Atmospheric observations of the water vapour continuum in the near-infrared windows between 2500 and 6600 cm-1

Water vapour continuum absorption is potentially important for both closure of the Earth's energy budget and remote sensing applications. Currently, there are significant uncertainties in its characteristics in the near-infrared atmospheric windows at 2.1 and 1.6 µm. There have been several attempts to measure the continuum in the laboratory; not only are there significant differences amongst these measurements, but there are also difficulties in extrapolating the laboratory data taken at room temperature and above to temperatures more widely relevant to the atmosphere. Validation is therefore required using field observations of the real atmosphere. There are currently no published observations in atmospheric conditions with enough water vapour to detect a continuum signal within these windows or where the self-continuum component is significant. We present observations of the near-infrared water vapour continuum from Camborne, UK, at sea level using a Sun-pointing, radiometrically calibrated Fourier transform spectrometer in the window regions between 2000 and 10 000 cm−1. Analysis of these data is challenging, particularly because of the need to remove aerosol extinction and the large uncertainties associated with such field measurements. Nevertheless, we present data that are consistent with recent laboratory datasets in the 4 and 2.1 µm windows (when extrapolated to atmospheric temperatures). These results indicate that the most recent revision (3.2) of the MT_CKD foreign continuum, versions of which are widely used in atmospheric radiation models, requires strengthening by a factor of ∼5 in the centre of the 2.1 µm window. In the higher-wavenumber window at 1.6 µm, our estimated self- and foreign-continua are significantly stronger than MT_CKD. The possible contribution of the self- and foreign-continua to our derived total continuum optical depth is estimated by using laboratory or MT_CKD values of one, to estimate the other. The obtained self-continuum shows some consistency with temperature-extrapolated laboratory data in the centres of the 4 and 2.1 µm windows. The 1.6 µm region is more sensitive to atmospheric aerosol and continuum retrievals and therefore more uncertain than the more robust results at 2.1 and 4 µm. We highlight the difficulties in observing the atmospheric continuum and make the case for additional measurements in both the laboratory and field and discuss the requirements for any future field campaign

Can measurements of the near-infrared solar spectral irradiance be reconciled? A new ground-based assessment between 4000-10000 cm-1

The near-infrared solar spectral irradiance (SSI) is of vital importance for understanding the Earth’s radiation budget, and in Earth observation applications. Differences between previously published solar spectra (including the commonly-used ATLAS3 spectrum) reach up to 10% at the low-wavenumber end of the 4000-10000 cm-1 (2.5 – 1 μm) spectral region. The implications for the atmospheric sciences are significant, since this spectral region contains 25% of the incoming total solar irradiance. This work details an updated analysis of the CAVIAR SSI, featuring additional analysis techniques and an updated uncertainty budget using a Monte Carlo method. We report good consistency with ATLAS3 in the 7000-10000 cm-1 region where there is confidence in these results due to agreement with other spectra, but ~7% lower in the 4000-7000 cm-1 region, in general agreement with several other analyses

Measuring Spinal Mobility Using an Inertial Measurement Unit System: a Reliability study in Axial Spondyloarthritis

The objectives of this study were to evaluate the reliability of wearable inertial motion unit (IMU) sensors in measuring spinal range of motion under supervised and unsupervised conditions in both laboratory and ambulatory settings. A secondary aim of the study was to evaluate the reliability of composite IMU metrology scores (IMU-ASMI (Amb)). Forty people with axSpA participated in this clinical measurement study. Participant spinal mobility was assessed by conventional metrology (Bath Ankylosing Spondylitis Metrology Index, linear version—BASMILin) and by a wireless IMU sensor-based system which measured lumbar flexion-extension, lateral flexion and rotation. Each sensor-based movement test was converted to a normalized index and used to calculate IMU-ASMI (Amb) scores. Test-retest reliability was evaluated using intra-class correlation coefficients (ICC). There was good to excellent agreement for all spinal range of movements (ICC > 0.85) and IMU-ASMI (Amb) scores (ICC > 0.87) across all conditions. Correlations between IMU-ASMI (Amb) scores and conventional metrology were strong (Pearson correlation ≥ 0.85). An IMU sensor-based system is a reliable way of measuring spinal lumbar mobility in axSpA under supervised and unsupervised conditions. While not a replacement for established clinical measures, composite IMU-ASMI (Amb) scores may be reliably used as a proxy measure of spinal mobility

First Passage and Cooperativity of Queuing Kinetics

We model the kinetics of ligand-receptor systems, where multiple ligands may bind and unbind to the receptor, either randomly or in a specific order. Equilibrium occupation and first occurrence of complete filling of the receptor are determined and compared. At equilibrium, receptors that bind ligands sequentially are more likely to be saturated than those that bind in random order. Surprisingly however, for low cooperativity, the random process first reaches full occupancy faster than the sequential one. This is true {\it except} near a critical binding energy where a 'kinetic trap' arises and the random process dramatically slows down when the number of binding sites $N\geq 8$. These results demonstrate the subtle interplay between cooperativity and sequentiality for a wide class of kinetic phenomena, including chemical binding, nucleation, and assembly line strategies.Comment: 5pp, 5 figure

The Metallicity and Dust Content of HVC 287.5+22.5+240: Evidence for a Magellanic Clouds Origin

We estimate the abundances of S and Fe in the high velocity cloud HVC 287.5+22.5+240, which has a velocity of +240 km/s with respect to the local standard of rest and is in the Galactic direction l~287, b~23. The measurements are based on UV absorption lines of these elements in the Hubble Space Telescope spectrum of NGC 3783, a background Seyfert galaxy, as well as new H I 21-cm interferometric data taken with the Australia Telescope. We find S/H=0.25+/-0.07 and Fe/H=0.033+/-0.006 solar, with S/Fe=7.6+/-2.2 times the solar ratio. The S/H value provides an accurate measure of the chemical enrichment level in the HVC, while the super-solar S/Fe ratio clearly indicates the presence of dust, which depletes the gas-phase abundance of Fe. The metallicity and depletion information obtained here, coupled with the velocity and the position of the HVC in the sky, strongly suggest that the HVC originated from the Magellanic Clouds. It is likely (though not necessary) that the same process(es) that generated the Magellanic Stream is also responsible for HVC 287.5+22.5+240.Comment: AASTEX, 3 postscript figures, AJ, 1998, Jan issu

Using Biographical Texts as Linked Data for Prosopographical Research and Applications

This paper argues that representing texts as semantic Linked Data provides a useful basis for analyzing their contents in Digital Humanities research and for Cultural Heritage application development. The idea is to transform Cultural Heritage texts into a knowledge graph and a Linked Data service that can be used flexibly in different applications via a SPARQL endpoint. The argument is discussed and evaluated in the context of biographical and prosopographical research and a case study where over 13 000 life stories form biographical collections of Biographical Centre of the Finnish Literature Society were transformed into RDF, enriched by data linking, and published in a SPARQL endpoint. Tools for biography and prosopography, data clustering, network analysis, and linguistic analysis were created with promising first results.Peer reviewe

Cost-effectiveness of adrenaline for out-of-hospital cardiac arrest

Abstract: Background: The ‘Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration In Cardiac Arrest’ (PARAMEDIC2) trial showed that adrenaline improves overall survival, but not neurological outcomes. We sought to determine the within-trial and lifetime health and social care costs and benefits associated with adrenaline, including secondary benefits from organ donation. Methods: We estimated the costs, benefits (quality-adjusted life years (QALYs)) and incremental cost-effectiveness ratios (ICERs) associated with adrenaline during the 6-month trial follow-up. Model-based analyses explored how results altered when the time horizon was extended beyond 6 months and the scope extended to include recipients of donated organs. Results: The within-trial (6 months) and lifetime horizon economic evaluations focussed on the trial population produced ICERs of £1,693,003 (€1,946,953) and £81,070 (€93,231) per QALY gained in 2017 prices, respectively, reflecting significantly higher mean costs and only marginally higher mean QALYs in the adrenaline group. The probability that adrenaline is cost-effective was less than 1% across a range of cost-effectiveness thresholds. Combined direct economic effects over the lifetimes of survivors and indirect economic effects in organ recipients produced an ICER of £16,086 (€18,499) per QALY gained for adrenaline with the probability that adrenaline is cost-effective increasing to 90% at a £30,000 (€34,500) per QALY cost-effectiveness threshold. Conclusions: Adrenaline was not cost-effective when only directly related costs and consequences are considered. However, incorporating the indirect economic effects associated with transplanted organs substantially alters cost-effectiveness, suggesting decision-makers should consider the complexity of direct and indirect economic impacts of adrenaline

Differential Modulation of Angiogenesis by Erythropoiesis-Stimulating Agents in a Mouse Model of Ischaemic Retinopathy

BACKGROUND: Erythropoiesis stimulating agents (ESAs) are widely used to treat anaemia but concerns exist about their potential to promote pathological angiogenesis in some clinical scenarios. In the current study we have assessed the angiogenic potential of three ESAs; epoetin delta, darbepoetin alfa and epoetin beta using in vitro and in vivo models. METHODOLOGY/PRINCIPAL FINDINGS: The epoetins induced angiogenesis in human microvascular endothelial cells at high doses, although darbepoetin alfa was pro-angiogenic at low-doses (1-20 IU/ml). ESA-induced angiogenesis was VEGF-mediated. In a mouse model of ischaemia-induced retinopathy, all ESAs induced generation of reticulocytes but only epoetin beta exacerbated pathological (pre-retinal) neovascularisation in comparison to controls (p<0.05). Only epoetin delta induced a significant revascularisation response which enhanced normality of the vasculature (p<0.05). This was associated with mobilisation of haematopoietic stem cells and their localisation to the retinal vasculature. Darbepoetin alfa also increased the number of active microglia in the ischaemic retina relative to other ESAs (p<0.05). Darbepoetin alfa induced retinal TNFalpha and VEGF mRNA expression which were up to 4 fold higher than with epoetin delta (p<0.001). CONCLUSIONS: This study has implications for treatment of patients as there are clear differences in the angiogenic potential of the different ESAs

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points