15 research outputs found
Food and fasting: Representing the traditional role of women in Hindi cinema
- Author
- Publication venue
- UniversitĂ degli Studi di Milano
- Publication date
- 12/10/2018
- Field of study
Demure Heroines Expressing Sexual Desire. Hints of traditional motifs in popular Hindi cinema
- Author
- Publication venue
- 'Vilnius University Press'
- Publication date
- 01/01/2011
- Field of study
UniversitĂ degli Studi di MilanoIn some of the most successful and representative popular Hindi films released between the 1990s and the early 2000s, the depiction of amorous feelings often takes traditional forms. The reference here is essentially to those films that come more or less within the broad category of classical family dramas: love stories that come up against all sorts of opposition, characterised by the celebration of the traditional Hindu values and the sacrality of the Indian joint-family institution. A particularly interesting aspect emerging here lies in the way in which the sexual desire of the heroineâtypically a chaste and virtuous maidenâfinds representation. On the strength of studied re-elaboration of traditional themes and motifs, these films achieve high levels of stylistic inventiveness and poetic refinement, albeit often limited to certain individual sequences. The apparent purpose of this aesthetic sophistication is to endow amorous feelingsâalways leading inexorably in the direction of marriageâwith an aura of purity and authenticity. Indeed, it is a matter of sentiments so noble and intenseas to win over the consent and blessing of the families by the end of the film. The paper proposes to identify and analyse the conscious use of these traditional motifs in some of the most representative films in this area
Mutations impairing GSK3-mediated MAF phosphorylation cause cataract, deafness, intellectual disability, seizures, and a down syndrome-like facies
- Author
- Anselmi Massimiliano
- Bocchinfuso Gianfranco
- Boitani Carla
- Braddock Stephen R.
- Bruselles Alessandro
- Campeau Philippe M.
- Caputo Viviana
- Cecchetti Serena
- Ciolfi Andrea
- Fiorenza Maria T.
- Gillessen-Kaesbach Gabriele
- Gripp Karen W.
- Katsanis Nicholas
- Keppler-Noreuil Kim
- Kousi Maria
- Lee Brendan H.L.
- Leoni Chiara
- Nakane Takaya
- Niceta Marcello
- Niyazov Dmitriy
- Palleschi Antonio
- Philip Nicole
- Pouponnot Celio
- Prudente Sabrina
- Sol-Church Katia
- Stabley Deborah
- Stella Lorenzo
- Stellacci Emilia
- Tartaglia Marco
- Traversa Alice
- Zampino Giuseppe
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Transcription factors operate in developmental processes to mediate inductive events and cell competence, and perturbation of their function or regulation can dramatically affect morphogenesis, organogenesis, and growth. We report that a narrow spectrum of amino-acid substitutions within the transactivation domain of the v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF), a leucine zipper-containing transcription factor of the AP1 superfamily, profoundly affect development. Seven different de novo missense mutations involving conserved residues of the four GSK3 phosphorylation motifs were identified in eight unrelated individuals. The distinctive clinical phenotype, for which we propose the eponym Aymé-Gripp syndrome, is not limited to lens and eye defects as previously reported for MAF/Maf loss of function but includes sensorineural deafness, intellectual disability, seizures, brachycephaly, distinctive flat facial appearance, skeletal anomalies, mammary gland hypoplasia, and reduced growth. Disease-causing mutations were demonstrated to impair proper MAF phosphorylation, ubiquitination and proteasomal degradation, perturbed gene expression in primary skin fibroblasts, and induced neurodevelopmental defects in an in vivo model. Our findings nosologically and clinically delineate a previously poorly understood recognizable multisystem disorder, provide evidence for MAF governing a wider range of developmental programs than previously appreciated, and describe a novel instance of protein dosage effect severely perturbing developmen
Melanotic Neuroectodermal Tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A Medulloblastoma Signature by DNA Methylation Profiling
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 09/02/2021
- Field of study
MNTI is a rare tumor of indeterminate histogenesis and molecular signature. We performed methylation and copy number variation (CNV) profiles in patients with MNTI (n = 7) and PAT (n = 1) compared to the methylation brain tumor classifier v11b4 (BT-C) and the medulloblastoma (MB) classifier group 3/4 v1.0 (MB3/4-C). The patientsâ mean age was 8 months (range: 4â48). The BT-C classified five MNTIs and one PAT (relapse) as class family MB-G3/G4, subclass group 3 (score: >0.9). The remaining two MNTIs and PAT (primary) were classified as class family plexus tumor, subclass pediatric (scores: >0.45). The MB3/4-C classified all MNTIs as high-risk MB-G3, Subtype II (score: >0.45). The primary PAT was classified as subtype III (score: 0.99) and its relapse as subtype II/III. MNTI and PAT clustered close to MB-G3. CNV analysis showed multiple rearrangements in one PAT and two MNTIs. The median follow-up was 54 months (four MNTIs in remission, one PAT died). In conclusion, we demonstrated that MNTI shares a homogenous methylation profile with MB-G3, and possibly with PAT. The role of a multipotent progenitor cell (i.e., early cranial neural crest cell) in their histogenesis and the influence of the anatomical site, tumor microenvironment, and other cytogenetic events in their divergent biologic behavior deserve further investigation
Multi-messenger observations of a binary neutron star merger
- Author
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
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- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Multi-messenger Observations of a Binary Neutron Star Merger
- Author
- (Deeper DWF
- Aartsen M. G.
- Abbott B. P.
- Abbott R.
- Abbott T. D.
- Abbott T. M. C.
- Abe F.
- Acernese F.
- Acero F.
- Ackermann M.
- Ackley K.
- Adams C.
- Adams J.
- Adams S. M.
- Adams T.
- Addesso P.
- Adhikari R. X.
- Adya V. B.
- Affeldt C.
- Afrough M.
- Agarwal B.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- AGILE Team
- Agliozzo C.
- Aguiar O. D.
- Aguilar J. A.
- Ahlers M.
- Ahrens M.
- Aiello L.
- Ain A.
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 28/10/2022
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later
designated GW170817) with merger time 12:41:04 UTC was observed through
gravitational waves by the Advanced LIGO and Advanced Virgo detectors.
The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray
burst (GRB 170817A) with a time delay of ⌠1.7 {{s}} with respect to
the merger time. From the gravitational-wave signal, the source was
initially localized to a sky region of 31 deg2 at a
luminosity distance of {40}-8+8 Mpc and with
component masses consistent with neutron stars. The component masses
were later measured to be in the range 0.86 to 2.26 {M}ÈŻ
. An extensive observing campaign was launched across the
electromagnetic spectrum leading to the discovery of a bright optical
transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC
4993 (at ⌠40 {{Mpc}}) less than 11 hours after the merger by the
One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The
optical transient was independently detected by multiple teams within an
hour. Subsequent observations targeted the object and its environment.
Early ultraviolet observations revealed a blue transient that faded
within 48 hours. Optical and infrared observations showed a redward
evolution over âŒ10 days. Following early non-detections, X-ray and
radio emission were discovered at the transientâs position ⌠9
and ⌠16 days, respectively, after the merger. Both the X-ray and
radio emission likely arise from a physical process that is distinct
from the one that generates the UV/optical/near-infrared emission. No
ultra-high-energy gamma-rays and no neutrino candidates consistent with
the source were found in follow-up searches. These observations support
the hypothesis that GW170817 was produced by the merger of two neutron
stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and
a kilonova/macronova powered by the radioactive decay of r-process
nuclei synthesized in the ejecta.</p
«Only consideration is a good girl». Uno sguardo sulla societĂ contemporanea indiana attraverso unâanalisi degli annunci matrimoniali
- Author
- Publication venue
- UniversitĂ degli Studi di Milano
- Publication date
- 17/09/2020
- Field of study
Tutto Ăš sacro in India
- Publication venue
- place:Milano
- Publication date
- 01/01/2022
- Field of study
Tutto Ăš sacro in India torna in libreria in unâedizione interamente riveduta, ricca di contenuti aggiuntivi â in particolare gli interventi sulla condizione femminile e sul cinema â e con una nuova veste grafica, cui si accompagnano le fotografie di Christopher Taylor. La ricerca, che si propone di avvicinare il mondo orientale e la sua sensibilitĂ , approfondisce alcuni aspetti dellâinduismo. In particolare si Ăš cercato dâindagare come in India le grandissime trasformazioni in fieri interagiscano con lâinduismo, millenario non solo come religione, ma anche come modo di vita che impronta dai fondamenti lâintera esistenza del popolo indiano, fin nei piĂč piccoli gesti quotidiani
Expanding the spectrum of EWSR1-PATZ1 rearranged CNS tumors: An infantile case with leptomeningeal dissemination
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
We report on a case of EWSR1-PATZ1 rearranged brain tumor occurring in a 17 month-old child, originally interpreted as an infantile glioblastoma. Our case shows important analogies with the 2 previously reported cases, including the intraventricular location, the histologic appearance (pushing borders, oligodendrocyte-like morphology, rich vascular network) and the glioneural immunophenotype, supporting the role of these features as relevant clues to the diagnosis. On the other hand, our case displays unique characteristics, i.e. the onset in an infant, the presence of a focal high-grade component and the leptomeningeal dissemination, pointing to the importance of considering this entity in the differential diagnosis of an infantile glial/glioneural tumor