60 research outputs found
Field dependence of the electronic phase separation in Pr0.67Ca0.33MnO3 by small angle magnetic neutron scattering
We have studied by small angle neutron scattering the evolution induced by
the application of magnetic field of the coexistence of ferromagnetism (F) and
antiferromagnetism (AF) in a crystal of PrCaMnO. The
results are compared to magnetic measurements which provide the evolution of
the ferromagnetic fraction. These results show that the growth of the
ferromagnetic phase corresponds to an increase of the thickness of the
ferromagnetic ''cabbage'' sheets
Ferrets as models for influenza virus transmission studies and pandemic risk assessments
The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices. We also discuss current limitations of the ferret transmission model and highlight continued refinements and advances to this model ongoing in laboratories. Understanding, disclosing, and standardizing the critical parameters of ferret transmission studies will improve the comparability and reproducibility of pandemic influenza risk assessment and increase the statistical power and, perhaps, accuracy of this model
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
Search for supersymmetry in the photon(s) plus missing energy channels at =161 GeV and 172 GeV
Searches for supersymmetric particles in channels with one or more photons and missing energy have been performed with data collected by the ALEPH detector at LEP. The data consist of 11.1 \pb\ at , 1.1 \pb\ at 170 \gev\ and 9.5 \pb\ at 172 GeV. The \eenunu\ cross se ction is measured. The data are in good agreement with predictions based on the Standard Model, and are used to set upper limits on the cross sections for anomalous photon production. These limits are compared to two different SUSY models and used to set limits on the neutralino mass. A limit of 71 \gevsq\ at 95\% C.L. is set on the mass of the lightest neutralin o ( 3 ns) for the gauge-mediated supersymmetry breaking and LNZ models
Measurement of prompt hadron production ratios in collisions at 0.9 and 7 TeV
The charged-particle production ratios , , ,
, and are measured with the LHCb detector using of collisions delivered by the LHC at TeV and
at TeV. The measurements are performed as a
function of transverse momentum and pseudorapidity . The
production ratios are compared to the predictions of several Monte Carlo
generator settings, none of which are able to describe adequately all
observables. The ratio is also considered as a function of rapidity
loss, , and is used to constrain models of
baryon transport.Comment: Incorrect entries in Table 2 corrected. No consequences for rest of
pape
Sistemas produtivos de caprinocultura leiteira no semiĂĄrido nordestino: controle integrado das parasitoses gastrointestinais visando contornar a resistĂȘncia anti-helmĂntica
Readout technologies for directional WIMP Dark Matter detection
The measurement of the direction of WIMP-induced nuclear recoils is a compelling but technologically challenging
strategy to provide an unambiguous signature of the detection of Galactic dark matter. Most directional detectors aim
to reconstruct the dark-matter-induced nuclear recoil tracks, either in gas or solid targets. The main challenge with directional detection is the need for high spatial resolution over large volumes, which puts strong requirements on the
readout technologies. In this paper we review the various detector readout technologies used by directional detectors.
In particular, we summarize the challenges, advantages and drawbacks of each approach, and discuss future prospects
for these technologies
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases Omicronâs evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses. mRNA vaccination as a third vaccine dose rescues and broadens neutralization. Importantly, the antiviral drugs remdesivir and molnupiravir retain efficacy against Omicron BA.1. Replication was similar for Omicron and Delta virus isolates in human nasal epithelial cultures. However, in lung cells and gut cells, Omicron demonstrated lower replication. Omicron spike protein was less efficiently cleaved compared with Delta. The differences in replication were mapped to the entry efficiency of the virus on the basis of spike-pseudotyped virus assays. The defect in entry of Omicron pseudotyped virus to specific cell types effectively correlated with higher cellular RNA expression of TMPRSS2, and deletion of TMPRSS2 affected Delta entry to a greater extent than Omicron. Furthermore, drug inhibitors targeting specific entry pathways3 demonstrated that the Omicron spike inefficiently uses the cellular protease TMPRSS2, which promotes cell entry through plasma membrane fusion, with greater dependency on cell entry through the endocytic pathway. Consistent with suboptimal S1/S2 cleavage and inability to use TMPRSS2, syncytium formation by the Omicron spike was substantially impaired compared with the Delta spike. The less efficient spike cleavage of Omicron at S1/S2 is associated with a shift in cellular tropism away from TMPRSS2-expressing cells, with implications for altered pathogenesis
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