25 research outputs found
Differential effects of Radix Paeoniae Rubra (Chishao) on cytokine and chemokine expression inducible by mycobacteria
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Upon initial infection with mycobacteria, macrophages secrete multiple cytokines and chemokines, including interleukin-6 (IL-6), IL-8 and tumor necrosis factor-α (TNF-α), to mediate host immune responses against the pathogen. Mycobacteria also induce the production of IL-10 <it>via </it>PKR activation in primary human monocytes and macrophages. As an anti-inflammatory cytokine, over-expression of IL-10 may contribute to mycobacterial evasion of the host immunity. <it>Radix Paeoniae Rubra </it>(RPR, <it>Chishao</it>), a Chinese medicinal herb with potentials of anti-inflammatory, hepatoprotective and neuroprotective effects, is used to treat tuberculosis. This study investigates the immunoregulatory effects of RPR on primary human blood macrophages (PBMac) during mycobacterial infection.</p> <p>Methods</p> <p>The interaction of Bacillus Calmette-Guerin (BCG) with PBMac was used as an experimental model. A series of procedures involving solvent extraction and fractionation were used to isolate bioactive constituents in RPR. RPR-EA-S1, a fraction with potent immunoregulatory effects was obtained with a bioactivity guided fractionation scheme. PBMac were treated with crude RPR extracts or RPR-EA-S1 before BCG stimulation. The expression levels of IL-6, IL-8, IL-10 and TNF-α were measured by qPCR and ELISA. Western blotting was used to determine the effects of RPR-EA-S1 on signaling kinases and transcriptional factors in the BCG-activated PBMac.</p> <p>Results</p> <p>In BCG-stimulated macrophages, crude RPR extracts and fraction RPR-EA-S1 specifically inhibited IL-10 production while enhanced IL-8 expression at both mRNA and protein levels without affecting the expressions of IL-6 and TNF-α. Inhibition of BCG-induced IL-10 expression by RPR-EA-S1 occurred in a dose- and time-dependent manner. RPR-EA-S1 did not affect the phosphorylation of cellular protein kinases including MAPK, Akt and GSK3β. Instead, it suppressed the degradation of IκBα in the cytoplasm and inhibited the translocation of transcription factor NF-κB1 p50 to the nucleus.</p> <p>Conclusion</p> <p>RPR crude extracts and its fraction RPR-EA-S1 inhibited anti-inflammatory cytokine IL-10 and enhanced pro-inflammatory chemokine IL-8 expression in BCG-activated PBMac. The inhibitory effects of RPR-EA-S1 on IL-10 expression in BCG-activated PBMac may be due to the reduced nuclear translocation of NF-κB1 p50.</p
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
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- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
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- Aqeel Syed Talha Bin
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- Ferguson Neil
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- Figgitt Ethan
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- Giannakopoulos Konstantinos S
- Gidiem Doaa
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- Ibiyemi Femi
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- Ifoto Oghenekaro
- Iftikhar Hareem
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- Innes Michael
- Ioannidis Orestis
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- Ioannidis Orestis
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- Isah AliyuYabagi
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- Ismail Samir
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- Jamil Muhammad Badrul Hisyam Mohamad
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- Kalogiannidis Ioannis
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- Kechiche Nahla
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- Kejriwal Ritwik
- Keng Cambo
- Keramida Myrto D
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- Yildirim Yasemin
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- Yousri Mohamed
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- Youssef Arkan
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- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
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- Satoru Miyano
- Satoshi Hirano
- Savitri Krishnamurthy
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- Sebastian M Waszak
- Seiya Imoto
- Seong Gu Heo
- Serap Erkek
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- Stephan Ossowski
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- Suet-Feung Chin
- Sultan T Al-Sedairy
- Sung-Min Ahn
- Sung-Soo Yoon
- Sunghoon Cho
- Sunil R Lakhani
- Suresh Ramalingam
- Susan Bullman
- Susanna L Cooke
- Sushant Kumar
- Sushant Kumar
- Suyash S Shringarpure
- Syed Haider
- Sylvia Asa
- Søren Brunak
- Takafumi N Yamaguchi
- Takafumi N Yamaguchi
- Takanori Hasegawa
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- Taobo Hu
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- Tomoko Urushidate
- Torill Sauer
- Toru Nakamura
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- Venkata D Yellapantula
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- Wei Jiao
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- Wenyi Wang
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- Wheeler David A
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- Winghing Wong
- Wojciech Bazant
- Wolfgang Huber
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- Xavier Estivill
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- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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- Author
- Aaltonen Lauri A.
- Abascal Federico
- Abeshouse Adam
- Aburatani Hiroyuki
- Adams David J.
- Agrawal Nishant
- Ahn Keun Soo
- Ahn Sung-Min
- Aikata Hiroshi
- Akbani Rehan
- Akdemir Kadir C.
- Al-Ahmadie Hikmat
- Al-Sedairy Sultan T.
- Al-Shahrour Fatima
- Alawi Malik
- Albert Monique
- Aldape Kenneth
- Alexandrov Ludmil B.
- Ally Adrian
- Alsop Kathryn
- Alvarez Eva G.
- Amary Fernanda
- Amin Samirkumar B.
- Aminou Brice
- Ammerpohl Ole
- Anderson Matthew J.
- Ang Yeng
- Antonello Davide
- Anur Pavana
- Aparicio Samuel
- Appelbaum Elizabeth L.
- Arai Yasuhito
- Aretz Axel
- Arihiro Koji
- Ariizumi Shun-ichi
- Armenia Joshua
- Arnau Gisela Mir
- Arnould Laurent
- Asa Sylvia
- Assenov Yassen
- Atwal Gurnit
- Aukema Sietse
- Auman J. Todd
- Aure Miriam R.
- Awadalla Philip
- Aymerich Marta
- Bader Gary D.
- Baez-Ortega Adrian
- Bailey Matthew H.
- Bailey Peter J.
- Balasundaram Miruna
- Balu Saianand
- Bandopadhayay Pratiti
- Banks Rosamonde E.
- Barbi Stefano
- Barbour Andrew P.
- Barenboim Jonathan
- Barnholtz-Sloan Jill
- Barr Hugh
- Barrera Elisabet
- Bartlett John
- Bartolome Javier
- Bassi Claudio
- Bathe Oliver F.
- Baumhoer Daniel
- Bavi Prashant
- Baylin Stephen B.
- Bazant Wojciech
- Beardsmore Duncan
- Beck Timothy A.
- Behjati Sam
- Behren Andreas
- Bell Cindy
- Beltran Sergi
- Benz Christopher
- Berchuck Andrew
- Bergmann Anke K.
- Bergstrom Erik N.
- Berman Benjamin P.
- Berney Daniel M.
- Bernhart Stephan H.
- Beroukhim Rameen
- Berrios Mario
- Bersani Samantha
- Bertl Johanna
- Betancourt Miguel
- Bhandari Vinayak
- Bhosle Shriram G.
- Biankin Andrew V.
- Bieg Matthias
- Bigner Darell
- Binder Hans
- Birney Ewan
- Birrer Michael
- Biswas Nidhan K.
- Bjerkehagen Bodil
- Bodenheimer Tom
- Boice Lori
- Bonizzato Giada
- Boot Arnoud
- Bootwalla Moiz S.
- Borg Ake
- Borkhardt Arndt
- Boroevich Keith A.
- Borozan Ivan
- Borst Christoph
- Bosenberg Marcus
- Bosio Mattia
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- Hoyle Alan P.
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- Imielinski Marcin
- Imoto Seiya
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- Xi Liu
- Xia Tian
- Xiang Qian
- Xiao Xiao
- Xing Rui
- Xiong Heng
- Xu Qinying
- Xu Yanxun
- Xue Hong
- Yachida Shinichi
- Yakneen Sergei
- Yamaguchi Rui
- Yamaguchi Takafumi N.
- Yamamoto Masakazu
- Yamamoto Shogo
- Yamaue Hiroki
- Yang Fan
- Yang Huanming
- Yang Jean Y.
- Yang Liming
- Yang Lixing
- Yang Shanlin
- Yang Tsun-Po
- Yang Yang
- Yao Xiaotong
- Yaspo Marie-Laure
- Yates Lucy
- Yau Christina
- Ye Chen
- Ye Kai
- Yellapantula Venkata D.
- Yoon Christopher J.
- Yoon Sung-Soo
- Yousif Fouad
- Yu Jun
- Yu Kaixian
- Yu Willie
- Yu Yingyan
- Yuan Ke
- Yuan Yuan
- Yuen Denis
- Yugawa Takashi
- Yung Christina K.
- Zaikova Olga
- Zamora Jorge
- Zapatka Marc
- Zenklusen Jean C.
- Zenz Thorsten
- Zeps Nikolajs
- Zhang Cheng-Zhong
- Zhang Fan
- Zhang Hailei
- Zhang Hongwei
- Zhang Hongxin
- Zhang Jiashan
- Zhang Jing
- Zhang Junjun
- Zhang Xiuqing
- Zhang Xuanping
- Zhang Yan
- Zhang Zemin
- Zhao Zhongming
- Zheng Liangtao
- Zheng Xiuqing
- Zhou Wanding
- Zhou Yong
- Zhu Bin
- Zhu Hongtu
- Zhu Jingchun
- Zhu Shida
- Zou Lihua
- Zou Xueqing
- Publication venue
- Nature Communications
- Publication date
- 28/08/2020
- Field of study
Funder: Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology); doi: https://doi.org/10.13039/501100002790Funder: Genome Canada (Génome Canada); doi: https://doi.org/10.13039/100008762Funder: Canada Foundation for Innovation (Fondation canadienne pour l'innovation); doi: https://doi.org/10.13039/501100000196Funder: Terry Fox Research Institute (Institut de Recherche Terry Fox); doi: https://doi.org/10.13039/501100004376Abstract: Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- Aaltonen Lauri A.
- Abascal Federico
- Abeshouse Adam
- Aburatani Hiroyuki
- Adams David J.
- Agrawal Nishant
- Ahn Keun Soo
- Ahn Sung-Min
- Aikata Hiroshi
- Akbani Rehan
- Akdemir Kadir C.
- Al-Ahmadie Hikmat
- Al-Sedairy Sultan T.
- Al-Shahrour Fatima
- Alawi Malik
- Albert Monique
- Aldape Kenneth
- Alexandrov Ludmil B.
- Ally Adrian
- Alsop Kathryn
- Alvarez Eva G.
- Amary Fernanda
- Amin Samirkumar B.
- Aminou Brice
- Ammerpohl Ole
- Anderson Matthew J.
- Ang Yeng
- Antonello Davide
- Anur Pavana
- Aparicio Samuel
- Appelbaum Elizabeth L.
- Arai Yasuhito
- Aretz Axel
- Arihiro Koji
- Ariizumi Shun-ichi
- Armenia Joshua
- Arnau Gisela Mir
- Arnould Laurent
- Asa Sylvia
- Assenov Yassen
- Atwal Gurnit
- Aukema Sietse
- Auman J. Todd
- Aure Miriam R.
- Awadalla Philip
- Aymerich Marta
- Bader Gary D.
- Baez-Ortega Adrian
- Bailey Matthew H.
- Bailey Peter J.
- Balasundaram Miruna
- Balu Saianand
- Bandopadhayay Pratiti
- Banks Rosamonde E.
- Barbi Stefano
- Barbour Andrew P.
- Barenboim Jonathan
- Barnholtz-Sloan Jill
- Barr Hugh
- Barrera Elisabet
- Bartlett John
- Bartolome Javier
- Bassi Claudio
- Bathe Oliver F.
- Baumhoer Daniel
- Bavi Prashant
- Baylin Stephen B.
- Bazant Wojciech
- Beardsmore Duncan
- Beck Timothy A.
- Behjati Sam
- Behren Andreas
- Bell Cindy
- Beltran Sergi
- Benz Christopher
- Berchuck Andrew
- Bergmann Anke K.
- Bergstrom Erik N.
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- Berney Daniel M.
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- Yachida Shinichi
- Yakneen Sergei
- Yamaguchi Rui
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- Yamamoto Masakazu
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- Yang Yang
- Yao Xiaotong
- Yaspo Marie-Laure
- Yates Lucy
- Yau Christina
- Ye Chen
- Ye Kai
- Yellapantula Venkata D.
- Yoon Christopher J.
- Yoon Sung-Soo
- Yousif Fouad
- Yu Jun
- Yu Kaixian
- Yu Willie
- Yu Yingyan
- Yuan Ke
- Yuan Yuan
- Yuen Denis
- Yugawa Takashi
- Yung Christina K.
- Zaikova Olga
- Zamora Jorge
- Zapatka Marc
- Zenklusen Jean C.
