Evidence for Fast Electron Transfer between the High-Spin Haems in Cytochrome bd-I from Escherichia coli

Cytochrome bd-I is one of the three proton motive force-generating quinol oxidases in the O2-dependent respiratory chain of Escherichia coli. It contains one low-spin haem (b558) and the two high-spin haems (b595 and d) as the redox-active cofactors. In order to examine the flash-induced intraprotein reverse electron transfer (the so-called ''electron backflow''), CO was photolyzed from the ferrous haem d in one-electron reduced (b558 3+b595 3+d2+-CO) cytochrome bd-I, and the fully reduced (b5582+b5952+d2+-CO) oxidase as a control. In contrast to the fully reduced cytochrome bd-I, the transient spectrum of one-electron reduced oxidase at a delay time of 1.5 μs is clearly different from that at a delay time of 200 ns. The difference between the two spectra can be modeled as the electron transfer from haem d to haem b595 in 3–4% of the cytochrome bd-I population. Thus, the interhaem electron backflow reaction induced by photodissociation of CO from haem d in one-electron reduced cytochrome bd-I comprises two kinetically different phases: the previously unnoticed fast electron transfer from haem d to haem b595 within 0.2–1.5 μs and the slower well-defined electron equilibration with τ ~16 μs. The major new finding of this work is the lack of electron transfer at 200 ns

The last integrable case of kozlov-Treshchev Birkhoff integrable potentials

We establish the integrability of the last open case in the Kozlov-Treshchev classification of Birkhoff integrable Hamiltonian systems. The technique used is a modification of the so called quadratic Lax pair for $D_n$ Toda lattice combined with a method used by M. Ranada in proving the integrability of the Sklyanin case.Comment: 13 page

Bacterial oxidases of the cytochrome bd family : redox enzymes of unique structure, function, and utility as drug targets

Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many bacterial pathogens and, surprisingly, in bacteria formally denoted as anaerobes. It endows bacteria with resistance to various stressors and is a potential drug target. Recent Advances: We summarize recent advances in the biochemistry, structure, and physiological functions of cytochrome bd in the light of exciting new three-dimensional structures of the oxidase. The newly discovered roles of cytochrome bd in contributing to bacterial protection against hydrogen peroxide, nitric oxide, peroxynitrite, and hydrogen sulfide are assessed. Critical Issues: Fundamental questions remain regarding the precise delineation of electron flow within this multihaem oxidase and how the extraordinarily high affinity for oxygen is accomplished, while endowing bacteria with resistance to other small ligands. Future Directions: It is clear that cytochrome bd is unique in its ability to confer resistance to toxic small molecules, a property that is significant for understanding the propensity of pathogens to possess this oxidase. Since cytochrome bd is a uniquely bacterial enzyme, future research should focus on harnessing fundamental knowledge of its structure and function to the development of novel and effective antibacterial agents

Measurement of xF3xF_3 and F2F_2 Structure Functions in Low Q2Q^2 Region with the IHEP-JINR Neutrino Detector

The isoscalar structure functions $xF_3$ and $F_2$ are measured as functions of $x$ averaged over all $Q^2$ permissible for the range of 6 to 28 GeV of incident neutrino (anti-neutrino) energy at the IHEP-JINR Neutrino Detector. The QCD analysis of $xF_3$ structure function provides $\Lambda_{\bar{MS}}^{(4)} = (411 \pm 200)$ MeV under the assumption of QCD validity in the region of low $Q^2$. The corresponding value of the strong interaction constant $\alpha_S (M_Z) = 0.123^{+0.010}_{-0.013}$ agrees with the recent result of the CCFR collaboration and with the combined LEP/SLC result.Comment: 11 pages, 1 Postscript figure, LaTeX. Talk given at the 7th International Workshop on Deep Inelastic Scattering and QCD (DIS 99), Zeuthen, Germany, 19-23 Apr 199

Determination of the high-twist contribution to the structure function xF3νNxF^{\nu N}_3

We extract the high-twist contribution to the neutrino-nucleon structure function $xF_3^{(\nu+\bar{\nu})N}$ from the analysis of the data collected by the IHEP-JINR Neutrino Detector in the runs with the focused neutrino beams at the IHEP 70 GeV proton synchrotron. The analysis is performed within the infrared renormalon (IRR) model of high twists in order to extract the normalization parameter of the model. From the NLO QCD fit to our data we obtained the value of the IRR model normalization parameter $\Lambda^2_{3}=0.69\pm0.37~({\rm exp})\pm0.16~({\rm theor})~{\rm GeV}^2$. We also obtained $\Lambda^2_{3}=0.36\pm0.22~({\rm exp})\pm0.12~({\rm theor})~{\rm GeV}^2$ from a similar fit to the CCFR data. The average of both results is $\Lambda^2_{3}=0.44\pm0.19~({\rm exp})~{\rm GeV}^2$.Comment: preprint IHEP-01-18, 7 pages, LATEX, 1 figure (EPS

Permutation Branes

N-fold tensor products of a rational CFT carry an action of the permutation group S_N. These automorphisms can be used as gluing conditions in the study of boundary conditions for tensor product theories. We present an ansatz for such permutation boundary states and check that it satisfies the cluster condition and Cardy's constraints. For a particularly simple case, we also investigate associativity of the boundary OPE, and find an intriguing connection with the bulk OPE. In the second part of the paper, the constructions are slightly extended for application to Gepner models. We give permutation branes for the quintic, together with some formulae for their intersections.Comment: 27 page

Point vortices and classical orthogonal polynomials

Stationary equilibria of point vortices with arbitrary choice of circulations in a background flow are studied. Differential equations satisfied by generating polynomials of vortex configurations are derived. It is shown that these equations can be reduced to a single one. It is found that polynomials that are Wronskians of classical orthogonal polynomials solve the latter equation. As a consequence vortex equilibria at a certain choice of background flows can be described with the help of Wronskians of classical orthogonal polynomials.Comment: 20 pages, 12 figure

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio