103 research outputs found
Economics of neuraminidase inhibitor stock piling for pandemic influenza, Singapore.
- Publication venue
- 'Centers for Disease Control and Prevention (CDC)'
- Publication date
- 01/01/2006
- Field of study
We compared strategies for stock piling neuraminidase inhibitors to treat and prevent influenza in Singapore. Cost-benefit and cost-effectiveness analyses, with Monte Carlo simulations, were used to determine economic outcomes. A pandemic in a population of 4.2 million would result in an estimated 525-1,775 deaths, 10,700-38,600 hospitalization days, and economic costs of 0.7 dollars to 2.2 billion Singapore dollars. The treatment-only strategy had optimal economic benefits: stock piles of antiviral agents for 40% of the population would save an estimated 418 lives and 414 million dollars, at a cost of 52.6 million dollars per shelf-life cycle of the stock pile. Prophylaxis was economically beneficial in high-risk subpopulations, which account for 78% of deaths, and in pandemics in which the death rate was >0.6%. Prophylaxis for pandemics with a 5% case-fatality rate would save 50,000 lives and 81 billion dollars. These models can help policymakers weigh the options for pandemic planning
New record of the Japanese seahorse Hippocampus mohnikei Bleeker, 1853 (Syngnathiformes: Syngnathidae) in Hong Kong waters
- Author
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Funding: This study was supported by the Consultancy Project (AFCD/SQ/13/17) of the Agriculture, Fisheries and Conservation Department of the Government of the Hong Kong SAR and the Collaborative Research Fund (C7013-19G) of the Hong Kong Research Grants Council.A new record of Hippocampus mohnikei Bleeker, 1853 was confirmed in Hong Kong through morphological and molecular identification. It is highly possible that there is an established population of H. mohnikei in Hong Kong due to continuous sightings by citizen scientists in the past nine years. The record is significant from a biogeographical perspective as it connects the distributions of known populations in northern China and Japan to those spanning Thailand to India. This further affirms the status of Hong Kong as a hotspot for seahorse biodiversity and conservation in China.Publisher PDFPeer reviewe
Locating delaminations in laminated composite beams using nonlinear guided waves
- Author
- Aryan
- Bermes
- Blanloeuil
- Blanloeuil
- Cawley
- Ching-Tai Ng
- Chow
- Donskoy
- Dziedziech
- Giurgiutiu
- Hagedorn
- Haynes
- He
- He
- He
- Hong
- Hu
- Ihn
- Kazakov
- Kim
- Kim
- Klepka
- Konstantinidis
- Lam
- Lee
- Li
- Martin
- Mitra
- Naugolnykh
- Ng
- Ng
- Ng
- Ng
- Ng
- Orban
- Ostachowicz
- Rajagopal
- Ramdhas
- Ramos
- Reza Soleimanpour
- Rose
- Sahin
- Salawu
- Santos
- Selva
- Sohn
- Soleimanpour
- Soleimanpour
- Soleimanpour
- Soleimanpour
- Solodv
- Stewart
- Wang
- Yeum
- Yin
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Available online 14 November 2016This paper proposes a new method for detecting and locating delaminations in laminated composite beams using nonlinear guided wave. It is shown that when incident wave interacts at the delamination, the nonlinear effect of wave interaction with contact interfaces at the delamination generates higher harmonic guided waves due to contact acoustic nonlinearity (CAN). The proposed method employs a transducer network to detect and locate the delamination using the higher harmonic guided waves. A sequential scan is used to inspect the laminated composite beams by actuating the fundamental anti-symmetric mode (A0) of guided wave at one of the transducers while the rest of the transducers are used for measuring the impinging waves. A series of numerical case studies are performed using three-dimensional explicit finite element simulations, which consider different delamination locations, lengths and through-thickness locations. Experimental case studies are carried out to further validate and demonstrate the capability of the proposed method. The results show that the proposed method is able to accurately detect and locate the delamination in the laminated composite beams using the higher harmonic guided waves. One of the advantages of the proposed method is that it does not rely on baseline data to detect and locate the delamination, and hence, it has less influence by varying operational and environmental conditions.Reza Soleimanpour, Ching-Tai N
Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan
- Author
- Chan Chia-Hao
- Chang Cheng-Chang
- Chang Chih-Long
- Chang Shing-Jyh
- Chang Ting-Chen
- Chang Wei-Chun
- Chang Wen-Chun
- Chang Wen-Hsun
- Chang Yen-Hou
- Chang Yi
- Chao Hsiang-Tai
- Chao Kuan-Chong
- Chen Chih-Ping
- Chen Chih-Yao
- Chen Chii-Hou
- Chen Ching-Hui
- Chen Jen-Ruei
- Chen Kuo-Hu
- Chen Ruey-Jian
- Chen San-Nung
- Chen Tze-Chien
- Chen Tze-Ho
- Chen Yi-Jen
- Chiang An-Jen
- Chiou Jyh-Shin
- Chow Song-Nan
- Chu Ching-Chuang
- Chuang Chi-Mu
- Chuang Fei-Chi
- Fu Hung-Chun
- Ho Chi-Hong
- Horng Huann-Cheng
- Hsiao Sheng-Mou
- Hsieh Ching-Hung
- Hsu Shih-Tien
- Hsu Yen-Mei
- Huang Ben-Shian
- Huang Chen-Yu
- Huang Jian-Pei
- Huang Kuan-Hui
- Huang Kuo-Feng
- Huang Lee-Wen
- Huang Ming-Chao
- Huang Shu-Yun
- Hung Jeng-Hsiu
- Hung Man-Jung
- Hung Yao-Ching
- Jiang Ling-Yu
- Ju Fong-Yuan
- Ke Yu-Min
- Kung Fu-Tsai
- Lai Hung-Cheng
- Lai Tsung-Hsuan
- Lee Fa-Kung
- Lee Na-Rong
- Lee Wen-Ling
- Li Hsin-Yang
- Li Ju-Yueh
- Li Yiu-Tai
- Lien Yih-Ron
- Lin Li-Te
- Lin Wu-Chou
- Liu Chia-Hao
- Liu Jah-Yao
- Liu Wei-Min
- Lu Chien-Hsing
- Lu Yen-Feng
- Seow Kok-Min
- Sheu Bor-Ching
- Shih Chuan-Chi
- Su Her-Young
- Sun Hsu-Dong
- Sun Lou
- Sun Pi-Lin
- Teng Sen-Wen
- Torng Pao-Ling
- Tsai Chih-Ping
- Tsai Hsiao-Wen
- Tsui Kuan-Hao
- Wang Chin-Jung
- Wang Kuan-Chin
- Wang Peng-Hui
- Wang Po-Hui
- Wang Yeou-Lih
- Wang Yu-Chi
- Wen Kuo-Chang
- Wu Hua-Hsi
- Wu Meng-Hsing
- Wu Wen-Yih
- Yen Men-Luh
- Yen Ming-Shyen
- Yu Hann-Chin
- Yu Mu-Hsien
- Yuan Chiou-Chung
- Publication venue
- , the Chinese Medical Association. Published by Elsevier Taiwan LLC.
- Publication date
- 30/11/2016
- Field of study
AbstractEndometriosis, defined by the presence of viable extrauterine endometrial glands and stroma, can grow or bleed cyclically, and possesses characteristics including a destructive, invasive, and metastatic nature. Since endometriosis may result in pelvic inflammation, adhesion, chronic pain, and infertility, and can progress to biologically malignant tumors, it is a long-term major health issue in women of reproductive age. In this review, we analyze the Taiwan domestic research addressing associations between endometriosis and other diseases. Concerning malignant tumors, we identified four studies on the links between endometriosis and ovarian cancer, one on breast cancer, two on endometrial cancer, one on colorectal cancer, and one on other malignancies, as well as one on associations between endometriosis and irritable bowel syndrome, one on links with migraine headache, three on links with pelvic inflammatory diseases, four on links with infertility, four on links with obesity, four on links with chronic liver disease, four on links with rheumatoid arthritis, four on links with chronic renal disease, five on links with diabetes mellitus, and five on links with cardiovascular diseases (hypertension, hyperlipidemia, etc.). The data available to date support that women with endometriosis might be at risk of some chronic illnesses and certain malignancies, although we consider the evidence for some comorbidities to be of low quality, for example, the association between colon cancer and adenomyosis/endometriosis. We still believe that the risk of comorbidity might be higher in women with endometriosis than that we supposed before. More research is needed to determine whether women with endometriosis are really at risk of these comorbidities
The ubiquitin proteasome system in neuropathology
- Author
- A Buchberger
- A Chenn
- A Cuesta
- A Dil Kuazi
- A Hershko
- A Iwata
- A Kinoshita
- A Mishra
- A Williams
- A Zimprich
- AL Haas
- AL Schwartz
- AL Ström
- AS Fleisher
- AS Lebre
- B Boland
- B Gong
- B Varghese
- B Yang
- BE Riley
- BY Kim
- C Chen
- C Gaig
- C Song
- C Wojcik
- C Wojcik
- CC Weihl
- CJ Braun
- CT Chu
- D Guardavaccaro
- D Nonis
- DM Koepp
- DP Huynh
- DW Cleveland
- E Allen
- E Liani
- EC VanderPorten
- EJ Bennett
- EJ Eide
- EM Tank
- EP Grant
- EW Verschuren
- FR Westwood
- G Morreale
- G Murakami
- GT Wong
- H Xiong
- HC Ardley
- HC Tai
- HK Wong
- HL Wang
- HS Ko
- IE Holm
- IR Mackenzie
- J Dong
- J Dusonchet
- J Fortun
- J Hanai
- J Lagirand-Cantaloube
- J Miklossy
- J Ramesh Babu
- J Schimmel
- J Wang
- JA Golden
- JC Cook
- JD Lathia
- JD Reimann
- JF Staropoli
- JH Vissers
- JJ Miller
- JJ Yi
- JP Kruse
- JP Kruse
- JT Glessner
- JT Lee
- JY Hsu
- K Makedonski
- K Neben
- K Shiba
- K Yamanaka
- KA Josephs
- L Hesson
- LD Mayo
- M Arrasate
- M Cully
- M Fujiwara
- M Hart
- M Koegl
- M Kristiansen
- M Kristiansen
- M Neumann
- MB Michalowski
- ME Cockman
- ME Lusher
- MG Manfredi
- MJ Kim
- N Chow
- N Parkinson
- NL Lehman
- NL Lehman
- NL Lehman
- NL Lehman
- Norman L. Lehman
- PG Richardson
- Q Zhai
- R Buslei
- R Rott
- R Sadeh
- R Setsuie
- RJ Jones
- RM Liscic
- RR Kopito
- S Dayal
- S Engelender
- S Finkbeiner
- S Hong
- S Liu
- S Muller
- S Roeber
- S Sartori
- S Sekine
- S Tydlacka
- SE Gibson
- SE Lloyd
- SH Kim
- SJ Berke
- SJ Song
- SV Todi
- T Kawashima
- TJ Kannanayakal
- V Kirkin
- WG Kaelin
- X Lu
- Y Chen
- Y Chen
- Y Elgersma
- Y Huang
- Y Kang
- Y Konishi
- Y Morishima
- Y Mosesson
- Y Sheng
- Y Xia
- Y Yang
- YC Liu
- Z Feng
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
The ubiquitin proteasome system (UPS) orchestrates the turnover of innumerable cellular proteins. In the process of ubiquitination the small protein ubiquitin is attached to a target protein by a peptide bond. The ubiquitinated target protein is subsequently shuttled to a protease complex known as the 26S proteasome and subjected to degradative proteolysis. The UPS facilitates the turnover of proteins in several settings. It targets oxidized, mutant or misfolded proteins for general proteolytic destruction, and allows for the tightly controlled and specific destruction of proteins involved in development and differentiation, cell cycle progression, circadian rhythms, apoptosis, and other biological processes. In neuropathology, alteration of the UPS, or mutations in UPS target proteins may result in signaling abnormalities leading to the initiation or progression of tumors such as astrocytomas, hemangioblastomas, craniopharyngiomas, pituitary adenomas, and medulloblastomas. Dysregulation of the UPS may also contribute to tumor progression by perturbation of DNA replication and mitotic control mechanisms, leading to genomic instability. In neurodegenerative diseases caused by the expression of mutant proteins, the cellular accumulation of these proteins may overload the UPS, indirectly contributing to the disease process, e.g., sporadic Parkinsonism and prion diseases. In other cases, mutation of UPS components may directly cause pathological accumulation of proteins, e.g., autosomal recessive Parkinsonism and spinocerebellar ataxias. Defects or dysfunction of the UPS may also underlie cognitive disorders such as Angelman syndrome, Rett syndrome and autism, and muscle and nerve diseases, e.g., inclusion body myopathy and giant axon neuropathy. This paper describes the basic biochemical mechanisms comprising the UPS and reviews both its theoretical and proven involvement in neuropathological diseases. The potential for the UPS as a target of pharmacological therapy is also discussed
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Bergsten Laura
- Beringer Jürg
- Berlendis Simon
- Bernard Nathan
- Bernardi Gregorio
- Bernius Catrin
- Bernlochner Florian
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
- Betti Alessandra
- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
- Biebel Otmar
- Biedermann Dustin
- Bielski Rafal
- Bierwagen Katharina
- Biesuz Nicolo
- Biglietti Michela
- Billoud Thomas
- Bilokon Halina
- Bindi Marcello
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Bisanz Tobias
- Bittrich Carsten
- Bjergaard David
- Black James
- Black Kevin
- Blair Robert
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bokan Petar
- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
- Burch Tyler
- Burdin Sergey
- Burgard Carsten
- Burger Angela
- Burghgrave Blake
- Burka Klaudia
- Burke Stephen
- Burmeister Ingo
- Burr Jonathan
- Bussey Peter
- Butler John
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrancesco
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- C-Q Changqiao
- Cabrera Urbán Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Callea Giuseppe
- Caloba Luiz
- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- Carrá Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
- Chan Yat
- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
- Ciocio Alessandra
- Cirotto Francesco
- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
- Corriveau Francois
- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa María
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey
- Daneri Maria
- Dang Nguyen
- Daniells Andrew
- Dann Nicholas
- Danninger Matthias
- Dano Hoffmann Maria
- Dao Valerio
- Darbo Giovanni
- Darmora Smita
- Dassoulas James
- Dattagupta Aparajita
- Daubney Thomas
- Davey Will
- David Claire
- Davidek Tomas
- Davis Douglas
- Davison Peter
- Dawe Edmund
- Dawson Ian
- de Asmundis Riccardo
- De Benedetti Abraham
- De Castro Stefano
- De Cecco Sandro
- De Groot Nicolo
- De Jong Paul
- De la Torre Hector
- De Lorenzi Francesco
- De Maria Antonio
- De Pedis Daniele
- De Salvo Alessandro
- De Sanctis Umberto
- De Santo Antonella
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- Webb Samuel
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- Weber Sebastian
- Weber Stefan
- Weber Stephen
- Webster Jordan
- Weidberg Anthony
- Weinert Benjamin
- Weingarten Jens
- Weirich Marcel
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- Yamamoto Shimpei
- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
- Yoshihara Keisuke
- Young Charles
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- Yu Jaehoon
- Yu Jie
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zacharis Georgios
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
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- Álvarez ÉMC
- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
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- Acevedo-Arozena A.