- Zenz Thorsten
- Zeps Nikolajs
- Zhang Cheng-Zhong
- Zhang Fan
- Zhang Hailei
- Zhang Hongwei
- Zhang Hongxin
- Zhang Jiashan
- Zhang Jing
- Zhang Junjun
- Zhang Xiuqing
- Zhang Xuanping
- Zhang Yan
- Zhang Zemin
- Zhao Zhongming
- Zheng Liangtao
- Zheng Xiuqing
- Zhou Wanding
- Zhou Yong
- Zhu Hongtu
- Zhu Jingchun
- Zhu Shida
- Zou Lihua
- Zou Xueqing
- Publication venue
- Nature Communications
- Publication date
- 21/09/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Sex differences in oncogenic mutational processes
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam Margolin
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
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- Serap Erkek
- Serena Nik-Zainal
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- Seung Jun Shin
- Seung-Hyup Jeon
- Shadrielle M G Espiritu
- Shailja Gupta
- Shankar Vembu
- Shanlin Yang
- Shantao Li
- Shaoke Lou
- Shaolong Cao
- Shaowu Meng
- Sharmila Sothi
- Shaun R Preston
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- Sheng-Ben Liang
- Shengjie Gao
- Shida Zhu
- Shimin Shuai
- Shinichi Mizuno
- Shinichi Yachida
- Shinya Hayami
- Shogo Yamamoto
- Shona MacRae
- Shriram G Bhosle
- Shuai Ding
- Shumpei Ishikawa
- Shun-Ichi Ariizumi
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- Sian Fereday
- Siegfried Haas
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- Siliang Li
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- Sissel Juul
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- Sonia Grimaldi
- Sonia Puig
- Stacey B Gabriel
- Stefan C Dentro
- Stefan G Stark
- Stefan M Pfister
- Stefan Schreiber
- Stefania Tommasi
- Stefano Barbi
- Stefano Serra
- Stephan H Bernhart
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- Stephan Wolf
- Stephanie Sungalee
- Stephen B Baylin
- Stephen H Kazakoff
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- Steven Gallinger
- Steven Hazell
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- Stian Knappskog
- Stuart Edmonds
- Stuart R Jefferys
- Su Pin Choo
- Subhajit Sengupta
- Sue Merson
- Suet-Feung Chin
- Sultan T Al-Sedairy
- Sun Ren X
- Sung-Min Ahn
- Sung-Soo Yoon
- Sunghoon Cho
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- Susan Bullman
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- Tal Shmaya
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- Tapio Visakorpi
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- Vincent Khoo
- Vincenzo Corbo
- Vishal S Chandan
- Volker Hovestadt
- W Kimryn Rathmell
- W M Linehan
- Wan Choi
- Wanding Zhou
- Wei Jiao
- Wei Jiao
- Wenyi Wang
- William B Isaacs
- William C Faquin
- William C Faquin
- William Friedman
- William Howat
- William Meyerson
- Willie Yu
- Winghing Wong
- Wojciech Bazant
- Wolfgang Huber
- Wolfram Klapper
- Xavier Estivill
- Xavier Pivot
- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Yousif Fouad
- Youyong Lu
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.Peer reviewe
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
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- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
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- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
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- Borislav C Rusev
- Bradly G Wouters
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- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
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- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos López-Otín
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
- Charles David Imbusch
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- Charles Saller
- Charles Short
- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
- Chen Ye
- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
- Chip Stewart
- Choon Kiat Ong
- Chris Lawerenz
- Chris Mitchell
- Chris Sander
- Christian von Mering
- Christiane Buchholz
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- Christina K Yung
- Christina Yau
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- Christine Chomienne
- Christine Desmedt
- Christine P'ng
- Christof von Kalle
- Christoph Borst
- Christoph Plass
- Christopher A Miller
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- Christopher J Scarlett
- Christopher J Yoon
- Christopher K Wong
- Christopher M Lalansingh
- Christopher M Lalansingh
- Christopher Ogden
- Christopher S Foster
- Christopher Umbricht
- Christopher W Toon
- Christos Sotiriou
- Cindy Bell
- Cinzia Cantù
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- Clarissa Gerhauser
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- Claudiu Farcas
- Clemency Jolly
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- Cyril Fisher
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- Darell Bigner
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- Dirk Schadendorf
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- Edward W Rowe
- Eigo Shimizu
- Ekta Khurana
- Elaine R Mardis
- Electron Kebebew
- Elena Piñeiro-Yáñez
- Elena Provenzano
- Elias Campo
- Elisabet Barrera
- Elisabetta Sereni
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- Elli Papaemmanuil
- Ellrott Kyle
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- Esther Rheinbay
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- Eunjung Alice Lee
- Eva G Alvarez
- Eva Hellstrom-Lindberg
- Ewan Birney
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- Fabien C Lamaze
- Fabien Calvo
- Fabio C P Navarro
- Faiyaz Notta
- Fan Yang
- Fan Zhang
- Faraz Hach
- Faraz Hach
- Faridah Mbabaali
- Fatima Al-Shahrour
- Federico Abascal
- Fei-Fei Liu
- Felicity Newell
- Fenglin Liu
- Fernanda Amary
- Ferran Muiños
- Florian Markowetz
- Fouad Yousif
- Francesc Muyas
- Francesco Favero
- Francisco M De La Vega
- Francisco Sanchez-Vega
- Fraser R Duthie
- Fred Sweep
- Freddie C Hamdy
- Fruzsina Molnár-Gábor
- Fumie Hosoda
- G Petur Nielsen
- G Steven Bova
- Gad Getz
- Gad Getz
- Gad Getz
- Gaetan MacGrogan
- Gaetano Finocchiaro
- Gary D Bader
- Gavin Ha
- Gavin W Wilson
- Genta Nagae
- Geoff Macintyre
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- Georgia Escaramis
- Georgina V Long
- Gerd Nettekoven
- German M Demidov
- German Ott
- Gerrit K Hooijer
- Gerstein Mark B
- Gert G Van den Eynden
- Getz Gad
- Ghislaine Scelo
- Giada Bonizzato
- Giampaolo Tortora
- Gilles Romieu
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- Giuseppe Malleo
- Gloria M Petersen
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- Gordon B Mills
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- Grace Tiao
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- Grant Sanders
- Gu Kong
- Guanming Wu
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- Gun Ho Jang
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- Gurnit Atwal
- Hailei Zhang
- Haiyan Irene Li
- Han Liang
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- Hans-Jörg Warnatz
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- Henrik Hornshøj
- Henry Lee-Six
- Hideki Ohdan
- Hidenori Ojima
- Hidewaki Nakagawa
- Hikmat Al-Ahmadie
- Hilda A Pickett
- Hirofumi Rokutan
- Hirokazu Taniguchi
- Hiroki Yamaue
- Hiroko Tanaka
- Hiromi Nakamura
- Hiroshi Aikata
- Hiroto Katoh
- Hiroyuki Aburatani
- Hitoshi Katai
- Hitoshi Nakagama
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- Holmfridur Hilmarsdottir
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- Hong Xue
- Hong Xue
- Hongtu Zhu
- Hongwei Zhang
- Hongxin Zhang
- Hsiao-Wei Chen
- Huanming Yang
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- Hui Shen
- Husen M Umer
- Huy Q Dinh
- Hyung-Lae Kim
- Hyung-Lae Kim
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- Ian Welch
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- Ignaty Leshchiner
- Ignaty Leshchiner
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- Ivo Buchhalter
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- Ivo G Gut
- Ivon Harliwong
- Izar Villasante
- Iñigo Martincorena
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- J Robert O'Neill
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- Jakob Skou Pedersen
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- Jared T Simpson
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- Josep L L Gelpi
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- Joshua M Stuart
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- Kai Ye
- Kai Ye
- Kaixian Yu
- Kami Chiotti
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- Keiran M Raine
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- Ken Chen
- Ken Chen
- Ken Dutton-Regester
- Kenji Tatsuno
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- Kortine Kleinheinz
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- Kui Wu
- Kunihito Gotoh
- Kwun M Fong
- Kyle Covington
- Kyle Covington
- Kyle Ellrott
- Kyle Ellrott
- Kyle Ellrott
- L Van't Veer
- Lara Jerman
- Lara Urban
- Lars Feuerbach
- Larsson Omberg
- Laura Planko
- Laurence B Lovat
- Laurent Arnould
- Lauri A Aaltonen
- Lawrence E Heisler
- Layla Oesper
- Lee E Timms
- Lei Song
- Leigh B Thorne
- Leng Han
- Leonidas Salichos
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- Leszek J Klimczak
- Levi Garraway
- Lewis Jonathan Dursi
- Lewis Jonathan Dursi
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- Li Ding
- Li Ding
- Li Ding
- Li Shantao
- Liang Wen-Wei
- Liangtao Zheng
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- Stephanie Sungalee
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- Takafumi N Yamaguchi
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- Thomas J Hudson
- Thomas J Matthew
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- Vincenzo Corbo
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- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
- Weerasinghe Amila
- Wei Jiao
- Wendl Michael C
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- William C Faquin
- William Friedman
- William Howat
- William U Meyerson
- Willie Yu
- Winghing Wong
- Wojciech Bazant
- Wolfgang Huber
- Wolfram Klapper
- Xavier Estivill
- Xavier Pivot
- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts.The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that -80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAFPeer reviewe
Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)
- Author
- Aisa Jensen Lee
- Aisa Jensen Lee
- Aisa Jensen Lee
- Aizzuddin Mirasin
- Akihiro Hayashi
- Akihiro Sato
- Akihiro Sato
- Aliyah Ahmad
- Aliyah Ahmad
- Allan Alde
- Allan Alde
- Allan Alde
- Alyona Lavrineko
- Alyona Lavrinenko
- Alyona Lavrinenko
- Alyona Lavrinenko
- Amalina AbuBakar
- Amalina Sidek
- Amalina Sidek
- Amanie Shafiee
- An-Chi Chen
- Ana Hutchinson
- Anar Turmuhambetova
- Anar Turmuhambetova
- Anar Turmuhambetova
- Anar Turmuhambetova
- Andrea Driscoll
- Angela Chow
- Angela Chow
- Angela Chow
- Angela Chow
- Angela Chow
- Angela Chow
- Angela Chow
- Angelo Macatibag
- Anh Pham Phuong Dinh
- Anna Josea Sanchez
- Annie F. Y. Leung
- Anry Nakphunsung
- Antonella Cheşcă
- Antonella Cheşcă
- Antonella Cheşcă
- Antonella Cheşcă
- Anucha Apisarnthanarak
- Anucha Apisarnthanarak
- Anusha Rohit
- Arlene Joy Esteban
- Arlene Joy Esteban
- Arlene Joy Esteban
- Asma Aziz
- Asma Aziz
- Asylkhan Alibecov
- Atsushi Komano
- Atsushi Umetsu
- Attanayaka Mudiyanselage Chulani Niroshika
- Aung Kyaw Wynn
- Aung-Aung Hein
- Aung-Aung Hein
- Aung-Aung Hein
- Avel Bathan
- Ayaka Tsukimori
- Azizah Samsuddin
- Bee Fong Poh
- Bee-Fong Poh
- Benjamin Ng
- Benny Setiawan
- Bente Borgen
- Bodhipakshage Rohini Hemamala
- Boon Chu
- Boon Chu
- Brenda Ang
- Brenda Ang
- Brenda Ang
- Brenda Ang
- Brenda Ang
- Brenda Ang
- Brenda Ang
- Brenda Ang
- Buachan Thongchuea
- C. H. Kan
- C. K. C. Lai
- C. P. Chen
- Cecilia Chan
- Chadanan Prasertpan
- Chadanan Prasertpan
- Chalermpong Saenjum
- Chalermpong Saenjum
- Chalermpong Saenjum
- Chang Yong-Yuan
- Chang-Pan Liu
- Chang-pan Liu
- Chang-pan Liu
- Chang-pan Liu
- Charles John Palenik
- Charles John Palenik
- Chen Jyh-Jou
- Cheng-Wei Chu
- Cheng-Wei Chu
- Cheng-Yu Lu
- Chi-Fen Taou
- Chia-Chun Chi
- Chia-Hua Mao
- Chia-Yun Pan
- Chiao-Hui Lin
- Chien-Feng Li
- Chih-Chien Wang
- Chikako Matuoka
- Chin-cheng Lin
- Chin-Te Lu
- Chin-Yu Chen
- Chin-Yu Chen
- Ching-I Ting
- Chittima Srithong
- Chiu-Yin Yeh
- Chiu-yin Yeh
- Chiu-Yuch Yea
- Chiung-Ling Lai
- Chiung-Wen Chan
- Cho-Ching Sun
- Cho-Ching Sun
- Choi-Ian Vong
- Chollathip Bunyaphongphan
- Chonlada Piwpong
- Chonnikarnt Beowsomboon
- Christina W. Y. Cheung
- Christopher Gordon
- Christopher Koon Chi Lai
- Chua Chor Guek
- ChungHsu Lai
- Cindy F. Y. Leung
- Collette Duley
- Conita H. S. Lam
- Cucunawangsih Cucunawangsih
- Cucunawangsih Cucunawangsih
- D. N. C. Tsang
- Dahae Yang
- Darintr Sosothikul
- David Macinga
- Dg Azizah Samsuddin
- Dimingo Kankanamalage Diana Grace Fernando
- Dinh Pham Phuong Anh
- Dmitriy Babenko
- Dmitriy Babenko
- Dmitriy Babenko
- Dmitriy Babenko
- Dmitry Babenko
- Dongmei Li
- Dorairajan Sureshkumar
- Dorairajan Sureshkumar
- Dorairajan Sureshkumar
- Dorota Borys
- Dorota Borys
- Dung Khu
- Dung Khu
- Egil Lingaas
- Elizabeth De Nardo
- Elizabeth DeNardo
- Eng Hwa Wong
- Eu Chiow Kian
- Eu Suk Kim
- Eugene Sheck
- Eui-Chong Kim
- Faezah Binte Adam
- Farzana Zaman
- Farzana Zaman
- Florian H. H. Brill
- Francis Alvarez Palana
- Fu Der Wang
- Fu-Chieh Chang
- Fu-chieh Chang
- Fu-chieh Chang
- Fu-chieh Chang
- Fumiyo Hieda
- Fung Yuk Ling
- G. K. Siu
- Geetha Samethadka
- Gloria Chor Shan Chiu
- Grace Tin
- Grace Tin
- Grace Tin
- Grace Tin
- Guo Siao-Pei
- Hang Thi Phan
- Hans Liu
- Harding Williams
- Haruo Nakayama
- Heinz-Peter Werner
- Hidehiro Watanabe
- Hiroaki Fujita
- Hiroki Shirakawa
- Hiroshi Watanabe
- Hiroyuki Kitajima
- Hiroyuki Moriuchi
- Hisanori Nishio
- Hitomi Asada
- Hitomi Mori
- Holly H. S. Cheng
- Hong Bin Kim
- Hsiang-Ju Chiu
- Hsiang-Ju Chiu
- Hsiao-Shan Chen
- Hsin-Hua Lin
- Hsin-Ling Yang
- Hsuehlan Chao
- Huan-Yu Huang
- Huey-Jen Huang
- Huey-Jen Huang
- Huey-Jen Huang
- Hui Wang
- Hui-Chen Kuan
- Hui-Chuan Pan
- Hui-Chun Yang
- Hui-Chun Yang
- Hui-Zhu Chen
- Hung-Jen Tang
- Huwi-chun Chao
- Huwi-chun Chao
- Huwi-chun Chao
- Hye Kyung Seo
- Hyukmin Lee
- I-Ju Chuang
- Il Kwon Bae
- Ilya Azizov
- Ilya Azizov
- Ilya Azizov
- Ilya Azizov
- Ilya Azizov
- Isadora L. C. Wong
- Itaru Nakamura
- Itaru Nakamura
- Itthaporn Kumkoom
- Jackson Tan
- Jae Hyeon Park
- Jae Hyun Lee
- Jamilah Binte Jantan
- Jauharatud DiniSuhaimi
- Javier Ruiz-Guiñazú
- Javier Ruiz-Guiñazú
- Jeannica Kriselle Lerios
- Jeong Su Park
- Ji-Sheng Zhang
- Jia Hao Chang
- Jia Qi Kum
- Jia-Wei Lim
- Jia-Wei Lim
- Jia-Wei Lim
- Jian-Feng Li
- Jian-Feng Li
- Jiqiu Kuang
- Jirachaya Sophonphan
- Jittaporn Chitreecheur
- JoAnne D. Whitney
- Jocelyn Koh
- Joo-Hee Hwang
- Jose Acuin
- Jose Lito Acuin
- Jose Paulo Flor
- Jose Paulo Flor
- Jose Paulo Flor
- Jose Paulo Flor
- Jose Paulo Flor
- Joseph Kam
- Jothymani Hemalatha
- Julaini Safar
- Julia Yaeko Kawagoe
- Julie Considine
- Jumpei Hasegawa
- Jung Ok Kim
- Junpen Pawapotako
- Justine Vergara
- Justine Vergara
- Justine Vergara
- Justine Vergara
- Justine Vergara
- Jyh-Jou Chen
- K. W. Mui
- Kalisvar Marimuthu
- Kalisvar Marimuthu
- Kaluarachchige Anoma Kaluarachchi Perera
- Kalyanaraman Supraja
- Karen Kam LingChong
- Kavitha Prabu
- Kavitha Prabu
- Kayoko Kjiwara
- Kazuhiro Toyoda
- Kazunori Tomono
- Kee Peng Ng
- Keithleen Chavez
- Keitleen Chavez
- Keitleen Chavez
- Kentaro Kodama
- Kenyuu Hashimoto
- Kersten Timbad Castro
- Khalequ Zaman
- Khalequ Zaman
- Kirati Kengkla
- Knut Elvelund
- Kulada Peautiwat
- Kumiko Yamamoto
- Kumthorn Malathum
- Kumthorn Malathum
- Kumthorn Malathum
- Kumthorn Malathum
- Kumthorn Malathum
- Kumthorn Malathum
- Kumthorn Malathum
- Kunyanut Payuk
- Kyoung Un Park
- Kyoung-Ho Song
- Kyungwon Lee
- L. K. P. Suen
- Lady S. H. Ng
- Lai-Si Un
- Lam Nguyen
- Lau Edna
- Laurent Poirel
- Leah May Estacio
- Lenina S. L. Poon
- Leon Worth
- Leslie Than
- Leung Annie
- Leung Pak-On
- Leyland Chuang
- Li Xiao-long
- Li-Chu Lee
- Li-Chu Li
- Li-Chu Li
- Li-Hung Wu
- Lih-Yue Li
- Lin Li
- Lin Yu-Hsiu
- Lin Yu-Hsiu
- Lindy M. T. Wong
- Lisa Cushinotto
- Liu Jien-Wei
- Luciana Barbosa
- Lucy Choy
- Luk Kristine
- Lung-Chih Chen
- Lutfe Ara
- Lyudmila L. Akhmaltdinova
- M. M. O’Donoghue
- M. V. Boost
- Mabel Yin ChunYau
- Madonna Baloria
- Magali Traskine
- Magali Traskine
- Makiko Kiyosuke
- Makiko Mieno
- Man Ying Kong
- Man-Ling Yu
- Man-Ling Yu
- Manu Deeudom
- Mar-Kyaw Win
- Margaret M. Heitkemper
- Margulan Kozhamuratov
- Mari Botti
- Maria Fe Tayzon
- Maria Fe Tayzon
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- Mariko Tateishi
- Mariko Tateishi
- Marimuthu Kalisvar
- Marion Kwek
- Marion Kwek
- Marion Kwek
- Marion Kwek
- Marion Kwek
- Marionne Geronimo
- Marit Johnsen
- Mark A. Toleman
- Mark A. Toleman
- Mark A. Toleman
- Mark Albert Magsakay
- Marko Bautista
- Marko Bautista
- Marko Bautista
- Marko Bautista
- Marko Bautista
- Marta Aires de Sousa
- Mary K. L. Lai
- Maryanne W. N. Kwok
- Masanobu Ohtsuka
- Masao Katayama
- May Chow
- Mehrdad Askarian
- Mehrdad Askarian
- Mei-chi Wu
- Mei-Fe Sie
- Mei-feng Lo
- Mei-ling Chou
- Melecia A. Velmonte
- Melecia Velmonte
- Melecia Velmonte
- Michelle Gracia
- Miho Miura
- Mikhail Edelstein
- Mikie Kabashima
- Min-Chi Lu
- Min-Chi Lu
- Ming-Chin Chan
- Ming-Hsien Chu
- Mitsuhiro Yamaguchi
- Mohd Nasir Mohd Desa
- Mukkapon Punpop
- Mutsuko Mihashi
- Mutsuko Mihashi
- Myoung Jin Shin
- Nahid Hatam
- Nantanit Sutthiruk
- Naoki Tachibana
- Naoko Shirane
- Naoko Suzuki
- Napatnun Nilchon
- Nattapol Pruetpongpun
- Nattawipa boon kirdram
- Ng Po Yan
- Ng Po Yan
- Ng Po Yan
- Ngai Chong Tsang
- Ngai Le
- Ngai Le
- Nicolas Kieffer
- Nicolaski Lumbuun
- Nicolo Andrei Añonuevo
- Nicolo Andrei Añonuevo
- Nicolo Andrei Añonuevo
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- Nitchawan Hirunprapakorn
- Nobuyuki Shimono
- Nongkran Viseskul
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- Nongyao Kasatpibal
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- Noraini Ajis
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- Nuttha Thongnuanual
- Onaiwu Enabulele
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- Pak-On Leung
- Pakpoom Maneepongpermpoon
- Pampe Anak Pirido
- Pansachee Damronglerd
- Patchanee Paepong
- Patcharee Prasajak
- Patchareeyawan Srimuan
- Patrice Nordmann
- Patricia Mays-Suko
- Patricia T. Y. Ching
- Pattama Khamfu
- Pattarin Jaisamoot
- Patty McBride
- Pauline Bass
- Pawin Wanasitchaiwat
- Pei-Chen Cheng
- Pei-Chen Cheng
- Pei-Chen Cheng
- Pei-Yun Hon
- Pei-Yun Hon
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- Pei-Yun Hon
- Pei-Yun Hon
- Pei-Yun Hon
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- Phan Thi Hang
- Phisit Ouirungroj
- Phisit Ouirungroj
- Phisit Uirungroj
- Phisit Uirungroj
- Pimpaporn Klunklin
- Ping-Chin Chang
- PinRu ChangChien
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- Pitak Santanirand
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- Porntip Malathum
- Prasit Tharavichitkul
- Priya Madhavan
- Queenie W. L. Chan
- Rachel Leslie
- Radley H. C. Ching
- Rajwinder Kaur
- Rajwinder Kaur
- Ram Gopalakrishnan
- Ranganathan Jayapradha
- Rashidah Ahmad
- Rashidah Ahmad
- Ratchanee wongsaen
- Ratchanee Wongsaen
- Ratchanee Wongsaen
- Ratchanee Wongsaen
- Rathina Kumar Shanmugakani
- Razila Yacob
- Regina F. Y. Chan
- Ren Wei
- Rocio Alvarez Marin
- Roel Beltran Castillo
- Rong Liu
- Roopa Durairaj
- Rozita Bte Abu Hassan
- Ru-Hui Chao
- Rujipat Samransamruajkit
- Ryuichi Hirano
- S. K. Fong
- S. S. Lam
- Sachie Yasunaga
- Sachiko Wakai
- Sajeerat Kosol
- Samatanet Tariyo
- Samattanet Tariyo
- Samettanet Tariyo
- Samuel Abumhere Aziegbemhin
- Sangwan Paengta
- Sangwan Paengta
- Sarah Edmonds- Wilson
- Sartaj Alam
- Sasinuch Rutjanawech
- Sasithorn Sirilun
- Satoshi Shinomiya
- Saujanya Saravanakumar
- Sawalee Jansanga
- Sayeed-Bin Faisal
- Sayeed-Bin Faisal
- Seok Hoon Jeong
- Seyed Sadeq Seyed Nematian
- Seyed Sadeq Seyed Nematian
- Shaikh Mahmud Kamal Vashkar
- Shao-Xing Dong
- Sharifah Azura Salleh
- Sharina Hamzah
- Sheikh Farzana Zaman
- Sheikh Farzana Zaman
- Shen-Min Huang
- Sherly Agustinus
- Shih-Ming Tsao
- Shin Yu Chen
- Shinji Fukushima
- Shio-ShinJean
- Shirley S. Y. Lee
- Shoji Yamamoto
- Shoujun Wang
- Shu-Hua Lu
- Shu-Ju Huang
- Shu-Ju Huang
- Shu-Ju Huang
- Shu-Yuan Kuo
- Shuji Hatakeyama
- Sie Mei-Fe
- Silom Jamulitrat
- Silom Jamulitrat
- Silom Jamulitrat
- Silverose Ann A. Bacolcol
- Silverose Ann Andales Bacolcol
- Silverose Ann Bacolcol
- Sin-Man Chu
- Sireekul Petyu
- Siriluk Apivanich
- Sirilux Apivanich
- Siti Rokiah Yusof
- Soe Pyae Tun
- Somporn Somsakul
- Somporn Somsakul
- Songyos Rajborirug
- Songyos Rajborirug
- Soundararajan Sharmila
- Su Li-Hsiang
- Su Mon Thi Ha
- Su Young Kim
- Su-Fang Yu
- Su-Fang Yu
- Su-Fang Yu
- Su-Jung Chen
- Su-Jung Chen
- Su-Yin Li
- Subramanian Sreevidya
- Suchada Sukkra
- Sue Borrell
- Suet Yi Lee
- Sumawadee Skuntaniyom
- Sumawadee Skuntaniyom
- Sungwan Paengta
- Sunisa Dissayasriroj
- Surasak Saokaew
- Susylawathi Magon
- Susylawathi Magon
- Sutasinee Thana
- Sutima Plongpunth
- Sutthiphan Thanomphan
- Sutthiphan Thanomphan
- Sutthiphun thanomphan
- Sutthipun Thanompan
- Suttsiphan Thanompan
- Suvaporn Anugulruengkit
- Suwanna Trakulsomboon
- Svetlana Kolesnichenko
- Svetlana Kolesnichenko
- Syed Mohammad Niaz Mowla
- Taek Soo Kim
- Tai-Chin Hsieh
- Takaaki Yamada
- Takayuki Yamanaka
- Takehito Kobayashi
- Takuya Kodera
- Tang Ya-Fen
- Teerapat Ouirungrog
- Teerapat Ouirungrog
- Teerapat Ouirungrog
- Terrence Chinniah
- Terrence Rohan Chinniah
- Tetsuhiro Noda
- Tetsuya Matsumoto
- Tetsuya Matsumoto
- Thana Khawcharoenporn
- Thanomvong Muntajit
- ThanyaweePuthanakit
- Tharntip Sangsuwan
- Tharntip Sangsuwan
- Thiba Peremalo
- Tina See
- Todd Cartner
- Toshiko Ota
- Tran Thi My Hanh
- Tran Thi Thuy Hang
- Ttipakorn Pornmee
- Tun-chieh Chen
- Tun-chieh Chen
- Tuyet Thi Kim Nguyen
- Tze OnLi
- Tzu Hao Lien
- Tzu-Ping Shih
- Tzu-Ping Shih
- Tzu-Yin Liu
- Tzu-Yin Liu
- Ursula Jadczak
- V James De Roxas
- V. James De Roxas
- V. James De Roxas
- V. Jay De Roxas
- V. Jay De Roxas
- Vanessa Lim
- Vanessa Lim
- Vanessa Lim
- Venkatasubramanian Ramasubramanian
- Veronica Wiwing
- Vivien Puspitasari
- Wai Fong Chan
- Wan-ju Yang
- Wan-Yi Lin
- Wantana Sakolwirat
- Wantanee Malaihuan
- Warisra Jaikampun
- Wei Zhang
- WeiFang Chen
- Wen-Chi Cheng
- Wen-Chi Cheng
- Wen-Chih Wu
- Wen-Chih Wu
- Wen-Hao Tsou
- Wen-Hao Tsou
- Wendy Wai Yee Lam
- Wilawan Picheansathian
- Wilawan Picheansathian
- Wipa Vanishakije
- Wipaporn Natalie Songtaweesin
- Wison Laochareonsuk
- Woonhyoung Lee
- Woranan Boonsomsuk
- Xue Xiaoting
- Ya-Ching Tsao
- Ya-Ling Shih
- Ya-Ling Shih
- Yada Pruekrattananapa
- Yada Pruekrattananapa
- Yan Gao
- Yan-Ru Chen
- Yao Xue-hua
- Yao-Shen Tung
- Yee-Sin Leo
- Yekaterina Serbo
- Yekatherine Serbo
- Yeng May Ho
- Yerbol Tishkambayev
- Yerbol Tishkambayev
- Yi Shun Chen
- Yi-Chieh Lee
- Yi-Chun Lin
- Yi-ChunCho
- Yichun Chen
- Yin Phyu Thinn
- Yin Yin Chen
- Ying-Ling Chen
- Ying-Yun Chang
- Yoshiko Morokuma
- Yoshiro Sakai
- Youngwon Nam
- Yu Shan Huang
- Yu-Fen Chiu
- Yu-Hsiu Lin
- Yu-Hsiu Lin
- Yu-Huan Huang
- Yu-Huan Huang
- Yu-Ping Wu
- Yu-Shan Chien
- Yuan-Ti Lee
- Yuan-Ti Lee
- Yuan-Ti Lee
- Yuho Horikoshi
- Yui-Yein Yang
- Yuichi Sakamoto
- Yuka Sato
- Yuka Sato
- Yukihiro Akeda
- Yun Ji Hong
- Yunxiao Hao
- Zhang Wei
- Zhang Xia Zeng
- Zhao Xian-li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2017
- Field of study
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
- Author
- Aaltonen Lauri A.
- Abascal Federico
- Abeshouse Adam
- Aburatani Hiroyuki
- Adams David J.
- Agrawal Nishant
- Ahn Keun Soo
- Ahn Sung-Min
- Aikata Hiroshi
- Akbani Rehan
- Akdemir Kadir C.
- Akdemir Kadir C.
- Al-Ahmadie Hikmat
- Al-Sedairy Sultan T.
- Al-Shahrour Fatima
- Alawi Malik
- Albert Monique
- Aldape Kenneth
- Alexandrov Ludmil B.
- Ally Adrian
- Alsop Kathryn
- Alvarez Eva G.
- Alvarez Eva G.
- Amary Fernanda
- Amin Samirkumar B.
- Aminou Brice
- Ammerpohl Ole
- Anderson Matthew J.
- Ang Yeng
- Antonello Davide
- Anur Pavana
- Aparicio Samuel
- Appelbaum Elizabeth L.
- Arai Yasuhito
- Aretz Axel
- Arihiro Koji
- Ariizumi Shun-ichi
- Armenia Joshua
- Arnau Gisela Mir
- Arnould Laurent
- Asa Sylvia
- Assenov Yassen
- Atwal Gurnit
- Aukema Sietse
- Auman J. Todd
- Aure Miriam R. R.
- Awadalla Philip
- Aymerich Marta
- Bader Gary D.
- Baez-Ortega Adrian
- Baez-Ortega Adrian
- Bailey Matthew H.
- Bailey Peter J.
- Balasundaram Miruna
- Balu Saianand
- Bandopadhayay Pratiti
- Banks Rosamonde E.
- Barbi Stefano
- Barbour Andrew P.
- Barenboim Jonathan
- Barnholtz-Sloan Jill
- Barr Hugh
- Barrera Elisabet
- Bartlett John
- Bartolome Javier
- Bassi Claudio
- Bathe Oliver F.
- Baumhoer Daniel
- Bavi Prashant
- Baylin Stephen B.
- Bazant Wojciech
- Beardsmore Duncan
- Beck Timothy A.
- Behjati Sam
- Behren Andreas
- Bell Cindy
- Beltran Sergi
- Benz Christopher
- Berchuck Andrew
- Bergmann Anke K.
- Bergstrom Erik N.
- Berman Benjamin P.
- Berney Daniel M.
- Bernhart Stephan H.
- Beroukhim Rameen
- Beroukhim Rameen
- Berrios Mario
- Bersani Samantha
- Bertl Johanna
- Betancourt Miguel
- Bhandari Vinayak
- Bhosle Shriram G.
- Biankin Andrew V.
- Bieg Matthias
- Bigner Darell
- Binder Hans
- Birney Ewan
- Birrer Michael
- Biswas Nidhan K.
- Bjerkehagen Bodil
- Bodenheimer Tom
- Boice Lori
- Bonizzato Giada
- Boot Arnoud
- Bootwalla Moiz S.
- Borg Ake
- Borkhardt Arndt
- Boroevich Keith A.
- Borozan Ivan
- Borst Christoph
- Bosenberg Marcus
- Bosio Mattia
- Boultwood Jacqueline
- Bourque Guillaume
- Boutros Paul C.
- Boutros Paul C.
- Bova G. Steven
- Bowen David T.
- Bowlby Reanne
- Bowtell David D. L.
- Bowtell David D. L.
- Boyault Sandrine
- Boyce Rich
- Boyd Jeffrey
- Brazma Alvis
- Brennan Paul
- Brewer Daniel S.
- Brinkman Arie B.
- Bristow Robert G.
- Broaddus Russell R.
- Brock Jane E.
- Brock Malcolm
- Broeks Annegien
- Brooks Angela N.
- Brooks Denise
- Brors Benedikt
- Brors Benedikt
- Brunak Søren
- Bruxner Timothy J. C.
- Bruzos Alicia L.
- Buchanan Alex
- Buchhalter Ivo
- Buchholz Christiane
- Bullman Susan
- Burke Hazel
- Burkhardt Birgit
- Burns Kathleen H.
- Burns Kathleen H.
- Busanovich John
- Bustamante Carlos D.
- Butler Adam P.
- Butte Atul J.
- Byrne Niall J.
- Børresen-Dale Anne-Lise
- Caesar-Johnson Samantha J.
- Cafferkey Andy
- Cahill Declan
- Calabrese Claudia
- Caldas Carlos
- Calvo Fabien
- Camacho Niedzica
- Campbell Peter J.
- Campbell Peter J.
- Campo Elias
- Cantù Cinzia
- Cao Shaolong
- Carey Thomas E.
- Carlevaro-Fita Joana
- Carlsen Rebecca
- Cataldo Ivana
- Cazzola Mario
- Cebon Jonathan
- Cerfolio Robert
- Chadwick Dianne E.
- Chakravarty Dimple
- Chalmers Don
- Chan Calvin Wing Yiu
- Chan Kin
- Chan Kin
- Chan-Seng-Yue Michelle
- Chandan Vishal S.
- Chang David K.
- Chanock Stephen J.
- Chantrill Lorraine A.
- Chateigner Aurélien
- Chatterjee Nilanjan
- Chayama Kazuaki
- Chen Hsiao-Wei
- Chen Jieming
- Chen Ken
- Chen Ken
- Chen Yiwen
- Chen Zhaohong
- Cherniack Andrew D.
- Chien Jeremy
- Chiew Yoke-Eng
- Chin Suet-Feung
- Cho Juok
- Cho Sunghoon
- Choi Jung Kyoon
- Choi Wan
- Chomienne Christine
- Chong Zechen
- Choo Su Pin
- Chou Angela
- Christ Angelika N.
- Christie Elizabeth L.
- Chuah Eric
- Cibulskis Carrie
- Cibulskis Kristian
- Cingarlini Sara
- Clapham Peter
- Claviez Alexander
- Cleary Sean
- Cloonan Nicole
- Cmero Marek
- Collins Colin C.
- Connor Ashton A.
- Cooke Susanna L.
- Cooper Colin S.
- Cope Leslie
- Corbo Vincenzo
- Cordes Matthew G.
- Cordner Stephen M.
- Cortés-Ciriano Isidro
- Cortés-Ciriano Isidro
- Cortés-Ciriano Isidro
- Covington Kyle
- Cowin Prue A.
- Craft Brian
- Craft David
- Creighton Chad J.
- Cun Yupeng
- Curley Erin
- Cutcutache Ioana
- Czajka Karolina
- Czerniak Bogdan
- Dagg Rebecca A.
- Danilova Ludmila
- Davi Maria Vittoria
- Davidson Natalie R.
- Davies Helen
- Davis Ian J.
- Davis-Dusenbery Brandi N.
- Dawson Kevin J.
- De Bono Johann S.
- De La Vega Francisco M.
- De Paoli-Iseppi Ricardo
- deFazio Anna
- Defreitas Timothy
- Delaneau Olivier
- Demchok John A.
- Demeulemeester Jonas
- Demidov German M.
- Demircioğlu Deniz
- Dennis Nening M.
- Denroche Robert E.
- Dentro Stefan C.
- Desai Nikita
- Deshpande Vikram
- Deshwar Amit G.
- Desmedt Christine
- Deu-Pons Jordi
- Dhalla Noreen
- Dhani Neesha C.
- Dhingra Priyanka
- Dhir Rajiv
- Diamanti Klev
- DiBiase Anthony
- Ding Li
- Ding Shuai
- Dinh Huy Q.
- Dirix Luc
- Doddapaneni HarshaVardhan
- Donmez Nilgun
- Dow Michelle T.
- Drapkin Ronny
- Drechsel Oliver
- Drews Ruben M.
- Dudderidge Tim
- Dueso-Barroso Ana
- Dueso-Barroso Ana
- Dunford Andrew J.
- Dunford Andrew J.
- Dunn Michael
- Dursi Lewis Jonathan
- Duthie Fraser R.
- Dutton-Regester Ken
- Eagles Jenna
- Easton Douglas F.
- Edmonds Stuart
- Edwards Paul A.
- Edwards Paul A.
- Edwards Sandra E.
- Eeles Rosalind A.
- Ehinger Anna
- Eils Juergen
- Eils Roland
- El-Naggar Adel
- Eldridge Matthew
- Ellrott Kyle
- Erkek Serap
- Escaramis Georgia
- Espiritu Shadrielle M. G.
- Estivill Xavier
- Estivill Xavier
- Etemadmoghadam Dariush
- Etemadmoghadam Dariush
- Eyfjord Jorunn E.
- Faltas Bishoy M.
- Fan Daiming
- Fan Yu
- Faquin William C.
- Farcas Claudiu
- Fassan Matteo
- Fatima Aquila
- Favero Francesco
- Fayzullaev Nodirjon
- Felau Ina
- Fereday Sian
- Ferguson Martin L.
- Ferretti Vincent
- Feuerbach Lars
- Feuerbach Lars
- Field Matthew A.
- Fink J. Lynn
- Fink J. Lynn
- Finocchiaro Gaetano
- Fisher Cyril
- Fittall Matthew W.
- Fitzgerald Anna
- Fitzgerald Rebecca C.
- Flanagan Adrienne M.
- Fleshner Neil E.
- Flicek Paul
- Foekens John A.
- Fong Kwun M.
- Fonseca Nuno A.
- Foster Christopher S.
- Fox Natalie S.
- Fraser Michael
- Frazer Scott
- Frenkel-Morgenstern Milana
- Frenkel-Morgenstern Milana
- Friedman William
- Frigola Joan
- Fronick Catrina C.
- Fujimoto Akihiro
- Fujita Masashi
- Fukayama Masashi
- Fulton Lucinda A.
- Fulton Robert S.
- Furuta Mayuko
- Futreal P. Andrew
- Füllgrabe Anja
- Gabriel Stacey B.
- Gallinger Steven
- Gambacorti-Passerini Carlo
- Gao Jianjiong
- Gao Shengjie
- Garraway Levi
- Garred Øystein
- Garrison Erik
- Garsed Dale W.
- Garsed Dale W.
- Gehlenborg Nils
- Gelpi Josep L. L.
- George Joshy
- Gerhard Daniela S.
- Gerhauser Clarissa
- Gershenwald Jeffrey E.
- Gerstein Mark
- Gerstein Mark
- Gerstung Moritz
- Getz Gad
- Ghori Mohammed
- Ghossein Ronald
- Giama Nasra H.
- Gibbs Richard A.
- Gibson Bob
- Gill Anthony J.
- Gill Pelvender
- Giri Dilip D.
- Glodzik Dominik
- Gnanapragasam Vincent J.
- Goebler Maria Elisabeth
- Goldman Mary J.
- Gomez Carmen
- Gonzalez Santiago
- Gonzalez-Perez Abel
- Gordenin Dmitry
- Gordenin Dmitry A.
- Gordenin Dmitry A.
- Gossage James
- Gotoh Kunihito
- Govindan Ramaswamy
- Göke Jonathan
- Grabau Dorthe
- Graham Janet S.
- Grant Robert C.
- Green Anthony R.
- Green Eric
- Greger Liliana
- Grehan Nicola
- Grimaldi Sonia
- Grimmond Sean M.
- Grossman Robert L.
- Grundhoff Adam
- Gundem Gunes
- Guo Qianyun
- Gupta Manaswi
- Gupta Shailja
- Gut Ivo G.
- Gut Marta
- Ha Gavin
- Haake Andrea
- Haan David
- Haan David
- Haas Siegfried
- Haase Kerstin
- Haber James E.
- Haber James E.
- Habermann Nina
- Hach Faraz
- Haider Syed
- Hama Natsuko
- Hamdy Freddie C.
- Hamilton Anne
- Hamilton Mark P.
- Han Leng
- Hanna George B.
- Hansmann Martin
- Haradhvala Nicholas J.
- Harismendy Olivier
- Harliwong Ivon
- Harmanci Arif O.
- Harrington Eoghan
- Hasegawa Takanori
- Haussler David
- Hawkins Steve
- Hayami Shinya
- Hayashi Shuto
- Hayes D. Neil
- Hayes Stephen J.
- Hayward Nicholas K.
- Hazell Steven
- He Yao
- Heath Allison P.
- Heath Simon C.
- Hedley David
- Hegde Apurva M.
- Heiman David I.
- Heinold Michael C.
- Heins Zachary
- Heisler Lawrence E.
- Hellstrom-Lindberg Eva
- Helmy Mohamed
- Heo Seong Gu
- Hepperla Austin J.
- Heredia-Genestar José María
- Herrmann Carl
- Hersey Peter
- Hess Julian M.
- Hess Julian M.
- Hilmarsdottir Holmfridur
- Hinton Jonathan
- Hirano Satoshi
- Hiraoka Nobuyoshi
- Hoadley Katherine A.
- Hobolth Asger
- Hodzic Ermin
- Hoell Jessica I.
- Hoffmann Steve
- Hofmann Oliver
- Holbrook Andrea
- Holik Aliaksei Z.
- Hollingsworth Michael A.
- Holmes Oliver
- Holt Robert A.
- Hong Chen
- Hong Eun Pyo
- Hong Jongwhi H.
- Hooijer Gerrit K.
- Hornshøj Henrik
- Hosoda Fumie
- Hou Yong
- Hovestadt Volker
- Howat William
- Hoyle Alan P.
- Hruban Ralph H.
- Hu Jianhong
- Hu Taobo
- Hua Xing
- Huang Kuan-lin
- Huang Mei
- Huang Mi Ni
- Huang Vincent
- Huang Yi
- Huber Wolfgang
- Hudson Thomas J.
- Hummel Michael
- Hung Jillian A.
- Huntsman David
- Hupp Ted R.
- Huse Jason
- Huska Matthew R.
- Hutter Barbara
- Hutter Barbara
- Hutter Carolyn M.
- Hübschmann Daniel
- Iacobuzio-Donahue Christine A.
- Imbusch Charles David
- Imielinski Marcin
- Imielinski Marcin
- Imoto Seiya
- Isaacs William B.
- Isaev Keren
- Ishikawa Shumpei
- Iskar Murat
- Islam S. M. Ashiqul
- Ittmann Michael
- Ivkovic Sinisa
- Izarzugaza Jose M. G.
- Jacquemier Jocelyne
- Jain Dhawal
- Jakrot Valerie
- Jamieson Nigel B.
- Jan Komorowski null
- Jang Gun Ho
- Jang Se Jin
- Jayaseelan Joy C.
- Jayasinghe Reyka
- Jäger Natalie
- Jefferys Stuart R.
- Jegalian Karine
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- Zhang Jing
- Zhang Junjun
- Zhang Xiuqing
- Zhang Xuanping
- Zhang Yan
- Zhang Zemin
- Zhao Zhongming
- Zheng Liangtao
- Zheng Xiuqing
- Zhou Wanding
- Zhou Yong
- Zhu Bin
- Zhu Hongtu
- Zhu Jingchun
- Zhu Shida
- Zou Lihua
- Zou Xueqing
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50% in several cancer types. Whereas canonical chromothripsis profiles display oscillations between two copy-number states, a considerable fraction of events involve multiple chromosomes and additional structural alterations. In addition to non-homologous end joining, we detect signatures of replication-associated processes and templated insertions. Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. These findings show that chromothripsis is a major process that drives genome evolution in human cancer