Planning for Space Station Freedom laboratory payload integration

Space Station Freedom is being developed to support extensive missions involving microgravity research and applications. Requirements for on-orbit payload integration and the simultaneous payload integration of multiple mission increments will provide the stimulus to develop new streamlined integration procedures in order to take advantage of the increased capabilities offered by Freedom. The United States Laboratory and its user accommodations are described. The process of integrating users' experiments and equipment into the United States Laboratory and the Pressurized Logistics Modules is described. This process includes the strategic and tactical phases of Space Station utilization planning. The support that the Work Package 01 Utilization office will provide to the users and hardware developers, in the form of Experiment Integration Engineers, early accommodation assessments, and physical integration of experiment equipment, is described. Plans for integrated payload analytical integration are also described

Neptune Polar Orbiter with Probes

The giant planets of the outer solar system divide into two distinct classes: the gas giants Jupiter and Saturn, which consist mainly of hydrogen and helium; and the ice giants Uranus and Neptune, which are believed to contain significant amounts of the heavier elements oxygen, nitrogen, and carbon and sulfur. Detailed comparisons of the internal structures and compositions of the gas giants with those of the ice giants will yield valuable insights into the processes that formed the solar system and, perhaps, other planetary systems. By 2012, Galileo, Cassini and possibly a Jupiter Orbiter mission with microwave radiometers, Juno, in the New Frontiers program, will have yielded significant information on the chemical and physical properties of Jupiter and Saturn. A Neptune Orbiter with Probes (NOP) mission would deliver the corresponding key data for an ice giant planet. Such a mission would ideally study the deep Neptune atmosphere to pressures approaching and possibly exceeding 1000 bars, as well as the rings, Triton, Nereid, and Neptune s other icy satellites. A potential source of power would be nuclear electric propulsion (NEP). Such an ambitious mission requires that a number of technical issues be investigated, however, including: (1) atmospheric entry probe thermal protection system (TPS) design, (2) probe structural design including seals, windows, penetrations and pressure vessel, (3) digital, RF subsystem, and overall communication link design for long term operation in the very extreme environment of Neptune's deep atmosphere, (4) trajectory design allowing probe release on a trajectory to impact Neptune while allowing the spacecraft to achieve a polar orbit of Neptune, (5) and finally the suite of science instruments enabled by the probe technology to explore the depths of the Neptune atmosphere. Another driving factor in the design of the Orbiter and Probes is the necessity to maintain a fully operational flight system during the lengthy transit time from launch through Neptune encounter, and throughout the mission. Following our response to the recent NASA Research Announcement (NRA) for Space Science Vision Missions for mission studies by NASA for implementation in the 2013 or later time frame, our team has been selected to explore the feasibility of such a Neptune mission

The Effects of Prophylactic Cyclosporin A on Experimental Allergic Neuritis (EAN) in the Lewis Rat: Induction of Relapsing EAN Using Low Dose Cyclosporin A

Experimental allergic neuritis (EAN) was induced in Lewis rats by inoculation with bovine intradural root myelin plus adjuvants. Animals treated with high dose (30 mg/kg) cyclosporin A (CsA) 3 times per week did not develop clinical EAN during the period of CsA treatment, but had an episode of EAN after cessation of CsA treatment. Animals treated with low dose (4 mg/kg) CsA 3 times per week developed EAN during the period of treatment, and after cessation of CsA treatment all of these animals developed relapsing EAN with disease continuing for up to four episodes. In contrast, 30-40% of untreated animals had a mild second episode of EAN but no further attacks. Histological studies performed in treated and untreated animals at the time of clinical episodes revealed inflammation and demyelination in the spinal roots and dorsal root ganglia. When animals were challenged with a second inoculation at age 7 months, one of 15 untreated control animals but none of the CsA treated animals developed an episode of EAN

Site Selection and Deployment Scenarios for Servicing of Deep-Space Observatories

The deep-space environment and relative transportation accessibility of the Weak Stability Boundary (WSB) region connecting the Earth-Moon and Sun-Earth libration points makes the Sun-Earth L2 an attractive operating location for future observatories. A summary is presented of key characteristics of future observatories designed to operate in this region. The ability to service observatories that operate within the region around the Lagrange points may greatly enhance their reliability, lifetime, and scientific return. The range of servicing missions might begin with initial deployment, assembly, test, and checkout. Post-assembly servicing missions might also include maintenance and repair, critical fluids resupply, and instrument upgrades. We define the range of servicing missions that can be performed with extravehicular activity, with teleoperated robots, and with autonomous robots. We then describe deployment scenarios that affect payload design. A trade study is summarized of the benefits and risks of alternative servicing sites, including at the International Space Station, at other low-Earth-orbit locations, at the Earth-Moon L1 location, and on-site at the Sun-Earth L2 location. Required technology trades and development issues for observatory servicing at each site, and with each level of autonomy, are summarized

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

Background Rosiglitazone is a thiazolidinedione that reduces insulin resistance and might preserve insulin secretion. The aim of this study was to assess prospectively the drugs ability to prevent type 2 diabetes in individuals at high risk of developing the condition