Lixiviação de diuron, hexazinone e sulfometuron-methyl em formulação comercial e isoladamente em dois solos contrastantes

The objective of this research was to evaluate contrasting textures soils (clay and loamy sand) in the leaching of diuron + hexazinone + sulfometuron-methyl (1386.9 + 391 + 33.35 g ha-1) commercial formulation, and also hexazinone (391 g ha-1), diuron (1386.9 g ha-1) and sulfometuron-methyl (33.35 g ha-1), in soil columns mounted in PVC pipes. One day after the herbicide application, half of the columns received 40 mm of simulated rainfall and Ipomoea triloba weed was sown. At 21 and 30 days after sowing, it was accomplished the evaluation about percentage of weed control. For the clay texture soil, diuron + hexazinone + sulfometuron-methyl and hexazinone herbicides reached approximately 10 to 13 cm deep with 0 and 40 mm, respectively. In loamy sand texture soil, herbicides leaching was evident up to 20 cm deep, with 40 mm of precipitation. For diuron and sulfometuron-methyl herbicides, leaching tended to approach to clay texture soil with 40 mm and to loamy sand texture soil in the two simulated precipitations. Hexazinone and D+H+SMM were the herbicides that presented the highest trend to leaching, facilitated in loamy sand texture soil. Diuron and sulfometuron-methyl herbicides’ leaching was lower, fact that exposes hexazinone influence in the leaching of the evaluated commercial formulation. DOI: http://dx.doi.org/10.7824/rbh.v11i2.172O objetivo desse trabalho foi avaliar a influência de texturas contrastantes (argilosa e areia franca) na lixiviação de diuron, hexazinone e sulfometuron-methyl em formulação comercial (D+H+SMM) e aplicados isoladamente, quando submetidos à 0 e 40 mm de simulação de precipitação. O experimento consistiu na aplicação de diuron + hexazinone + sulfometuron-methyl (1386,9 + 391 + 33,35 g ha-1), hexazinone (391 g ha-1), diuron (1386,9 g ha-1) e sulfometuron-methyl (33,35 g ha-1) em colunas de solo montadas em tubos de PVC. Um dia após a aplicação, metade das colunas recebeu simulação de precipitação de 40 mm e a planta daninha Ipomoea triloba foi semeada. Aos 21 e 30 dias após a semeadura foi feita avaliação de porcentagem de controle. Para o solo de textura argilosa, os herbicidas D+H+SMM e hexazinone chegaram a aproximadamente 10 e 13 cm de profundidade com 0 e 40 mm, respectivamente. No solo de textura arenosa, a lixiviação desses herbicidas foi evidente até os 20 cm de profundidade, com 40 mm de precipitação. Para os herbicidas diuron e sulfometuron-methyl as lixiviações tenderam a se aproximar para o solo de textura argilosa com 40 mm e para o solo de textura arenosa nas duas simulações de precipitação. Hexazinone e D+H+SMM foram os herbicidas que apresentaram maior tendência de lixiviação, facilitada no solo de textura arenosa. Já a lixiviação dos herbicidas diuron e sulfometuron-methyl foi baixa, o que expõe a influência do hexazinone na lixiviação da formulação comercial avaliada. DOI: http://dx.doi.org/10.7824/rbh.v11i2.17

T Cells home to the thymus and control infection

The thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) T cells, which stimulates infected cells and controls bacterial growth in the thymus. Importantly, the responding T cells are mature peripheral T cells that recirculate back to the thymus. The recruitment of these cells is associated with an increased expression of Th1 chemokines and an enrichment of CXCR3(+) mycobacteria-specific T cells in the thymus. Finally, we demonstrate it is the mature T cells that home to the thymus that most efficiently control mycobacterial infection. Although the presence of mature T cells in the thymus has been recognized for some time, to our knowledge, these data are the first to show that T cell recirculation from the periphery to the thymus is a mechanism that allows the immune system to respond to thymic infection. Maintaining a functional thymic environment is essential to maintain T cell differentiation and prevent the emergence of central tolerance to the invading pathogens.This work was supported by Portuguese Foundation for Science and Technology Grant PTDC/SAU-MII/101663/2008 and individual fellowships to C.N., C.N.-A., B.C.-R., S.R., and P.B.-S. S.M.B. was supported by National Institutes of Health Grant R01 AI067731. The Small Animal Biocontainment Suite was supported in part by Center for AIDS Research Grant P30 AI 060354

Eficácia de herbicidas em condições controladas para o controle de gramíneas infestantes de canaviais em estiagem

Chemical control of weeds in sugarcane crop may be performed in dry season, mainly due to agricultural operations planning, and logistics in relation to the use of equipment and labor. This study aimed to evaluate the agronomic efficacy of herbicides for controlling sugarcane grass weeds by using different periods of water restriction. Evaluated weeds were Digitaria nuda, Panicum maximum and Brachiaria decumbens. Herbicides treatments applied in total pre-emergency condition were: diuron + hexazinone + sulfometuron-methyl (1387 + 391 + 33.35; 1507.5 + 425 + 36.25 1658.25 + 467.5 + 39.87 and 1809 + 510 + 43.5 g a.i. ha-1; amicarbazone (1190 g a.i. ha-1); amicarbazone + isoxaflutole (840 + 82.5 g a.i. ha-1) and an check without application. After application, plots were submitted to 0, 30, 60 and 90 days of water restriction. Control visual evaluations were performed 28 days after humidity restoration, with the weeds biomass determination. All studied doses of diuron + hexazinone + sulfometuron-methyl were effective in controlling the plants studied in all water restriction periods. Amicarbazone sprayed alone was not efficient on weeds control under the condition of 60 days with water restriction. Amicarbazone + isoxaflutole presented satisfactory weeds control, except for Digitaria nuda, in 60 days of water restriction.O controle químico das plantas daninhas em canaviais pode ser realizado no período de estiagem devido, principalmente, planejamento de operações agrícolas, e logística quanto ao uso de equipamentos e mão-de-obra. O presente estudo teve como objetivo avaliar a eficácia agronômica de herbicidas para o controle de plantas daninhas gramíneas infestantes de canaviais, utilizando diferentes períodos de restrição hídrica em condições controladas. As plantas daninhas avaliadas foram Digitaria nuda, Panicum maximum e Brachiaria decumbens. Os tratamentos herbicidas aplicados em pré-emergência total das plantas daninhas foram: diuron + hexazinone + sulfometuron-methyl (1387 + 391 + 33,35; 1507,5 + 425 + 36,25; 1658,25 + 467,5 + 39,87 e 1809 + 510 + 43,5 g i.a. ha-1); amicarbazone (1190 g i.a. ha-1); amicarbazone + isoxaflutole (840 + 82,5 g i.a. ha-1) e uma testemunha sem aplicação. Após a aplicação, as parcelas foram submetidas a 0, 30, 60 e 90 dias de restrição hídrica. Foram realizadas avaliações visuais de controle e aos 28 dias após o restabelecimento da umidade, determinada a biomassa das plantas daninhas. Todas as doses de diuron + hexazinone + sulfometuron-methyl foram eficazes no controle das espécies estudadas em todos os períodos de restrição hídrica. Amicarbazone aplicado isoladamente foi ineficiente no controle das plantas daninhas sob a condição de 60 dias de seca. Amicarbazone + isoxaflutole, apresentou bom controle das plantas daninhas, com exceção de Digitaria nuda, quando na condição a 60 dias de seca

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

2 nd Brazilian Consensus on Chagas Disease, 2015

Abstract Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. Methods The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODErn), to generate cause fractions and cause specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised. Findings At the broadest grouping of causes of death (Level 1), non-communicable diseases (NC Ds) comprised the greatest fraction of deaths, contributing to 73.4% (95% uncertainty interval [UI] 72.5-74.1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional (CMNN) causes accounted for 186% (17.9-19.6), and injuries 8.0% (7.7-8.2). Total numbers of deaths from NCD causes increased from 2007 to 2017 by 22.7% (21.5-23.9), representing an additional 7.61 million (7. 20-8.01) deaths estimated in 2017 versus 2007. The death rate from NCDs decreased globally by 7.9% (7.08.8). The number of deaths for CMNN causes decreased by 222% (20.0-24.0) and the death rate by 31.8% (30.1-33.3). Total deaths from injuries increased by 2.3% (0-5-4-0) between 2007 and 2017, and the death rate from injuries decreased by 13.7% (12.2-15.1) to 57.9 deaths (55.9-59.2) per 100 000 in 2017. Deaths from substance use disorders also increased, rising from 284 000 deaths (268 000-289 000) globally in 2007 to 352 000 (334 000-363 000) in 2017. Between 2007 and 2017, total deaths from conflict and terrorism increased by 118.0% (88.8-148.6). A greater reduction in total deaths and death rates was observed for some CMNN causes among children younger than 5 years than for older adults, such as a 36.4% (32.2-40.6) reduction in deaths from lower respiratory infections for children younger than 5 years compared with a 33.6% (31.2-36.1) increase in adults older than 70 years. Globally, the number of deaths was greater for men than for women at most ages in 2017, except at ages older than 85 years. Trends in global YLLs reflect an epidemiological transition, with decreases in total YLLs from enteric infections, respirator}, infections and tuberculosis, and maternal and neonatal disorders between 1990 and 2017; these were generally greater in magnitude at the lowest levels of the Socio-demographic Index (SDI). At the same time, there were large increases in YLLs from neoplasms and cardiovascular diseases. YLL rates decreased across the five leading Level 2 causes in all SDI quintiles. The leading causes of YLLs in 1990 neonatal disorders, lower respiratory infections, and diarrhoeal diseases were ranked second, fourth, and fifth, in 2017. Meanwhile, estimated YLLs increased for ischaemic heart disease (ranked first in 2017) and stroke (ranked third), even though YLL rates decreased. Population growth contributed to increased total deaths across the 20 leading Level 2 causes of mortality between 2007 and 2017. Decreases in the cause-specific mortality rate reduced the effect of population growth for all but three causes: substance use disorders, neurological disorders, and skin and subcutaneous diseases. Interpretation Improvements in global health have been unevenly distributed among populations. Deaths due to injuries, substance use disorders, armed conflict and terrorism, neoplasms, and cardiovascular disease are expanding threats to global health. For causes of death such as lower respiratory and enteric infections, more rapid progress occurred for children than for the oldest adults, and there is continuing disparity in mortality rates by sex across age groups. Reductions in the death rate of some common diseases are themselves slowing or have ceased, primarily for NCDs, and the death rate for selected causes has increased in the past decade. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.Peer reviewe

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised