In vivo measurements of muscle specific tension in adults and children

This article is available open access through the publisher’s website at the link below. Copyright @ 2009 The Authors.To better understand the effects of pubertal maturation on the contractile properties of skeletal muscle in vivo, the present study investigated whether there are any differences in the specific tension of the quadriceps muscle in 20 adults and 20 prepubertal children of both sexes. Specific tension was calculated as the ratio between the quadriceps tendon force and the sum of the physiological cross-sectional area (PCSA) multiplied by the cosine of the angle of pennation of each head within the quadriceps muscle. The maximal quadriceps tendon force was calculated from the knee extension maximal voluntary contraction (MVC) by accounting for EMG-based estimates of antagonist co-activation, incomplete quadriceps activation using the interpolation twitch technique and magnetic resonance imaging (MRI)-based measurements of the patellar tendon moment arm. The PCSA was calculated as the muscle volume, measured from MRI scans, divided by optimal fascicle length, measured from ultrasound images during MVC at the estimated angle of peak quadriceps muscle force. It was found that the quadriceps tendon force and PCSA of men (11.4 kN, 214 cm2) were significantly greater than those of the women (8.7 kN, 152 cm2; P 0.05) between groups: men, 55 ± 11 N cm−2; women, 57.3 ± 13 N cm−2; boys, 54 ± 14 N cm−2; and girls, 59.8 ± 15 N cm−2. These findings indicate that the increased muscle strength with maturation is not due to an increase in the specific tension of muscle; instead, it can be attributed to increases in muscle size, moment arm length and voluntary activation level

Differentiating maturational influence on training-induced strength and endurance adaptations in prepubescent children

To analyze the effect of biological maturation on training-induced strength and endurance adaptations in the prepubertal growth spurt. One hundred and twenty-five healthy children (58 boys, 67 girls), aged 10-11 years old (10.8 ± 0.4 years), who were self-assessed as belonging to Tanner stages I and II, were randomly divided into two experimental groups, a strength training group (19 boys, 22 girls) and an endurance training group (21 boys, 24 girls) that would train twice a week for 8 weeks, as well as a control group (18 boys, 21 girls; no training program). After 8 weeks of training, there were improvements in all strength and endurance measures (P 0.05). These data suggest that more biologically mature prepubescent children seem to have no advantage in training-induced strength and endurance adaptations compared with their less mature peers. Additionally, gender did not affect the training-induced changes in strength or aerobic fitness. These results are meaningful for the development of optimized well-rounded training programs in prepubertal children.info:eu-repo/semantics/publishedVersio

Star-shaped fluorene-BODIPY oligomers: versatile donor-acceptor systems for luminescent solar concentrators

Energy transfer in star-shaped donor–acceptor molecules reduces self-absorption in luminescent solar concentrators.N. J. L. K. D. is supported by the Cambridge Commonwealth European and International Trust, Cambridge Australian Scholarships and Mr Charles K Allen. R. W. M. acknowledges funding from the Initiative and Networking Fund of the Helmholtz Association. S. T. E. J. is supported by the Royal society. RGDT is supported by the EPSRC. D. C. thanks the Royal Society. PJS thanks the Royal Society for a Wolfson Research Merit Award. This work as supported by the EPSRC [EP/M005143/1, EP/M014797/1, EP/L012200/1]

Social Class

Discussion of class structure in fifth-century Athens, historical constitution of theater audiences, and the changes in the comic representation of class antagonism from Aristophanes to Menander

Reliability, validity, and maturation-related differences of frontal and sagittal plane landing kinematic measures during drop jump and tuck jump screening tests in male youth soccer players

Objectives: To determine the inter-rater and intra-rater reliability of frontal and sagittal plane landing kinematic measures during drop jump (DVJ) and tuck jump (TJA) tasks in male youth soccer players, to assess the concurrent validity between DVJ and TJA tests, and to evaluate the ability of both tasks to detect differences between players’ stage of maturation. Design: Cross-sectional study. Participants: 223 male youth soccer players. Main outcome measures: Frontal plane knee projection angles (FPPA) , and hip (HF), knee (KF) and ankle (AF) flexion angles at initial contact (IC) and peak flexion (PF) (i.e., the deepest landing position) in the sagittal plane were assessed. Results: Good-to-excellent inter- and intra-rater reliability (ICC>0.75; TEMST 10; error0.6) were only identified for the TJA. Pre-PHV group reported higher FPPA, HF-IC, HF-PF, and KF-IC values, as well as lower AF-IC than post-PHV. Pre-PHV also displayed greater HF-IC and KF-IC than circa-PHV group. Conclusions: Although both tests are reliable, the TJA might be viewed as a more informative tool given it shows greater FPPA and can also detect differences by maturity status

Managing Forests for Both Downstream and Downwind Water

Forests and trees are key to solving water availability problems in the face of climate change and to achieving the United Nations Sustainable Development Goals. A recent global assessment of forest and water science posed the question: How do forests matter for water? Here we synthesize science from that assessment, which shows that forests and water are an integrated system. We assert that forests, from the tops of their canopies to the base of the soils in which trees are rooted, must be considered a key component in the complex temporal and spatial dimensions of the hydrologic cycle. While it is clear that forests influence both downstream and downwind water availability, their actual impact depends on where they are located and their processes affected by natural and anthropogenic conditions. A holistic approach is needed to manage the connections between forests, water and people in the face of current governance systems that often ignore these connections. We need policy interventions that will lead to forestation strategies that decrease the dangerous rate of loss in forest cover and that – where appropriate – increase the gain in forest cover. We need collective interventions that will integrate transboundary forest and water management to ensure sustainability of water supplies at local, national and continental scales. The United Nations should continue to show leadership by providing forums in which interventions can be discussed, negotiated and monitored, and national governments must collaborate to sustainably manage forests to ensure secure water supplies and equitable and sustainable outcomes

Postnatal Changes in the Expression Pattern of the Imprinted Signalling Protein XLαs Underlie the Changing Phenotype of Deficient Mice

The alternatively spliced trimeric G-protein subunit XLαs, which is involved in cAMP signalling, is encoded by the Gnasxl transcript of the imprinted Gnas locus. XLαs deficient mice show neonatal feeding problems, leanness, inertia and a high mortality rate. Mutants that survive to weaning age develop into healthy and fertile adults, which remain lean despite elevated food intake. The adult metabolic phenotype can be attributed to increased energy expenditure, which appears to be caused by elevated sympathetic nervous system activity. To better understand the changing phenotype of Gnasxl deficient mice, we compared XLαs expression in neonatal versus adult tissues, analysed its co-localisation with neural markers and characterised changes in the nutrient-sensing mTOR1-S6K pathway in the hypothalamus. Using a newly generated conditional Gnasxl lacZ gene trap line and immunohistochemistry we identified various types of muscle, including smooth muscle cells of blood vessels, as the major peripheral sites of expression in neonates. Expression in all muscle tissues was silenced in adults. While Gnasxl expression in the central nervous system was also developmentally silenced in some midbrain nuclei, it was upregulated in the preoptic area, the medial amygdala, several hypothalamic nuclei (e.g. arcuate, dorsomedial, lateral and paraventricular nuclei) and the nucleus of the solitary tract. Furthermore, expression was detected in the ventral medulla as well as in motoneurons and a subset of sympathetic preganglionic neurons of the spinal cord. In the arcuate nucleus of Gnasxl-deficient mice we found reduced activity of the nutrient sensing mTOR1-S6K signalling pathway, which concurs with their metabolic status. The expression in these brain regions and the hypermetabolic phenotype of adult Gnasxl-deficient mice imply an inhibitory function of XLαs in energy expenditure and sympathetic outflow. By contrast, the neonatal phenotype of mutant mice appears to be due to a transient role of XLαs in muscle tissues

2016 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1003/thumbnail.jp