Forced Swim Reliability for Exercise Testing in Rats by a Tethered Swimming Apparatus

To assess the physical capacity of rats in forced swim tests, the animal should perform a continuous activity (CON) at the surface to avoid apnea. Bobbing movement (BOB), vigorous paddling known as climbing (CLI), and diving activity (DIV) are inadequate swimming patterns known to increase the exercise intensity variability, impairing the test reliability. Thus, the exercise work accomplished and related physiological variables, such as the blood lactate concentration, may be unreproducible in forced swim. This study aimed to verify the exercise work reproducibility in rats with a 30-min test–retest at maximal lactate steady state (MLSS) intensity using a tethered-swimming apparatus that analyzes swimming patterns by the direct measurement of swimming force. Additionally, it was determined the swimming force and duration of CON, BOB, CLI, and DIV at physiologically different exercise-intensities. The swimming force at MLSS (n = 64) was 38 ± 7 gf.Kg-1, while the blood lactate concentration was 4.2 ± 1.6 mmol.L-1. In the test–retest (N = 23), swimming force (36.6 ± 7 gf.Kg-1 vs. 36.4 ± 7 gf.Kg-1) and blood lactate concentration (4.7 ± 1.7 mmol.L-1 vs. 4.2 ± 1.7 mmol.l-1) were similar, but only the swimming force was highly correlated (0.90 and 0.31). Although it was not statistically different, the swimming force for CON tends to be slightly lower than CLI and slightly higher than BOB independently of exercise-intensity. The CON pattern predominates (∼52.8 ± 18%) at intensities below and of MLSS but BOB was the swimming pattern more often observed above MLSS-intensity (52.6 ± 18%). The present study used a tethered swimming apparatus to investigate the reliability of forced swim tests for exercise testing in rats and better understand the swimming patterns when determining the MLSS, but the results can be extended to any study that rely on forced swim for exercise testing and training. The result suggests that, at least at intensities of physiological stability, the exercise work accomplished by rats is reproducible in forced swim, but the blood lactate concentration seems to be affected by other factors, such as the apnea and stress caused by the possibility of drowning, besides the exercise-intensity

Computational and Complex Network Modeling for Analysis of Sprinter Athletes’ Performance in Track Field Tests

The article of record as published may be located at https://doi.org/10.3389/fphys.2018.00843Sports and exercise today are popular for both amateurs and athletes. However, we continue to seek the best ways to analyze best athlete performances and develop specific tools that may help scientists and people in general to analyze athletic achievement. Standard statistics and cause-and-effect research, when applied in isolation, typically do not answer most scientific questions. The human body is a complex holistic system exchanging data during activities, as has been shown in the emerging field of network physiology. However, the literature lacks studies regarding sports performance, running, exercise, and more specifically, sprinter athletes analyzed mathematically through complex network modeling. Here, we propose complex models to jointly analyze distinct tests and variables from track sprinter athletes in an untargeted manner. Through complex propositions, we have incorporated mathematical and computational modeling to analyze anthropometric, biomechanics, and physiological interactions in running exercise conditions. Exercise testing associated with complex network and mathematical outputs make it possible to identify which responses may be critical during running. The physiological basis, aerobic, and biomechanics variables together may play a crucial role in performance. Coaches, trainers, and runners can focus on improving specific outputs that together help toward individuals’ goals. Moreover, our type of analysis can inspire the study and analysis of other complex sport scenarios

Computational and Complex Network Modeling for Analysis of Sprinter Athletes’ Performance in Track Field Tests

Sports and exercise today are popular for both amateurs and athletes. However, we continue to seek the best ways to analyze best athlete performances and develop specific tools that may help scientists and people in general to analyze athletic achievement. Standard statistics and cause-and-effect research, when applied in isolation, typically do not answer most scientific questions. The human body is a complex holistic system exchanging data during activities, as has been shown in the emerging field of network physiology. However, the literature lacks studies regarding sports performance, running, exercise, and more specifically, sprinter athletes analyzed mathematically through complex network modeling. Here, we propose complex models to jointly analyze distinct tests and variables from track sprinter athletes in an untargeted manner. Through complex propositions, we have incorporated mathematical and computational modeling to analyze anthropometric, biomechanics, and physiological interactions in running exercise conditions. Exercise testing associated with complex network and mathematical outputs make it possible to identify which responses may be critical during running. The physiological basis, aerobic, and biomechanics variables together may play a crucial role in performance. Coaches, trainers, and runners can focus on improving specific outputs that together help toward individuals’ goals. Moreover, our type of analysis can inspire the study and analysis of other complex sport scenarios

Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory

The Pierre Auger Collaboration has reported evidence for anisotropy in the distribution of arrival directions of the cosmic rays with energies $E>E_{th}=5.5\times 10^{19}$ eV. These show a correlation with the distribution of nearby extragalactic objects, including an apparent excess around the direction of Centaurus A. If the particles responsible for these excesses at $E>E_{th}$ are heavy nuclei with charge $Z$, the proton component of the sources should lead to excesses in the same regions at energies $E/Z$. We here report the lack of anisotropies in these directions at energies above $E_{th}/Z$ (for illustrative values of $Z=6,\ 13,\ 26$). If the anisotropies above $E_{th}$ are due to nuclei with charge $Z$, and under reasonable assumptions about the acceleration process, these observations imply stringent constraints on the allowed proton fraction at the lower energies

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe