8 research outputs found

    Evaluación de la digestibilidad y disponibilidad de nutrientes del polen apícola al aplicar diferentes pretratamientos

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    (Eng) Bee pollen is characterized by its high nutritional value that could be used in human diet, specifically for its value in protein and antioxidant capacity. Different studies emphasize that pollen shows a restriction in nutrient absorption caused by its complex external cell wall, being not easily digestible by monogastric species as bees and humans. The objective of this study was to apply different pretreatments: enzymatic, alkaline, dry thermal and wet thermal. In order to evaluate the effect of each pretreatment, protein by Bradford method, in vitro digestibility, antioxidant capacity and total phenols were quantified. Protein estimated by Bradford method decreased in pretreated pollen, due to the breakage of peptide bonds, and the digestibility raise from 62% in untreated pollen to 85-98% in pretreated pollen. In relation to antioxidant capacity, it showed a non-representative decrease regarding other vegetable matrices, with the exception of a raise in phenols for some pretreatments. Such results coincide with microstructural changes observed in pretreated pollen micrographs.(Spa) El polen apícola se caracteriza por su alto contenido nutricional que podría ser empleado en la alimentación de los seres humanos, específicamente por su valor en proteína y capacidad antioxidante. Diferentes estudios resaltan que el polen presenta restricción en su absorción de nutrientes por su compleja pared celular externa, siendo poco digerible para especies monogástricas como abejas y seres humanos. El objetivo de este estudio fue aplicar diferentes pretratamientos: enzimático, alcalino, térmico seco y térmico húmedo. Para evaluar el efecto de los pretratamientos, se cuantificó proteína por el método de Bradford, digestibilidad in vitro, capacidad antioxidante y fenoles totales. Se encontró una disminución de proteína para el polen pretratado por el método de Bradford, debido al rompimiento de los enlaces peptídicos, así como el incremento en la digestibilidad del polen sin tratar del 62% al 85-98% del polen pretratado. En cuanto a la capacidad antioxidante presentó una disminución no representativa respecto a otras matrices vegetales, excepto para los fenoles al revelar un incremento para algunos pretratamientos, resultados que concuerdan con los cambios microestructurales de las micrografías del polen pretratado. Finalmente todos los pretratamientos presentaron diferencias al correlacionar las variables evaluadas mediante un análisis de componentes principales

    Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

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    This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

    Evaluación de la digestibilidad y disponibilidad de nutrientes del polen apícola al aplicar diferentes pretratamientos

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    Bee pollen is characterized by its high nutritional value that could be used in human diet, specifically for its value in protein and antioxidant capacity. Different studies emphasize that pollen shows a restriction in nutrient absorption caused by its complex external cell wall, being not easily digestible by monogastric species as bees and humans. The objective of this study was to apply different pretreatments: enzymatic, alkaline, dry thermal and wet thermal. In order to evaluate the effect of each pretreatment, protein by Bradford method, in vitro digestibility, antioxidant capacity and total phenols were quantified. Protein estimated by Bradford method decreased in pretreated pollen, due to the breakage of peptide bonds, and the digestibility raise from 62% in untreated pollen to 85-98% in pretreated pollen. In relation to antioxidant capacity, it showed a non-representative decrease regarding other vegetable matrices, with the exception of a raise in phenols for some pretreatments. Such results coincide with microstructural changes observed in pretreated pollen micrographs. Finally, the variables assessed by principal component analysis showed differences for every pretreatment.El polen apícola se caracteriza por su alto contenido nutricional que podría ser empleado en la alimentación de los seres humanos, específicamente por su valor en proteína y capacidad antioxidante. Diferentes estudios resaltan que el polen presenta restricción en su absorción de nutrientes por su compleja pared celular externa,siendo poco digerible para especies monogástricas como abejas y seres humanos. El objetivo de este estudio fue aplicar diferentes pretratamientos: enzimático, alcalino, térmico seco y térmico húmedo. Para evaluar el efecto de los pretratamientos, se cuantificó proteína por el método de Bradford, digestibilidad in vitro, capacidad antioxidante y fenoles totales. Se encontró una disminución de proteína para el polen pretratado por el método de Bradford, debido al rompimiento de los enlaces peptídicos, así como el incremento en la digestibilidad del polen sin tratar del 62% al 85-98% del polen pretratado. En cuanto a la capacidad antioxidante presentóuna disminución no representativa respecto a otras matrices vegetales, excepto para los fenoles al revelar un incremento para algunos pretratamientos, resultados que concuerdan con los cambios microestructurales de las micrografías del polen pretratado. Finalmente todos los pretratamientos presentaron diferencias al correlacionar las variables evaluadas mediante un análisis de componentes principales

    Delaying surgery for patients with a previous SARS-CoV-2 infection

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    The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

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    AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

    Outcomes from elective colorectal cancer surgery during the SARS‐CoV‐2 pandemic

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    Aim This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. Method This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data. Results From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58–14.06), postoperative SARS-CoV-2 (16.90, 7.86–36.38), male sex (2.46, 1.01–5.93), age >70 years (2.87, 1.32–6.20) and advanced cancer stage (3.43, 1.16–10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%). Conclusion Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks

    Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

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