Industrial Nostalgia and Working-Class Identity

This chapter brings together important contributions from geographers, historians, sociologists and media theorists, and looks at these through the lens of social philosophy on the nature of resistance and oppression, to articulate and understand both the positive and negative ways in which industrial nostalgia shapes present-day working-class identities. Celebrations of abandoned industrial sites have been criticised by some as inflicting a form of violence on working-class people (High and Lewis 2007), transforming sites of working-class loss into objects of nostalgic appreciation in ways which marginalise those who worked there, and which close the past off from the working-class present (Lasch 1991). More positive views about industrial nostalgia argue that it provides a way to assert working-class pride in hostile environments, serving as a basis for present-day solidarity (Loveday 2014; Gibbs 2021). By examining this existing literature on deindustrialisation through a social philosophical perspective, our aim here is to shed some light on this phenomenon, in which industrial nostalgia can function both as a tool of oppression but also as a form of resistance against oppression

Epistemic Injustice and the Attention Economy

From Springer Nature via Jisc Publications RouterHistory: registration 2020-08-26, online 2020-09-05, pub-electronic 2020-09-05, pub-print 2020-11Publication status: PublishedFunder: University of ManchesterAbstract: In recent years, a significant body of literature has emerged on the subject of epistemic injustice: wrongful harms done to people in their capacities as knowers (Fricker 2007). Up to now this literature has ignored the role that attention has to play in epistemic injustice. This paper makes a first step towards addressing this gap. We argue that giving someone less attention than they are due, which we call an epistemic attention deficit, is a distinct form of epistemic injustice. We begin by outlining what we mean by epistemic attention deficits, which we understand as a failure to pay someone the attention they are due in their role as an epistemic agent. We argue that these deficits constitute epistemic injustices for two reasons. First, they affect someone’s ability to influence what others believe. Second, they affect one’s ability to influence the shared common ground in which testimonial exchanges take place. We then outline the various ways in which epistemic attention deficits harm those who are subject to them. We argue that epistemic attention deficits are harms in and of themselves because they deprive people of an essential component of epistemic agency. Moreover, epistemic attention deficits reduce an agent’s ability to participate in valuable epistemic practices. These two forms of harm have important impacts on educational performance and the distribution of resources. Finally, we argue that epistemic attention deficits both hinder and shape the development of epistemic agency. We finish by exploring some practical implications arising from our discussion

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

The Gulf Crisis : implications for the environment: OIES paper: GWO8

The Gulf crisis has thrown into sharp relief matters of key concern to national, regional and global security. It has refocused political attention and jerked nations out of an earlier complacency regarding such varied but key issues as the Palestinian question, energy security and the development process. It occurs in a new global context of changed East-West relations, and historic developments in the Soviet Union and Eastern Europe. With political will, it could be the catalyst for accelerated action on another issue of global concern: the environment

Epistemic Injustice and the Attention Economy

In recent years, a significant body of literature has emerged on the subject of epistemic injustice: wrongful harms done to people in their capacities as knowers (Fricker 2007). Up to now this literature has ignored the role that attention has to play in epistemic injustice. This paper makes a first step towards addressing this gap. We argue that giving someone less attention than they are due, which we call an epistemic attention deficit, is a distinct form of epistemic injustice. We begin by outlining what we mean by epistemic attention deficits, which we understand as a failure to pay someone the attention they are due in their role as an epistemic agent. We argue that these deficits constitute epistemic injustices for two reasons. First, they affect someone’s ability to influence what others believe. Second, they affect one’s ability to influence the shared common ground in which testimonial exchanges take place. We then outline the various ways in which epistemic attention deficits harm those who are subject to them. We argue that epistemic attention deficits are harms in and of themselves because they deprive people of an essential component of epistemic agency. Moreover, epistemic attention deficits reduce an agent’s ability to participate in valuable epistemic practices. These two forms of harm have important impacts on educational performance and the distribution of resources. Finally, we argue that epistemic attention deficits both hinder and shape the development of epistemic agency. We finish by exploring some practical implications arising from our discussion