- Adamopoulos I. E.
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- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
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- Alcocer-Gomez E.
- Alessandri C.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Recommended from our members
Analyses of pig genomes provide insight into porcine demography and evolution
- Author
- Ahn Hyeonju
- Aken Bronwen L.
- Anselmo Anna
- Anthon Christian
- Archibald Alan L.
- Auvil Loretta
- Badaoui Bouabid
- Beattie Craig W.
- Bendixen Christian
- Berman Daniel
- Blecha Frank
- Blomberg Jonas
- Bolund Lars
- Bosse Mirte
- Botti Sara
- Bujie Zhan
- Bystrom Megan
- Caccamo Mario
- Capitanu Boris
- Carvalho-Silva Denise
- Chardon Patrick
- Chen Celine
- Cheng Ryan
- Choi Sang-Haeng
- Chow William
- Churcher Carol
- Clark Richard C.
- Clee Christopher
- Crooijmans Richard P. M. A.
- Dawson Harry D.
- De Sapio Fioravante
- Dehais Patrice
- Dibbits Bert
- Drou Nizar
- Du Zhi-Qiang
- Eversole Kellye
- Fadista João
- Fairley Susan
- Faraut Thomas
- Faulkner Geoffrey J.
- Fowler Katie E.
- Frantz Laurent A. F.
- Fredholm Merete
- Fritz Eric
- Gilbert James G. R.
- Giuffra Elisabetta
- Gorodkin Jan
- Griffin Darren K.
- Groenen Martien A. M.
- Harrow Jennifer L.
- Hayward Alexander
- Hornshøj Henrik
- Howe Kerstin
- Hu Zhi-Liang
- Humphray Sean J.
- Hunt Toby
- Jeon Jin-Tae
- Jern Patric
- Jones Matthew
- Jurka Jerzy
- Kanamori Hiroyuki
- Kapetanovic Ronan
- Kim Heebal
- Kim Jae-Hwan
- Kim Jaebum
- Kim Kyu-Won
- Kim Tae-Hun
- Larkin Denis M.
- Larson Greger
- Lee Kyooyeol
- Lee Kyung-Tai
- Leggett Richard
- Lewin Harris A.
- Li Shengting
- Li Yingrui
- Liu Wansheng
- Loveland Jane E.
- Lu Yao
- Lunney Joan K.
- Ma Jian
- Madsen Ole
- Mann Katherine
- Matthews Lucy
- McLaren Stuart
- Megens Hendrik-Jan
- Milan Denis
- Morozumi Takeya
- Murtaugh Michael P.
- Narayan Jitendra
- Ni Peixiang
- Oh Song-Jung
- Onteru Suneel
- Panitz Frank
- Park Chankyu
- Park Eung-Woo
- Park Hong-Seog
- Pascal Geraldine
- Paudel Yogesh
- Perez-Enciso Miguel
- Ramirez-Gonzalez Ricardo
- Reecy James M.
- Rodriguez-Zas Sandra
- Rogel-Gaillard Claire
- Rogers Jane
- Rohrer Gary A.
- Rothschild Max F.
- Rund Lauretta
- Sang Yongming
- Schachtschneider Kyle
- Schook Lawrence B.
- Schraiber Joshua G.
- Schwartz John
- Scobie Linda
- Scott Carol
- Searle Stephen
- Servin Bertrand
- Southey Bruce R.
- Sperber Goran
- Stadler Peter
- Sweedler Jonathan V.
- Tafer Hakim
- Takeuchi Yasuhiro
- Thomsen Bo
- Truong Nguyen Dinh
- Tuggle Christopher K.
- Uenishi Hirohide
- Wali Rashmi
- Wang Jian
- Wang Jun
- White Simon
- Xu Xun
- Yerle Martine
- Zhang Guojie
- Zhang Jianguo
- Zhang Jie
- Zhao Shuhong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model
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