76 research outputs found
A "modernização" e os contingentes imigratórios em Santa Catarina
(1º parágrafo do artigo)
O que se vai ler é uma tentativa de colocar os dados disponíveis dentro de um “modelo” de “modernização”. As colocações dos vários dados não completam, sistematicamente, o quadro que se pretendia preenchido. Tal fato é devido à falta de novas e importantes pesquisas. Infelizmente não se pode equacionar, convenientemente, o tema, dada a precariedade das informações obtidas e, aqui, compendiadas. Caracteriza-se, pois, com este estudo preliminar, a necessidade de um planejamento conveniente de pesquisa, a ser efetuada, para a verificação dos fatores positivos e negativos da “modernização” face à imigração para o Estado de Santa Catarina
Quantum properties of the Dirac field on BTZ black hole backgrounds
We consider a Dirac field on a -dimensional uncharged BTZ black hole
background. We first find out the Dirac Hamiltonian, and study its
self-adjointness properties. We find that, in analogy to the Kerr-Newman-AdS
Dirac Hamiltonian in dimensions, essential self-adjointness on
of the reduced (radial) Hamiltonian is implemented
only if a suitable relation between the mass of the Dirac field and the
cosmological radius holds true. The very presence of a boundary-like
behaviour of is at the root of this problem. Also, we determine in a
complete way qualitative spectral properties for the non-extremal case, for
which we can infer the absence of quantum bound states for the Dirac field.
Next, we investigate the possibility of a quantum loss of angular momentum for
the -dimensional uncharged BTZ black hole. Unlike the corresponding
stationary four-dimensional solutions, the formal treatment of the level
crossing mechanism is much simpler. We find that, even in the extremal case, no
level crossing takes place. Therefore, no quantum loss of angular momentum via
particle pair production is allowed.Comment: 19 pages; IOP styl
Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia
<p>Abstract</p> <p>Background</p> <p>One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to patients who do not have an optimal response to clozapine has been cited as the most common reason for simultaneously prescribing a second antipsychotic drug in combination treatment strategies. In a clinical area where the pressing need of providing therapeutic answers has progressively increased the occurrence of antipsychotic polypharmacy, despite the lack of robust evidence of its efficacy, we sought to implement a pre-planned protocol where two alternative therapeutic answers are systematically provided and evaluated within the context of a pragmatic, multicentre, independent randomised study.</p> <p>Methods/Design</p> <p>The principal clinical question to be answered by the present project is the relative efficacy and tolerability of combination treatment with clozapine plus aripiprazole compared with combination treatment with clozapine plus haloperidol in patients with an incomplete response to treatment with clozapine over an appropriate period of time. This project is a prospective, multicentre, randomized, parallel-group, superiority trial that follow patients over a period of 12 months. Withdrawal from allocated treatment within 3 months is the primary outcome.</p> <p>Discussion</p> <p>The implementation of the protocol presented here shows that it is possible to create a network of community psychiatric services that accept the idea of using their everyday clinical practice to produce randomised knowledge. The employed pragmatic attitude allowed to randomly allocate more than 100 individuals, which means that this study is the largest antipsychotic combination trial conducted so far in Western countries. We expect that the current project, by generating evidence on whether it is clinically useful to combine clozapine with aripiprazole rather than with haloperidol, provides physicians with a solid evidence base to be directly applied in the routine care of patients with schizophrenia.</p> <p>Trial Registration</p> <p><b>Clincaltrials.gov Identifier</b>: NCT00395915</p
Hint of an exocomet transit in the CHEOPS light curve of HD 172555
HD 172555 is a young (~20 Myr) A7V star surrounded by a 10 au wide debris disk suspected to be replenished partly by collisions between large planetesimals. Small evaporating transiting bodies, that is exocomets, have also been detected in this system by spectroscopy. After β Pictoris, this is another example of a system possibly witnessing a phase of the heavy bombardment of planetesimals. In such a system, small bodies trace dynamical evolution processes. We aim to constrain their dust content by using transit photometry. We performed a 2-day-long photometric monitoring of HD 172555 with the CHEOPS space telescope in order to detect shallow transits of exocomets with a typical expected duration of a few hours. The large oscillations in the light curve indicate that HD 172555 is a δ Scuti pulsating star. After removing those dominating oscillations, we found a hint of a transient absorption. If fitted with an exocomet transit model, it would correspond to an evaporating body passing near the star at a distance of 6.8±1.4R★ (or 0.05±0.01 au) with a radius of 2.5 km. These properties are comparable to those of the exocomets already found in this system using spectroscopy, as well as those found in the β Pic system. The nuclei of the Solar System's Jupiter family comets, with radii of 2-6 km, are also comparable in size. This is the first piece of evidence of an exocomet photometric transit detection in the young system of HD 172555
Prediction of second neurological attack in patients with clinically isolated syndrome using support vector machines
The aim of this study is to predict the conversion from clinically isolated syndrome to clinically definite multiple sclerosis using support vector machines. The two groups of converters and non-converters are classified using features that were calculated from baseline data of 73 patients. The data consists of standard magnetic resonance images, binary lesion masks, and clinical and demographic information. 15 features were calculated and all combinations of them were iteratively tested for their predictive capacity using polynomial kernels and radial basis functions with leave-one-out cross-validation. The accuracy of this prediction is up to 86.4% with a sensitivity and specificity in the same range indicating that this is a feasible approach for the prediction of a second clinical attack in patients with clinically isolated syndromes, and that the chosen features are appropriate. The two features gender and location of onset lesions have been used in all feature combinations leading to a high accuracy suggesting that they are highly predictive. However, it is necessary to add supporting features to maximise the accuracy. © 2013 IEEE
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)
GOVERNO REVOLUCIONÁRIO DO DESTERRO
Palavras-chave: revolucionárias, resultados, separatismo, desenvolvimento, político administrativo
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