Superhydrophobicity, Microwave Absorbing Property of NiFe 2

Magnetic NiFe2O4 nanoparticles were successfully deposited on the wood surface via a hydrothermal process at 70°C. The surface of the as-prepared magnetic NiFe2O4/wood hybrids (MWHs) was covered by spherical-like NiFe2O4 particles with an average size of 50 nm. MWH exhibited the thermostability, microwave absorbability, and superparamagnetism with saturation magnetization (Ms) of 1.79 emu·g−1. With further modification by 1H,1H,2H,2H-perfluorodecyltrimethoxysilane (FAS-17), MWH expressed superhydrophobic performances with a water contact angle of 158°. Its superparamagnetism stably remained under harsh conditions after chemical solutions corrosion and physical frozen test

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world

Imaging dataset acquired by PCAT

<p>The "concave" and "convex" contain 8*8 time-series signals of ultrasonic bulk wave array inspection by the 8-element PCAT with concave and convex surfaces, respectively. The "resonance" contains frequency spectra of the ultrasonic local resonances excited by a single PCAT element  with scanning lateral distance. The imaging algorithms are easy to reproduce. Other data will be made available on request.</p&gt

Imaging dataset acquired by PCAT

<p>The "concave" and "convex" contain 8*8 time-series signals of ultrasonic bulk wave array inspection by the 8-element PCAT with concave and convex surfaces (Figure 7c and d), respectively. The "resonance" contains frequency spectra of the ultrasonic local resonances excited by a single PCAT element with scanning lateral distance (Figure 11a). The imaging algorithms are easy to reproduce. Other data will be made available on request.</p&gt

Hydrothermal Synthesis of Nanooctahedra MnFe2O4 onto the Wood Surface with Soft Magnetism, Fire Resistance and Electromagnetic Wave Absorption

In this study, nanooctahedra MnFe2O4 were successfully deposited on a wood surface via a low hydrothermal treatment by hydrogen bonding interactions. As-prepared MnFe2O4/wood composite (MW) had superior performance of soft magnetism, fire resistance and electromagnetic wave absorption. Among them, small hysteresis loops and low coercivity (<±5 Oe) were observed in the magnetization-field curve of MW with saturation magnetization of 28.24 emu/g, indicating its excellent soft magnetism. The MW also exhibited a good fire-resistant property due to its initial burning time at 20 s; while only 6 s for the untreated wood (UW) in combustion experiments. Additionally, this composite revealed good electromagnetic wave absorption with a minimum reflection loss of −9.3 dB at 16.48 GHz. Therefore, the MW has great potential in the fields of special decoration and indoor electromagnetic wave absorbers

LPS restores protective immunity in macrophages against Mycobacterium tuberculosis via autophagy

Autophagy has been identified as an important immune regulatory mechanism. Recent studies have linked macrophage autophagy with innate immune responses against Mycobacterium tuberculosis (M. tuberculosis), which can survive within macrophages by blocking fusion of the phagosome with lysosomes. These findings suggest that autophagy is a regulatable cellular mechanism of M. tuberculosis defense in macrophages. Transcriptomic profiles in human blood in TB patients suggest that M. tuberculosis affects autophagy related pathways. In order to better understand the role of macrophage autophagy in enhancing protective immunity against M. tuberculosis, in this study, we investigate the effects of the autophagy activators rapamycin and LPS in macrophage autophagy and immunity against M. tuberculosis. We confirm that rapamycin and LPS induce autophagy in M. tuberculosis infected THP-1-derived macrophages or PMA primed THP-1 macrophages [THP-1(A)]. LPS restores M. tuberculosis-inhibited IL-12 synthesis and secretion in THP-1(A) cells via autophagy. Similarly, autophagy activators increase IL-12 synthesis and secretion in THP-1(A) cells. These studies demonstrate the importance of autophagy in M. tuberculosis elimination in macrophages and may lead to novel therapies for tuberculosis and other bacterial infections.Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Identification, Characterization, Synthesis, and Strategy for Minimization of Potential Impurities Observed in the Synthesis of Solithromycin

Potential causes for the formation of synthetic impurities that are present in solithromycin (<b>1</b>) during laboratory development are studied in the article. These impurities were monitored by HPLC, and their structures are identified on the basis of MS and NMR spectroscopy. In addition to the synthesis and characterization of these seven impurities, strategies for minimizing them to the level accepted by the International Conference on Harmonization (ICH) are also described

PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation

Abstract The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its mechanism remain unclear. Here we revealed that downregulation of the deacetylase Sirtuin 3 (SIRT3) mediated the hyperacetylation and inactivation of pyruvate dehydrogenase E1 component subunit alpha (PDHA1), resulting in lactate overproduction in renal tubular epithelial cells. We then found that the incidence of SAKI and renal replacement therapy (RRT) in septic patients with blood lactate ≥ 4 mmol/L was increased significantly, compared with those in septic patients with blood lactate < 2 mmol/L. Further in vitro and in vivo experiments showed that additional lactate administration could directly promote SAKI. Mechanistically, lactate mediated the lactylation of mitochondrial fission 1 protein (Fis1) lysine 20 (Fis1 K20la). The increase in Fis1 K20la promoted excessive mitochondrial fission and subsequently induced ATP depletion, mitochondrial reactive oxygen species (mtROS) overproduction, and mitochondrial apoptosis. In contrast, PDHA1 activation with sodium dichloroacetate (DCA) or SIRT3 overexpression decreased lactate levels and Fis1 K20la, thereby alleviating SAKI. In conclusion, our results show that PDHA1 hyperacetylation and inactivation enhance lactate overproduction, which mediates Fis1 lactylation and exacerbates SAKI. Reducing lactate levels and Fis1 lactylation attenuate SAKI