51 research outputs found
Genomic evaluation of multiparametric magnetic resonance imaging-visible and -nonvisible lesions in clinically localised prostate cancer
- Author
- Ali Adnan
- Antonello Jenny
- Baena Esther
- Barros-Silva João Diogo
- Brady Ged
- Cannistraci Alessio
- Clarke Noel W.
- Dhomen Nathalie
- Dive Caroline
- Hambrock Thomas
- Lau Maurice
- Leong Hui Sun
- Marais Richard
- Miller Crispin
- Nonaka Daisuke
- Oliveira Pedro
- Parry Marina A.
- Ramani Vijay
- Shanks Jonathan
- Srivastava Shambhavi
- Ubertini Valentina
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2019
- Field of study
Background:
The prostate cancer (PCa) diagnostic pathway is undergoing a radical change with the introduction of multiparametric magnetic resonance imaging (mpMRI), genomic testing, and different prostate biopsy techniques. It has been proposed that these tests should be used in a sequential manner to optimise risk stratification.
Objective:
To characterise the genomic, epigenomic, and transcriptomic features of mpMRI-visible and -nonvisible PCa in clinically localised disease.
Design, setting, and participants:
Multicore analysis of fresh prostate tissue sampled immediately after radical prostatectomy was performed for intermediate- to high-risk PCa.
Intervention:
Low-pass whole-genome, exome, methylation, and transcriptome profiling of patient tissue cores taken from microscopically benign and cancerous areas in the same prostate. Circulating free and germline DNA was assessed from the blood of five patients.
Outcome measurement and statistical analysis:
Correlations between preoperative mpMRI and genomic characteristics of tumour and benign prostate samples were assessed. Gene profiles for individual tumour cores were correlated with existing genomic classifiers currently used for prognostication.
Results and limitations:
A total of 43 prostate cores (22 tumour and 21 benign) were profiled from six whole prostate glands. Of the 22 tumour cores, 16 were tumours visible and six were tumours nonvisible on mpMRI. Intratumour genomic, epigenomic, and transcriptomic heterogeneity was found within mpMRI-visible lesions. This could potentially lead to misclassification of patients using signatures based on copy number or RNA expression. Moreover, three of the six cores obtained from mpMRI-nonvisible tumours harboured one or more genetic alterations commonly observed in metastatic castration-resistant PCa. No circulating free DNA alterations were found. Limitations include the small cohort size and lack of follow-up.
Conclusions:
Our study supports the continued use of systematic prostate sampling in addition to mpMRI, as avoidance of systematic biopsies in patients with negative mpMRI may mean that clinically significant tumours harbouring genetic alterations commonly seen in metastatic PCa are missed. Furthermore, there is inconsistency in individual genomics when genomic classifiers are applied.
Patient summary:
Our study shows that tumour heterogeneity within prostate tumours visible on multiparametric magnetic resonance imaging (mpMRI) can lead to misclassification of patients if only one core is used for genomic analysis. In addition, some cancers that were missed by mpMRI had genomic aberrations that are commonly seen in advanced metastatic prostate cancer. Avoiding biopsies in mpMRI-negative cases may mean that such potentially lethal cancers are missed
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
- Author
- Adams Corey
- Adams David
- Akiri Tarek
- Alion Tyler
- Anderson Kris
- Andreopoulos Costas
- Andrews Mike
- Anghel Ioana
- Anjos João Carlos Costa dos
- Antonello Maddalena
- Arrieta-Diaz Enrique
- Artuso Marina
- Asaadi Jonathan
- Bai Xinhua
- Baibussinov Bagdat
- Baird Michael
- Balantekin Baha
- Baller Bruce
- Baptista Brian
- Barker D'Ann
- Barker Gary
- Barletta William A.
- Barr Giles
- Bartoszek Larry
- Bashyal Amit
- Bass Matt
- Bellini Vincenzo
- Benetti Pietro Angelo
- Berger Bruce E.
- Bergevin Marc
- Berman Eileen
- Berns Hans-Gerd
- Bernstein Adam
- Bernstein Robert
- Bhandari Babu
- Bhatnagar Vipin
- Bhuyan Bipul
- Bian Jianming
- Bishai Mary
- Blake Andrew
- Blaszczyk Flor
- Blaufuss Erik
- Bleakley Bruce
- Blucher Edward
- Blusk Steve
- Bocean Virgil
- Boffelli F.
- Boissevain Jan
- Bolton Timothy
- Bonesini Maurizio
- Boyd Steve
- Brandt Andrew
- Breedon Richard
- Bromberg Carl
- Brown Ralph
- Brunetti Giullia
- Buchanan Norman
- Bugg Bill
- Busenitz Jerome
- Calligarich E.
- Camilleri Leslie
- Carminati Giada
- Carr Rachel
- Castromonte Cesar
- Cavanna Flavio
- Centro Sandro
- Chen Alex
- Chen Hucheng
- Chen Kai
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Choudhary Brajesh Chandra
- Christodoulou Georgios
- Christofferson Cabot-Ann
- Church Eric
- Cline David
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Coleman Stephen
- Conrad Janet M.
- Convery Mark
- Corey Robert
- Corwin Luke
- Cranshaw Jack
- Cronin-Hennessy Daniel
- Curioni A.
- da Motta Helio
- Davenne Tristan
- Davies Gavin S.
- Dazeley Steven
- de Geronimo Gianluigi
- de Gouvea Andre
- de Jong Jeffrey K.
- De Kaushik
- Demuth David
- Densham Chris
- Diwan Milind
- Djurcic Zelimir
- Dolfini R.
- Dolph Jeffrey
- Drake Gary
- Dye Stephen
- Dyuang Hongue
- Edmunds Daniel
- Elliott Steven
- Elnimr Muhammad
- Eno Sarah
- Enomoto Sanshiro
- Escobar Carlos O.
- Evans Justin
- Falcone A.
- Falk Lisa
- Farbin Amir
- Farnese Christian
- Fava Angela
- Felde John
- Fernandes S.
- Ferroni Fernando
- Feyzi Farshid
- Fields Laura
- Finch Alex
- Fitton Mike
- Fleming Bonnie
- Fowler Jack
- Fox Walt
- Friedland Alex
- Fuess Stu
- Fujikawa Brian
- Gallagher Hugh
- Gandhi Raj
- Garvey Gerald
- Gehman Victor M.
- Gibin Daniele
- Gill Ronald
- Gomes Ricardo A.
- Goodman Maury C.
- Goon Jason
- Graf Nicholas
- Graham Mathew
- Gran Rik
- Grant Christopher
- Grant Nick
- Greenlee Herbert
- Greenler Leland
- Grullon Sean
- Guardincerri Elena
- Guarino Victor
- Guarnaccia Evan
- Guedes Germano
- Guenette Roxanne
- Guglielmi Alberto
- Guzzo Marcelo M.
- Habig Alec T.
- Hackenburg Robert W.
- Hadavand Haleh
- Hahn Alan
- Haigh Martin
- Haines Todd
- Handler Thomas
- Hans Sunej
- Hartnell Jeff
- Harton John
- Hatcher Robert
- Hatzikoutelis Athans
- Hays Steven
- Hazen Eric
- Headley Mike
- Heavey Anne
- Heeger Karsten
- Heise Jaret
- Hellauer Robert
- Hewes Jeremy
- Himmel Alexander
- Hogan Matthew
- Holanda Pedro
- Holin Anna
- Horton-Smith Glenn
- Howell Joe
- Hurh Patrick
- Huston Joey
- Hylen James
- Imlay Richard
- Insler Jonathan
- Introzzi G.
- Isvan Zeynep
- Jackson Chris
- Jacobsen John
- Jaffe David E.
- James Cat
- Jen Chun-Min
- Johnson Marvin
- Johnson Randy
- Johnson Robert
- Johnson Scott
- Johnston William
- Johnstone John
- Jones Ben J. P.
- Jostlein H.
- Junk Thomas
- Kadel Richard
- Kaess Karl
- Karagiorgi Georgia
- Kaspar Jarek
- Katori Teppei
- Kayser Boris
- Kearns Edward
- Keener Paul
- Kemp Ernesto
- Kettell Steve H.
- Kirby Mike
- Klein Joshua
- Koizumi Gordon
- Kopp Sacha
- Kormos Laura
- Kropp William
- Kudryavtsev Vitaly A.
- Kumar Ashok
- Kumar Jason
- Kutter Thomas
- La Zia Franco
- Lande Kenneth
- Lane Charles
- Lang Karol
- Lanni Francesco
- Lanza Richard
- Latorre Tony
- LBNE Collaboration
- Learned John
- Lee David
- Lee Kevin
- Li Qizhong
- Li Shaorui
- Li Yichen
- Li Zepeng
- Libo Jiang
- Linden Steve
- Ling Jiajie
- Link Jonathan
- Littenberg Laurence
- Liu Hu
- Liu Qiuguang
- Liu Tiankuan
- Losecco John
- Louis William
- Lundberg Byron
- Lundin Tracy
- Lundy Jay
- Machado Ana Amelia
- Maesano Cara
- Magill Steve
- Mahler George
- Malon David
- Malys Stephen
- Mammoliti Francesco
- Mandal Samit Kumar
- Mann Anthony
- Mantsch Paul
- Marchionni Alberto
- Marciano William
- Mariani Camillo
- Maricic Jelena
- Marino Alysia
- Marshak Marvin
- Marshall John
- Matsuno Shiegenobu
- Mauger Christopher
- Mavrokoridis Konstantinos
- Mayer Nate
- McCauley Neil
- McCluskey Elaine
- McDonald Kirk
- McFarland Kevin
- McKee David
- McKeown Robert
- McTaggart Robert
- Mehdiyev Rashid
- Mei Dongming
- Menegolli A.
- Meng Guang
- Meng Yixiong
- Mertins David
- Messier Mark
- Metcalf William
- Milincic Radovan
- Miller William
- Mills Geoff
- Mishra Sanjib R.
- Mokhov Nikolai
- Montanari Claudio
- Montanari David
- Moore Craig
- Morfin Jorge
- Morgan Ben
- Morse William
- Moss Zander
- Moura Célio A.
- Mufson Stuart
- Muller David
- Musser Jim
- Naples Donna
- Napolitano Jim
- Newcomer Mitch
- Nichol Ryan
- Nicholls Tim
- Niner Evan
- Norris Barry
- Nowak Jaroslaw
- O'Keeffe Helen
- Oliveira Roberto
- Olson Travis
- Page Brian
- Pakvasa Sandip
- Palamara Ornella
- Paley Jon
- Paolone Vittorio
- Papadimitriou Vaia
- Park Seongtae
- Parsa Zohreh
- Partyka Kinga
- Paulos Bob
- Pavlovic Zarko
- Peeters Simon
- Perch Andy
- Perkin Jon D.
- Petti Roberto
- Petukhov Andre
- Pietropaolo Francesco
- Plunkett Robert
- Polly Chris
- Pordes Stephen
- Potekhin Maxim
- Potenza Renato
- Prakash Arati
- Prokofiev Oleg
- Qian Xin
- Raaf Jennifer L.
- Radeka Veljko
- Rakhno Igor
- Ramachers Yorck
- Rameika Regina
- Ramsey John
- Rappoldi A.
- Raselli G. L.
- Ratoff Peter
- Ravindra Shreyas
- Rebel Brian
- Reichenbacher Juergen
- Reitzner Dianne
- Rescia Sergio
- Richardson Martin
- Rielage Kieth
- Riesselmann Kurt
- Robinson Matt
- Rochester Leon
- Ronquest Michael
- Rosen Marc
- Rossella M.
- Rubbia Carlo
- Rucinski Russ
- Sahijpal Sandeep
- Sahoo Himansu
- Sala Paola
- Salmiera Delia
- Samios Nicholas
- Sanchez Mayly
- Scaramelli Alberto
- Schellman Heidi
- Schmitt Richard
- Schmitz David
- Schneps Jack
- Scholberg Kate
- Segreto Ettore
- Seibert Stanley
- Sexton-Kennedy Liz
- Shaevitz Mike
- Shanahan Peter
- Sharma Rahul
- Shaw Terri
- Simos Nikolaos
- Singh Venktesh
- Sinnis Gus
- Sippach William
- Skwarnicki Tomasz
- Smy Michael
- Sobel Henry
- Soderberg Mitch
- Sondericker John
- Sondheim Walter
- Sousa Alexandre
- Spooner Neil J. C.
- Stancari Michelle
- Stancu Ion
- Stefan Dorota
- Stefanik Andy
- Stewart James
- Stone Sheldon
- Strait James
- Strait Matthew
- Striganov Sergei
- Sullivan Gregory
- Sun Yujing
- Suter Louise
- Svenson Andrew
- Svoboda Robert
- Szczerbinska Barbara
- Szelc Andrzej
- Szydagis Matthew
- Söldner-Rembold Stefan
- Talaga Richard
- Tamsett Matthew
- Tariq Salman
- Tayloe Rex
- Taylor Charles
- Taylor David
- Teymourian Artin
- Themann Harry
- Thiesse Matthew
- Thomas Jenny
- Thompson Lee F.
- Thomson Mark
- Thorn Craig
- Thorpe Matt
- Tian Xinchun
- Tiedt Doug
- Toki Walter
- Tolich Nikolai
- Torti M.
- Toups Matt
- Touramanis Christos
- Tripathi Mani
- Tropin Igor
- Tsai Yun-Tse
- Tull Craig
- Tzanov Martin
- Urheim Jon
- Usman Shawn
- Vagins Mark
- Valdiviesso Gustavo
- Van Berg Rick
- Van de Water Richard
- Van Gemmeren Peter
- Varanini Filippo
- Varner Gary
- Vaziri Kamran
- Velev Gueorgui
- Ventura Sandro
- Vignoli Chiara
- Viren Brett
- Wahl Dan
- Waldron Abby
- Walter Christopher W.
- Wang Hanguo
- Wang Wei
- Warburton Karl
- Warner David
- Wasserman Ryan
- Watson Blake
- Weber Alfons
- Wei Wenzhao
- Wells Douglas
- Wetstein Matthew
- White Andy
- White Hywel
- Whitehead Lisa
- Whittington Denver
- Willhite Joshua
- Wilson Robert J.
- Winslow Lindley
- Wood Kevin
- Worcester Elizabeth
- Worcester Matthew
- Xin Tian
- Yarritu Kevin
- Ye Jingbo
- Yeh Minfang
- Yu Bo
- Yu Jae
- Yuan Tianlu
- Zani A.
- Zeller Geralyn P.
- Zhang Chao
- Zhang Chao
- Zimmerman Eric D.
- Zwaska Robert
- Publication venue
- Publication date
- 28/07/2013
- Field of study
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
- Amorosi Vittoria
- Arif Tahera
- Armstrong Alexander
- Asaad Oubida
- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
- Bains Salena
- Bajrusevic Sladana
- Balasubramanian Balapathiran
- Balata Safa Ahmed
- Bali Radhika
- Barnes Nicola
- Barnes Nicola LP
- Barrows Sara
- Barry Peter
- Barua Ellora
- Basu Naren
- Bathla Sonia
- Benyon Sarah L
- Bernaudo Lorenzo
- Bhaskar Pud
- Bibi Saira
- Biddle M
- Bignell Kym
- Biswas Bashishta
- Blazeby Jane
- Bourne Roger
- Brock Lisa
- Brown Victoria
- Bucata Claudiu
- Bucknor Alexandra
- Byrne Miriam
- Cain Henry
- Callaghan Maria
- Canny Rebecca
- Catanuto Giuseppe
- Cawthorn Simon
- Ceccarino Raffaele
- Chagla Leena
- Challoner Tom
- Chana Jagdeep
- Chand Natalie
- Chandrashekar Mysore
- Charalambous Michalis
- Charalampou-Dis Petros
- Chew Ben
- Chicken Dennis Wayne
- Chin Kian
- Chong Kelvin
- Choy Christina
- Christopoulos Petros
- Chrysafi Ada
- Clark Sarah
- Clarke Natalie
- Coco Guido
- Colizzi Livio
- Collab Breast Reconstruction Res
- Collis Nick
- Conroy Elizabeth
- Constantinou Chloe
- Critchley Adam
- Cullinane Carolyn
- Curnier Alain
- Curran Terry-Ann
- Dauria Marta
- Dave Rajiv
- Dave Rajiv V
- Dave Rajiv V
- Davey Simon
- de Sousa Emma
- Debanth Debasish
- Depasquale Ivan
- Devane Liam
- Dhooma Naseem
- Di Micco Rosa
- Dixon JM
- Dordea Matei
- Douek Michael
- Down Sue
- Downey Sarah
- Dragoumis Dimitris
- Dumitru Dorin
- Dunn Julie
- Durbar Michael
- El-Sharief Deena
- Elahi Bilal
- Elfadl Dalia
- Epurescu Daniel
- Evoy Denis
- Exarchos Georgios
- Fabio Santanelli di Pompeo
- Fafemi Oladapo
- Fage Elena
- Farrell Eric
- Ferguson Douglas
- Fiddes Roanne
- Figus Andrea
- Fopp Laura
- Foster Rachel
- Fuller Mairi
- Fustaino Loredana
- Gahir Jasdeep
- Gandamihardja Tasha
- Gandhi Ashu
- Gardiner Matthew
- Gardiner Matthew
- Garg Neeraj
- Garnsey Clare
- Geraghty James
- Geropantas Konstantinos
- Ghali Shadi
- Ghilli Matteo
- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
- Graja Tomasz
- Granger Emily
- Grassi Veronica
- Grover Kartikae
- Grp iBRA-2 Steering
- Guest Francesca
- Gui Gerald
- Gutteridge Eleanor
- Gvaramadze Anzors
- Hallam Kelly
- Hamad Ahmed
- Hamed Hisham
- Hamilton Stephen
- Hamnett Kathryn
- Hamo Ishrak
- Haq Anwar
- Harcourt Ruth
- Harding-MacKean Claudia
- Harnett Adrian
- Harnett Adrian
- Harnett Adrian
- Harris Chad
- Harris Kevin
- Harris Paul
- Harvey James
- Harvey Kate L
- Haywood Richard M
- Healy Samuel
- Henderson Julia
- Henry Francis P
- Hernan Izaro
- Heys Steven
- Hignett Susan
- Hill Arnold DK
- Hogan Brian
- Holcombe Chris
- Holcombe Chris
- Holcombe Chris
- Hollywood Ciaran
- Holt Simon
- Horgan Kieran
- Howes Rachel
- Hu Jennifer
- Humphreys Laura
- Hunter Judith
- Hussien Maged I
- Ihsan Naila
- Iqbal Azhar
- Irakleidis Foivos
- Irwin Gareth
- Irwin Michael S
- Isherwood Jennifer
- Ives Charlotte
- Jafferbhoy Sadaf
- Jafferbhoy Sadaf
- Jain Yogesh
- Jallali Navid
- James Karen
- James Ruth
- James Stuart
- Jibril Jibril A
- Jiwa Natasha
- Johns Neil
- Johnson Laura
- Johnson Richard
- Jones Ben Mancey
- Jones Robin
- Kalles Vasileios
- Kalra Loraine
- Kaushik Monika
- Kearns Marie
- Kelsall Jennett
- Kennedy Katy
- Kenny Frances
- Khalil Haitham
- Khan Mansoor
- Khan Shazia M
- Khattak Ilyas
- Khawaja Saira
- Khout Hazem
- Kirby Robert
- Kirchhoff Chris
- Kirkpatrick Katharine
- Kiruparan Pasupathy
- Kirwan Cliona C
- Kleidi Eleftheria
- Kneeshaw Peter
- Kokan Jalal
- Koris Jacob
- Kothari Ashutosh
- Kovacs Tibor
- Krupa Jaroslaw
- Krupa Katerine
- Kryjak Zbigniew
- Kulkarni Dhananjay
- Lai Lee Min
- Lambert Kelly
- Lampropoulos Pavlos
- Lane Risha
- Langlands Fiona
- Lansdown Mark
- Laurence Nicola
- Lawlor Catriona
- Laws Siobhan
- Ledwidge Serena
- Lee Jason
- Lewis Rebecca
- Li Alessandro Quattrini
- Liccardo Raffaele
- Limite Gennaro
- Lo Michelle
- Lund Jonathan
- Lymperopoulos N
- Maalo Joseph
- Mackay Iain
- MacLean Gael
- MacLennan Louise
- Macmillan Douglas
- MacNeill Fiona
- Mahapatra Tapan
- Majeed Yousef
- Malata Charles M
- Mallon Peter
- Malyon Andy
- Mansfield Lucy
- Mariniello Maria Donatella
- Marsh Daniel
- Marzia Lo Russo
- Masannat Yazan A
- Masood Mohammad
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathew Tom
- Mazari Fayyaz
- McCartan Damian
- McCulley Stephen
- McDermott Enda
- McEvoy Kat
- McGill David
- McGuiness Caroline
- McIntosh Jamie
- McIntosh Stuart A
- Mckenzie Shireen
- McManus Penelope
- Mehmood Iftikhar
- Mehta Disha
- Michalakis Ioannis
- Michieletto Silvia
- Milligan Robert
- Misky Adam
- Mitchell Geraldine
- Monib Sherif
- Morgan Mary
- Morrison Colin
- Mortimer Caroline
- Mosahebi Afshin
- Moss Sarah
- Muhibullah Nazli
- Mullan Michelle
- Munot Kailas
- Murali Kothandaraman
- Murphy Claire
- Murphy Declan C
- Murphy John
- Mustafa Mohammed
- Mylvaganam Senthurun
- Nagachandra Geerthan
- Narayanan Sankaran
- Naseem Salma
- Nasr Rana
- Navin Channegowda
- Nguyen Dai
- Nizamoglu Metin
- O'Brien Ciara
- O'Brien Ciara
- O'Brien James
- O'Connell Rachel
- O'Connell Rachel L
- O'Donoghue Joe
- O'Leary Peter
- Okwemba Sylvia
- Oliver James
- Olsen Sisse
- Oluwajana Michael
- Otieno Charlene
- Pain Simon J
- Park Alan
- Parvanta Laila
- Patel Ashraf
- Patel Krupali
- Peel Anthony
- Pereira Bernadette
- Pereira Jerome
- Pikoulas Panagiotis
- Pilgrim Simon
- Piper Jenny
- Poonawala Shabbir
- Popa Elena
- Pope Vanessa
- Potter Shelley
- Potter Shelley
- Potter Shelley
- Power Kieran
- Prichard Ruth
- Prousskaia Elena
- Pujji Ojas
- Rainsbury Dick
- Ramakrishnan Venkat
- Ramsey Kelvin
- Rasheed Tuabin
- Rattay Tim
- Rattay Tim
- Ravichandran Duraisamy
- Ray Biswajit
- Rayter Zenon
- Refsum Sigi
- Reissis Dimitris
- Remoundos Dionysios Dennis
- Ribas Maria Dalmau
- Rizkalla Maged
- Rizki Hirah
- Rocco Nicola
- Roche Nicola
- Roncella Manuela
- Roshanlall Chandeena
- Rossetti Elena
- Rothwell Jane
- Roy Pankaj
- Rusby Jennifer
- Sahu Ajay
- Saibene Tania
- Saleem Talha
- Sami AS
- Sassoon EM
- Scott John
- Seetharam Seema
- Sethu Claire
- Seward Joanna
- Shanks Lindsay
- Shariaha Yousef
- Sherwin Liz
- Shetty Geeta
- Shokuhi Sheila
- Shrestha Deepak
- Sircar Tapan
- Sirianni Chiara
- Sirianni Chiara
- Sjokvist Olivia
- Skillman Joanna
- Skillman Joanna
- Slade-Sharman Diana
- Sloan Samantha
- Smyth Elizabeth
- Sojitra Nilesh
- Soulsby Rachel
- Soumian Soni
- Sowdi Ravi
- Stebbing Anne
- Sundaramoorthy Souganthy
- Sutton Richard
- Svenning Matilda
- Syed Farah
- Tadros Amir
- Taghizadeh Rieka
- Tansley Anne
- Tasoulis Marios
- Tayeh Salim
- Taylor Amanda
- Taylor Jevan
- Taylor Lauren
- Tebbal Sally
- Tevlin Ruth
- Thekkinkattil Dinesh
- Thomas Rachel Bright
- Thomson Simon
- Thorne Amanda
- Thrush Steven
- Tillett Rachel
- To Natalie
- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
- Whisker Lisa
- Wilkins Alex
- Williamson Paula
- Wilson Rebecca
- Wilson Sherif
- Windle Rebecca
- Wintrip Dorothy
- Wood Simon
- Wooler Brendan
- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
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- Solovyanov O
- Soltveit HK
- Song H
- Sopicki P
- Sorbi M
- Spallino L
- Spannowsky M
- Spataro B
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- Thomas S
- Tiirakari MT
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
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- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
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- Appleby RB
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- Assmann RW
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- Bermudez SI
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- Bernet C
- Bernhardt JM
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
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- Allport PP
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- Altmannshofer W
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- Eskola KJ
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
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- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
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- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
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- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
FCC-ee: The Lepton Collider – Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- Alía R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- Apolinário L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
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- Arı V.
- Arias S.
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- Arnaldi R.
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- Yazgan E.
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- Yilmaz A.
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- Zurita J.
- Özcan V.
- Özdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 14/11/2019
- Field of study
HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- Alía R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- Apolinário L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
- Apyan A.
- Apyan A.
- Arbey A.
- Arbuzov A.
- Arduini G.
- Arı V.
- Arias S.
- Armesto N.
- Arnaldi R.
- Arsenyev S. A.
- Arzeo M.
- Asai S.
- Aslanides E.
- Astapovych D.
- Atanasov M.
- Atieh S.
- Attié D.
- Auchmann B.
- Audurier A.
- Aull S.
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- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
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- Aguilera-Verdugo JJ
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- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
HE-LHC: The High-Energy Large Hadron Collider
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
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- Acar AO
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
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