462 research outputs found

    Expressão dos genes Braf e C-Kit e sua correlação com fatores prognósticos em melanomas cutâneos

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    Resumo: Dados clinicos e histologicos de melanomas cutaneos primarios fornecem informacoes prognosticas uteis, porem o curso clinico de determinada lesao e imprevisivel. Fatores adicionais para prever sua evolucao sao necessarios e tecnicas de biologia molecular permitem a identificacao de marcadores moleculares que podem ter valor prognostico em melanomas. O presente estudo avaliou mutacoes BRAF e c-Kit em 96 especimens cirurgicos de melanomas cutaneos primarios e 15 lesoes metastaticas correspondentes em uma serie de pacientes brasileiros, atraves da tecnica TaqMan Real-Time polymerase chain reaction (PCR) e correlacionou estes dados com fatores prognosticos clinicos e anatomopatologicos atualmente conhecidos. Esta analise nao identificou mutacoes no gene c-Kit e mostrou uma frequencia baixa de mutacoes BRAF em melanomas cutaneos primarios (39%) e metastaticos (40%). Essas mutacoes ocorreram em estagio inicial durante a progressao da neoplasia e nao estiveram envolvidas na transicao de melanomas finos (.1mm) para grossos (>1mm). Essas mutacoes estavam presentes em pacientes mais jovens e se correlacionaram com o padrao de exposicao solar dos pacientes estudados, mas nao houve correlacao com nenhum fator prognostico histologico ou sobrevida global dos mesmos. A identificacao de ambas as mutacoes BRAF e c- kit nao servem como indicadores de prognostico na populacao brasileira. Alem disso, a baixa frequencia de mutacoes BRAF encontrada neste estudo nos faz questionar se esta mutacao realmente tem um papel chave na patogenese do melanoma

    Sebaceous carcinoma in a mature teratoma of the ovary

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    The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings

    Sebaceous carcinoma in a mature teratoma of the ovary

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    The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings

    Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

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    Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

    Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

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    This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

    Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

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    One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

    Search for stop and higgsino production using diphoton Higgs boson decays

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    Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass
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