60 research outputs found
Recent atmospheric neutrino results from Soudan 2
An updated measurement of the atmospheric nu_mu/nu_e ratio-of-ratios,
0.68+-0.11+-0.06, has been obtained using a 4.6-kty exposure of the Soudan-2
iron tracking calorimeter. The L/E distributions have been analyzed for effects
of nu_mu -> nu_x oscillations, and an allowed region in the Delta m^2 vs. sin^2
2 theta plane has been determined.Comment: 3 pages, 4 figures; presented at TAUP99, the 6th Int. Workshop on
Topics in Astroparticle and Underground Physics, Sept. 6-10, 1999, College de
France, Paris, Franc
Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial
IMPORTANCE Preventive interventions are needed to protect residents and staff of skilled nursing and assisted living facilities from COVID-19 during outbreaks in their facilities. Bamlanivimab, a neutralizing monoclonal antibody against SARS-CoV-2, may confer rapid protection from SARS-CoV-2 infection and COVID-19. OBJECTIVE To determine the effect of bamlanivimab on the incidence of COVID-19 among residents and staff of skilled nursing and assisted living facilities. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, single-dose, phase 3 trial that enrolled residents and staff of 74 skilled nursing and assisted living facilities in the United States with at least 1 confirmed SARS-CoV-2 index case. A total of 1175 participants enrolled in the study from August 2 to November 20, 2020. Database lock was triggered on January 13, 2021, when all participants reached study day 57. INTERVENTIONS Participants were randomized to receive a single intravenous infusion of bamlanivimab, 4200mg (n = 588), or placebo (n = 587). MAIN OUTCOMES AND MEASURES The primary outcomewas incidence of COVID-19, defined as the detection of SARS-CoV-2 by reverse transcriptase–polymerase chain reaction and mild or worse disease severity within 21 days of detection, within 8 weeks of randomization. Key secondary outcomes included incidence of moderate or worse COVID-19 severity and incidence of SARS-CoV-2 infection. RESULTS The prevention population comprised a total of 966 participants (666 staff and 300 residents) who were negative at baseline for SARS-CoV-2 infection and serology (mean age, 53.0 [range, 18-104] years; 722 [74.7%] women). Bamlanivimab significantly reduced the incidence of COVID-19 in the prevention population compared with placebo (8.5%vs 15.2%; odds ratio, 0.43 [95%CI, 0.28-0.68]; P < .001; absolute risk difference, −6.6 [95%CI, −10.7 to −2.6] percentage points). Five deaths attributed to COVID-19 were reported by day 57; all occurred in the placebo group. Among 1175 participants who received study product (safety population), the rate of participants with adverse events was 20.1% in the bamlanivimab group and 18.9% in the placebo group. The most common adverse events were urinary tract infection (reported by 12 participants [2%] who received bamlanivimab and 14 [2.4%] who received placebo) and hypertension (reported by 7 participants [1.2%] who received bamlanivimab and 10 [1.7%] who received placebo). CONCLUSIONS AND RELEVANCE Among residents and staff in skilled nursing and assisted living facilities, treatment during August-November 2020 with bamlanivimab monotherapy reduced the incidence of COVID-19 infection. Further research is needed to assess preventive efficacy with current patterns of viral strains with combination monoclonal antibody therapy
CMS physics technical design report : Addendum on high density QCD with heavy ions
Peer reviewe
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Exclusive photoproduction of pi degrees up to large values of Mandelstam variables s, t, and u with CLAS
Exclusive photoproduction cross sections have been measured for the process
with the Dalitz decay final state
using tagged photon energies in the range of GeV.
The complete angular distribution of the final state , for the entire
photon energy range up to large values of and , has been measured for
the first time. The data obtained show that the cross section , at
mid to large angles, decreases with energy as . This is in
agreement with the perturbative QCD quark counting rule prediction of . Paradoxically, the size of angular distribution of measured cross sections
is greatly underestimated by the QCD based Generalized Parton Distribution
mechanism at highest available invariant energy GeV. At the same
time, the Regge exchange based models for photoproduction are more
consistent with experimental data.Comment: 7 pages, 6 figure
Measurement of the anomalous precession frequency of the muon in the Fermilab Muon g-2 Experiment
The Muon g-2 Experiment at Fermi National Accelerator Laboratory (FNAL) has
measured the muon anomalous precession frequency to an uncertainty
of 434 parts per billion (ppb), statistical, and 56 ppb, systematic, with data
collected in four storage ring configurations during its first physics run in
2018. When combined with a precision measurement of the magnetic field of the
experiment's muon storage ring, the precession frequency measurement determines
a muon magnetic anomaly of (0.46 ppm). This article describes the multiple techniques employed
in the reconstruction, analysis and fitting of the data to measure the
precession frequency. It also presents the averaging of the results from the
eleven separate determinations of \omega_a, and the systematic uncertainties on
the result.Comment: 29 pages, 19 figures. Published in Physical Review
Measurement of the Positive Muon Anomalous Magnetic Moment to 0.46 ppm
We present the first results of the Fermilab Muon g-2 Experiment for the
positive muon magnetic anomaly . The anomaly is
determined from the precision measurements of two angular frequencies.
Intensity variation of high-energy positrons from muon decays directly encodes
the difference frequency between the spin-precession and cyclotron
frequencies for polarized muons in a magnetic storage ring. The storage ring
magnetic field is measured using nuclear magnetic resonance probes calibrated
in terms of the equivalent proton spin precession frequency
in a spherical water sample at 34.7C. The
ratio , together with known fundamental
constants, determines
(0.46\,ppm). The result is 3.3 standard deviations greater than the standard
model prediction and is in excellent agreement with the previous Brookhaven
National Laboratory (BNL) E821 measurement. After combination with previous
measurements of both and , the new experimental average of
(0.35\,ppm) increases the
tension between experiment and theory to 4.2 standard deviationsComment: 10 pages; 4 figure
Search for magnetic monopoles in electron-positron collisions at 34 GeV c.m. energy
SIGLEDEGerman
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Cygnus X-3 revisited: 10 years of muon and radio observations.
The Soudan 2 deep underground tracking calorimeter has recorded cosmic ray muon tracks from the direction of the galactic x-ray binary Cygnus X-3 on most transits during the interval 1989-1998. We analyze these events in the context of previous reports of Cygnus X-3-related muon flux during major radio flares of that source. We find some evidence for excess flux during a small number of transits coincident with major radio flares. We also find an indication that these events maybe distributed around the source with a Gaussian point spread function with {sigma} = 1.3{degree}, larger than the instrumental angular spread of < 0.3{degree}, verified by observation of the shadow of the moon
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