Discovery learning approach to classic electrical machines principles

This paper aims at presenting the concept of Socratic interactions and discovery learning of classic electrical machines principles. The theories of electrical machines are by nature quite boring and abstract although there are a lot of experiments supported the theories. Traditional, students learnt the subject by drill and practice approach with standard textbooks. In the past two decades, computer is no doubt recognized to be the educational tool. The so-called “interactive” approach is applied to the learning process. Most of this approach applied to various subjects in different levels is mainly based on drill and practice. However, few packages are developed for electrical machine subject. In this paper, two different approaches “Rote Learning” and “Discovery Learning” applied to the interactive computer aided learning package of classic electric machine principles are discussed. Design of a discovery learning approach will also be presented

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.

We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is not known

Measurement of the Z boson differential cross section in transverse momentum and rapidity in proton-proton collisions at 8 TeV

We present a measurement of the Z boson differential cross section in rapidity and transverse momentum using a data sample of pp collision events at a centre-of-mass energy s=8 TeV, corresponding to an integrated luminosity of 19.7 fb-1. The Z boson is identified via its decay to a pair of muons. The measurement provides a precision test of quantum chromodynamics over a large region of phase space. In addition, due to the small experimental uncertainties in the measurement the data has the potential to constrain the gluon parton distribution function in the kinematic regime important for Higgs boson production via gluon fusion. The results agree with the next-to-next-to-leading-order predictions computed with the fewz program. The results are also compared to the commonly used leading-order MadGraph and next-to-leading-order powheg generators. © 2015 CERN for the benefit of the CMS Collaboration

Cytogenetic Prognostication Within Medulloblastoma Subgroups

PURPOSE: Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. PATIENTS AND METHODS: Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models. RESULTS: Subgroup information improves the predictive accuracy of a multivariable survival model compared with clinical biomarkers alone. Most previously published cytogenetic biomarkers are only prognostic within a single medulloblastoma subgroup. Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas. CONCLUSION: Combining subgroup and cytogenetic biomarkers with established clinical biomarkers substantially improves patient prognostication, even in the context of heterogeneous clinical therapies. The prognostic significance of most molecular biomarkers is restricted to a specific subgroup. We have identified a small panel of cytogenetic biomarkers that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials

Measurement of the Z boson differential cross section in transverse momentum and rapidity in proton-proton collisions at 8 TeV

Peer reviewe

Making tastes for everything : omnivorousness and cultural abundance

This paper offers some speculative discussion about the current state of the "omnivore" debate, instigated by Richard A. Peterson. It argues that debates about the social patterning of tastes need to take greater account of changed practices of cultural production as well as consumption through the identification of two "stories of abundance" in the cultural realm. The first relates to accounts of the changing and expanding cultural industries, whilst the second considers the rich variety of widely available culture enabled by various technologies of distribution. Taking these stories into account, the paper argues that sociological analyses of cultural hierarchy might lag behind those that are mundane and everyday to both cultural producers and consumers and that an orientation to culture that ranges across established hierarchies is increasingly unremarkable. Such a change is related to the structural and discursive means through which culture is circulated. The paper concludes that cultural analysts need to modify their theoretical models and their methodological approaches to better reflect a variegated field of culture and a more fluid cultural hierarchy. In the tradition of both Peterson and Bourdieu, contemporary analyses of patterns of cultural consumption and taste need to take fuller account of the ways in which culture is produced, circulated and valued if they are to maintain their explanatory power