548 research outputs found
The Effects of Irreversible Electroporation (IRE) on Nerves
- Author
- AC Fullarton
- B Rubinsky
- B Rubinsky
- C Ball
- E Maor
- E Maor
- E Tekle
- EW Lee
- EW Lee
- G Lundborg
- G Onik
- G Onik
- GM Hare
- GS Abramov
- H Shafiee
- Ilya Ulasov
- JK Terzis
- JR Bain
- JR Hess
- K Thomson
- LT George
- M Fernandes
- M Pech
- M Rafiuddin Ahmed
- MG Burnett
- PC Ferguson
- Qingyu Fan
- RV Davalos
- SN Goldberg
- SY Fu
- T Gordon
- T Tsuchihara
- Wei Li
- Xiuchun Qiu
- Y Guo
- Y Suzuki
- YS Choi
- Zhao Li
- Zhenwei Ji
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Background: If a critical nerve is circumferentially involved with tumor, radical surgery intended to cure the cancer must sacrifice the nerve. Loss of critical nerves may lead to serious consequences. In spite of the impressive technical advancements in nerve reconstruction, complete recovery and normalization of nerve function is difficult to achieve. Though irreversible electroporation (IRE) might be a promising choice to treat tumors near or involved critical nerve, the pathophysiology of the nerve after IRE treatment has not be clearly defined. Methods: We applied IRE directly to a rat sciatic nerve to study the long term effects of IRE on the nerve. A sequence of 10 square pulses of 3800 V/cm, each 100 ms long was applied directly to rat sciatic nerves. In each animal of group I (IRE) the procedure was applied to produce a treated length of about 10 mm. In each animal of group II (Control) the electrodes were only applied directly on the sciatic nerve for the same time. Electrophysiological, histological, and functional studies were performed on immediately after and 3 days, 1 week, 3, 5, 7 and 10 weeks following surgery. Findings: Electrophysiological, histological, and functional results show the nerve treated with IRE can attain full recovery after 7 weeks. Conclusion: This finding is indicative of the preservation of nerve involving malignant tumors with respect to the application of IRE pulses to ablate tumors completely. In summary, IRE may be a promising treatment tool for any tumor involving nerves
Derangement of body representation in complex regional pain syndrome: report of a case treated with mirror and prisms
- Author
- A Maravita
- AF AbuRahma
- AL Oaklander
- B Pleger
- BS Galer
- C Maihofner
- C Maihofner
- CS McCabe
- CS McCabe
- CS McCabe
- DC Manning
- E Torebjork
- FC Schasfoort
- FJ Huygen
- G Wasner
- GL Moseley
- GL Moseley
- GM Alexander
- HC Dijkerman
- HS Levin
- J Maleki
- JA Evans
- Janet H. Bultitude
- JE Greenleaf
- JS Lewis
- KK Lam
- L Laan van der
- L Pisella
- M Mos de
- M Sarri
- M Stanton-Hicks
- M Sumitani
- N Gordon
- P Berger
- P Doury
- P Sudeck
- PH Veldman
- PR McCrory
- RD McIntosh
- Robert D. Rafal
- S Bruehl
- S Forderreuther
- SW Mitchell
- T Anderson
- VS Ramachandran
- WM Bortz 2nd
- Y Rossetti
- YIGV Tichelaar
- YS Choi
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Perhaps the most intriguing disorders of body representation are those that are not due to primary disease of brain tissue. Strange and sometimes painful phantom limb sensations can result from loss of afference to the brain; and Complex Regional Pain Syndrome (CRPS)—the subject of the current report—can follow limb trauma without pathology of either the central or peripheral nervous system. This enigmatic and vexing condition follows relatively minor trauma, and can result in enduring misery and a useless limb. It manifests as severe pain, autonomic dysfunction, motor disability and ‘neglect-like’ symptoms with distorted body representation. For this special issue on body representation we describe the case of a patient suffering from CRPS, including symptoms suggesting a distorted representation of the affected limb. We report contrasting effects of mirror box therapy, as well as a new treatment—prism adaptation therapy—that provided sustained pain relief and reduced disability. The benefits were contingent upon adapting with the affected limb. Other novel observations suggest that: (1) pain may be a consequence, not the cause, of a disturbance of body representation that gives rise to the syndrome; (2) immobilisation, not pain, may precipitate this reorganisation of somatomotor circuits in susceptible individuals; and (3) limitation of voluntary movement is neither due to pain nor to weakness but, rather, to derangement of body representation which renders certain postures from the repertoire of hand movements inaccessible
The organelle of differentiation in embryos: the cell state splitter
- Author
- A Eldar
- A Ephrussi
- A Schnittger
- AC Martin
- AD Lander
- AD Lander
- AG Jacobson
- AJ Putnam
- AM Berezhkovskii
- AM Deaton
- AM Lachapelle De
- AT Esser
- B Alicea
- B Galatis
- B Greese
- C Nouri
- CC Martin
- CJ Miller
- CM Child
- CM Child
- CX Yang
- D Lobo
- D Patterson
- DH Jewson
- DH Kim
- DW Thompson
- E Aaku-Saraste
- E Bianconi
- E Bülbring
- E Eisenberg
- E Emberly
- E Fosslien
- E Li
- EV Entchev
- F Dominguez
- F Hamaratoglu
- F Pagès
- F Tang
- FE Round
- FM Leslie
- G Marnellos
- G Struhl
- G Swiers
- GA Deblandre
- GJ Arnold
- GW Brodland
- GW Brodland
- GW Brodland
- H Akashi
- H Nishida
- H Spemann
- H Yasuo
- HK MacWilliams
- HL Knudsen
- HW Yin
- HW Yin
- HW Yin
- HW Yin
- I Peter
- J Burša
- J Schulze
- J Zhu
- J-L Plouhinec
- JA Tuszynski
- JB Gurdon
- JB Tucker
- JBL Bard
- JC Larkin
- JH Woodger
- JL Christian
- JL England
- JL Stubbs
- JP Bothma
- JR Lucas
- JS Kanodia
- JT Bonner
- JY Kim
- JZ Lei
- KE Yutzey
- KK Chiou
- L Serna
- L Wolpert
- LF Jaffe
- LJ Pillitteri
- LN Ma
- LS Quinn
- M Aliee
- M Grbić
- M Grebe
- M Ibanes
- M Inui
- M Kerszberg
- M Kerszberg
- M Kerszberg
- M Kieny
- M Lobikin
- M Nahmad
- MB Burnside
- MB Burnside
- MB Gerstein
- MB Stein
- MH Schaefer
- MJ Herriges
- MT Kirber
- N Barkai
- N Lee
- N Ohura
- Natalie K. Gordon
- NK Björklund
- NK Gordon
- NP Bordzilovskaya
- P Barlow
- P McHale
- PC Baker
- PG Cranston
- PJ Rudall
- PM Burton
- R Gordon
- R Gordon
- R Gordon
- R Gordon
- R Gordon
- R Gordon
- R Kumar
- R Wall
- RA Irizarry
- RE Baker
- Richard Gordon
- RR Kay
- RS Illingworth
- RT Franceschi
- S Bergmann
- S Bergmann
- S Crawford-Young
- S Dalessi
- S Ishihara
- S Ishihara
- S Payne
- SE Siegrist
- SL Berger
- SS Choi
- T Glimm
- T Glimm
- T Gregor
- T Sachs
- T Saunders
- V Conte
- V Hamburger
- V Nigon
- VD Varner
- Y Morishita
- Y Zhang
- YF Wu
- YS Chatzizisis
- YS Rao
- Z Tamari
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
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- Balli F
- Balunas WK
- Balz J
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- Bohm C
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- Booth CD
- Borecka-Bielska HM
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- Borisov A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Systematic review of methods used in meta-analyses where a primary outcome is an adverse or unintended event
- Author
- A Cobitz
- A Lee
- A Lethaby
- A Pfahlberg
- A Seto
- A Sutton
- AC Verhoeven
- AG Johnson
- AI Ismail
- AJ Sutton
- Alex J Sutton
- AW Hoes
- B Takkouche
- B Uzzan
- BA Brumback
- BF Hwang
- BG Bender
- BJ Lipworth
- BM Jolles
- BW Mol
- C Anderson-Hanley
- C Barbui
- C Chapron
- C Cutler
- C Dezfulian
- C Mardirosoff
- CB Begg
- CD Furberg
- CH Chang
- Collaborative Group on Hormonal Factors in Breast Cancer
- CU Correll
- D Ashby
- D Ashby
- D Grady
- D Henry
- D O’Connell
- D Spiegelhalter
- DA Schaumberg
- DB Allen
- DB Allison
- DCE Warltier
- DDZ Zaric
- DE Kellstein
- DJ Torgerson
- DJ Torgerson
- DM Ashcroft
- DT Ko
- DT Ko
- E Ashraf
- E Banks
- E Bernal-Delgado
- E Fernandez
- E Grossman
- E Kozer
- E Oger
- E Raaijmakers
- E Trindade
- EC Janowsky
- EC Vamvakas
- EC Vamvakas
- EC Vamvakas
- EH Liu
- EJ Kongnyuy
- EJ Waterman
- ES LeBlanc
- EW Dong
- F Grodstein
- F Reynolds
- FA McAlister
- FC Warren
- FD Reid
- Fiona C Warren
- G Duffy
- G Jones
- GA Diamond
- GD Graham
- H Sakai
- I Nazareth
- J He
- J Lazarou
- J Miller
- JA Berlin
- JB Carlin
- JC Hauth
- JD Douketis
- JE Barone
- JG Ray
- JJ Ofman
- JJ Ofman
- JM Guise
- JM Henk
- JM Kemmeren
- Jonker-Pool
- JPA Ioannidis
- JPT Higgins
- JPT Higgins
- JQ Huang
- JR Sneyd
- JS Brown
- JS Smith
- JW Anderson
- JW Eikelboom
- JW Robinson
- K Nanda
- K Wilson
- K Yaffe
- Keith R Abrams
- L Nalysnyk
- L Park-Wyllie
- LA Garcia Rodriguez
- LA Garcia Rodriguez
- LA Gillum
- LL Humphrey
- LR Dolovich
- LW Doyle
- M Doren
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- M Egger
- M Etminan
- M Etminan
- M Etminan
- M Pladevall-Vila
- M Sachdev
- M Sagsveen
- M Wehling
- MB Bracken
- ME Cardwell
- MF Muldoon
- MJ Bradburn
- MJ Sweeting
- MR DiMatteo
- MR Tramer
- N Hébert-Croteau
- N Mantel
- N Safdar
- NF Col
- NJ Welton
- O Heisel
- O Olsen
- OT Rutschmann
- P Gupta
- P Impicciatore
- P Schoenfeld
- P von Dadelszen
- P Wiffen
- PC Lambert
- PJ Caraballo
- PM Rothwell
- PM Rothwell
- PP Garg
- PT Choi
- PV Gordon
- R DerSimonian
- R Gabriel Sánchez
- R Ivanov
- R Marcolongo
- RG Hart
- RM Leipzig
- RM Leipzig
- RM Turner
- S Ben-David
- S Brown
- S Derry
- S Derry
- S Duval
- S Golder
- S Golder
- S Golder
- S Golder
- S Greenland
- S Hennessy
- S Moiniche
- S Nissen
- S Ruesch
- S Torvaldsen
- S Yusuf
- SB Vercauteren
- SC Cannegieter
- SC Johnston
- SC MacLennan
- SD Ross
- SD Ross
- SE Nissen
- SR Mehta
- SR Salpeter
- SR Salpeter
- SR Salpeter
- SR Salpeter
- SR Salpeter
- SS Coughlin
- Su Golder
- T Berglundh
- T Caro-Paton
- TC Prevost
- TM Lee
- VL Serebruany
- VR Cornelius
- VR Vorperian
- WB Stason
- WB Stason
- WS Chan
- X Xiong
- YK Loke
- YK Loke
- YK Loke
- YS Khader
- Z Alfirevic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
addresses: Peninsula College of Medicine and Dentistry, St Luke's Campus, University of Exeter, Exeter, UK. [email protected]: PMCID: PMC3528446types: Journal Article; Research Support, Non-U.S. Gov't© 2012 Warren et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Adverse consequences of medical interventions are a source of concern, but clinical trials may lack power to detect elevated rates of such events, while observational studies have inherent limitations. Meta-analysis allows the combination of individual studies, which can increase power and provide stronger evidence relating to adverse events. However, meta-analysis of adverse events has associated methodological challenges. The aim of this study was to systematically identify and review the methodology used in meta-analyses where a primary outcome is an adverse or unintended event, following a therapeutic intervention
Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?
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- A Compston
- A Doring
- A Doring
- A Jacob
- A Jacob
- A Jacob
- A Kutzelnigg
- A Stroet
- A Zini
- AC Ludolph
- AE Handel
- AE Handel
- AE Handel
- AE Handel
- AK Andreasen
- AK Sachdeva
- AM Haque
- AU Brandt
- B Frei
- B Kandinov
- B Uttara
- BA Sutherland
- BA Sutherland
- BM Greenberg
- BT Zhu
- C Behl
- C Chanvillard
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- C Otto
- C Papeix
- C Quinn
- C Roodveldt
- C Urbanek
- C Veauthier
- C Veauthier
- C Voisine
- C Zuccato
- CF Pfueller
- CF Pfueller
- CH Hawkes
- CM Ellis
- CM Lloyd
- CW Chou
- CW Olanow
- CY Kim
- D Baker
- D Bates
- D Harman
- D Mereles
- D Wu
- DA Balentine
- DA Trojan
- DB Bichuetti
- DB Drachman
- DE Ehrnhoefer
- DK Chan
- DM Wingerchuk
- DS Goodin
- E Gordon-Lipkin
- E Mazzone
- E Mix
- E Rubino
- EL Wightman
- EN Benveniste
- F Agosta
- F Paul
- F Paul
- F Thielecke
- G Comi
- G Giovannoni
- G Hu
- G Nie
- GA Donnan
- GX Li
- H Checkoway
- H Faber
- H Lee
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- H Yoshioka
- H Zimmermann
- HM Vesterinen
- HN Graham
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- J Brettschneider
- J Ding
- J Dorr
- J Dörr
- J Lindsey
- J Palace
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- J Ratelade
- J Shimizu
- J Smolders
- J Vogt
- J Wang
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- J Yu
- JA Cabrera-Gomez
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- L Arab
- L Elbling
- L Granieri
- L Reznichenko
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- M Citron
- M Dinkin
- M He
- M Kinoshita
- M Pae
- M Storoni
- M Suganuma
- M Suzuki
- M Valko
- M Varrin-Doyer
- MA Felix
- MA Weber
- MB D'hooghe
- ME Alexianu
- ME Letelier
- MF McCarty
- MH Barnett
- MK Brown
- MK Racke
- MM Pabon
- N Borisow
- N Jain
- N Saleh
- N Weinges-Evers
- NM Walton
- NP Evans
- O Aktas
- O Golubnitschaja
- O Stuve
- OM Dorchies
- OM Dorchies
- P Kumar
- P Lillo
- P Pacher
- P Sundstrom
- PA Abboud
- PA Nelson
- PE Le
- PG Ince
- PL De Jager
- PS Espinosa
- PS Sorensen
- Q Meng
- Q Ye
- R Aneja
- R Baran
- R Dutta
- R Li
- R Srividhya
- R Srividhya
- RC Rose
- RD Simmons
- RM Lucas
- RM Rahman
- S Abbas
- S Goffette
- S Hunot
- S Jarius
- S Jarius
- S Jarius
- S Jarius
- S Jarius
- S Kim
- S Kuriyama
- S Lee
- S Mader
- S Noval
- S Przedborski
- S Saadoun
- S Sang
- SA Mandel
- SA Mandel
- SH Appel
- SH Kim
- SH Kim
- SH Koh
- SM Lin
- SN Williams
- SR Kalluri
- SY Lee
- T Castillo-Trivino
- T Itoh
- T Oberwahrenbrock
- T Pan
- T Sinnecker
- T Sinnecker
- TJ Shafer
- TM Buetler
- TV Bliss
- U Gundimeda
- U Ullmann
- V Sanchez-Guajardo
- VA Lennon
- W Le
- Y Levites
- Y Levites
- Y Levites
- Y Nakae
- Y Nakae
- Y Shimizu
- Y Yuan
- YB Choi
- YS Ho
- YT Choi
- Z Lu
- Z Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
- Author
- Adair LS
- Adeyemo A
- Aguilar-Salinas CA
- Ahlqvist E
- Ahluwalia TS
- Ahsan H
- An P
- Anand SS
- Arruda AL
- Becker DM
- Below JE
- Bertoni A
- Bharadwaj D
- Bielak LF
- Bocher O
- Boehnke M
- Bonnefond A
- Bork-Jensen J
- Bowden DW
- Bragg F
- Brandslund I
- Broadaway KA
- Brody JA
- Buchanan TA
- Burant CF
- Butterworth AS
- Cade BE
- Canouil M
- Chai J-F
- Chambers JC
- Chan JCN
- Chandak GR
- Chang K-M
- Chang L-C
- Chee M-L
- Chen C-H
- Chen G
- Chen J
- Chen S-H
- Chen W-M
- Chen Y-DI
- Chen Y-T
- Chen Z
- Cheng C-Y
- Cho YS
- Choi HS
- Chuang L-M
- Collins FS
- Cook JP
- Cruz M
- Cui J
- Cushman M
- Danesh J
- Das SK
- de Silva HJ
- Dedoussis G
- Denny JC
- Dimitrov L
- Doumatey AP
- Du S
- Duan Q
- Dupuis J
- Eckardt K-U
- Emery LS
- Engert JC
- Evans DS
- Evans MK
- Finer S
- Fischer K
- Florez JC
- Floyd JS
- Ford I
- Fornage M
- Franco OH
- Frayling TM
- Freedman BI
- Froguel P
- Genter P
- Gerstein HC
- Ghanbari M
- Giedraitis V
- Gieger C
- González-Villalpando C
- González-Villalpando ME
- Goodarzi MO
- Gordon-Larsen P
- Graff M
- Grallert H
- Grarup N
- Gross M
- Guare LA
- Guo X
- Hackinger S
- Hai Y
- Haiman CA
- Hakaste L
- Han S
- Hanis CL
- Hansen T
- Hattersley AT
- Hatzikotoulas K
- Hayes MG
- Herder C
- Horikoshi M
- Howard A-G
- Hsueh W
- Huang M
- Huang W
- Huerta-Chagoya A
- Hung Y-J
- Hwang MY
- Hwu C-M
- Ichihara S
- Igase M
- Ikram MA
- Ingelsson E
- Ingelsson M
- Ipp E
- Islam MT
- Isono M
- Jang H-M
- Jasmine F
- Jiang G
- Jonas JB
- Joo YY
- Jukema JW
- Jørgensen T
- Kabagambe E
- Kadowaki T
- Kals M
- Kamali Z
- Kamanu FK
- Kandeel FR
- Kanoni S
- Kardia SLR
- Kasturiratne A
- Kato N
- Katsuya T
- Kaur V
- Kawaguchi T
- Keaton JM
- Kho AN
- Khor C-C
- Kibriya MG
- Kim B-J
- Kim D-H
- Kim YJ
- Koh W-P
- Kooner JS
- Kooperberg C
- Kronenberg F
- Kuusisto J
- Kwak S-H
- Köttgen A
- Laakso M
- Lamri A
- Lange LA
- Langenberg C
- Lee J
- Lee J-J
- Lee KM
- Lee M-S
- Lee NR
- Lee SSK
- Leong A
- Li L
- Li Y
- Li-Gao R
- Ligthart S
- Lim VJY
- Lin K
- Lind L
- Lindgren CM
- Linneberg A
- Liu C-T
- Liu J
- Liu S
- Liu Y
- Locke AE
- Long J
- Loos RJF
- Lorenz KM
- Louie T
- Luan J
- Luk AO
- Luo X
- Lv J
- Lynch JA
- Lyssenko V
- Läll K
- Ma RCW
- Maeda S
- Mahajan A
- Mamakou V
- Mandla R
- Mansuri SR
- Marston NA
- Matsuda F
- Matsuda K
- McCarthy MI
- McKean-Cowdin R
- Meigs JB
- Meitinger T
- Melander O
- Melloni GEM
- Mercader JM
- Metspalu A
- Millwood IY
- Mo H
- Mohlke KL
- Mook-Kanamori DO
- Moon S
- Morris AD
- Morris AP
- Motala AA
- Moura FA
- Mägi R
- Nadler JL
- Nakatochi M
- Nalls MA
- Namba S
- Nano J
- Nayak U
- Ng MCY
- Nicolas A
- Nongmaithem SS
- Noordam R
- North KE
- Nousome D
- Ntalla I
- Okada Y
- Orozco L
- Palmer CNA
- Pan I
- Pankow JS
- Park K-S
- Parra EJ
- Paré G
- Patel SR
- Patil S
- Pedersen O
- Pei P
- Pereira MA
- Peters A
- Petty LE
- Peyser PA
- Pirie FJ
- Polikowsky HG
- Porneala B
- Prasad G
- Preuss MH
- Prins BP
- Province MA
- Psaty BM
- Rader DJ
- Raffel LJ
- Raffield LM
- Rasmussen-Torvik LJ
- Rayner NW
- Redline S
- Reiner AP
- Rich SS
- Ritchie MD
- Roden M
- Rohde R
- Roll K
- Rotimi CN
- Rotter JI
- Ruff CT
- Sabanayagam C
- Sale MM
- Saleheen D
- Sandow K
- Sankareswaran A
- Sarnowski C
- Sattar N
- Schroeder P
- Schönherr S
- Scott RA
- Shahriar M
- Shen B
- Sheu WHH
- Shi J
- Shin DM
- Shojima N
- Shu X-O
- Sim X
- Smith JA
- So WY
- Sofer T
- Sonehara K
- Southam L
- Spracklen CN
- Stančáková A
- Stefansson K
- Steinthorsdottir V
- Stilp AM
- Strauch K
- Sun M
- Suzuki K
- Tabara Y
- Tai E-S
- Takeuchi F
- Taliun D
- Tam CHT
- Tan J
- Taylor HJ
- Taylor KD
- Thangam M
- Thorand B
- Thorleifsson G
- Thorsteinsdottir U
- Tomlinson B
- Tong L
- Tran TC
- Trompet S
- Tsai F-J
- Tsao PS
- Tuomi T
- Tuomilehto J
- Tusie-Luna T
- Udler MS
- VA Million Veteran Program
- Valladares-Salgado A
- van Dam RM
- van Dijk KW
- van Heel DA
- van Klinken JB
- Vanderwerff B
- Varma R
- Voight BF
- Vujkovic M
- Wacher-Rodarte N
- Walters RG
- Wang Y-X
- Wareham NJ
- Wheeler E
- Wickremasinghe AR
- Williamson A
- Wilson JG
- Witte DR
- Wong T-Y
- Wu J-Y
- Wuttke M
- Xiang AH
- Yajnik CS
- Yamamoto K
- Yamamoto K
- Yamauchi T
- Yanek LR
- Yao J
- Yin X
- Yokota M
- Yoon K
- Yu C
- Yuan J-M
- Yusuf S
- Zawistowski M
- Zeggini E
- Zhang L
- Zhang W
- Zheng W
- Zonderman AB
- Zöllner S
- Publication venue
- Nature Research
- Publication date
- 19/02/2024
- Field of study
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
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- Antonucci E
- Antón DG
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- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
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- Arias-Verdu MD
- Arias-Verdu MD
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- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
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- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
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- Baquero JD
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- CAPCRI Study
- Capellier G
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- Charitidou E
- Charpentier C
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- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
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- Chelly J
- Chemam S
- Chen CM
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- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
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- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
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- Choi YY
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- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
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- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
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- Dalhuisen A
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- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
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- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
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- de Molina FJ
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- de Oca Sandoval MA
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- de Vera AP
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- E YY
- Ebeling G
- Echeverri JE
- Echeverría JG
- Ediboglu O
- Ediboglu O
- Egea-Guerero JJ
- Egginton JS
- Egi M
- El Adawy AS
- El Hamid MA
- El Hossainy R
- El Sayed E
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- El Sayed I
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- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
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- Emmanuel J
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- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
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- Escribá A
- Escórcio S
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- Esteban A
- Estella A
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- Fang M
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- Farias P
- Faulds MC
- Fave G
- Feehan A
- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
- Fernandes N
- Fernandez NG
- Fernandez R
- Fernandez-Zamora MD
- Fernández IF
- Fernández L
- Fernández MV
- Fernández PA
- Fernández-Barat L
- Fernández-Mondéjar E
- Fernández-Ortega JF
- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
- Ferré A
- Ferrón FR
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- Fiks T
- Fiks T
- Fileković S
- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
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- Follin A
- Follin A
- Fong KY
- Fontaiña LP
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- Fontenot T
- Forel JM
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- Frat JP
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- Freile MT
- Frenzel T
- Frigeni B
- Frithiof R
- Fritz C
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- Fromentin M
- Frontera PR
- Fuentes M
- Fumagalli F
- Fumagalli F
- Fumis RR
- Fushimi K
- Gabán-Díez Á
- Gadgil S
- Gaide-Chevronnay L
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- Gaite FB
- Gaizauskas E
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- Galache JA
- Gallego-Corpa AI
- Gameiro J
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- Gando S
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- Gandola A
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- Ganuza MS
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- Garcia M
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- Garcia-Alvarez JM
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- Garcia-Delgado M
- Garcia-Gigorro R
- García MF
- García-Martínez MV
- García-Olivares P
- Garnacho-Montero J
- Garrido BB
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- Garrido EM
- Garrouste M
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- Gasparovic V
- Gattinoni L
- Gaudard P
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- Gavrychenko D
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- Gemmell L
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- Genc D
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- Geri G
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- GETGAG/SEMICYUC
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- Gherli T
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- Giannantonio M
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- Gimenez J
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- Gordo F
- Gordon M
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- Gorjup V
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- Gottlieb J
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- Grassi L
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- Hatakeyama J
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- Hayashi K
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- Hickey S
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- Hofmeijer J
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- Hom H
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- Hrachovina M
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- Jardim JJ
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Kirca H
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- Kleinpell R
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- Kokkini S
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- Kwon HM
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- Lafaurie M
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- Lebiedz P
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- Lortat-Jacob B
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- Macfarlane B
- MacKay A
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- Maekawa K
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- Maertens B
- Maggiorini M
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- Magnanimi E
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- Mainardi JL
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- Martínez F
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- Mistry M
- Mistry N
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- Mitchell S
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- Mlcek M
- Moerer O
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- Pinsky M
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- Pérez AG
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- Sanz NM
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- St George’s University of London
- Stamm J
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- Stubbs C
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- Wijayatilake DS
- Wildenberg L
- Wilks M
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- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
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- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
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- Yamazaki A
- Yan WW
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- Yang JH
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- Yasuda H
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- Yebenes JC
- Yeh YC
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- Yılmaz G
- Yilmazer F
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- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
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- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
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- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zibandah N
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- Zimmerman J
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- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
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- Aguilar-Saavedra JA
- Ahlen SP
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- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
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- Alhroob M
- Ali B
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- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
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- Alstaty MI
- Alvarez Gonzalez B
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
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- Anders JK
- Anderson KJ
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- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya S Tapia
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
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- Artamonov A
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- Bahrasemani H
- Baines JT
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- Baker OK
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- Black JE
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- Blunier Dr
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
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- Boeriu OE Vickey
- Boerner D
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- Bogdanchikov AG
- Bohm C
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- Borisov A
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- Bortfeldt J
- Bortoletto D
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- Boscherini D
- Bosman M
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- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt A
- Brandt G
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- Braren F
- Bratzler U
- Brau B
- Brau JE
- Brendlinger K
- Brennan AJ
- Brenner L
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- Bressler S
- Bret M Cano
- Briglin DL
- Bristow TM
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks T
- Brooks WK
- Brost E
- Broughton JH
- Bruncko D
- Bruni A
- Bruni G
- Bruni LS
- Bruno S
- Brunt BH
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Buescher D
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- Bugge MK
- Bulekov O
- Bullock D
- Burch TJ
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- Burgard CD
- Burger AM
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- Burka K
- Burke S
- Burmeister I
- Burr JTP
- Buschmann E
- Bussey P
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund O Bessidskaia
- Cabras G
- Cabrera Urban S
- Caforio D
- Cai H
- Cairo VMM
- Cakir I Turk
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
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- Camincher C
- Campana S
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- Camplani A
- Campoverde A
- Canale V
- Cantero J
- Cao T
- Cao Y
- Caprini I
- Caprini M
- Capua M
- Carbone RM
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- Cardillo F
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carra S
- Carrillo-Montoya GD
- Casadei D
- Casado MP
- Casha AF
- Casolino M
- Casper DW
- Castelijn R
- Castillo Gimenez V
- Castillo LR Flores
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli D
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- Cavasinni V
- Celebi E
- Ceradini F
- Cerda Alberich L
- Cerqueira AS
- Cerri A
- Cerrito L
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- Cervelli A
- Cetin SA
- Chafaq A
- Chakraborty D
- Chan SK
- Chan WS
- Chan YL
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- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouzeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
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- Alconada Verzini MJ
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- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
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- Zhemchugov A
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- Zoccoli A
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- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
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