KERAJINAN ANYAMAN SEBAGAI POTENSI EKONOMI LOKAL : PENINGKATAN KUALITAS PRODUK DAN PEMASARAN UNTUK MENINGKATKAN DAYA SAING

Rajapolah menjadi basis pengrajin pandan sejak zaman Belanda, turun temurun, kreativitas para leluhur mengalir sampai sekarang. Khususnya di daerah kami sebagai sentra kerajinan anyaman pandan yaitu Desa Sukaruas, Sukaraja, Rajapolah, Tasikmalaya. Produk buatan tangan asli Rajapolah dikenal luas di pasar dalam negeri. Kerajinan Rajapolah memiliki berbagai macam kerajinan tangan. CV. Disha Crafindo merupakan UMKM kerajinan anyaman pandan yang fokus menjual topi dengan berbagai macam bentuk topi. Selain topi, ada beberapa jenis kerajinan anyaman seperti tas anyaman, kotak tisu, dan kotak payung. Adapun kendala yang dihadapi adalah manajemen produksi, pemasaran, dan tenaga kerja dalam memproduksi dan pemahaman dalam peningkatan kualitas produk dan pemasaran. Pemasaran kerajinan anyaman pandan selama ini masih mengandalkan toko retail dalam memasarkan hasil produksi kerajinan anyaman pandan baik di dalam negeri maupun luar negeri, pangsa pasar CV. Disha Crafindo tidak hanya di Jawa Barat, tetapi sudah masuk ke pasar luar negeri seperti Jepang. Target luaran dalam pengabdian ini tersampaikannya informasi produk dan pemasaran melalui media sosial (facebook, Instagram dan GoogleMyBusiness), E-commerce (Lazada, Tokopedia, Bukalapak, Shopee), Social video marketing (youtube), Social messenger (Whatsapp) dan media cetak online

PENINGKATAN KESADARAN LEGALITAS DALAM INOVASI PEMASARAN UMKM

Usaha Mikro, Kecil, dan Menengah (UMKM) memiliki potensi besar untuk berkontribusi pada pertumbuhan ekonomi dan penciptaan lapangan kerja di berbagai negara. Dalam era digital yang terus berkembang, inovasi pemasaran menjadi kunci untuk meningkatkan visibilitas dan daya saing UMKM. Namun, seringkali aspek legalitas dalam inovasi pemasaran terabaikan, menyebabkan risiko hukum yang dapat membahayakan keberlanjutan bisnis UMKM. Melalui pendekatan pengabdian masyarakat, kita dapat memberikan pelatihan dan sumber daya kepada UMKM untuk membantu mereka memahami dan mematuhi regulasi hukum yang relevan. Kami juga membahas berbagai aspek legalitas dalam inovasi pemasaran, termasuk hak cipta, merek dagang, privasi data, dan perpajakan. Dengan pemahaman yang lebih baik tentang legalitas, UMKM dapat mengembangkan strategi pemasaran yang sesuai dengan hukum, mengurangi risiko, dan menciptakan fondasi yang kuat untuk pertumbuhan bisnis mereka. Dengan berkolaborasi, kita dapat menciptakan lingkungan yang mendukung inovasi pemasaran yang bertanggung jawab secara hukum bagi UMKM. Akhirnya, peningkatan kesadaran legalitas dalam inovasi pemasaran diharapkan dapat memperkuat daya saing UMKM, mendukung pertumbuhan ekonomi lokal, dan memberikan kontribusi yang berkelanjutan bagi masyarakat dan perekonomian

Potent interaction of flavopiridol with MRP1

The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase 1 trials for its anti-proliferative characteristics, interacts with MRP1 in a potent way. Flavopiridol, as well as other (iso)flavonoids stimulate the ATPase activity of MRP1 in a dose-dependent way at low micromolar concentrations. A new specific monoclonal antibody against MRP1 (MIB6) inhibits the (iso)flavonoid-induced ATPase activity of plasma membrane vesicles prepared from the MRP1 overexpressing cell line GLC4/ADR. The accumulation of daunorubicin in GLC4/ADR cells is increased by flavopiridol and by other non-glycosylated (iso)flavonoids that interact with MRP1 ATPase activity. However, flavopiridol is the only tested compound that affects the daunorubicin accumulation when present at concentrations below 1 μM. Glycosylated (iso)flavonoids do not affect MRP1-mediated transport or ATPase activity. Finally, MRP1 overexpressing and transfected cells are resistant to flavopiridol, but not to other (iso)flavonoids tested. These findings may be of relevance for the development of anticancer therapies with flavopiridol. © 1999 Cancer Research Campaig

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an ischemic stroke model of rats that inhibiting HIF-1 and its downstream genes by 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) significantly increases mortality and enlarges infarct volume evaluated by MRI and histological staining. Interestingly, the HIF-1 inhibition remarkably ameliorates ischemia-induced blood-brain barrier (BBB) disruption determined by Evans blue leakage although it does not affect brain edema. The result demonstrates that HIF-1 inhibition has differential effects on ischemic outcomes and BBB permeability. It indicates that HIF-1 may have different functions in different brain cells. Further analyses show that ischemia upregulates HIF-1 and its downstream genes erythropoietin (EPO), vascular endothelial growth factor (VEGF), and glucose transporter (Glut) in neurons and brain endothelial cells and that YC-1 inhibits their expression. We postulate that HIF-1-induced VEGF increases BBB permeability while certain other proteins coded by HIF-1's downstream genes such as epo and glut provide neuroprotection in an ischemic brain. The results indicate that YC-1 lacks the potential as a cerebral ischemic treatment although it confers certain protection to the cerebral vascular system

Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector

This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}$and correspond to an integrated luminosity of$4.6\;{\rm f}{{{\rm b}}^{-1}}$. The measurement is performed by reconstructing the boosted W or Z bosons in single jets. The reconstructed jet mass is used to identify the W and Z bosons, and a jet substructure method based on energy cluster information in the jet centre-of-mass frame is used to suppress the large multi-jet background. The cross-section for events with a hadronically decaying W or Z boson, with transverse momentum${{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}$and pseudorapidity$|\eta |\lt 1.9$, is measured to be${{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques

Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector

The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV

Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV

The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

Mesenchymal stem cell (MSC) differentiation is regulated in part by tissue stiffness, yet MSCs can often encounter stiffness gradients within tissues caused by pathological, e.g., myocardial infarction ∼8.7±1.5 kPa/mm, or normal tissue variation, e.g., myocardium ∼0.6±0.9 kPa/mm; since migration predominantly occurs through physiological rather than pathological gradients, it is not clear whether MSC differentiate or migrate first. MSCs cultured up to 21 days on a hydrogel containing a physiological gradient of 1.0±0.1 kPa/mm undergo directed migration, or durotaxis, up stiffness gradients rather than remain stationary. Temporal assessment of morphology and differentiation markers indicates that MSCs migrate to stiffer matrix and then differentiate into a more contractile myogenic phenotype. In those cells migrating from soft to stiff regions however, phenotype is not completely determined by the stiff hydrogel as some cells retain expression of a neural marker. These data may indicate that stiffness variation, not just stiffness alone, can be an important regulator of MSC behavior