding of tropical forests and reduce uncertainty about these ecosystems under climate change. Location Tropical and subtropical moist forests. Time period Current. Major taxa studied Palms (Arecaceae). Methods We assembled a pantropical dataset of 2,548 forest plots (covering 1,191 ha) and quantified tree palm (i.e., ≥10 cm diameter at breast height) abundance relative to co‐occurring non‐palm trees. We compared the relative abundance of tree palms across biogeographical realms and tested for associations with palaeoclimate stability, current climate, edaphic conditions and metrics of forest structure. Results On average, the relative abundance of tree palms was more than five times larger between Neotropical locations and other biogeographical realms. Tree palms were absent in most locations outside the Neotropics but present in >80% of Neotropical locations. The relative abundance of tree palms was more strongly associated with local conditions (e.g., higher mean annual precipitation, lower soil fertility, shallower water table and lower plot mean wood density) than metrics of long‐term climate stability. Life‐form diversity also influenced the patterns; palm assemblages outside the Neotropics comprise many non‐tree (e.g., climbing) palms. Finally, we show that tree palms can influence estimates of above‐ground biomass, but the magnitude and direction of the effect require additional work. Conclusions Tree palms are not only quintessentially tropical, but they are also overwhelmingly Neotropical. Future work to understand the contributions of tree palms to biomass estimates and carbon cycling will be particularly crucial in Neotropical forests

Overview of the first Wendelstein 7-X long pulse campaign with fully water-cooled plasma facing components

After a long device enhancement phase, scientific operation resumed in 2022. The main new device components are the water cooling of all plasma facing components and the new water-cooled high heat flux divertor units. Water cooling allowed for the first long-pulse operation campaign. A maximum discharge length of 8 min was achieved with a total heating energy of 1.3 GJ. Safe divertor operation was demonstrated in attached and detached mode. Stable detachment is readily achieved in some magnetic configurations but requires impurity seeding in configurations with small magnetic pitch angle within the edge islands. Progress was made in the characterization of transport mechanisms across edge magnetic islands: Measurement of the potential distribution and flow pattern reveals that the islands are associated with a strong poloidal drift, which leads to rapid convection of energy and particles from the last closed flux surface into the scrape-off layer. Using the upgraded plasma heating systems, advanced heating scenarios were developed, which provide improved energy confinement comparable to the scenario, in which the record triple product for stellarators was achieved in the previous operation campaign. However, a magnetic configuration-dependent critical heating power limit of the electron cyclotron resonance heating was observed. Exceeding the respective power limit leads to a degradation of the confinement

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms