CORRECTION OF BONE MINERAL TISSUE DENSITY OF PATIENTS WITH CHRONICAL INFLAMMATORY BOWEL DISEASES

The article is connected with the efficiency of «Calcium-D3 Nicomed» drug at treatment of osteopenia syndrome of patients suffering from ulcerative colitis and Crohn’s disease. Positive influence of the drug on the structural-functional state of bone tissue was confirmed with the help of ultrasound densitometry and examination of calcium-phosphoric metabolism

Psychological and Pedagogical Conditions and Means of Development of Professional Reflection of Teachers in the System of Methodical Work

The article considers general psychological and methodical patterns of mathematics teachers’ professional reflection in the system of methodical work. It proves the hypothesis that one can model and implement specific psychological and pedagogical conditions, thus promoting the development of professional reflection. Besides, the article shows that the specified pedagogical conditions for the successful development of professional reflection of teachers of mathematical disciplines in the system of methodical work are: ensuring awareness of the teacher of mathematical disciplines of the content, structure and means of development of professional reflection; formation of an objective self-assessment of the personality and own professional activity of teachers of mathematical disciplines; introduction of individual and group means of development of professional reflection in the system of methodical work of pedagogical college; creation of a reflective environment in the system of methodical work of a pedagogical institution. Psychological and pedagogical means for the development of professional reflection of teachers of mathematical disciplines in the system of methodological work of a pedagogical college are: means of individual reflection (repetition technique, counselling, individual reflection games, solving reflective problems, keeping a reflection diary); collective means of developing professional reflection of the teacher (reflective debates, reflex interviews, reflective classes, consultation, tutorial, group reflection games, development of programs for monitoring their (or colleagues) actions in professionally significant situations with subsequent analysis of the received materials, training on the development of professional pedagogical reflection); introduction of a special training course "Development of professional reflection of teachers of mathematical disciplines in the system of methodical work of the pedagogical college".</em

NADP-Dependent Aldehyde Dehydrogenase from Archaeon Pyrobaculum sp.1860

We present the functional and structural characterization of the first archaeal thermostable NADP-dependent aldehyde dehydrogenase AlDHPyr1147. In vitro, AlDHPyr1147 catalyzes the irreversible oxidation of short aliphatic aldehydes at 60–85°С, and the affinity of AlDHPyr1147 to the NADP+ at 60°С is comparable to that for mesophilic analogues at 25°С. We determined the structures of the apo form of AlDHPyr1147 (3.04 Å resolution), three binary complexes with the coenzyme (1.90, 2.06, and 2.19 Å), and the ternary complex with the coenzyme and isobutyraldehyde as a substrate (2.66 Å). The nicotinamide moiety of the coenzyme is disordered in two binary complexes, while it is ordered in the ternary complex, as well as in the binary complex obtained after additional soaking with the substrate. AlDHPyr1147 structures demonstrate the strengthening of the dimeric contact (as compared with the analogues) and the concerted conformational flexibility of catalytic Cys287 and Glu253, as well as Leu254 and the nicotinamide moiety of the coenzyme. A comparison of the active sites of AlDHPyr1147 and dehydrogenases characterized earlier suggests that proton relay systems, which were previously proposed for dehydrogenases of this family, are blocked in AlDHPyr1147, and the proton release in the latter can occur through the substrate channel

Trainings Usage in the Professional Education of Future Sociocultural Activity Managers

У статті представлено аналіз, систематизація й узагальнення наукових досліджень щодо обґрунтування особливостей використання тренінгів у професійній підготовці майбутніх менеджерів соціокультурної діяльностіВступ. Сьогодні зростає актуальність управління соціокультурною галуззю. У зв’язку із залученням в цей процес менеджера, зміст діяльності якого полягає в керуванні зберіганням та розповсюдженням культурних цінностей, виникає необхідність висвітлення інноваційних форм навчання майбутніх менеджерів соціокультурної діяльності. Мета і методи. Мета – теоретичний аналіз, систематизація й узагальнення наукових досліджень щодо обґрунтування особливостей використання тренінгів у професійній підготовці майбутніх менеджерів соціокультурної діяльності. У ході дослідження використано загальнонаукові методи аналізу, синтезу, систематизації й узагальнення теоретичних положень, а також конкретнонаукові методи термінологічного аналізу, ретроспективний, системно-структурний і структурно-функціональний. Результати. Висвітлено ключові моменти в історії виникнення та розвитку тренінгів. Розкрито види тренінгів: особистісно-орієнтований, вироблення навичок, маркетинговий, управлінський, кадровий та організаційний. Систематизовано структуру підготовки тренінгу у професійному навчанні майбутніх менеджерів соціокультурної діяльності, яка конкретизована за такими показниками: етапи, розділи, мета та зміст етапів, приклади застосування. Проаналізовано зміст тренінгів та подано їх орієнтовну тематику. Виокремлено особисті якості викладача-тренера та виявлено елементи його професійної майстерності. Висновки та обговорення. Наукова новизна одержаних результатів полягає у конкретизації поняття «тренінг», систематизуванні структури підготовки тренінгу та поданні орієнтовної тематики тренінгів для навчання майбутніх менеджерів соціокультурної діяльності, а практичне значення – в можливості використання досягнутих результатів у навчальному процесі вищих закладів освіти.Сегодня возрастает актуальность управления социокультурной отраслью. В связи с вовлечением в этот процесс менеджера, содержание деятельности которого заключается в управлении хранением и распространением культурных ценностей, возникает необходимость освещения инновационных форм обучения будущих менеджеров социокультурной деятельности. Цель и методы. Цель - теоретический анализ, систематизация и обобщение научных исследований по обоснованию особенностей использования тренингов в профессиональной подготовке будущих менеджеров социокультурной деятельности. В ходе исследования использованы общенаучные методы анализа, синтеза, систематизации и обобщения теоретических положений, а также конкретнонаукови методы терминологического анализа, ретроспективный, системно-структурный и структурно-функциональный. Результаты. Освещены ключевые моменты в истории возникновения и развития тренингов. Раскрыто виды тренингов: личностно-ориентированный, выработки навыков, маркетинговый, управленческий, кадровый и организационный. Систематизированы структуру подготовки тренинга в профессиональном обучении будущих менеджеров социокультурной деятельности, конкретизирована по таким показателям: этапы, разделы, цель и содержание этапов, примеры применения. Проанализировано содержание тренингов и представлены их ориентировочную тематику. Выделены личные качества преподавателя-тренера и выявлены элементы его профессионального мастерства. Выводы и обсуждение. Научная новизна исследования заключается в конкретизации понятия «тренинг», систематизации структуры подготовки тренинга и представлении ориентировочной тематики тренингов для обучения будущих менеджеров социокультурной деятельности, а практическое значение - в возможности использования достигнутых результатов в учебном процессе высших учебных заведений.Introduction. The relevance of the sociocultural field is growing now. There is a necessity of highlighting the innovative forms of future sociocultural activity managers’ education, connected with manager activity content, dealing with keeping and sharing of cultural values management. Purpose and methods. The purpose of the article is theoretical analysis, systematization, and generalization of the scientific research concerning the justification of trainings usage peculiarities in future sociocultural activity managers’ education. In the course of the research, such general scientific methods as analysis, synthesis, systematization, and generalization of theoretical issues have been used, as well as specific scientific methods of terminological, retrospective, systematic-structural, and structural-functional analysis. Results. Key moments in the history of trainings emergence and development have been highlighted. Kinds of trainings have been analysed: personal-oriented, skills-building, marketing, managerial, staff training, and organizational ones. The structure of trainings preparation in the professional education of future sociocultural managers has been systematized, which is specified under the following indicators: stages, sections, aim, examples of implementation. Trainings content has been analysed and its illustrative subject matter has been presented. Teacher-trainer personal qualities have been distinguished, and his professional excellence elements have been detected. Conclusions and discussion. The scientific novelty of obtained results is in the concretization of the concept “training”, systematization of training preparation structure, and providing illustrative subject matter of trainings for future sociocultural activity managers’ education; practical value is in the possibility of obtained results usage in the universities’ education process

A review of career devoted to biophotonics-in memoriam to Ekaterina Borisova (1978-2021)

Regretfully, because of her sudden demise, Assoc. Prof. Ekaterina Borisova is no longer amongst us. COVID-19 pulled away a brilliant scientist during the peak of her scientific career (see Fig. 1). All authors would like to express deepest condolences and sincere support to her family, friends, relatives and colleagues! We, therefore, rightfully commemorate her dedicated and devoted contribution to biophotonics, her readiness to always support, help, motivate and inspire all her colleagues and collaborators

Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6&nbsp;years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P &lt; 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100&nbsp;years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p &lt; 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe