Actor Denied Straight Nose : Louis Wolheim and the Gendered Practice of Plastic Surgery in Silent-Era Hollywood

Hollywood\u27s embrace of plastic surgery as a means of sculpting performers\u27 bodies to meet standards of youth and beauty is a long-standing phenomenon. Using archival materials available in the Howard Hughes Motion Picture Records at the University of Nevada, Las Vegas, this article offers a case study of Louis Wolheim (1881–1931), a motion-picture star under contract to Caddo, Howard Hughes\u27s production company, from the late 1920s until the time of his death. Wolheim caused a national sensation in 1927 when he told reporters about his plan to have his iconic hard-boiled facial features surgically altered

Extensive Bioprosthetic Aortic Valve Annual Abscess

Case Introduction: Infective endocarditis (IE) is a relatively common, usually subacute infection involving heart valves. IE is often preceded by bacteremia in patients with prosthetic hardware, artificial heart valves, vascular access catheters, or in patients with risk factors such as intravenous drug use. Normally, IE is found during work-up for bacteremia and is best evaluated with echocardiography. Prolonged IV antibiotics are the treatment of choice unless the patient has an indication for surgery such as a large vegetation or signs acute heart failure, among others. Case Description: A 75-year-old male with a past medical history of aortic stenosis status-post bioprosthetic aortic valve (AV) replacement presented with back pain. At the time of admission, labs were notable for acute kidney injury, transaminase elevation, leukocytosis, and lactic acidosis. Subsequent blood cultures grew Enterococcus faecalis. Transthoracic echocardiography confirmed endocarditis with a mobile mass involving the tricuspid valve (TV). Transesophageal echocardiography further demonstrated a large bioprosthetic aortic valve annular abscess extending into the ascending and descending aorta. Direct visualization in the OR confirmed native TV endocarditis and an AV annular abscess eroding into the atria and left ventricular outflow tract (LVOT). He underwent AV/LVOT abscess debridement, repair of aortic root using autologous pericardium with coronary reimplantation, and TV debridement and repair. His postoperative course was complicated by ventricular tachycardia and refractory cardiogenic shock secondary to right ventricular failure. He was transferred to an outlying facility for extracorporeal membrane oxygenation (ECMO) support, but ultimately passed away. Just two weeks prior to this aforementioned admission, the patient underwent transthoracic echocardiography for new onset atrial fibrillation which demonstrated a bioprosthetic aortic valve with normal pressure gradients and without vegetation. Case Discussion: The incidence of perivalvular abscess among patients with bioprosthetic valve endocarditis is between 30% to 40%. What makes this case interesting is not only the impressive local extent of abscess, but also the aggressive nature of the infection given negative imaging just weeks prior. This case illustrates the need for rapid identification, early initiation of treatment, and availability of post-operative mechanical support for patients with bioprosthetic valve abscess from endocarditis. Ramos Tuarez FJ, Yelamanchili VS, Law MA. Cardiac Abscess. [Updated 2020 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459132/N

Calibrating CHIME, A New Radio Interferometer to Probe Dark Energy

The Canadian Hydrogen Intensity Mapping Experiment (CHIME) is a transit interferometer currently being built at the Dominion Radio Astrophysical Observatory (DRAO) in Penticton, BC, Canada. We will use CHIME to map neutral hydrogen in the frequency range 400 -- 800\,MHz over half of the sky, producing a measurement of baryon acoustic oscillations (BAO) at redshifts between 0.8 -- 2.5 to probe dark energy. We have deployed a pathfinder version of CHIME that will yield constraints on the BAO power spectrum and provide a test-bed for our calibration scheme. I will discuss the CHIME calibration requirements and describe instrumentation we are developing to meet these requirements

Modeling and mapping isotopic patterns in the Northwest Atlantic derived from loggerhead sea turtles

Stable isotope analysis can be used to infer geospatial linkages of highly migratory species. Identifying foraging grounds of marine organisms from their isotopic signatures is becoming de rigueur as it has been with terrestrial organisms. Sea turtles are being increasingly studied using a combination of satellite telemetry and stable isotope analysis; these studies along with those from other charismatic, highly vagile, and widely distributed species (e.g., tuna, billfish, sharks, dolphins, whales) have the potential to yield large datasets to develop methodologies to decipher migratory pathways in the marine realm. We collected tissue samples (epidermis and red blood cells) for carbon (delta C-13) and nitrogen (delta N-15) stable isotope analysis from 214 individual loggerheads (Caretta caretta) in the Northwest Atlantic Ocean (NWA). We used discriminant function analysis (DFA) to examine how well delta C-13 and delta N-15 classify loggerhead foraging areas. The DFA model was derived from isotopic signatures of 58 loggerheads equipped with satellite tags to identify foraging locations. We assessed model accuracy with the remaining 156 untracked loggerheads that were captured at their foraging locations. The DFA model correctly identified the foraging ground of 93.0% of individuals with a probability greater than 66.7%. The results of the external validation (1) confirm that assignment models based on tracked loggerheads in the NWA are robust and (2) provide the first independent evidence supporting the use of these models for migratory marine organisms. Additionally, we used these data to generate loggerhead-specific delta C-13 and delta N-15 isoscapes, the first for a predator in the Atlantic Ocean. We found a latitudinal trend of delta C-13 values with higher values in the southern region (20-25 degrees N) and a more complex pattern with delta N-15, with intermediate latitudes (30-35 degrees N) near large coastal estuaries having higher delta N-15-enrichment. These results indicate that this method with further refinement may provide a viable, more spatially-explicit option for identifying loggerhead foraging grounds

CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

CMB-S4---the next-generation ground-based cosmic microwave background (CMB) experiment---is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semi-analytic projection tool, targeted explicitly towards optimizing constraints on the tensor-to-scalar ratio, $r$, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2--3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments given a desired scientific goal. To form a closed-loop process, we couple this semi-analytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for $r > 0.003$ at greater than $5\sigma$, or, in the absence of a detection, of reaching an upper limit of $r < 0.001$ at $95\%$ CL.Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note: text overlap with arXiv:1907.0447

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 7- or 12-gene signature. Last, we built a machine learning framework, SepstratifieR, to deploy SRSq in adult and pediatric bacterial and viral sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing some of the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, bringing us closer to precision medicine in infection.peer-reviewe

Gothic Revival Architecture Before Horace Walpole's Strawberry Hill

The Gothic Revival is generally considered to have begun in eighteenth-century Britain with the construction of Horace Walpole’s villa, Strawberry Hill, Twickenham, in the late 1740s. As this chapter demonstrates, however, Strawberry Hill is in no way the first building, domestic or otherwise, to have recreated, even superficially, some aspect of the form and ornamental style of medieval architecture. Earlier architects who, albeit often combining it with Classicism, worked in the Gothic style include Sir Christopher Wren, Nicholas Hawksmoor, William Kent and Batty Langley, aspects of whose works are explored here. While not an exhaustive survey of pre-1750 Gothic Revival design, the examples considered in this chapter reveal how seventeenth- and eighteenth-century Gothic emerged and evolved over the course of different architects’ careers, and how, by the time that Walpole came to create his own Gothic ‘castle’, there was already in existence in Britain a sustained Gothic Revivalist tradition

CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

Abstract: CMB-S4—the next-generation ground-based cosmic microwave background (CMB) experiment—is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2–3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5σ, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL

Documenting Deforestation at Sidd al-Ahmar, Petra Region, Jordan

This study documented the decline of the forests of the Petra Region of Jordan, as represented at Sidd al-Ahmar, within the Petra Archaeological Park. Biogeographical and anthropological methods were employed to explore the history of the forests. Archaeology and historical narratives provided a portrait of the study area from prehistory to the early 20th century. Aerial surveys from 1924 and 2002 were analyzed to quantify changes in forest cover. Mapping and inventory of indicator species measured short-term change between 2003 and 2006. Interviews, field observation and participant observation in the tourist industry provided a socio-cultural context for quantitative analysis and for recommendations for remediation of pressures on the remaining forest. The research documents a 58% decline in tree cover between 1924-2002, and a decline of 4.23% between 2003-2006. The conclusions question concepts such as "landscape integrity" and the usefulness of non-interventionist ideology in an historic and rapidly changing region